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US20130216560 Lipidomic Biomarkers for Identification of High-Risk Coronary Artery Disease Patients  
The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a...
US20140336142 Method For Treatment Of Macular Degeneration By Modulating P2Y12 or P2X7 Receptors  
Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal...
US20120264708 Method For Treatment Of Macular Degeneration By Modulating P2Y12 or P2X7 Receptors  
Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal...
US20110166114 METHOD FOR TREATING SNORING AND SLEEP APNEA WITH LEUKOTRIENE ANTAGONISTS  
A method of treating snoring and/or sleep apnea comprising administering to a patient in need of such treatment a therapeutically effective amount of a leukotriene receptor antagonist.
US20120157420 TREATMENT AND PREVENTION OF SECONDARY INJURY AFTER TRAUMA OR DAMAGE TO THE CENTRAL NERVOUS SYSTEM  
A method of administering one or multiple medications to human patients with CNS injury through oral or parenteral (including transdermal, intravenous, subcutaneous, intramuscular) routes....
US20150154345 REPROGRAMMING EFFECTOR PROTEIN INTERACTIONS TO CORRECT EPIGENETIC DEFECTS IN CANCER  
Methods of “reprogramming” epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset...
US20120029001 METHOD OF TREATMENT OF NEPHROGENIC DIABETES INSIPIDUS  
Nephrogenic diabetes insipidus is treated with statins.
US20090137620 USE OF GALLIUM(III) COMPLEXES FOR THE TREATMENT OF MELANOMAS  
The invention relates to the use of gallium (III) complexes for the treatment of melanomas.
US20140364452 METHODS TO DETERMINE SUSCEPTIBILITY TO TREATMENT WITH LEUKOTRIENE MODIFIERS  
The present invention provides a method of determining the susceptibility of a subject to treatment with a leukotriene modifier by determining the subject's cysteinyl leukotriene (CysLT) level and...
US20150253327 DIAGNOSIS AND TREATMENT OF ASPIRIN-EXACERBATED RESPIRATORY DISEASE (AERD)  
Described herein are assays and methods relating to the diagnosis, prognosis, and treatment of aspirin-exacerbated respiratory disease (AERD) by detecting and/or measuring the level of...
US20120156255 DRUG ELUTING PATCH FOR THE TREATMENT OF LOCALIZED TISSUE DISEASE OR DEFECT  
A polymeric matrix for delivery of an HMG CoA reductase inhibitor such as a statin to tissue such as cardiac tissue in need thereof for the treatment or prevention of a disease or defect such as...
US20150031677 TRIOXANE THIOACETAL MONOMERS AND DIMERS AND METHODS OF USE THEREOF  
Monomeric and dimeric trioxane thioacetals and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic...
US20110245283 Methods for predicting the response to statins  
The invention provides methods for optimizing therapeutic efficacy for treating hypercholesterolemia in a subject having a cardiovascular disease (CVD), comprising (a) determining subject...
US20110224128 METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY  
The invention features methods, compositions, and kits useful for the treatment of muscular dystrophy, e.g., Duchenne muscular dystrophy, in a patient.
US20150005260 METHODS FOR THE DETECTION AND THE TREATMENT OF DIASTOLIC DYSFUNCTION  
The present invention relates to methods and kits for detecting diastolic dysfunction in subjects without clinical signs of heart failure.
US20130190315 SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION  
Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions...
US20120107401 OSTEOCONDUCTIVE MATRICES COMPRISING STATINS AND METHODS OF USING THE SAME  
Osteoconductive matrices and methods are provided that have one or more statins disposed therein. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for...
US20120027723 TAURINE OR TAURINE-LIKE SUBSTANCES FOR THE PREVENTION AND TREATMENT OF A DISEASE ASSOCIATED WITH RETINAL GANGLION CELL DEGENERATION  
The present invention relates to taurine or taurine-like substances for the prevention and treatment of a disease associated with retinal ganglion cell degeneration. More particularly the...
US20140113930 THERAPEUTIC COMBINATION FOR CANCER TREATMENT  
This invention relates to a synergistic pharmaceutical combination of glucose lowering drugs and autophagy inhibitors, kits containing such combinations, and methods of using such combinations to...
US20110123617 CLIOQUINOL FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES  
The present invention relates to compositions and methods for treating hematological malignancies and proliferative diseases, disorders and conditions involving increased D-cyclin expression. In...
US20110118292 METHOD OF TREATING ATHEROSCLEROSIS, DYSLIPIDEMIAS AND RELATED CONDITIONS  
A method of treating atherosclerosis is disclosed wherein nicotinic acid or another nicotinic acid receptor agonist is administered to the patient in combination with a DP receptor antagonist. The...
US20110091421 Methods of Novel Therapeutic Candidate Identification Through Gene Expression Analysis in Vascular-Related Diseases  
The present invention discloses multiple treatment regimens for vascular-related diseases and disorders. The present invention provides for methods of treating vascular-related disorders based on...
US20140323520 Compositions and Methods for Increasing Proliferation of Adult Salivary Stem Cells  
The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an...
US20130303568 Substituted 2-Aminoacetamides and the Use Thereof  
The invention is directed to substituted 2-aminoacetamides represented by formula (II): and to pharmaceutically acceptable salts and prodrugs thereof, wherein the substituents are defined herein....
US20140128352 COMPOUNDS AND METHODS FOR MODULATING MITOCHONDRIAL METABOLISM AND REACTIVE OXYGEN SPECIES PRODUCTION  
Compounds that modulate mitochondrial reactive oxygen species (ROS) production are provided. The compounds may modulate ROS production at defined sites without also altering energy production....
