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US20090325980 |
PIPERIDINE OR PIPERAZINE SUBSTITUTED TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID MTP INHIBITING COMPOUNDS
The present invention is concerned with novel piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant...
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US20090306110 |
N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR
The present invention provides compounds of formula (I), which are antagonists of the 5-HT 6 receptor.
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US20090306047 |
HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS
Disclosed are compounds of the formula I
or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof,
wherein
W is a bond, —C(═S)—, —S(O)—, —S(O) 2...
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US20090298864 |
Methods for Treating Mild Cognitive Impairment
The present invention relates to compounds, compositions, and methods useful for: (i) treating or preventing mild cognitive impairment, or (ii) delaying the progression from mild cognitive...
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US20090298879 |
Impurities of Donepezil
The present invention relates to impurities of donepezil, or a pharmaceutically acceptable salt thereof, which may be produced during synthesis and storage of donepezil, or a...
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US20090291127 |
TRANSDERMAL ANTI-DEMENTIA ACTIVE AGENT FORMULATIONS AND METHODS FOR USING THE SAME
A transdermal antidementia active agent formulation is provided. In certain embodiments, the formulation includes a backing, an active agent reservoir layer including an antidementia active agent,...
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US20090275556 |
Aryl sulfonamides useful as inhibitors of chemokine receptor activity
The present invention provides compounds of general formula I:
or a pharmaceutically acceptable salt thereof, wherein R 1 , X, Z, R 2 , X 1 , Ar, n, R 3 and R 4 are defined generally and in...
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US20090264467 |
Agents and crystals for improving excretory potency of urinary bladder
Agents for improving potency of the urinary bladder which comprise an amine compound of non-carbamate-type having an acetylcholinesterase-inhibiting action. Particularly, crystals of a tricyclic,...
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US20090253746 |
Synthesis and Preparations of Intermediates and New Polymorphs Thereof Useful For The Preparation Of Donepezil Hydrochlcoride
The invention relates to an improved process for preparing 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyin-dan- 1 -one (a key intermediate in the synthesis of donepezil hydrochloride),...
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US20090252704 |
THERAPIES FOR COGNITION AND LEARNING ENHANCEMENT
The invention relates to a combination comprising an amount of an NO donor, such as ISDN, and/or an amount of another pharmaceutical agent that enhances neurotransmission or which acts as...
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US20090247582 |
METHODS OF TREATING ATHEROSCLEROSIS
The present invention relates to a method for the prevention, delay the onset and treatment of atherosclerosis which method comprises administering to a warm-blooded animal, in need thereof, a...
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US20090233966 |
Analogues of the Azinomycins as Anti-Tumour Agents and as Prodrugs
Compounds of general formula (I) or a salt thereof in which R 1 is preferably an aromatic DNA binding subunit are oxidation-activated prodrugs. The compounds are expected to be converted into an...
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US20090221627 |
Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an...
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US20090208579 |
Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
A matrix type sustained-release preparation and a manufacturing method therefor are provided wherein dissolution with low pH dependence of a basic drug or a salt thereof at the early stage of...
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US20090209514 |
Tetrahydro-Naphthalene Derivatives as Vanilloid Receptor Antagonists
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydronaphthalene derivatives of the...
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US20090203738 |
Pharmaceutical Composition for Treating Bulimia and Depression Arising from Bulimia
Provided is a pharmaceutical composition for the treatment of bulimia in which a cholinesterase inhibitor is combined with at least one member selected from the group consisting of sibutramine, a...
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US20090186107 |
Orally Administrable Films and Preparation Thereof
The invention relates to an orally administrable mucoadhesive film which comprises one or more bioactive ingredients and, as a major film-forming polymer, at least one alginate which is capable of...
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US20090175929 |
Transdermally absorbable Donepezil Preparation
Disclosed is a donepezil-containing transdermally absorbable preparation which develops reduced adverse side effects and shows a satisfactory level of therapeutic effect. The preparation comprises...
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US20090156561 |
Use of Cholinesterase Inhibitors In Smoking Cessation
A method of causing a patient to reduce or cease tobacco use that involves the administration of a cholinesterase inhibitor.
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US20090156639 |
COMPOSITIONS AND METHODS OF TREATMENT USING L-TYPE CALCIUM CHANNEL BLOCKERS AND CHOLINESTERASE INHIBITORS
The present invention relates to composition comprising at least one L-type calcium channel blocker, particularly the compound (+)-isopropyl 2-methoxyethyl...
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US20090149465 |
AMINOTETRALIN COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
The invention provides aminotetralin compounds of formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , n, and m are defined in the specification, or a pharmaceutically-acceptable salt...
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US20090143431 |
PESTICIDE NAPHTHYLOXY SUBSTITUTED PHENYLAMIDINE DERIVATIVES
The present invention relates to 2,5-di-substituted-4-naphthyloxy-substituted-phenyl-amidine derivatives of formula (I) wherein the substituents are as in the description, their process of...
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US20090137629 |
Sigma receptor binding agent containing indanone derivative
A method for treatment of a mental disorder containing the step of administering a therapeutically effective amount of a sigma receptor binding agent containing an indanone compound represented by...
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US20090136473 |
BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS
The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial...
