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US20050159368 Wound treatment composition and process of manufacture  
A wound treatment composition contains one or more antimicrobial agents that alone or in combination have antibacterial and antifungal properties, a vasoconstriction agent, a steroidal...
US20090305891 CYCLOALKYLPHENYL SUBSTITUTED CYCLIC KETOENOLS  
The disclosure relates to novel cycloalkylphenyl-substituted cyclic ketoenols of the formula (I) in which J, X, Y, m and CKE are as defined above, to processes and intermediates for their...
US20090137558 Pyridine based compounds useful as intermediates for pharmaceutical or agricultural end-products  
The present invention relates to substituted pyridine compounds of Formula (I) and derivatives thereof, and to a process for preparing these substituted pyridines. The invention also relates to...
US20120034270 S1P Receptors Modulators  
The invention relates to novel compounds that have S1P receptor modulating activity and, preferably, apoptotic activity and/or anti proliferative activity against cancer cells and other cell...
US20150175548 INHIBITORS OF THE NOTCH SIGNALLING PATHWAY AND SECRETION FOR USE IN MEDICINE  
The invention relates to dihydropyridine compounds as inhibitors of the notch signalling pathway and/or inhibitors of secretion for the treatment of secretion-dependent disease, such as cancer or...
US20140370060 Tear Film Stability  
The present invention relates to a method of stabilising a tear film in an individual having an ocular surface inflammatory disorder by providing a compound to an ocular surface of the individual...
US20140135320 HETEROARYL DERIVATIVES AND USES THEREOF  
The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to...
US20110263564 PYRIDINE, BICYCLIC PYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS  
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or...
US20100057047 DELIVERY DEVICE AND METHOD  
A nasal delivery device for and method of delivering substance to the middle meatus in a nasal cavity of a subject in the treatment of a condition, in particular an inflammatory or infectious...
US20090239906 ALKOXYALKYL-SUBSTITUTED CYCLIC KETOENOLS  
The invention relates to new alkoxyalkyl-substituted cyclic ketoenols of the formula (I) in which A, B, D, G, W, X and Y have the definitions indicated above, to processes and intermediates for...
US20060058307 Combination of an atp-competitive inhibitor of bcr/abl kinase activity and a tyrphostin analog  
The present invention relates to a combination of (a) an ATP-competitive inhibitor of Bcr/abl kinase activity and (b)) a tyrphostin analog, and the use of said combination or product for the...
US20100152207 GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO  
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the...
US20100234407 PREVENTIVES/REMEDIES FOR MYELOMA TUMOR AND METHOD FOR DIAGNOSING THE SAME  
The present invention provides a preventive or therapeutic drug for a myeloma tumor and osteoclastic bone loss associating therewith, the drug containing as an active ingredient an...
US20070184101 Stable pharmaceutical formulations of montelukast sodium  
The invention encompasses stable pharmaceutical compositions comprising montelukast or salts thereof and methods of preparing the same.
US20100324075 THERAPEUTIC USE OF CARBOXYL ESTER LIPASE INHIBITORS  
Compounds, pharmaceutical compositions, and their methods of use in raising serum HDL levels in subjects in need thereof are provided. Also provided are compounds, pharmaceutical compositions, and...
US20070197538 Anti-vascular and anti-proliferation methods, therapies, and combinations employing specific tyrosine kinase inhibitors  
This invention is directed to potent inhibitors of protein tyrosine kinase alone or in synergistic combination with antiangiogenic or chemotherapeutic agents for the abrogation of mature...
US20110014174 Lysozyme, A Novel Vasodilator of Sepsis that can be inhibited by a Peroxidase and Hydroxyl Radical Scavengers  
A method of reducing a vasodilatory response comprising administering to an individual in need of such treatment an effective amount of a guanylate cyclase pathway inhibitor selected from the...
US20080312277 Gpr41 and Modulators Thereof for the Treatment of Insulin-Related Disorders  
The present invention relates to a method for identifying a glycemic stabilizing compound by: a) contacting a candidate compound with GPR41, and b) determining whether GPR41 functionality is...
US20060009487 Heterocyclic derivatives for treatment of hyperlipidemia and related diseases  
The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or...
US20140275162 INHIBITION OF LEUKOTRIENE SYNTHESIS AND ACTIVITY IN THE TREATMENT OF SONIC HEDGEHOG-ASSOCIATED MEDULLOBLASTOMA  
Treating Sonic Hedgehog-Associated Medulloblastoma comprises inhibiting the synthesis or biologic activity of leukotrienes that drive Nestin expression in cancerous or precancerous granule neuron...
US20120088746 AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME  
Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and...
US20110033393 Hydrazone Compounds and Their Use  
The present invention relates to hydrazone compounds of Formula I: and pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3, R4, L1, and L2 are defined as set forth in...
US20090263453 Methods and Compositions for Treating Pain Comprising a Statin  
Methods and compositions are provided for reducing, treating or preventing pain and/or inflammation in a patient in need of such treatment, the methods and compositions comprising administering a...
US20120094958 QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE  
The invention relates to a compound of formula (I) wherein the substituents are as described in the specification, which are useful as farnesyl pyrophosphate synthase modulators, e.g. in the...
US20120101127 NOVEL TETRAHYDROQUINOLINE DERIVATIVES  
The present invention relates to compounds according to formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R1 to R7 have the significance given herein. The compounds are...
US20150141415 Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases  
The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The...
