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US20090306016 |
FATTY ACID AMIDE HYDROLASE INHIBITORS
Disclosed are compounds of formula R—X—Y that may be used to inhibit the action of fatty acid amide hydrolase (FAAH). Inhibition of fatty acid amide hydrolase (FAAH) will slow the normal...
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US20090298894 |
AMINO ACID COMPOUNDS
[Problem] To provide novel compounds that are S1P1 receptor agonists and exhibit an immunosuppressive activities by inducing lymphocyte sequestration in secondary lymphoid tissues. In addition, to...
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US20090298871 |
SULFONYL-PHENYL-2H-[1,2,4]OXADIAZOL-5-ONE DERIVATIVES , PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
The invention relates to sulfonyl-phenyl-oxadiazolones and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARgamma agonist...
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US20090298811 |
BENZIMIDAZOLONE DERIVATIVES
This invention relates to compounds and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a...
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US20090291991 |
ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE
Novel isoindoline compounds are disclosed. Methods of treating, preventing and/or managing cancer, diseases and disorders associated with, or characterized by, undesired angiogenesis, and diseases...
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US20090291990 |
OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS
Oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutically acceptable salts thereof, compositions comprising oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof...
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US20090291967 |
SMALL MOLECULE MODULATORS OF CELL ADHESION
Compounds, particularly compounds having activity as modulators of cadherin-mediated cell adhesion having the following structure:
or a pharmaceutically acceptable salt, stereoisomer or prodrug...
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US20090291965 |
Histone Deacetylase Inhibitors With Aryl-Pyrazolyl-Motifs
The present invention relates to a novel class of histone deacetylase inhibitors with aryl-pyrazolyl motifs. The compounds of this invention can be used to treat cancer. The compounds of this...
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US20090286837 |
Oxadiazole compounds as urokinase inhibitors
The present invention relates to novel compounds which inhibit urokinase-plasminogen activator (uPA), have a high bioavailability and can be administered orally, and to their use as therapeutic...
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US20090281084 |
PHENYL-1,2,4-OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
The invention relates to phenyl-1,2,4-oxadiazolone derivatives with phenyl group and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist...
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US20090275621 |
1, 3, 4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS AND THEIR USE THEREOF
The present invention is directed to 1,3,4-oxadiazalones, compounds of formula I and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. Novel compounds include...
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US20090275620 |
SUBSTITUTED 5- PHENYLAMINO- 1, 3, 4-OXADIAZOL-2-YLCARBONYLAMINO-4-PHENOXY-CYCLOHEXANE CARBOXYLIC ACID AS INHIBITORS OF ACETYL COENZYME A DIACYLGLYCEROL ACYLTRANSFERASE
Compounds of formula (I), or salts thereof, which inhibit acetyl CoA (acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided,
wherein R 1 , R 2 and R 3 are each...
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US20090270464 |
Benzimidazole derivative and use as a II receptor antagonist
The present invention relates to a compound represented by the formula (I)
wherein R 1 is a group represented by the formula
wherein R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each...
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US20090270463 |
AMIDO DERIVATIVES-CONTAINED PHARMACEUTICAL COMPOSITION
The present invention relates to a pharmaceutical composition containing a solid dispersion comprising an amide derivative or a salt thereof and a water-soluble polymer, wherein the pharmaceutical...
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US20090264482 |
CHEMICAL COMPOUNDS
This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
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US20090264481 |
Compounds, Compositions and Methods Comprising Oxadiazole Derivatives
The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance...
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US20090258913 |
Triazole Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1
Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as...
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US20090258891 |
Macrocyclic Compounds As Antiviral Agents
The present invention relates to macrocyclic compounds of formula (I): wherein W, n, R 1 , R a , R b , R 3 , R 4 , M, Z, ring A and ring B are defined herein, and pharmaceutically acceptable salts...
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US20090258868 |
HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS
Disclosed are compounds of the formula I
or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein
W is a bond, —C(═S)—, —S(O)—, —S(O) 2...
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US20090253761 |
BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY
Benzocycloheptyl analogs that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs, which, after phosphorylation, can behave as agonists at...
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US20090253760 |
HYDRINDANE ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONIST ACTIVITY
Hydrindane analogs that have agonist activity at one or more of the S 1 P receptors are provided. The compounds are sphingosine analogs, which, after phosphorylation, can behave as agonists at S 1...
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US20090253759 |
TETRALIN ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE AGONIST ACTIVITY
Tetralin analogs that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs, which, after phosphorylation, can behave as agonists at S1P...
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US20090253758 |
Selective androgen receptor modulators
This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, and or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, Ie, and a...
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US20090253699 |
Compounds for Nonsense Suppression, and Methods for Their Use
The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or...
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US20090253676 |
Heteroaryl Benzamide Derivatives for Use as GLK Activators in the Treatment of Diabetes
Compounds of Formula (I):
wherein:
R 1 is hydroxymethyl; R 2 is selected from —C(O)NR 4 R 5 , —SO 2 NR 4 R 5 , —S(O) p R 4 and HET-2; HET-1 is a 5- or 6-membered, optionally...
