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US20090304632 |
HETEROCYCLIC NF-kB INHIBITORS
The present invention relates to compounds of the general formula (Ihb) or pharmaceutically acceptable salts thereof with an acid or a base or a stereoisomer thereof for the prevention and/or...
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US20090275609 |
Carboxamide Compounds and Methods for Using The Same
Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure
in which R 1 , R 2 , R 3 , R 4 , D, J, Z, T, p,...
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US20090275528 |
ANTITUBERCULOUS COMPOSITION COMPRISING OXAZOLE COMPOUNDS
The present invention provides antituberculous therapeutic drugs with a higher potency. The present invention provides also antituberculous therapeutic drugs containing oxazole compounds...
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US20090270372 |
NOVEL DERIVATIVES OF BENZIMIDAZOLE AND IMIDAZO-PYRIDINE AND THEIR USE AS MEDICAMENTS
A subject of the present Application is novel derivatives of benzimidazole and imidazopyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4...
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US20090270366 |
Benzoimidazole compounds
Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor, and in treating conditions such as inflammation, H 4 ...
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US20090264457 |
Combination of at least two 5HT6-Ligands
The present invention relates to a Combination of at least two 5HT6-Ligands of which one is a partial or agonist while the other is a full antagonist or an inverse agonist, a medicament comprising...
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US20090264468 |
Methods for treating a disease in which Rho kinase is involved
A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the...
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US20090253747 |
Remedy for sleep disturbance
The present invention has been made based on the finding that a compound acting on the ORL-1 receptor as an agonist acts as a non-photic entrainment factor, and advances the circadian rhythm phase,...
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US20090247508 |
Benzoimidazole Compounds
Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor, and in treating conditions such as inflammation, H 4 ...
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US20090239880 |
COMBINATIONS OF MONOAMINE REUPTAKE INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS
This invention provides pharmaceutical compositions comprising therapeutically effective amounts of a monoamine reuptake inhibitor and an SK inhibitor. In another aspect the invention provides...
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US20090227630 |
Pharmaceutical Composition Achieving Excellent Absorbency of Pharmacologically Active Substance
The present invention provides a pharmaceutical composition that can efficiently achieve its medicinal action by having excellent basic pharmacologically active substance absorbency, even the basic...
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US20090221641 |
Diaza-spiro--nonane derivatives as neurokinin (nk1) antagonists
This invention concerns substituted diaza-spiro-[4.4]-nonane derivatives having neurokinin antagonistic activity, in particular NK1 antagonist ic activity, their preparation, compositions...
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US20090221642 |
MUSCARINIC RECEPTOR AGONISTS, COMPOSITIONS, METHODS OF TREATMENT THEREOF, AND PROCESSES FOR PREPARATION THEREOF-176
Compounds of Formula 1, or pharmaceutically acceptable salts thereof:
wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , n, m, and p are as defined in the specification as well as salts and pharmaceutical...
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US20090215824 |
INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE SENSITIVE LIPASE
The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use...
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US20090203676 |
G-protein Coupled Receptor Agonists
Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
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US20090197856 |
ANTIVIRAL COMPOUNDS
Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae...
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US20090197886 |
HEXAHYDRO-CYCLOHEPTAPYRAZOLE CANNABINOID MODULATORS
This invention is directed to a hexahydro-cycloheptapyrazole cannabinoid modulator compound of formula (I):
and a method for use in treating, ameliorating or preventing a cannabinoid receptor...
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US20090197882 |
INDAZOLE DERIVATIVES FOR THE TREATMENT OF HSP90-INDUCED DISEASES
Novel indazole derivatives of the formula (I), in which R 1 -R 3 have the meanings indicated in Claim ( 1 ), are HSP90 inhibitors and can be used for the preparation of a medicament for the...
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US20090192169 |
Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators
Compounds of Formula I:
wherein A, B, D, L, R 1 , R 2 , R 3 , R 4 , m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the...
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US20090186891 |
ORGANIC COMPOUNDS
The present invention provides compounds of the following structure;
A-Q-B—C-D
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US20090181957 |
BENZIMIDAZOLONE DERIVATIVES AS CB2 RECEPTOR LIGANDS
This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: A, B, R 1 , R 2 and R 3 are each as described herein, and compositions containing...
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US20090176831 |
Compounds and Methods for Treating Cancer and Diseases of the Central Nervous System
Disclosed are compounds of the general formula (I):
compositions comprising an effective amount of said compounds either alone or in combination with other chemotherapeutic agents, and methods...
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US20090163472 |
MINERALOCORTICOID RECEPTOR ANTAGONISTS AND METHODS OF USE
The present invention provides a compound of Formula (I):
or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a...
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US20090163547 |
INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
The present invention makes reference to new indene derivatives with general formula (I), as well as to their preparation procedures, their application as medicament and the pharmaceutical...
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US20090156613 |
Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor
Bicyclic heteroaryl-substituted imidazole compounds are described, which are useful as H 4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the...
