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US20150087674 COMPOSITIONS AND METHODS FOR THE TREATMENT OF SEVERE PAIN  
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical...
US20120184556 SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS  
Disclosed are substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mGluR4 potentiators.
US20130289020 CXCR4 Receptor Antagonists  
Disclosed are compounds that are antagonists of the CXCR4 receptor.
US20110190327 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS  
A method of modulating the activity of the GPR119 G protein-coupled receptor comprising administering to a mammalian patient in need thereof a therapeutically effective amount of at least one...
US20120321615 Assay for Metastatic Colorectal Cancer  
Disclosed herein is a method for predicting the prognosis, the likelihood of metastasis in, or the desirability of administering an aggressive therapy to, a subject with colorectal cancer,...
US20110280808 Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins  
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and...
US20110256064 Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins  
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and...
US20120129834 SEROTONIN RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF HUNTINGTON'S DISEASE  
Methods are provided for the treatment and/or prophylaxis of Huntington's disease. In various embodiments the methods involve administration of one or more serotonin receptor antagonists. In...
US20140128397 SYNTHETIC LETHAL TARGETING OF GLUCOSE TRANSPORT  
The present invention provides methods for inhibiting growth and proliferation of HIF pathway proficient cells by administering GLUT1 inhibitors of the invention to HIF pathway proficient cells.
US20140329761 PREVENTION AND TREATMENT OF ACUTE INFLAMMATORY CONDITIONS  
The present invention relates generally to methods for the prevention and treatment of acute inflammatory conditions in individuals using an agonist of the complement C3a receptor.
US20150094520 METHOD OF INHIBITING C-KIT KINASE  
A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or...
US20130078252 COMBINATION TREATMENTS COMPRISING C-MET ANTAGONISTS AND B-RAF ANTAGONISTS  
The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention relates to therapies for the treatment of pathological...
US20130263297 METHODS OF TREATING CANCER  
The present invention relates to metastases. More specifically, the invention relates to compositions and methods for the inhibition of metastases of cancer cells, such as prostate cancer cells,...
US20140128432 ANAPLASTIC THYROID CANCERS HARBOR NOVEL ONCOGENIC MUTATIONS OF THE ALK GENE  
The present invention relates to diagnostic, therapeutic and prognostic methods for thyroid cancers. In one embodiment, the present invention provides a method for treating a an anaplastic thyroid...
US20120003156 METHODS FOR TREATING NEOPLASIA BY INHIBITING LACTATE DEHYDROGENASE AND/OR NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE  
The invention provides compositions for the diagnosis or treatment of neoplasias, including lymphomas, leukemias, brain cancers (e. glioblastomas, medulloblastomas), breast cancer, colon cancer,...
US20120198576 METHODS FOR MAKING EMBRYONIC CELLS, EMBRYOS, AND ANIMALS SENSITIZED TO STRESS  
Embodiments of the invention are based upon the discovery that exposure of cleavage-stage embryos to a stress inducer, e.g. heat shock or chemical, renders the exposed embryos more sensitive to a...
US20150182532 COMPOSITIONS AND METHODS OF TREATING CELL PROLIFERATION DISORDERS  
The invention relates to compounds and methods for treating cell proliferation disorders.
US20150119403 Mutant ROS Expression In Human Cancer  
The invention provides the identification of the presence of mutant ROS protein in human cancer. In some embodiments, the mutant ROS are FIG-ROS fusion proteins comprising part of the FIG protein...
US20110065748 COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF GASTROINTESTINAL MOTILITY  
Disclosed are methods of treating disorders of gastrointestinal motility by administering to a patient in need of such treatment a compound having the following formula:
US20110281872 COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER  
The invention relates to compositions and methods for the treatment and prevention of cancer and other cell proliferative disorders.
US20140371238 COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS  
The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to...
US20140288116 Classification and Actionability Indices for Lung Cancer  
The disclosure provides compositions, kits, and methods for detecting a plurality of genes and associated variants in a sample from a subject with lung cancer. The compositions, kits, and methods...
US20120309742 USE OF METABOTROPIC GLUTAMATE RECEPTORS  
The invention concerns the use an mGluR modulator, e.g. an mGluR5 modulator, for the treatment, prevention or delay of progression of cognitive dysfunction.
US20120294940 RAPIDLY DISINTEGRATING TABLET IN ORAL CAVITY  
The present invention provides a method of suppressing the bitter taste of a drug when a rapidly disintegrating tablet in an oral cavity is produced. When a rapidly disintegrating tablet in an...
