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US20090312374 |
DERIVATIVES OF 4,6-DISUBSTITUTED 1,2,4-TRIAZOLO- 1,3,4-THIADIAZOLE, A PROCESS AND USES THEREOF
The present invention is in relation to the derivatives of 4,6-disubstituted 1,2,4-triazolo-1,3,4-thiadiazole and a process to synthesize the said derivatives. Also, the present invention was able...
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US20090298836 |
Thiadiazole modulators of PKB
The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the...
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US20090253699 |
Compounds for Nonsense Suppression, and Methods for Their Use
The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or...
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US20090253758 |
Selective androgen receptor modulators
This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, and or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, Ie, and a...
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US20090247500 |
NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS
Disclosed herein are compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 25a , R 26a , X, and n are as defined in the specification. Pharmaceutical compositions comprising such compounds, and...
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US20090227639 |
HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
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US20090227638 |
Novel Pharmaceutical Compounds
The instant invention provides compounds of Formula (Ia) which are leukotriene biosynthesis inhibitors, wherein X is O or S, Y is O, S, —NR 6 —CHR 7 — or —NR 8 —C(O)— and A is selected...
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US20090181943 |
Inhibitors of Histone Deacetylase
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I)
and N-oxides,...
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US20090170845 |
USE OF IMIDAZO[2,1-b]-1,3,4-THIADIAZOLE-2-SULFONAMIDE COMPOUNDS TO TREAT NEUROPATHIC PAIN
Disclosed herein are methods and compositions for treating and/or prophylaxis of neuropathic pain in a subject. The methods comprise administering to the subject suffering from neuropathic pain, a...
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US20090136473 |
BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS
The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial...
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US20090131490 |
METHODS OF TREATING PULMONARY DISEASE USING ACETAZOLAMIDE AND STRUCTURALLY RELATED DERIVATIVES
The present invention is directed to a method of treating a subject for a pulmonary disease by administering a therapeutically effective amount of a compound of the formula:
wherein R 1 , R 2 ...
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US20090118286 |
Heterobicyclic Acrylamides
Use of heterobicyclic acrylamides of the formula (I)
in which A 1 , A 2 , R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description,
for controlling pests, novel heterobicyclic...
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US20090105240 |
Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same
The present disclosure relates to methods for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome and acute myelogenous leukemia. The present disclosure further relates...
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US20090105306 |
NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS
The present invention relates compounds of formula (I)
wherein A and R 1 are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating...
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US20090099233 |
HETEROARYL AMIDES USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of...
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US20090093527 |
Azacyclopentane Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
Azacyclopentane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The...
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US20090060874 |
BICYCLIC PYRROLIDINE DERIVATIVES
The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which inhibit RNA-containing virus, particularly the hepatitis C...
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US20090062286 |
Crystal Structure of SMYD3 Protein
The invention relates to SMYD3 methyltransferase (SMYD3), SMYD3 binding pockets or SMYD3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the...
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US20090054494 |
N-[1,3,4]-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR THEIR THERAPEUTIC USE
The present invention comprises N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, their physiologically acceptable salts and functional derivatives that exhibit peroxisome proliferator activated...
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US20090048228 |
Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors
The present invention relates to compounds of formula I:
or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the...
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US20090042953 |
IMIDAZO [2,1,-b]-1,3,4-THIADIAZOLE SULFONAMIDES
This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous...
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US20090012131 |
4-OXY-N-[1,3,4]-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR THERAPEUTIC USE
The present invention comprises 4-Oxy-N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, the derivatives thereof and salts thereof as well as processes for their preparation and methods for their use...
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US20080312163 |
Treatment of pulmonary hypertension with carbonic anhydrase inhibitors
This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating...
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US20080299176 |
DRUG DELIVERY DEVICE COMPRISING CROSSLINKED POLYURETHANE-SILOXANE-CONTAINING COPOLYMERS
A drug delivery device for placement in the eye includes a drug core comprising a hydrophobic pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material...
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US20080280959 |
CYCLIC N-[1,3,4]-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THE THERAPEUTIC USE THEREOF
The present invention comprises cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, their functional derivatives as well as their physiologically acceptable salts and pharmaceutical compositions...
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US20080280915 |
Insecticidal n-substituted (heteroaryl)alkyl sulfilimines
N-Substituted (heteroaryl)alkyl sulfilimines are effective at controlling insects.
