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US20110015225 Heterocyclic compound  
The present invention provides to a compound having melanin-concentrating hormone receptor antagonistic action and low toxicity, and useful as a agent for the prophylaxis or treatment of obesity...
US20080226622 Hif Inhibitors  
HIF-1 inhibitors and methods of use thereof are provided.
US20080221159 Inhibitors of human immunodeficiency virus replication  
Compounds of formula I: wherein a, b, c, X, R2, R3, R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
US20100087480 SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS  
This invention provides a compound of the formula (I). These compounds are useful for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in...
US20070213365 Novel polymorphs of montelukast ammonium salts and processes for preparation therefor  
Novel crystalline forms I, II, III, IV, V, VI, VII, VIII, IX, and X of montelukast ammonium salts are provided, and novel methods of making these forms are disclosed.
US20140038962 Flavivirus Inhibitors and Methods of Their Use  
Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a...
US20110224207 FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE  
Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a...
US20090162439 SILK FIBROIN COATING  
The present invention is directed to compositions and methods for preventing or inhibiting biofilm formation on a solid substrate comprising an antimicrobial agent and a biofilm-degrading enzyme...
US20150141422 HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK  
Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human...
US20100069393 METHOD OF TREATMENT AND AGENTS USEFUL FOR SAME  
The present invention relates generally to therapeutic agents, formulations comprising them and their use in the treatment, amelioration and/or prophylaxis of glioma brain tumours and related...
US20120040993 NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM  
Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective...
US20080058293 Quinoline Derivates and Their Use in Therapy  
The invention provides compounds of formula (I) wherein n, p, q, X, R1, R2, R3, R4, R5 and R6 are as defined in the specification; processes for their preparation, pharmaceutical compositions...
US20130225610 ANTIMETASTATIC COMPOUNDS  
Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of...
US20130035348 ANTIMETASTATIC COMPOUNDS  
Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of...
US20110152250 CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF  
Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L,...
US20080096894 Anti-Bacterial Compounds  
Compounds of formula (I), or salts or solvates thereof, in vitro as inhibitors of growth of Gram-positive bacteria, where A is selected from formula (a).
US20070270462 8-hydroxyquinoline compounds for treating a polyglutamine (polyQ)-expansion disease  
The present invention provides compositions and methods of treating a polyglutamine (poly Q) expansion disease in a subject using an 8-hydroxyquinoline compound.
US20120064160 Fibrate-statin Combinations with Reduced Fed-fasted Effects  
This invention discloses an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the...
US20110306621 ACYLGUANIDINE DERIVATIVES  
An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on a serotonin 5-HT5A receptor modulating action. It was confirmed that...
US20100074951 CONTROLLED RELEASE COMPLEX COMPOSITION COMPRISING ANGIOTENSIN-II-RECEPTOR BLOCKERS AND HMG-COA REDUCTASE INHIBITORS  
Disclosed herein is a lag time delayed-release combination pharmaceutical composition comprising of an angiotensin-II-receptor blocker and an HMG-CoA reductase inhibitor, as well as a preparation...
US20090253740 SUBSTITUTED N-BICYCLICALKYL BICYCLICCARBOXYAMIDE COMPOUNDS  
This invention provides a compound of the formula (I): And their use for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This...
US20060147482 Oral liquid pharmaceutical composition of leukotriene antagonists  
An oral liquid pharmaceutical composition of leukotriene antagonists is described and is used an anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agent. The composition is a...
US20060100202 Novel compounds  
Compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein, R1, R2, P, p and n are as defined in the specification, a process for preparing such compounds, a...
US20070167350 Quinaldine based semisquaraines and squaraine dyes, process for preparation thereof and use thereof  
The present invention provides quinaldine-based semisquaraines, symmetrical and unsymmetrical squaraine dyes represented by the general formulae 1, 2 and 3 and/or pharmaceutically acceptable...
US20070249577 Method for reducing the risk of or preventing infection due to surgical or invasive medical procedures  
The present invention relates to methods for reducing the risk of infection due to surgical or invasive medical procedures. The present invention also relates to methods for preventing infection...
US20140286931 BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR  
The present invention relates to new biphenyl-3-carboxylic acid modulators of beta-3-adrenoceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
US20110144154 Salts of 2-Substituted Quinolines  
The invention relates to salts of 2-substituted quinolines, the manufacturing method for same, and use of the same for the production of drugs. Said salts are advantageous in that the same can be...
