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US20090318467 |
NOVEL HETEROARYL CARBOXAMIDE DERIVATIVES
The invention is concerned with novel heteroaryl carboxamide derivatives of formula (I),
wherein
m, X, Y, R 1 , R 2 , R 3 and R 4 are as defined in the description and in the claims, as well...
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US20090318464 |
New Pyridine Analogues V
The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y 12 inhibitors and as anti-trombotic agents etc,...
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US20090312304 |
ORGANIC COMPOUNDS
3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that...
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US20090312308 |
COMPOUNDS AND COMPOSITIONS AS HEDGEHOG SIGNALING PATHWAY MODULATORS
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from...
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US20090312368 |
Pyridine Analogues IV
The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y 12 inhibitors and as anti-thrombotic agents etc,...
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US20090306043 |
PYRROLIDINE ETHER DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS
The present invention relates to compounds of formula I
wherein R 1 , R 2 , R 3 , R′, Ar, m, n, and o are as defined herein. The invention also relates to pharmaceutical compositions...
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US20090306136 |
Benzenesulfonamide Compounds and the Use Thereof
The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 -R...
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US20090306118 |
Trisubstituted Thiophenes as Progesterone Receptor Modulators
The present invention is directed to novel trisubstituted thiophene derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases...
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US20090306047 |
HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS
Disclosed are compounds of the formula I
or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof,
wherein
W is a bond, —C(═S)—, —S(O)—, —S(O) 2...
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US20090306042 |
Novel Compounds 010
The present invention provides compounds of formula (I)
in which n, y, X 1 , X 2 , A, B, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, a process for their preparation,...
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US20090298855 |
Protein Tyrosine Kinase Inhibitors
The present invention relates to compounds of the Formula I, the pharmaceutically acceptable salts and stereoisomers thereof, which inhibit, regulate and/or modulate tyrosine kinase signal...
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US20090298813 |
USE OF NEUROPROTECTIVE COMPOUNDS IN OBTAINING MEDICAMENTS INTENDED FOR THE TREATMENT OF NEURODEGENERATING DISEASES
Use of neuroprotective compounds in obtaining medicaments intended for the curative treatment of neurodegenerative disease and/or the prevention of the appearance of disorders ensuing from those...
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US20090298878 |
OXIME COMPOUNDS AND THE USE THEREOF
The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally...
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US20090286831 |
VR1 Receptor Ligands and u-Opioid Receptor Ligands for the Treatment of Pain
A pharmaceutical composition comprising i) at least one composition that has affinity to the μ-opioid receptor, and at least one compound that has affinity to the VR1 receptor, or ii) at least one...
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US20090281060 |
HETEROCYCLIC DERIVATIVES AS GPCR RECEPTOR AGONISTS
Compounds of Formula (I), R 1 -A-V—B—R 2 ; or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful as regulators of satiety, e.g. for the treatment of obesity, and...
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US20090281116 |
PYRROLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
The invention relates to compounds having the formula (I):
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 9 and A-R 9 are as defined herein. Also disclosed are the preparative methods...
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US20090281143 |
Dose Reduction of a Cannabinoid CB1 Receptor Antagonist in the Treatment of Overweight or Obesity
O-(3-Piperidino-2-hydroxy-1-propyl)-nicotinic amidoxime or a pharmaceutically acceptable acid addition salt thereof is administered to patients suffering from overweight or obesity and treated with...
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US20090275556 |
Aryl sulfonamides useful as inhibitors of chemokine receptor activity
The present invention provides compounds of general formula I:
or a pharmaceutically acceptable salt thereof, wherein R 1 , X, Z, R 2 , X 1 , Ar, n, R 3 and R 4 are defined generally and in...
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US20090275609 |
Carboxamide Compounds and Methods for Using The Same
Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure
in which R 1 , R 2 , R 3 , R 4 , D, J, Z, T, p,...
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US20090270451 |
Piperdine Glycine Transporter Inhibitors
The present invention is directed to piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with...
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US20090270393 |
Iminopyridine Derivatives and Use Thereof
The present invention aims to provide an iminopyridine derivative compound having an α 1D adrenergic receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of...
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US20090270366 |
Benzoimidazole compounds
Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor, and in treating conditions such as inflammation, H 4 ...
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US20090270382 |
Soluble epoxide hydrolase inhibitors
Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for...
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US20090270452 |
USE OF SOLUBLE EPOXIDE HYDROLASE INHIBITORS IN THE TREATMENT OF SMOOTH MUSCLE DISORDERS
Disclosed herein are compounds, compositions, and methods for enhancing smooth muscle function in a subject by administration of soluble epoxide hydrolase inhibitors and for treating subjects with...
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US20090264466 |
Certain Chemical Entities, Compositions and Methods
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin...
