Matches 1 - 50 out of 79 1 2 >


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US20150191467 AGONISTS OF SRC HOMOLOGY-2 CONTAINING PROTEIN TYROSINE PHOSPHATASE-1 AND TREATMENT METHODS USING THE SAME  
The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment...
US20140200239 AGONISTS OF SRC HOMOLOGY-2 CONTAINING PROTEIN TYROSINE PHOSPHATASE-1 AND TREATMENT METHODS USING THE SAME  
The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment...
US20140148482 METHOD FOR SCREENING ANTI-CANCER DRUGS AND METHOD OF CANCER TREATMENT  
The present application provides a method for screening compounds for cancer treatment comprising treating cancer cells with a candidate compound for sufficient time for detectable expression of a...
US20140080873 TREATMENT OF CEREBRAL ISCHEMIA  
The present invention relates to new compositions and methods for protecting neuronal cells from ischemic or hypoxic events. More precisely, this invention provides new combinatorial therapies...
US20130085122 BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS  
The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present...
US20110104235 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF THE NAIL UNIT  
The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems...
US20110230452 Compounds and methods for the treatment of pain and other diseases  
The present invention relates generally to pharmaceutical agents, and in particular, to metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of dual...
US20140038927 COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS  
The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present...
US20150024032 METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCLE WASTING, MUSCLE WEAKNESS, AND/OR CACHEXIA  
Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness,...
US20130012530 New Positive allosteric modulators of nicotinic acetylcholine receptor  
The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The...
US20120108640 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS  
The present invention relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders by administering agents that are effective in reducing the effective amount,...
US20130102639 INHIBITORS OF PROTEIN PRENYLTRANSFERASES  
The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of protein prenyltransferases including GGTase I and/or RabGGTase. The compounds can...
US20120270836 THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER'S DISEASE  
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial...
US20100190731 METHODS FOR TREATING ACUTE MYOCARDIAL INFARCTIONS AND ASSOCIATED DISORDERS  
The invention relates to methods of treating patients who have suffered an acute myocardial infarction (AMI) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs...
US20090023714 COMBINED PREPARATION OF A THIAZIDE DIURETIC AND A LOOP DIURETIC  
The invention relates to pharmaceutical preparations which contain a combination of a thiazide diuretic and a low-dose loop diuretic and which are particularly useful for treating hypertension and...
US20130203769 Targeting Metabolic Adaptive Responses to Chemotherapy  
Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC, or upstream or...
US20120053211 TREATMENT OF PANCREATIC CANCER  
The present invention relates to the field of oncology and relates to use of (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxy phenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide...
US20080280956 Heteroarylsulfonyl Stilbenes as 5-Ht2a Antagonists  
Compounds of formula I: are potent and selective antagonists of the 5-HT2A receptor, and hence are useful in treatment of various 10 CNS disorders.
US20070244164 PYRIDONE SULFONAMIDES AND PYRIDONE SULFAMIDES AS MEK INHIBITORS  
This invention concerns N-(ortho phenylamino dihydropyridyl)sulfonamides and N-(ortho phenylamino dihydropyridyl), N′-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment...
US20110021505 Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain  
The present invention relates to the use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides of the formula I, wherein A and R1 to R6 have the meanings indicated in the claims, for...
US20110190227 Antagonists of Prostaglandin D2 Receptors  
Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are...
US20120234721 DIURETIC AND DIURETIC-LIKE COMPOUND ANALOGS  
The present invention provides compounds that are effective in treating central nervous system disorders and maintaining normal brain function. Methods of making and using the compounds are also...
US20070238696 Dosage unit for cardioprotection  
A method for secondary cardiovascular prevention in a patient includes formulating a single dosage unit containing a beta-adrenergic blocking agent and a cholesterol-lowering agent that is a...
US20150057316 NOVEL SULFONATE-BASED TRIMEBUTINE SALTS  
The present description relates to compounds of Formula I (A+ X−), a diastereoisomer, an enantiomer, or a mixture thereof, pharmaceutical composition comprising same and uses thereof for...
US20140194476 PYRIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELORIATION OR PREVENTION OF A VIRAL DISEASE  
The present invention relates to a compound having the general formula (II), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer,...
US20090312328 SULFONAMIDE COMPOUND OR SALT THEREOF  
[Object] A compound that can be used as an agent for treating a disease associated with an EP1 receptor, in particular, a lower urinary tract symptom. [Means for Solution] It was confirmed that a...