US20090137393 2,4,6-TRIALKYLPHENYL SUBSTITUTED CYCLOPENTANE-1,3-DIONE  
The invention relates to novel 2,4,6-trialkylphenyl-substituted cyclopentane-1,3-diones of the formula (I) in which X, Y, A, B, Q1, Q2 and G have the meanings given above, to a plurality of...
US20140364454 METAL-CHELATING COMPOUNDS HAVING AT LEAST ONE POLYAMINO CHAIN  
The invention relates to metal-chelating compounds comprising one or more 8-hydroxyquinoline units substituted in position 2 with a nitrogenous group comprising a polyamino chain, wherein the...
US20080032986 BENZYL AMINES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS  
The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
US20110082116 NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS  
The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds,...
US20070054839 Method of inhibiting remnant lipoprotein production  
The present invention aims at provision of a method for inhibiting remnant lipoprotein production and a remnant lipoprotein production inhibitor, which includes administering a compound having a...
US20100240683 COMBINATION THERAPY, COMPOSITION AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS  
The present invention relates to a combination therapy for the treatment of cardiovascular disorders. More particularly, the invention relates to compositions combining long-chain optionally...
US20070155786 Methods for treating oral aphthous stomatitis and oral mucositis  
The invention provides a composition comprising certain quinoline derivatives for ameliorating, treating, and preventing aphthous stomatitis and oral mucositis. The composition, optionally...
US20090298742 PROCESS FOR MANUFACTURING LACTOSE  
A process for forming crystalline lactose suitable for use in a pharmaceutical formulation comprises subjecting a solution comprising a plurality of nanosized lactose particles to conditions...
US20130131088 TREATING CANCER WITH STATINS AND COMPOUNDS HAVING DIPYRIDAMOLE ACTIVITY  
The disclosure pertains to methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a statin in combination with an effective amount of a...
US20120302566 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS  
The present invention relates to compounds defined by formula (I) wherein the variables R1, R2, R3, m, and n are defined as in claim 1, possessing valuable pharmacological activity. Particularly,...
US20110243940 BICYCLIC PYRANONE DERIVATIVES AND METHODS OF USE THEREOF  
The present invention relates to Bicyclic Pyranone Derivatives, their compositions and uses for treating or preventing a metabolic disorder, dyslipidemia, a cardiovascular disease, a neurological...
US20120308606 BICYCLIC DERIVATIVES AS MODULATORS OF VOLTAGE GATED ION CHANNELS  
Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
US20050148627 Benzopyran compounds for use in the treatment and prevention of inflammation related conditions  
The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are...
US20090076480 Active Ingredient-Containing Silicone Elastomers  
The invention relates to compositions comprising silicone elastomers and antimicrobially active substances in homogeneous distribution, a process for their production and their use in medical...
US20110053941 IDO Inhibitors  
Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound...
US20100041694 AGRICULTURAL COMPOSITION FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENIC MICROBES  
An agricultural composition comprising an amide compound represented by the following formula (I), a salt thereof, or a hydrate thereof is effective for controlling or preventing plant diseases...
US20110281879 SULFONYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS  
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by...
US20110293615 Use of Combination of Anti-Angiogenic Substance and c-kit Kinase Inhibitor  
The object of the present invention is to find a pharmaceutical composition and a method for treating cancer that show an excellent antitumor effect. Combinational use of...
US20130137720 HISTONE DEMETHYLASE INHIBITORS AND METHODS FOR USING THE SAME  
The present invention provides compounds, or derivatives or prodrugs thereof, that comprise a methyllysine mimic, and an α-ketoglutarate mimic that are attached through a linker and methods for...
US20100086602 PHARMACEUTICAL COMPOSITION CONTAINING STATIN-ENCAPSULATED NANOPARTICLE  
The present invention provides a novel nanotechnology-based strategy for therapeutic neovascularization. Said statin-loaded nanoparticle allows local delivery of statin and thus improves...
US20060258668 Use of phosphatase inhibitors as adjunct therapy for psychiatric disorders  
The use of a phosphatase inhibitor in conjunction with psychotherapy provides enhanced therapeutic results in the treatment of psychiatric disorders including, for example, specific phobias, panic...
US20080220003 C5a Receptor Antagonists  
The present invention is related to a compound, preferably a C5a receptor antagonist, having the following structure, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17,...
US20090182008 CRYSTALLINE FORMS OF PITAVASTATIN CALCIUM  
The present invention is directed to new crystalline forms of Pitavastatin hemicalcium salt, referred to hereinafter as polymorphic Forms A, B, C, D, E and F, as well as the amorphous form....