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US20100004208 |
SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS
The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.
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US20090324570 |
Photostabilization of Retinoids with Alkoxycrylene Compounds
The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) α-cyanodiphenylacrylate...
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US20090318371 |
TOPICAL ANTIACNE PREPARATIONS CONTAINING RETINOID (TAZAROTENE OR ADAPALENE), ANTIBIOTIC (CLINDAMYCIN PHOSPHATE) AND/OR KERATOLYTIC (MICROSPONGED BENZOYL PEROXIDE)
The present invention relates to a topical preparation for treating acne in the form of a gel and cream comprising Retinoid (Tazarotene or Adapalene) Antibiotic (Clindamycin Phosphate) and/or...
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US20090306055 |
PHENYLAZOLE COMPOUNDS, PRODUCTION PROCESS AND ANTIOXIDANTS
The present invention is directed to compounds represented by the formula (1): B-D-Z (1), wherein B represent the following formula (B-1),
A represents an optionally substituted imidazole or...
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US20090297476 |
NOVEL PEPTIDE INHIBITORS OF HEPATITIS C VIRUS REPLICATION
The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the...
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US20090297576 |
Local Delivery of PAR-1 Antagonists to Treat Vascular Complications
Described herein are methods and medical devices used to deliver bioactive agents locally to patients in need of treatment and/or prevention of cardiovascular conditions Local delivery of...
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US20090281146 |
PROCESS FOR THE PREPARATION OF N-(3,5-DICHLOROPYRID-4-YL)-4-DIFLUOROMETHOXY-8-METHANESULFONAMIDO-DIBENZO[B,D]FURAN-1-CARBOXAMIDE
The present invention relates to a method of preparing N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfon
amido-dibenzo[b,d]furan-1-carboxamide and pharmaceutically acceptable salts...
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US20090275550 |
Pyridyl Amide T-Type Calcium Channel Antagonists
The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which...
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US20090258906 |
CXCR2 ANTAGONISTS
The invention relates to compounds of the formula I
in which R1, R2, A, B, X and Y have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof....
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US20090257953 |
NOVEL FLUORINE-18 LABELED RHODAMINE DERIVATIVES FOR MYOCARDIAL PERFUSION IMAGING WITH POSITRON EMISSION TOMOGRAPHY
The present invention is directed toward novel fluorine-18 labeled rhodamine dye derivatives and methods of making the same. The present invention is also directed toward methods of using novel...
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US20090253715 |
HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS
Compounds and methods useful for treating and prevention of cancer, particularly hormone-dependent breast cancer. Provided are compounds of formula I:
wherein X is selected from O, N, S, SO, SO...
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US20090221564 |
Heterocyclic Compounds and Their Use in the Treatment of Cardiovascular Disease
Heterocyclic compounds of the formula (I) are provided: wherein ring A, ring B, R 1 , R 2 , R 3 , R 4 , Y, m, n and q are as identified herein. R 1 is in particular amidino. The invention further...
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US20090221644 |
Gpcr Agonists
Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
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US20090214675 |
4-Chromenonyl-1,4-dihydropyridinecarbonitriles and the use thereof
The present application relates to novel 4-chromenonyl-1,4-dihydropyridinecarbonitriles, processes for their preparation, pharmaceutical compositions containing them, and their use for the...
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US20090208449 |
Heterocyclic antiviral compounds
Compounds having the formula I wherein R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for...
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US20090209511 |
Benzofuran Derivatives
The present invention provides a benzofuran derivative of the formula [1]:
wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally...
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US20090202525 |
DIHYDROISOINDOLONES AS ALLOSTERIC MODULATORS OF GLUCOKINASE
The present invention relates to compounds of Formula (1),
methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating glucokinase mediated...
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US20090181968 |
Novel 3-Bicyclocarbonylaminopyridine-2-Carboxamides or 3-Bicyclocarbonylaminopyrazine-2-Carboxamides
The present invention relates to compounds of formula (I) [Chemical formula should be inserted here. Please see paper copy] as well as pharmaceutically acceptable salts and pharmaceutical...
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US20090182011 |
Chimeric Nitrate Esters and Use of the Same in a Treatment for Depression
Chimeric nitrate esters and their use in the treatment of depression are disclosed. The chimeric nitrate esters also are useful in the treatment of depression and comorbidity associated with aging.
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US20090170903 |
ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
The invention provides inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are new ester derivatives, methods of preparing such...
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US20090163550 |
RETINOID-CONTAINING SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND RELATED METHODS
Biocompatible intraocular implants include a retinoid component and a biodegradable polymer that is effective to facilitate release of the retinoid component into an eye for an extended period of...
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US20090149417 |
Methods and compositions for the treatment of cancer using benzopyrone-type PARP inhibitors
The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer...
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US20090149493 |
INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein...