US20150132317 METHODS AND COMPOSITIONS FOR TREATING NEUROBLASTOMA  
Methods and compositions for treating neuroblastoma are disclosed.
US20120295936 COMPOSITIONS AND METHODS FOR TREATING SEIZURE DISORDERS  
Disclosed are methods of treating a seizure disorder by administering to a patient in need of such treatment a compound having the following formula:
US20110065747 COMPOSITIONS AND METHODS FOR TREATING SEIZURE DISORDERS  
Disclosed are methods of treating a seizure disorder by administering to a patient in need of such treatment a compound having the following formula:
US20150141397 SUBSTITUTED ANILINES AS CCR(4) ANTAGONISTS  
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
US20130172315 SUBSTITUTED ANILINES AS CCR(4) ANTAGONISTS  
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
US20140135305 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY  
The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene,...
US20110112055 COMPOSITIONS AND METHODS FOR TREATING COLITIS  
Disclosed herein are compositions and methods for treating colitis and other inflammatory bowel diseases, inter alia, indeterminate colitis, Crohn's disease, irritable bowel syndrome and ischemic...
US20130131111 NMN MODULATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS  
The invention relates to a nicotinamide mononucleotide (NMN) modulator useful as a neuroprotective medicament in the treatment of neurodegenerative disorders, in particular but not exclusively...
US20110237586 BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE  
The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt...
US20140121195 SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR(4) ANTAGONISTS  
Benzimidazole, benzopyrazole and benzotriazole compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft...
US20130165423 SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR(4) ANTAGONISTS  
Benzimidazole, benzopyrazole and benzotriazole compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft...
US20120214809 Aminoindane Compounds and Use Thereof in Treating Pain  
The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by...
US20140128393 Methods of Treating Cancer  
The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also...
US20150099782 ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR  
Provided herein are antagonists of prostaglandin EP3 receptor, processes to make said antagonists, and methods comprising administering said antagonists to a mammal in need thereof.
US20090221639 Heterocyclic GPCR Agonists  
Compounds of formula (I) or pharmaceutically acceptable salts thereof, are agonists of GPR119 and are useful as regulators of satiety, e.g. for the treatment of obesity, and for the treatment of...
US20150118243 Methods and Compositions for Identifying, Diagnosing, and Treating Neuroblastoma  
Methods and compositions for identifying, diagnosing, and treating neuroblastoma are disclosed.
US20140051702 Use of Aminoindane Compounds in Treating Overactive Bladder and Interstitial Cystitis  
The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the...
US20110195934 AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS  
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable faints thereof according to wherein all of the variables are defined herein.
US20150126494 NON-RETINOID ANTAGONISTS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND STARGARDT DISEASE  
A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in mammals afflicted therewith, comprising administering to the mammal an effective amount of a...
US20110281853 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING ATRIAL FIBRILLATION  
The present invention provides compositions and methods for treating or preventing atrial fibrillation (AF). In particular, the present invention provides administration of muscarinic receptor...
US20140088147 METHOD OF INHIBITING MUTANT C-KIT  
The present invention includes a method of reducing or inhibiting the kinase activity of C-KIT mutant tyrosine kinase activity in a cell or a subject, and the use of such compound for treating...
US20150031724 AQUEOUS LIQUID PREPARATIONS AND LIGHT-STABILIZED AQUEOUS LIQUID PREPARATIONS  
An aqueous liquid preparation containing (+)-(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino] butyric acid or a pharmacologically acceptable acid addition salt thereof, which is stabilized...
US20140343099 AQUEOUS LIQUID PREPARATIONS AND LIGHT-STABILIZED AQUEOUS LIQUID PREPARATIONS  
An aqueous liquid preparation containing (+)-(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino] butyric acid or a pharmacologically acceptable acid addition salt thereof, which is stabilized...
US20120322825 AQUEOUS LIQUID PREPARATIONS AND LIGHT-STABILIZED AQUEOUS LIQUID PREPARATIONS  
An aqueous liquid preparation containing (+)-(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino] butyric acid or a pharmacologically acceptable acid addition salt thereof, which is stabilized...
US20140309181 TREATMENT OF DISEASES RELATED TO ALPHA SUBUNITS OF SODIUM CHANNELS, VOLTAGE-GATED (SCNxA) WITH SMALL MOLECULES  
Small compounds that modulate the expression of and/or function of sodium channel, voltage-gated, alpha subunit (SCNxA) are presented. Pharmaceutical compositions containing such small molecules...
US20120322804 N-LINKED HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS  
Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.