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US20090286773 |
Kinase inhibitors
The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate,...
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US20090275570 |
SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND PAK INHIBITORS
The invention relates to novel compounds of Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds possess CHK1 kinase inhibitory activity, PDK1...
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US20090275555 |
Substituted indole ligands for the ORL-1 receptor
New ligands for the ORL-1 receptor are described, useful for antagonising the activity of said receptors in a patient in need thereof, and for preventing and treating illnesses dependent on the...
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US20090270453 |
ANTI-MANIC EFFECTIVE DOSES OF SERTINDOLE
The present invention relates to uses of an anti-manic effective dose sertindole in the preparation of a pharmaceutical composition for the treatment of mania, and to methods of treating mania...
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US20090258883 |
1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds
Compounds of formula (I):
wherein:
A represents a divalent radical:
wherein:
Z represents an oxygen atom or a sulphur atom, R 6 represents a hydrogen atom, an alkyl,...
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US20090258881 |
ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT
The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives...
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US20090253682 |
HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS
Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
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US20090253653 |
ANALOGS OF BENZOQUINONE-CONTAINING ANSAMYCINS AND METHODS OF USE THEREOF
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present...
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US20090239877 |
NOVEL 1,2,4-TRIAZOLE DERIVATIVES AND PROCESS OF MANUFACTURING THEREOF
The invention provides 1,2,4-triazole compounds, compositions containing those compounds, methods of treating diseases and/or disorders with those compounds and processes of manufacturing...
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US20090239863 |
1-ARYL-OR 1- ALKYLSULFONYLBENZAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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US20090232796 |
METHOD OF TREATING CANCER BY ADMINISTERING AN IMMUNOMODULATORY COMPOUND IN COMBINATION WITH A CD40 ANTIBODY OR CD40 LIGAND
Provided herein relates to the field of cancer and its treatment by administering immunomodulatory compounds in combination with other compounds. In particular, a combination of an immunomodulatory...
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US20090232776 |
USE OF IMMUNOMODULATORY COMPOUNDS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION
Methods of treating, preventing or managing endothelial dysfunction and other disorders are disclosed. The methods encompass the administration of an immunomodulatory compound provided herein....
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US20090227538 |
N-(Hetero)Aryl Indole Derivatives as Pesticides
The invention relates to compounds of the general formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A, X, m and n have the significances given in claim 1 , and optionally the enantiomers...
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US20090221574 |
5-Lipoxygenase-Activating Protein (FLAP) Inhibitors
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods...
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US20090215774 |
USES OF INDANE COMPOUNDS
The invention provides methods of treating obesity and eating disorders, which comprise administering indane compounds of Formula (I):
where R 1 -R 6 , m and n are defined herein.
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US20090215772 |
Hydroxybenzamide derivatives and their use as inhibitors of HSP90
The invention provides compounds of the formula (I):
or salts, tautomers, solvates and N-oxides thereof; wherein R 1 is hydroxy or hydrogen; R 2 is hydroxy; methoxy or hydrogen; provided that...
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US20090203737 |
Pyrrole Derivatives as Positive Allosteric Modulators of Metabotropic Receptors
The present invention relates to new compounds which are Pyrrole derivatives of formula (I) wherein A, B, P, Q 5 W, R 1 and R 2 are defined in the description. Invention compounds are useful in...
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US20090203591 |
Methods and compositions for emergency contraception using endothelin receptor antagonists
Disclosed are methods and compositions containing endothelin receptor antagonists for emergency contraception.
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US20090197915 |
SIGMA RECEPTOR COMPOUNDS
The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the...
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US20090192195 |
Compounds Having CRTH2 Antagonist Activity
Compounds of general formula (I)
wherein
W is chloro or fluoro;
Z is a group SO 2 R 1 ;
wherein R 1 is —C 3 -C 8 cycloalkyl or heterocyclyl optionally substituted with one or more...
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US20090192157 |
INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN
The invention features methods of treating visceral pain or a condition in a mammal caused by the action of nitric oxide synthase (NOS) or by the action of serotonin 5HT1D/1B receptors, by...
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US20090192148 |
Organic Compounds
The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a...
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US20090176794 |
1H-INDOL-1-YL-UREA COMPOUNDS
Compounds of formula (I):
wherein: R 1 and R 2 , which may be the same or different, represent a hydrogen atom or a linear or branched (C 1 -C 6 )alkyl group, R 3 represents a hydrogen or...
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US20090175869 |
Pulsatile Dosing of Gossypol for Treatment of Disease
This invention relates to pulsatile dose administration of gossypol, a gossypol-related compound or pharmaceutical compositions thereof for treating diseases, disorders and conditions responsive to...
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US20090170835 |
ISOINDOLINE DERIVATIVES
Provided is a novel isoindoline compound of the formula (I):
The compound is useful for anesthesia by inducing sedation in a mammal.
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US20090163548 |
Method of using and comopositions comprising immunomodulatory compounds for the treatment and management of myeloproliferative diseases
Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically...
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US20090163451 |
METHODS FOR TREATING VISCERAL PAIN
The invention features methods of treating visceral pain in humans by administering an effective amount of a 5HT 1B or 5HT 1D receptor agonist, (e.g., a triptan). These methods can be used, for...