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US20090143439 |
NEW PYRIDINES AS FBPASE INHIBITORS FOR TREATMENT OF DIABETES
Compounds of formula (I)
as well as pharmaceutically acceptable salts and esters thereof wherein the residues have the significance given in claim 1 and which can be used in the form of...
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US20090143408 |
COMPOSITIONS AND METHODS FOR INHIBITING CYTOCHROME P450 2D6
Methods of inhibiting cytochrome P450 2D6 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450 2D6....
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US20090136496 |
CHRONIC LYMPHOCYTIC LEUKEMIA PROGNOSIS AND TREATMENT
Provided herein are methods for identifying a subject afflicted with chronic lymphocytic leukemia who is responsive to treatment with a chemotherapeutic agent by detecting the presence or absence...
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US20090131468 |
Bis-(Sulfonylamino) Derivatives in Therapy 065
The invention provides compounds of formula
wherein R 1 , R 2 , R 3 , A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically...
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US20090124613 |
Substituted Heterocyclic Ethers and Their Use in CNS Disorders
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders.
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US20090124629 |
3-(1,2,4-TRIAZOL-3YLALKYL) AZABRICLO (3.1.0) HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS
The present invention relates to novel compounds of formula (I) or pharmaceutically acceptable salt thereof:
wherein
G is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl...
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US20090093485 |
Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases
Compounds of formula (I) or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the...
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US20090082308 |
Benzothiophene derivatives
The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit...
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US20090062348 |
Antifungal Agent Containing Pyridine Derivative
The present invention provides an antifungal agent that has superior antifungal action and is also superior in terms of physical properties, safety and metabolic stability. The present invention...
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US20090062239 |
THROMBIN RECEPTOR ANTAGONISTS AS PROPHYLAXIS TO COMPLICATIONS FROM CARDIOPULMONARY SURGERY
Disclosed herein are methods of preventing, inhibiting, or ameliorating complications associated with cardiopulmonary bypass surgery by the use of a thrombin receptor antagonist compound. Among the...
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US20090036492 |
Novel Cercosporamide Derivative
The present invention relates to a novel cercosporamide derivative, a pharmacologically acceptable salt thereof or an ester thereof which has an excellent hypoglycemic effect and is useful as a...
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US20090030038 |
Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor
The present invention relates to new compounds of formula I. (I) wherein R 1 to R 12 , X, Q and n are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their...
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US20090012075 |
Fluorinated Arylamide Derivatives
The present invention relates to a novel class of fluorinated arylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit...
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US20090005421 |
Novel Pyridine Derivatives
The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
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US20080319021 |
Inhibition Of Phosphoinositide 3-Kinase Beta
The present invention relates to selective inhibitors of phosphoinositide (PI) 3-kinase β, use of the selective inhibitors in anti-thrombotic therapy, and a method for screening compounds useful...
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US20080293680 |
Substituted Ethane-1,2-Diamines for the Treatment of Alzheimer's Disease II
The invention relates to a compound of the formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are defined as in the specification and claims and to its use for treating or...
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US20080286204 |
MODULATORS OF CFTR
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including...
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US20080280875 |
FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS
The present invention relates to a compound of formula (I):
or a pharmaceutically acceptable salt or solvate thereof, wherein:
Ring A is (4-12)-membered heterocyclyl; Ring B is a fused...
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US20080275048 |
Substituted Diazabicycloalkane Derivates
Compounds of formula (I)
Z-Ar 1 —Ar 2 (I)
wherein Z is a diazabicyclic...
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US20080234236 |
REDUCTION OF ADVERSE EVENTS AFTER PERCUTANEOUS INTERVENTION BY USE OF A THROMBIN RECEPTOR ANTAGONIST
Disclosed are methods of preventing adverse clinical events in a patient undergoing a percutaneous coronary intervention procedure or a peripheral percutaneous interventional procedure comprising...
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US20080207696 |
Phenacyl 2-Hydroxy-3-Diaminoalkanes
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that...
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US20080207691 |
Cycloalkyl Lactam Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1
The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present invention further provides a...
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US20080194560 |
DISINTEGRATION PROMOTERS IN SOLID DOSE WET GRANULATION FORMULATIONS
Disclosed is a rapidly disintegrating solid dosage form comprising an active pharmaceutical ingredient, a disintegrant and a disintegration promoter, which formulation is obtainable by a wet...
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US20080193423 |
Small organic molecule regulators of cell proliferation
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain...
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US20080194637 |
Small organic molecule regulators of cell proliferation
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a compound. In certain...
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US20080194636 |
Enzyme Inhibitors and Uses Thereof
The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the...
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US20080194638 |
BIOAVAILABLE FORMULATIONS OF HETEROCYCLIC COMPOUNDS
The present invention relates to bioavailable pharmaceutical formulations of heterocyclic compounds, such as such as...
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