Matches 201 - 250 out of 352 < 1 2 3 4 5 6 7 8 >

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US20080125469 Thiadiazole compounds and methods of use thereof  
The present invention relates to Thiadiazole Compounds; compositions comprising an effective dose of a Thiadiazole Compound; and methods treating or preventing a metalloproteinase-related...
US20100069349 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS  
Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating...
US20100041721 SELECTIVE ANDROGEN RECEPTOR MODULATORS  
This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, Ie, If or Ig and a...
US20150218175 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS  
The present invention provides a compound of Formula (X) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The...
US20140206661 THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS  
The present invention provides a compound of Formula (X) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The...
US20140148489 2-Oxo-1-Imidazolidinyl Imidazothiadiazole Derivatives  
The present invention relates to 2-oxo-1-imidazolidinyl imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
US20120245208 2-Oxo-1-Pyrrolidinyl Imidazothiadiazole Derivatives  
The present invention relates to 2-oxo-1-pyrrolidine imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
US20120189670 PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME  
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
US20140187553 Azole Compounds as PIM Inhibitors  
The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3...
US20090247500 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS  
Disclosed herein are compounds of formula (I) wherein R1, R2, R3, R25a, R26a, X, and n are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods of...
US20130274256 NOVEL INHIBITORS OF BACTERIAL BIOFILMS AND RELATED METHODS  
Certain multi-cyclic compounds and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and...
US20120077806 Deubiquitinase Inhibitors and Methods for Use of the Same  
Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation,...
US20090048228 Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors  
The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present...
US20080260643 USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS  
A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a...
US20140107057 PESTICIDAL MIXTURES INCLUDING ISOXAZOLINE DERIVATIVES  
The present invention provides a combination product comprising a component A and a component B, wherein component A is a compound of formula (I) wherein A1, A2, L, p, R1, R2, R3, R4 and R5 are as...
US20100311759 ANTIPARASITIC AGENT FOR FISH AND METHOD OF CONTROLLING PROLIFERATION OF FISH PARASITES  
An antiparasitic agent for fish containing an inhibitor of folate synthesis and/or an inhibitor of folate activation as the active substance(s). A combination preparation composed of an inhibitor...
US20100249129 COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS  
Disclosed herein are compounds of formula (I) wherein Ring A and R1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions...
US20130109656 MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF  
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the...
US20120270803 Mitotic Kinesin Inhibitors and Methods of Use Thereof  
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the...
US20100331283 Mitotic kinesin inhibitors and methods of use thereof  
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the...
US20150218171 HIGHLY SELECTIVE C-MET INHIBITORS AS ANTICANCER AGENTS  
Disclosed are novel nitrogen-containing, heterocyclic, c-Met inhibitor compounds, processes for their preparation and formulations thereof. The compounds are useful as therapeutical agents for the...
US20120101103 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES  
Compounds of Formula I: (I) in which A, A1, R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treatment...
US20080064732 Substituted 4-hetarylpyrazolines  
The present invention relates to novel substituted pyrazolines of the formula (I) in which R1, R2, R3 and R4 are as defined in the disclosure, to a plurality of processes for preparing these...
US20120077847 ALPHA-KETOAMIDE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS  
The present invention is directed to α-ketoamide derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial...
US20150038416 NOVEL GLP-1 RECEPTOR MODULATORS  
The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds...
US20100184794 FUSED HETEROCYCLIC COMPOUND  
The present invention aims to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like, and the like. A...
US20100076014 MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF  
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, and/or AP-1, and/or NF-κB activity including...
US20080255123 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS  
The present invention relates to compounds of formula (I) wherein A, E, L2, R1, R3, R4 and R5 are as defined in the herein, compositions comprising such compounds, and methods of treating...
US20090054494 N-[1,3,4]-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR THEIR THERAPEUTIC USE  
The present invention comprises N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, their physiologically acceptable salts and functional derivatives that exhibit peroxisome proliferator activated...
US20120225878 COMPOUNDS  
The present invention relates to substituted triazole compounds of the formula (I): and salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the...
US20110028447 INDAZOLE DERIVATIVES  
This invention relates to compounds, pharmaceutical compositions and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which...
US20130345220 COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS  
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity...
US20120214812 COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS  
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity...
US20130109643 METABOLIC INHIBITOR AGAINST TUMORS HAVING AN IDH MUTATION  
Methods for treating a cancer having a mutant isocitrate dehydrogenase (IDH), including, but not limited to, a malignant low-grade glioma, a secondary glioblastoma, a transforming...
US20090326011 AZAB I CYCLO [3 . 1 . 0] HEXANE DERIVATIVES AS DOPAMIN D3 RECEPTOR MODULATORS  
Disclosed herein are compounds of formula (I) where G and Q are heteroaromatic groups. These compounds are useful for treating psychosis or a psychotic condition, substance abuse, premature...
US20110311485 1,2,4-OXADIAZOLE DERIVATIVES AND THEIR THERAPEUTIC USE  
The present disclosure relates to 1, 2, 4 oxadiazole derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the S1P1 receptors.
US20130085168 GAMMA-GLUTAMYL TRANSPEPTIDASE INHIBITORS AND METHODS OF USE  
Compositions and methods for inhibiting human gamma-glutamyl transpeptidase (GGT) in vivo or in vitro and for inhibiting and killing neoplastic cancer cells, for example for the treatment,...
US20110015158 METALLOENZYME INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES  
The presently disclosed subject matter is described to metalloenzyme inhibitors having metal binding moieties linked to a targeting moiety through a linking group or a direct bond, method of...
US20110059953 COMPOUNDS FOR USE IN STABILIZING P53 MUTANTS  
Compounds of formula (I): wherein X is selected from CRX and N; RN1 is selected from H and C1-4 alkyl, which may be substituted by SH or halo; RG1 is selected from H and SH; RC2 is selected from H...
US20110275617 OPHTHALMIC COMPOSITION  
The present invention provides an ophthalmic composition comprising a hyperbranched polymer. The ophthalmic compositions may also comprise carbonic anhydrase inhibitors, wherein the hyperbranched...
US20150202186 CYSTATHIONINE-(gamma)-LYASE (CSE) INHIBITORS FOR TREATING PAIN  
Described herein are methods for treating chemotherapy-induced peripheral neuropathy, or human immunodeficiency virus-associated sensory neuropathy, or symptoms thereof, comprising administering...
US20100168189 THERAPEUTIC SUBSTITUTED LACTAMS  
Therapeutic compounds, compositions, methods, and medicaments related thereto are disclosed herein.
US20080299176 DRUG DELIVERY DEVICE COMPRISING CROSSLINKED POLYURETHANE-SILOXANE-CONTAINING COPOLYMERS  
A drug delivery device for placement in the eye includes a drug core comprising a hydrophobic pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material...
US20080280875 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS  
The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl;Ring B is a fused benzene ring...
US20150166563 CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS  
The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also...
US20130289058 CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS  
The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also...
US20100249071 Modulators of S1P and Methods of Making And Using  
The invention is directed to Compounds of Formula I: as well as methods of making and using the compounds.
US20140088082 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS  
Disclosed are inhibitors of the plasmodial surface anion channel (PSAC) inhibitors and the use thereof in treating or preventing malaria in an animal such as a human, comprising administering an...
US20140080825 Modulators of ATP-binding cassette transporters  
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions...
US20110306637 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS  
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions...
Matches 201 - 250 out of 352 < 1 2 3 4 5 6 7 8 >