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US20090156641 |
INHIBITION OF CYCLOOXYGENASE-2 ACTIVITY
The present invention provides new methods for inhibiting the activity of the enzyme cycloxygenase-2 (or COX-2). Inhibitors of COX-2 are known to be useful anti-inflammatory, analgesic and...
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US20090149500 |
POLYMORPHIC FORMS OF 3-(4-AMINO-1-OXO-1,3 DIHYDRO-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE
Polymorphic forms of 3-(amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of making the polymorphic forms and methods...
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US20090143372 |
CHEMICAL COMPOUNDS
The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I:
where R1, R2, R3, U and V are defined below and to...
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US20090142297 |
5-SUBSTITUTED ISOINDOLINE COMPOUNDS
This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions...
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US20090137631 |
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REGULATION OF G- AND/OR GC-RICH NUCLEIC ACID EXPRESSION
Methods and pharmaceutical compositions for regulations of Guanosine- (G-) and/or Guanosine-cytosine-rich (GC-rich) nucleic acid expressions are provided. The methods include a step of interacting...
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US20090137566 |
Substituted Piperdines as Renin Inhibitors
The invention relates to substituted 3,4- or higher substituted piperididine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that...
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US20090131478 |
Growth Hormone Secretagogues
A family of peptides and peptidomimetic compounds useful as GHS analogs according to either formula (I) or (II) as depicted below: or a pharmaceutically acceptable salts thereof, wherein the...
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US20090124619 |
NOVEL COMPOUNDS
This invention relates to novel compounds useful in the treatment of diseases associated with TRPV4 channel receptor. More specifically, this invention relates to certain substituted morpholines...
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US20090124616 |
7-NONSUBSTITUTED INDOLE MCL-1 INHIBITORS
Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein...
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US20090124608 |
CB2 Receptor Modulators In Neurodegenerative Diseases And Applications Of The Same
Compositions for the treatment of neurodegenerative diseases are disclosed. Methods of treating and monitoring progression of a neurodegenerative disease are disclosed. According to the present...
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US20090124592 |
PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING A PATHOLOGY ASSOCIATED WITH AN OBSESSIONAL BEHAVIOR OR WITH OBESITY
This invention relates to the use of a ligand of the 5-HT 4 receptor or of a pharmaceutically acceptable salt of this ligand and to a nucleic acid coding for a 5-HT 4 receptor or of a...
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US20090123416 |
METHODS FOR THE TREATMENT OF BLADDER CANCER USING 3-(4-AMINO-1-OXO-1,3-DIHYDROISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE
Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass...
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US20090105216 |
3- (AMINOMETHYLIDEN) 2-INDOLINONE DERIVATES AND THEIR USE AS CELL PROLIFERATION INHIBITORS
The present invention encompasses compounds of general formula (1) wherein R 1 , R 2 , R 3 and X are defined as in claim 1 , which are suitable for the treatment of diseases characterised by...
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US20090104262 |
Chlorthalidone combinations
The invention relates to favourable combinations of the thiazide diuretic chlorthalidone with Angiotensin II Receptor Blockers (ARBs) for the treatment of hypertension.
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US20090088410 |
METHODS FOR THE TREATMENT AND MANAGEMENT OF MYELOPROLIFERATIVE DISEASES USING 4-(AMINO)-2-(2,6-DIOXO(3-PIPERIDYL)-ISOINDOLINE-1,3-DIONE IN COMBINATION WITH OTHER THERAPIES
Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of...
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US20090087407 |
METHODS FOR THE TREATMENT OF SCLERODERMA USING 1-OXO-2-(2,6-DIOXOPIPERIDIN-3-YL)-4-METHYLISOINDOLINE
Methods of treating, preventing, correcting and/or managing skin diseases or disorders characterized by overgrowths of the epidermis, keratoses, scleroderma, cutaneous vasculitis, acne or wrinkles...
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US20090082340 |
3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I
The present invention discloses and claims methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase Iε activity comprising the...
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US20090081203 |
Methods for treating lymphomas in certain patient populations and screening patients for said therapy
Methods for predicting a response of a patient having a lymphoma to a therapy regimen of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-d
ione using prognostic factors of a patient's...
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US20090076005 |
Kinase inhibitor compounds
The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein...
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US20090076004 |
Indoles Useful in the Treatment of Inflammation
There is provided compounds of formula (I), wherein X 1 , Q, T, Y, R 1 , R 2 , R 3 , R 4 and R 5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which...
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US20090075974 |
AGENT FOR PROPHYLAXIS AND TREATMENT OF PANCREATITIS
Disclosed is a pharmaceutical composition for prophylaxis and treatment of pancreatitis comprising a 5-HT2A receptor antagonist as an effective component, wherein the binding activity (pKi) of the...
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US20090075937 |
LHRH ANTAGONISTS FOR THE TREATMENT OF LOWER URINARY TRACT SYMPTOMS
The present invention provides at least one LHRH antagonist for the treatment or prophylaxis of at least one lower urinary tract symptom in mammals which is to be administered in an intermediate...
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US20090069379 |
DEUTERIUM-ENRICHED LENALIDOMIDE
The present application describes deuterium-enriched lenalidomide, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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