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US20090156554 |
P13-KINASES
New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic...
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US20090143434 |
Methods of using domperidone to terminate acute episodes of cardiac arrhythmia, to restore normal sinus rhythm or heart rate, to prevent recurrence of cardiac arrhythmia and to maintain normal sinus rhythm or heart rate in mammals
Disclosed are methods of terminating acute episodes of cardiac arrhythmia, such as atrial fibrillation or ventricular fibrillation, in a mammal, such as a human, by administering to that mammal an...
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US20090131470 |
PYRAZOLE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER AND AUTOIMMUNE DISORDERS
Compounds of formula (I) are inhibitors of PDK1 and CHK1 activity, and of use in the treatment of cancer and autoimmune disorders (I): wherein R 2 is a radical of formula R 7 —(CH 2 ) n− , or...
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US20090131413 |
Thienopyrazole Derivative Having PDE7 Inhibitory Activity
To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as...
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US20090124615 |
Benzimidazole Thiophene Compounds
The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
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US20090105275 |
PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE
The present invention relates to compounds of Formula I as shown below, wherein the definitions of Het, R 0 , R 1 R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are provided in the...
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US20090093474 |
THIAZOLYL-DIHYDRO-INDAZOLE
The present invention relates to new thiazolyl-dihydro-indazoles of general formula (I)
wherein the groups R 1 , R 2 and R 3 have the meanings given in the claims and specification, the...
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US20090088428 |
CYCLOHEXYLIMIDIAZOLE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
The present invention discloses novel compounds of Formula I: (I) having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention...
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US20090081288 |
Orodispersible Domperidone Tablets
The present invention relates to an orodispersible tablet comprised of, by weight: a maximum of 15% of a low-dose, therapeutically active substance; from 55% to 70% of mannitol of a particle size...
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US20090076078 |
New compounds 966
Compounds of Formula I, or pharmaceutically acceptable salts thereof:
wherein R 2 , R 3 , X, m and n are as defined in the specification as well as salts and pharmaceutical compositions...
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US20090062317 |
MEDICINAL USE OF RECEPTOR LIGANDS
Compounds of formula (I) are ligands of the melanin concentrating hormone-1 receptor (MCH-1R), useful in the treatment of diseases responsive to modulation of melanin concentrating hormone (MCH)...
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US20090054431 |
NOVEL HETEROCYCLE COMPOUNDS
The present invention relates to novel compounds which are antagonist or inverse agonists at an opioid receptor. Such compounds are useful in the treatment of obesity and related diseases and/or...
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US20090048227 |
Substituted-1-Phthalazinamines As Vr- 1 Antagonists
Substituted piperidine compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either...
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US20090042854 |
Hexahydro-3H-Pyrrolizin-3-Ones Useful as Tachykinin Receptor Antagonists
The present invention is directed to certain hexahydrpyrrolidinone compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance...
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US20090029966 |
COMBINATION THERAPY WITH PARP INHIBITORS
The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with temozolomide (TMZ).
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US20090030016 |
BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS
Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.
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US20090018132 |
Substituted Heterocyclic Ethers and Their Use in CNS Disorders
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders.
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US20090012055 |
Organic compounds
Novel substituted piperidines of the general formulae (I) and (II)
with the substituent definitions as explained in detail in the description are described. The compounds are suitable in...
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US20090012123 |
Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient
As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell...
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US20090005416 |
BENZIMIDAZOLE DERIVATIVES
The present invention relates to a compound of the Formula I
or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3A , R 3B , R 4 , R 5 , X, m, and n are as defined herein. Such...
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US20090005417 |
Substituted Indazolyl Sulfonamide and 2,3-Dihydro-Indolyl Sulfonamide Compounds, their Preparation and Use in Medicaments
The present invention relates to substituted indazolyl sulfonamide and 2,3-dihydroindolyl sulfonamide compounds of general formula I, a process for their preparation, medicaments comprising said...
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US20080318951 |
Dual-acting benzoimidazole antihypertensive agents
The invention is directed to compounds having the formula:
wherein: Ar, r, n, X, R 2-3 and R 5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These...
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US20080306112 |
Benzimidazolones Which Have Activity at M1 Receptor
Compounds of formula (I) and salts are provided:
wherein R 6 is selected from hydrogen, halogen, C 1-6 alkyl, C 1-6 alkyl substituted with one or more fluorine atoms, C 3-6 cycloalkyl, C 3-6...
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US20080299197 |
Triple Combination Release Multi-Layered Tablet
This invention pertains to a multi-layered tablet for a triple combination release of active agents to an environment of use. More particularly, the invention pertains to a multi-layered tablet ( 1...
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US20080300276 |
Heterocyclic Carboxylic Acide Amide Derivatives
The invention relates to new heterocyclic carboxylic acid amide derivatives of formula (I)—wherein the meaning of X is hydrogen or halogen atom, hydroxy, cyano, C 1 -C 4 alkylsulfonamido...
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