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US20090253673 |
Substituted Pyrazoles as Ghrelin Receptor Antagonists
Certain novel N-acylated spiropiperidine derivatives are ligands of the human ghrelin receptor(s) and, in particular, are antagonists/inverse agonists of the human ghrelin receptor. They are...
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US20090247591 |
SUBSTITUTED CYCLOHEXYLDIAMINES
The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these...
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US20090239915 |
Substituted 2-phenyl-benzimidazoles and their use as pharmaceuticals
The present invention relates to derivatives of 2-phenyl-benzimidazoles of the formula I,
in which X, R, R1 to R3 and n have the meanings indicated in the claims, which modulate the...
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US20090239909 |
TREATMENT OF METABOLIC SYNDROME WITH LACTAMS
The present invention relates to the treatment of metabolic syndrome or disorders associated with metabolic syndrome comprising administering a compound of the invention.
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US20090238771 |
PHARMACEUTICAL FORMULATIONS
An aspect of the present invention provides for a medicament including a solution containing pleconaril or a pharmaceutically acceptable salt thereof, wherein at least one solvent comprising said...
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US20090232780 |
COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION
This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a...
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US20090227642 |
NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION
The present invention provides a method for the treatment of head trauma, traumatic brain injury, and/or dementia pugilistica comprising administering a therapeutically effective amount of...
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US20090227641 |
CYCLOALKYLAMINO ACID DERIVATIVES
The invention relates to compounds of formula I
and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof. This invention also relates to a method of using such compounds...
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US20090227640 |
Heterocyclic compounds with carboxyl isostere groups and their use for the treatment of cardiovascular diseases
The present application relates to novel heterocyclic compounds, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments...
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US20090227638 |
Novel Pharmaceutical Compounds
The instant invention provides compounds of Formula (Ia) which are leukotriene biosynthesis inhibitors, wherein X is O or S, Y is O, S, —NR 6 —CHR 7 — or —NR 8 —C(O)— and A is selected...
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US20090221564 |
Heterocyclic Compounds and Their Use in the Treatment of Cardiovascular Disease
Heterocyclic compounds of the formula (I) are provided: wherein ring A, ring B, R 1 , R 2 , R 3 , R 4 , Y, m, n and q are as identified herein. R 1 is in particular amidino. The invention further...
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US20090221541 |
PHARMACEUTICAL FORMULATIONS
An aspect of the present invention provides for a medicament suitable for administration as a nasal inhalant including an aqueous carrier and suspended therein particulate pleconaril, the aqueous...
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US20090215839 |
SYDNONIMINES-SPECIFIC DOPAMINE REUPTAKE INHIBITORS AND THEIR USE IN TREATING DOPAMINE RELATED DISORDERS
Derivatives of Sydnonimine and its analogues, which bind selectively to dopamine transporter (DAT) proteins are useful for treating and delaying the progression of disorders and illnesses that are...
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US20090215779 |
OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS
Compounds of Formula (I):
wherein R 1 -R 2 , W and Y are as described in the specification,
and their salts and pro-drugs, are inhibitors of DGAT and are thereby useful in the treatment of,...
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US20090209533 |
ALDH-2 INHIBITORS IN THE TREATMENT OF ADDICTION
Disclosed are novel isoflavone derivatives having the structure of Formula I
which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example...
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US20090203752 |
COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE
The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or...
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US20090197926 |
BENZIMIDAZOLES AND THEIR USE FOR THE TREATMENT OF DIABETES
Compounds of formula (I), or salts thereof, which inhibit acetyl CoA (acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided,
wherein: R 1 is selected from optionally...
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US20090192158 |
Methods for Treating or Preventing Neoplasias
The present invention is directed to a method for treating or preventing a neoplasia in a human patient in need of such treatment comprising administering to the patient a compound that inhibits...
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US20090186909 |
Oxadiazolidinedione Compound
[Problem] A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the...
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US20090186891 |
ORGANIC COMPOUNDS
The present invention provides compounds of the following structure;
A-Q-B—C-D
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US20090182021 |
Tricyclic Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
The present invention is directed to tricyclic compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is...
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US20090182007 |
ORGANIC COMPOUNDS
The present invention provides a compound of formula (I):
said compound is inhibitor of aldosterone synthase, and thus can be employed for the treatment of a disorder or disease mediated by...
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US20090181965 |
MODULATORS FOR AMYLOID BETA
The invention relates to compounds of formula
wherein R 1 , R 2 , R 3 , R 4 , X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can be used...
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US20090170842 |
BRCA1-BASED BREAST OR OVARIAN CANCER PREVENTION AGENTS AND METHODS OF USE
A pharmaceutical composition for use in treating, inhibiting, and/or preventing breast and/or ovarian cancer can include: a molecule having a structure of one of Compounds 1-38, pharmaceutically...
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US20090163549 |
Pharmaceutical Composition Comprising an Amide Derivative
The present invention provides a novel modulator of the TRPV1-receptor function, comprising a compound of the formula; wherein ring A is an optionally substituted carbocycle or heterocycle, ring B...
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