US20090005413 Novel Salt of Montelukast  
The invention relates to a novel salt of montelukast with tert-butylamine and its use in the process for the preparation of highly pure free montelukast acid and/or pharmaceutically acceptable...
US20080026081 Methods of Treatment Using (+)-Isopropyl 2-Ethoxyethyl-4-(2-Chloro-3-Cyano-Phenyl)-1,4-Dihydro-2,6-Dimethyl-Pyridine-3,5-Dicarboxylate  
The present invention relates to methods of treatment using the compound (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin e-3,5-dicarboxylate, as a sole...
US20090018162 USE OF 6-(3-CHLORO-2-FLUOROBENZYL)-1-[(2S)-1-HYDROXY-3-METHYLBUTAN-2-YL]-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID OR SALT THEREOF FOR TREATING RETROVIRUS INFECTION  
The present invention provides a use of a therapeutically effective amount of 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan- 2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic...
US20140148481 PITAVASTATIN CALCIUM AND PROCESS FOR ITS PREPARATION  
The invention provides the process for the preparation of pitavastatin and its pharmaceutically acceptable salts thereof. In particular, the invention provides a process for the preparation of...
US20060228306 Combination antihistamine and steroid medication  
The invention provides a topical pharmaceutical composition for application to the nasal or ocular mucosa which comprises (1) a pharmaceutical excipient suitable for topical administration, (2) an...
US20060019987 Methods and compositions for inhibiting, destroying, and/or inactivating viruses  
The present disclosure provides compositions, methods, and processes for the inhibiting, destroying, and/or inactivating viral contaminants in a biological source material, or treatment of viral...
US20070149487 Antiviral Compositions and Methods  
Compositions and methods for treating, preventing, or ameliorating one or more symptoms, conditions, or disorders associated with coronavirus infections are provided, in particular small-molecule...
US20140286922 Method of Measuring the Metabolic Indicators of Hair Follicles  
A method of measuring the effect of an active agent or a stressor on the baseline metabolic indicators of one or more hair follicles, the method including (a) obtaining one or more hair follicles;...
US20150164916 ROFLUMILAST COMPOSITIONS FOR THE TREATMENT OF COPD  
The present invention relates to pharmaceutical compositions comprising roflumilast in combination with a corticosteroid and/or a leukotriene receptor antagonist. The invention also relates to the...
US20130172303 ROFLUMILAST COMPOSITIONS FOR THE TREATMENT OF COPD  
The present invention relates to pharmaceutical compositions comprising roflumilast in combination with a corticosteroid and/or a leukotriene receptor antagonist. The invention also relates to the...
US20070249519 METHODS FOR THE UPREGULATION OF GLUT4 VIA MODULATION OF PPAR DELTA IN ADIPOSE TISSUE AND FOR THE TREATMENT OF DISEASE  
The present invention is directed to novel compositions and their application as pharmaceuticals for the treatment of disease. Methods of upregulation of GLUT4 via activation of peroxisome...
US20140303151 Inhibitors of PI3K-Delta and Methods of Their Use and Manufacture  
The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
US20140045825 Inhibitors of PI3K-Delta and Methods of Their Use and Manufacture  
The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
US20120289510 Benzyl Amines, A Process For Their Production And Their Use As Anti-Inflammtory Agents  
The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
US20130116275 INHIBITORS OF HIF AND ANGIOGENESIS  
Inhibitors of the Hypoxia Inducible Factor (HIF) and angiogenesis and their methods of use including the treatment of cancer, hypoxia related pathologies, disorders leading to ischemia, for...
US20140017314 METHOD FOR MAKING HOMOGENEOUS SPRAY-DRIED SOLID AMORPHOUS DRUG DISPERSIONS UTILIZING MODIFIED SPRAY-DRYING APPARATUS  
Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time,...
US20100311790 AMIDE COMPOUNDS AND PLANT DISEASE CONTROLLING METHOD USING SAME  
The object of the present invention is to provide a compound having excellent controlling effect on plant diseases. An amide compound represented by the following formula (I) has excellent...
US20110263540 SMALL-MOLECULE INHIBITORS OF PROTEIN SYNTHESIS INACTIVATING TOXINS  
Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are...
US20150175547 CCR6 COMPOUNDS  
Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
US20080293676 Insecticidal Agents Based on Selected Insecticides and Safeners  
Insecticidal compositions characterized by an effective amount of an active ingredient combination comprising (a) one or more compounds selected from the group of acetylcholinesterase inhibitors,...
US20100022584 Modulation of Glutamine Synthetase Activity  
Methods of screening and designing compounds as inhibitors of glutamine synthetase are provided herein. Compounds, e.g., serine protease inhibitors, and compositions comprising the same, that are...
US20130303522 INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1  
The compounds of formula (I) are derived from perhydroquinoline and perhydroisoquinoline and are useful as active pharmaceutical ingredients for the prophylaxis or treatment of diseases caused by...
US20130310254 Alpha, beta-unsaturated imines  
The present application relates to novel alpha, beta-unsaturated imines, to processes for their preparation, to their use for controlling animal pests including arthropods and in particular...
US20070249603 3-Arylsulfonyl-Quinolines as 5-Ht6 Receptor Antagonists for the Treatment of Cns Disorders  
The present invention relates to novel quinoline derivatives such as compounds of the formula (I) which have antagonist potency for the 5-HT6 receptor: and the use of such compounds or...