US20120122787 METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES  
The present invention is directed to, inter alia, methods of treating or ameliorating an effect of a polycystic disease. This method include administering to a patient in need thereof an amount of...
US20110076244 SURFACE COATINGS FOR SKIN  
The present invention relates to skin coating compositions and methods and, in particular, to coatings containing an active agent. In some embodiments, the coating may be applied to a skin surface...
US20150051233 METHODS AND COMPOSITIONS FOR TREATMENT OF FIBROSIS  
Embodiments of the invention include methods of treating, preventing, and/or reducing the risk of fibrosis in an individual in need thereof. In some embodiments, particular small molecules are...
US20120107383 OSTEOCONDUCTIVE MATRICES COMPRISING CALCIUM PHOSPHATE PARTICLES AND STATINS AND METHODS OF USING THE SAME  
Osteoconductive matrices and methods are provided that have one or more statins disposed in calcium phosphate particles. The matrices may be injected into a fracture site. The osteoconductive...
US20110269793 METHOD FOR PREVENTING TAU PROTEIN AGGREGATION AND TREATING ALZHEIMER'S DISEASE WITH A QUINOLINE DERIVATIVE COMPOUND  
Method for the prevention of the tau protein aggregation and treating Alzheimer's disease by administering a quinoline derivative compound of formula wherein R2 is 2-(4-aminophenyl) or...
US20110275632 Method for preventing or treating a disease related to the glucocorticoid receptor  
A method for preventing or treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-dihydroquinoline compound.
US20110275620 Method for preventing or treating a disease related to the glucocorticoid receptor  
A method for preventing or treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-hydroquinoline compound.
US20120128778 COMPOSITIONS AND METHODS FOR ONCE-DAILY ADMINISTRATION OF A TRILAYER OSMOTIC TABLET  
A trilayer osmotic tablet is described. The tablet includes a core, a semi-permeable membrane disposed generally around the core, and an orifice in the semi-permeable membrane in fluid...
US20130045217 LIPIDOMIC BIOMARKERS FOR ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASE  
The present invention inter alia provides a method, and use thereof, of diagnosing and/or predicting atherosclerosis or CVD by detecting the lipid concentrations or lipid ratios of a biological...
US20120148530 Method for the treatment or prevention of virus infection using polybiguanide-based compounds  
An inexpensive, easily available, and convenient method of treating or preventing a virus infection is provided. The present invention relates to a method for the treatment or prevention of virus...
US20150164910 ANTIVIRAL COMPOUNDS AND METHODS OF USE  
Methods for treating enteroviral infections in cells are provided. Aspects of the methods include inhibiting the replication of enterovirus or replication of other virus and/or inhibiting cell...
US20130324523 TAU IMAGING PROBE  
An object of the present invention is to provide a probe for imaging a β-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy)...
US20140199291 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML)  
The invention relates to compositions, methods, and kits for treating subjects infected by or at risk of infection with a DNA virus (e.g., a JC Virus or a BK virus). Aspects of the invention are...
US20130183289 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML)  
The invention relates to compositions, methods, and kits for treating subjects infected by or at risk of infection with a DNA virus (e.g., a JC Virus or a BK virus). Aspects of the invention are...
US20120302581 Methods and Compositions for the Treatment of RAS Associated Disorders  
The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example,...
US20110263589 Method for preventing or treating a glucocorticoid receptor-related disease  
A method of preventing or treating a glucocorticoid receptor-related disease involving administering a therapeutically effective amount of a 1,2-dihydroquinoline compound or a pharmaceutically...
US20130030009 METHOD FOR THE TREATMENT AND/OR PREVENTION OF ORAL ALLERGIC SYMPTIONS OF THE LIPS DUE TO ORAL CONTACT WITH A FOOD ALLERGEN  
A method of applying a topical preparation of at least one of a mast cell stabilizer, an antihistamine, and a leukotriene inhibitor is disclosed for prevention and/or treatment of oral allergy...
US20110092488 Quninoline Methanol Compounds for the Treatment and Prevention of Parasitic Infections  
Malaria is responsible for 1-2 million deaths and 300-500 million clinical cases annually and is an ever present problem for the military, tourists and business travelers. Mefloquine is known and...
US20110281908 Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use  
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer...
US20110098314 STATINS FOR THE TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA  
The use of HMG-CoA reductase inhibitors (e.g., statins) to treat glaucoma, control intraocular pressure, preserve the trabecular meshwork, protect against ocular neurodegeneration and/or protect...
US20110288058 Methods for Preventing or Reducing Colon Carcinogenesis  
The present invention is directed in part to methods of preventing or reducing colon carcinogenesis comprising administering to a patient at risk of colorectal cancer, a pharmaceutical preparation...
US20130053413 CRYSTALLINE FORMS OF PITAVASTATIN CALCIUM  
The present invention is directed to new crystalline forms of Pitavastatin hemicalcium salt, referred to hereinafter as polymorphic Forms A, B, C, D, E and F, as well as the amorphous form....
US20120101126 CRYSTALLINE FORMS OF PITAVASTATIN CALCIUM  
The present invention is directed to new crystalline forms of Pitavastatin hemicalcium salt, referred to hereinafter as polymorphic Forms A, B, C, D, E and F, as well as the amorphous form....
US20140113012 COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS  
The present invention provides compounds and compositions for the amelioration of arthritis and joint injuries by inducing mesenchymal stem cells into chondrocytes.
US20110300137 Use of lumefantrine and related compounds in the treatment of cancer  
The present application discloses the use of the anti-malarial drug lumefantrine and related compounds in the treatment of cancer.