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US20090258851 |
DIARYL SUBSTITUTED ALKANES
The instant invention provides compounds of Formula II which are 5-lipoxygenase activating protein inhibitors.
Compounds of Formula II are useful as anti-atherosclerotic, anti-asthmatic,...
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US20090258868 |
HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS
Disclosed are compounds of the formula I
or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein
W is a bond, —C(═S)—, —S(O)—, —S(O) 2...
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US20090258900 |
AMIDE DERIVATIVE
Amide derivatives represented by the formula (I):
wherein:
A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb′)m-, and...
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US20090253674 |
Substituted Triazole Derivatives As Oxytocin Antagonists
The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility...
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US20090253745 |
MODULATORS OF OCULAR OXIDATIVE STRESS
Described herein are compounds, compositions and methods directed to the treatment of ophthalmic conditions characterized by oxidative stress or damage in a subject by reducing the reactive oxygen...
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US20090253744 |
Acylated piperidine derivatives as melanocortin-4 receptor modulators
Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They...
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US20090253690 |
PHARMACEUTICALLY EFFECTIVE COMPOUNDS
The subject invention relates to carboxamidine derivatives, to pharmaceutical compositions containing the carboxamidine derivatives of the invention, and the use thereof for the treatment of...
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US20090246137 |
PYRIDYL DERIVATIVES AS CFTR MODULATORS
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”),...
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US20090247552 |
AQUEOUS LIQUID PREPARATION CONTAINING AMIDE COMPOUND
An object of the present invention is to promote penetration of a compound having a Rho kinase inhibitory activity to a topical moiety, and provide an aqueous liquid preparation capable of...
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US20090247521 |
SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION
The present invention generally relates to methods useful for a therapy using a class of urea or amide compounds and related compositions, wherein the compound is a soluble epoxide hydrolase...
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US20090247508 |
Benzoimidazole Compounds
Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H 4 receptor, and in treating conditions such as inflammation, H 4 ...
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US20090239905 |
PIPERIDINES AND RELATED COMPOUNDS FOR THE TREATMENT OF DEMENTIA
Compounds of formula I: modulate the action of gamma secretase, and hence find use in treatment of Alzheimer's disease and related conditions.
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US20090239857 |
TRIAMINE DERIVATIVE
An object of the present invention is to provide a novel compound which has a potent inhibitory effect on FXa and exhibits an excellent antithrombotic effect when orally administered. The present...
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US20090233965 |
Alkyl Esters Of Cyclic Amino Alcohols With Muscarinic M3 Receptor Antagonist Activity, Useful For Treating E.G. Chronic Bronchial Obstruction, Asthma And Overactive Bladder
The invention provides compounds of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the specification, a process for their preparation, pharmaceutical compositions...
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US20090233917 |
Stroke recovery
The present invention provides methods of treating stroke comprising administering an effective amount of one or more of certain hydroxylamine derivatives to a subject in need thereof. The...
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US20090227566 |
AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS
This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use...
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US20090227558 |
AMINO-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE
This invention comprises the novel compounds of formula (I)
wherein n, m, t, R 1 , R 2 , L, Q, X, Y, Z and
have defined meanings, having histone deacetylase inhibiting enzymatic activity;...
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US20090227629 |
COMPOUNDS HAVING ACTIVITY AT THE GLYCINE TRANSPORTER GLYT1 AND USES THEREOF
The present invention relates to compounds of formula (I), salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in...
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US20090227555 |
Novel Pyridine Compounds
The present invention relates to certain novel pyridin compounds of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-thrombotic agents etc,...
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US20090227556 |
RECEPTOR TYROSINE KINASE INHIBITORS COMPRISING PYRIDINE AND PYRIMIDINE DERIVATIVES
A compound represented by the following formula, a salt thereof or a hydrate of the foregoing can inhibit VEGFR-1, VEGFR-2, VEGFR-3, RON, RET and/or KIT.
[R 1 represents a 3- to 10-membered...
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US20090227572 |
TREATMENT OF DIABETIC WOUNDS AND PERIPHERAL NEUROPATHIES
The present invention provides methods of enhancing healing of wound associated with diabetes, comprising administering an effective amount of one or more of certain hydroxylamine derivatives to a...
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US20090221424 |
PESTICIDES
Compounds having the following generic formula are disclosed.
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US20090221640 |
Novel Crystal Modifications
Novel crystal modifications of (5S)-5-[4-(5-chloro-pyridin-2-yloxy)-piperidine-1-sulfonylme
thyl]-5-methyl-imidazolidine-2,4-dione are disclosed together with processes for preparing such...
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US20090221639 |
Heterocyclic GPCR Agonists
Compounds of formula (I) or pharmaceutically acceptable salts thereof, are agonists of GPR119 and are useful as regulators of satiety, e.g. for the treatment of obesity, and for the treatment of...
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US20090215764 |
Antimicrobial agents
Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or...
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