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US20090137628 |
Formulations of Indanylamines and the Use Thereof as Local Anesthetics and as Medication for Chronic Pain
Dermal and mucosal formulations of 2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine, characterized by rapid dermal and mucosal absorption and long duration of therapeutic activity are provided....
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US20090131444 |
Aminopiperidine Quinolines and Their Azaisosteric Analogues with Antibacterial Activity
The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their...
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US20090130077 |
SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS
The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for...
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US20090130205 |
Solid Pharmaceutical Composition Comprising Donepezil Hydrochloride
The invention relates to a solid pharmaceutical composition comprising donepezil hydrochloride hydrate and a process for its preparation. In particular it relates to a composition and a process...
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US20090118267 |
INDANES
Compounds of the formula (I), in which R 1 , R 2 , R 3 , R 4 , and q have the meanings indicated in claim 1 , can be employed, inter alia, for the treatment of tumours.
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US20090118269 |
Methods for Treating Spinal Muscular Atrophy Using Tetracycline Compounds
Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
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US20090081314 |
Glycemic Control, Diabetes Treatment, and Other Treatments with Acetyl Cholinesterase Inhibitors
There is disclosed a method for glycemic control of a patient having a disease selected from the group consisting of type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance,...
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US20090069378 |
DEUTERIUM-ENRICHED DONEPEZIL
The present application describes deuterium-enriched donepezil, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20090048234 |
Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction
The present invention provides compositions and methods for preventing, treating or reversing neuronal dysfunction in a mammal resulting from exposure to organophosphate nerve agents,...
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US20090042857 |
Novel Pharmaceutical
A tissue-selective androgen receptor modulator containing a compound represented by the formula
wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents an...
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US20090042940 |
METHODS AND COMPOSITIONS USING CHOLINESTERASE INHIBITORS
The invention provides methods for treating and/or preventing Alzheimer's disease, psychiatric illnesses, encephalitis, meningitis, fetal alcohol syndrome, Karsakoff's syndrome, anoxic brain...
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US20090036487 |
Combinations
The instant invention relates to a combination of an alpha-2-delta ligand and an AChE inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain....
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US20090023705 |
DROXIDOPA AND PHARMACEUTICAL COMPOSITION THEREOF FOR THE TREATMENT OF MOOD DISORDERS, SLEEP DISORDERS OR ATTENTION DEFICIT DISORDERS
The present invention provides pharmaceutical compositions comprising droxidopa alone, or in combination with one or more further active ingredients, for the treatment of conditions, such as mood...
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US20090023778 |
Composition Containing Anti-Dementia Drug
An object of the present invention is to provide, for the case of implementing a therapeutic method in which at least two kinds of anti-dementia drugs are used together, a composition that has a...
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US20090017015 |
Dpp-iv inhibitors for treating neurodegeneration and cognitive disorders
The invention relates to the use of a Dipeptidyl peptidase IV inhibitor (DPP-IV inhibitor) or a pharmaceutically acceptable salt thereof for the prevention, delay of progression or the treatment of...
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US20080317853 |
Mouth Dissolving Pharmaceutical Composition and Process for Preparing the Same
Disclosed herein is a orally disintegrating and/or dissolving oral pharmaceutical composition, comprising one or more active pharmaceutical ingredients, one or more fillers having particle size of...
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US20080312189 |
Cadasil Treatment with Cholinesterase Inhibitors
The invention provides methods for treating and/or preventing cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in a patient in need thereof by...
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US20080300274 |
Novel Pyrrolidino-1,4-Naphthoquinone Deriviatives and their Use for Treating Malignancies and Cardiovascular Diseases
The invention provides pyrrolidino-substituted 1,4-naphthoquinone derivatives that modulate the activity of protein kinases, and it relates to the use of the derivatives in pharmaceutical...
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US20080269255 |
4-Phenylpiperidine Derivatives as Renin Inhibitors
Compounds of the present invention having the formula (I) exhibit inhibitory activity on the natural enzyme renin. Thus, compounds of formula (I) may be employed for the treatment of hypertension,...
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US20080261956 |
Substituted Phenols as Active Agents Inhibiting Vegf Production
The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for...
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US20080242657 |
Treatment of Tremor with Histamine H3 Inverse Agonists or Hist Amine H3 Antagonists
Histamine H3 inverse agonists or histamine H3 antagonists are useful, alone or in combination with a neuroleptic agent, for treating or preventing movement disorders, including tremor, such as...
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US20080227814 |
Selective Estrogen Receptor Modulators
The present invention relates to a selective estrogen receptor modulator selected from the group consisting of: (I) or a pharmaceutical salt thereof; useful, e.g., for treating endometriosis and...
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US20080226719 |
Combination of Rosiglitazone and Donepezil for Improvement of Cognitive Function
Disclosed is a pharmaceutical composition comprising both rosiglitazone or a pharmaceutically acceptable salt thereof and donepezil or a pharmaceutically acceptable salt thereof which is of use in...
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US20080213368 |
Method for Stabilizing Anti-Dementia Drug
The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding...
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US20080214572 |
Selected Tetracyclic Tetrahydrofuran Derivatives Containing a Cyclic Amine Side Chain
This invention concerns novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain with binding affinities towards serotonin receptors, in particular 5-HT 2A and 5-HT 2C ...
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US20080214612 |
SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP
The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine...
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