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US20080280875 |
FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS
The present invention relates to a compound of formula (I):
or a pharmaceutically acceptable salt or solvate thereof, wherein:
Ring A is (4-12)-membered heterocyclyl; Ring B is a fused...
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US20080260643 |
USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS
A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a...
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US20080261931 |
Method and Means of Preventing and Treating Sleep Disordered Breathing
A method of treating or preventing snoring, obstructive sleep apnea (OSA) and/or central sleep apnea (CSA) comprises administering a pharmacologically effective amount a salt of acetylhomotaurine...
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US20080253960 |
Lipoprotein-Based Nanoplatforms
The present invention provides a non-naturally occurring lipoprotein nanoplatform (“LBNP”) comprising at least one cell surface receptor ligand; at least one lipoprotein; and at least one...
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US20080255123 |
NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS
The present invention relates to compounds of formula (I)
wherein A, E, L 2 , R 1 , R 3 , R 4 and R 5 are as defined in the herein, compositions comprising such compounds, and methods of...
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US20080249093 |
(3,4-Disubstituted)Propanoic Carboxylates as Sip (Edg) Receptor Agonists
The present invention encompasses compounds of Formula I:
as well as the pharmaceutically acceptable salts thereof. The compounds are S1P 1 /Edg1 receptor agonists and thus have...
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US20080234233 |
MEDICAMENT FOR TREATMENT OF NEURODEGENERATIVE DISEASES
A medicament for preventive and/or therapeutic treatment of neurodegenerative diseases such as Alzheimer's disease or the like which comprises as an active ingredient a substance selected from the...
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US20080214547 |
METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS
This invention describes a series of methods and compositions for prevention and treatment of diseases such as cancer. One aspect of the invention describes small molecule-based drugs that can be...
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US20080207706 |
THIADIAZOLINE DERIVATIVE
(wherein R 1 and R 4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or...
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US20080207705 |
Heteroaryl-Imidazole Derivatives as Cannabinoid CB1 Receptor Antagonists
A novel heteroaryl-imidazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB 1 receptor inverse agonist or antagonist, which is useful for...
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US20080207636 |
Compounds Effecting Glucokinase
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R 1 , R 2 , R 3 , n and m are as described in the specification, in the preparation of a...
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US20080207704 |
HETEROARYL-IMIDAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS
A heteroaryl-imidazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB 1 receptor inverse agonist or antagonist, which is useful for...
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US20080200371 |
THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES
Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit...
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US20080176899 |
Modulators of ATP-Binding Cassette transporters
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”),...
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US20080159955 |
CA IX-Specific Inhibitors
Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds,...
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US20080146445 |
Nematicidal Compositions
The present invention concerns nematicidal compounds, their formulation as nematicidal composition and their use for controlling nematodes, preferably plant parasitic nematodes.
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US20080146625 |
Oxime glucokinase activators
Disclosed herein are pyrazole glucokinase activators of the formula (I):
that are useful for the treatment of metabolic diseases and disorders.
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US20080132551 |
Positive allosteric modulators of the nicotinic acetylcholine receptor
The invention provides compounds of Formula I:
wherein A, B, and X are described herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric...
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US20080125469 |
Thiadiazole compounds and methods of use thereof
The present invention relates to Thiadiazole Compounds; compositions comprising an effective dose of a Thiadiazole Compound; and methods treating or preventing a metalloproteinase-related disorder,...
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US20080096874 |
Oxadiazole Derivative as Dgat Inhibitors
Compounds of formula (I), and salts and pro-drugs thereof: Formula (I) wherein for example R 1 is optionally substituted aryl or heteroaryl; Y is a linking group selected from, for example, a...
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US20080081812 |
Heteroaryl-Pyrazole Derivatives as Cannabinoid CB1 Receptor Antagonists
A heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB 1 receptor inverse agonist or antagonist, which is useful for...
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US20080081822 |
Compounds which Modulate the CB2 Receptor
Compounds of formula (I)
are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating...
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US20080076741 |
ENHANCEMENT OF TIGECYCLINE POTENCY USING EFFLUX PUMP INHIBITORS
Disclosed herein are Efflux Pump Inhibitor (EPI) compounds that can be co-administered with antimicrobial agents for the treatment of infections caused by drug resistant pathogens. The EPI...
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US20080064732 |
Substituted 4-hetarylpyrazolines
The present invention relates to novel substituted pyrazolines of the formula (I)
in which R 1 , R 2 , R 3 and R 4 are as defined in the disclosure, to a plurality of processes for...
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