US20150202215 METHOD OF TREATING AND PREVENTING BRAIN IMPAIRMENT USING Na+-K+-2Cl- COTRANSPORTER ISOFORM 1 INHIBITORS  
The disclosure relates to a method of treating and/or preventing brain impairment in a subject that has or is susceptible to ammonia neurotoxicity (increased plasma ammonia), by administering a...
US20070238759 Novel Polymorph V of Torasemide  
The invention relates to a novel polymorph V of torasemide, to a process for its preparation, to its use as a raw material for the preparation of crystalline modifications I and III of torasemide,...
US20120065204 NOVEL N-HYDROXY-BENZAMIDS FOR THE TREATMENT OF CANCER  
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein R1 to R3 and X have the significances given herein. The...
US20110118248 Heteroaryl sulfonamides and CCR2/CCR9  
Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The...
US20080293720 Pyridinyl Sulfonamide Modulators of Chemokine Receptors  
The present invention relates to compounds of following formula: or pharmaceutically acceptable salts thereof; pharmaceutical compositions containing them, and their use in the treatment of...
US20120252795 ORAL LYSOPHILISATES CONTAINING PVP/VA  
The present invention relates to novel oral pharmaceutical compositions in lyophilized form, in which the dissolution and the bioavailability of the active ingredient that they contain are...
US20130196952 HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF DISEASES  
The invention relates to compounds of Formula (1) and to processes for the preparation of intermediates used in the preparation of compositions containing and the uses of such derivatives. The...
US20110201616 SULFONAMIDE COMPOUNDS OR SALTS THEREOF  
[Object] A compound which is useful as an EP1 receptor antagonist is provided. [Means for Solution] The present inventors investigated EP1 receptor antagonists, and confirmed that a compound...
US20120095024 TOLUIDINE SULFONAMIDES AND THEIR USE  
The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and...
US20140221337 Potassium Channel Blockers  
The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof wherein X1, R1, R2, R3, R4, and R5 are defined as set forth in the...
US20120095012 TOLUIDINE SULFONAMIDES AND THEIR USE  
The present invention provides compounds of formula (I), wherein R1 is a monocyclic 5- or 6-membered heteroaryl; R4 is phenyl or monocyclic 5- or 6-membered heteroaryl; and the other substituents...
US20130190325 COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS  
A compound of formula (I) or a pharmaceutically acceptable salt or solvate or physiologically hydrolysable, solubilising or immobilisable derivative thereof; wherein: any one or two of X., X2 and...
US20140235565 N-ALKYLTHIO BETA-LACTAMS, ALKYL-COENZYME A ASYMMETRIC DISULFIDES, AND ARYL-ALKYL DISULFIDES AS ANTI-BACTERIAL AGENTS  
The present invention provides N-alkylthio β-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and...
US20130225619 SUBSTITUTED HETEROCYCLIC COMPOUNDS FOR DISEASE TREATMENT  
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are...
US20080262086 SUBSTITUTED ANTHRANILIC ACIDS  
Disclosed herein are substituted anthranilic acids, pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and medical use of such compounds for the treatment...
US20110008428 SOLID PHARMACEUTICAL COMPOSITION COMPRISING A NON-PEPTIDE ANGIOTENSIN II RECEPTOR ANTAGONIST AND A DIURETIC  
The present invention relates to a solid pharmaceutical composition comprising at least two layers, wherein the first layer contains a non-peptide angiotensin II receptor antagonist or a...
US20130102609 BIARYL OXYACETIC ACID COMPOUNDS  
The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin. The compounds...
US20130225588 SUBSTITUTED NAPHTHYLACETIC ACIDS  
The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and X are defined in the detailed description and claims. In...
US20110112151 COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE  
There is provided a compound of formula R1—CO—X—Y—Z—R2 wherein X and Z are each optional groups that are, independently, saturated or unsaturated carbon chains having a length of 1 to 3 carbons; Y...
US20100233190 TARGETED POLYMERIC PRODRUGS CONTAINING MULTIFUNCTIONAL LINKERS  
The present invention provides single chain antibody-directed polymeric prodrugs containing multifunctional linkers. Methods of making the polymeric delivery systems and methods of treating...
US20120309796 BENZOCYCLOHEPTENE ACETIC ACIDS  
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
US20140275132 PYRIDINYL AND PYRIMIDINYL SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS  
The present invention relates to novel pyridine or pyrimidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators...
US20110166117 Novel Compounds  
The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for...
US20120004209 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Active Compounds  
A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are...

Matches 1 - 50 out of 79 1 2 >