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US20080287493 ARYLMETHYLEN SUBSTITUTED N-ACYL-Y-AMINOALCOHOLS  
The present invention relates to arylmethylen substituted N-acyl-Y-aminoalcohols of the general formula I in which Q, X, W, R1, R2, R3, R4 and R5 have the meaning as defined in the description.The...
US20110052683 PHARMACEUTICAL PREPARATION FOR TREATING CARDIOVASCULAR DISEASE  
The present invention provides a pharmaceutical preparation comprising a prior-release compartment containing a hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor as a pharmacologically...
US20080090842 Novel pyridyl cyanoguanidine compounds  
Compounds according to formula I wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C1-6 hydrocarbon radical, optionally substituted with...
US20120142727 NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE  
[Object] An excellent agent for preventing or treating dementia, schizophrenia, and the like, based on serotonin 5-HT5A receptor modulating action, is provided. [Means for Solution] It was...
US20070043024 Azacyclic compounds as inhibitors of sensory neurone specific channels  
Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents...
US20110217374 PHARMACEUTICAL COMPOSITION SIMULTANEOUSLY HAVING RAPID-ACTING PROPERTY AND LONG-ACTING PROPERTY  
Disclosed is a pharmaceutical composition simultaneously having a rapid acting property and a long-acting property, comprising a sustained-release part coated with a water-insoluble polymer on the...
US20090111849 CRYSTALLINE SALT OF MONTELUKAST  
Cyclopropylamine salt of montelukast in crystalline form and its use for the preparation of highly pure amorphous montelukast sodium.
US20090105278 Selective inhibitors of human corticosteroid syntheses  
The invention relates to compounds for selectively inhibiting human corticosteroid syntheses CYP11B1 and CYP11B2, to the production thereof and to their use for treating hypercortisolism and...
US20140038951 PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS  
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological...
US20090221535 IMMUNOGENIC COMPOSITIONS FOR GRAM POSITIVE BACTERIA SUCH AS STREPTOCOCCUS AGALACTIAE  
The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z. R4, R5a?, R5b, R5c, R6, m and n are defined herein) useful as antagonists...
US20110269786 TREATMENT OF MAJOR ADVERSE CARDIAC EVENTS AND ACUTE CORONARY SYNDROME IN DIABETIC PATIENTS USING SECRETORY PHOSPHOLIPASE A2 (SPLA2) INHIBITOR OR SPLA2 INHIBITOR COMBINATION THERAPIES  
Administration of sPLA2 inhibitors in combination with statins has been found to reduce the occurrence of major adverse cardiac events (MACEs), specifically unstable angina (UA) requiring urgent...
US20050187243 Montelukast free acid polymorphs  
The present invention relates to amorphous and polymorphic forms of montelukast free acid.
US20140323475 EP1 RECEPTOR LIGANDS  
The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The...
US20110172267 TSH receptor antagonizing tetrahydroquinoline compounds  
The present invention relates the use of a compound, a pharmaceutical composition, compounds and a kit for treating or preventing disorders in a mammal responsive to TSH receptor mediated...
US20080306030 Use of a TRPM5 Inhibitor to Regulate Insulin and GLP-1 Release  
The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric...
US20090162442 MULTI-PHASIC, NANO-STRUCTURED COMPOSITIONS CONTAINING A COMBINATION OF A FIBRATE AND A STATIN  
The present invention discloses a pharmaceutical formulation containing a multi-phasic pharmaceutical composition in an oral dosage form. The multi-phasic pharmaceutical composition contains: (a)...
US20140219960 NOVEL COMPOSITION FOR PREVENTING OR TREATING HEPATITIS C VIRUS, REGULATING PHOSPHORYLATION OF REPLICASE  
The present invention relates a novel composition for preventing or treating hepatitis C virus, regulating the phosphorylation of a replicase. More specifically, it is possible to prevent or treat...
US20090023772 Novel substituted heteroaryloxy alkylamines and their use as monoamine neurotransmitter re-uptake inhibitors  
This invention relates to novel substituted heteroaryloxy alkylamines useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these...
US20090176745 TRIARYLMETHANE ANALOGS AND THEIR USE IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and...
US20150239845 QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS  
The present invention is directed to quinoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders and conditions mediated by the CB-1...
US20150239844 QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS  
The present invention is directed to quinoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders and conditions mediated by the CB-1...
US20140113934 HETEROCYCLIC COMPOUNDS FOR TREATING HELMINTH INFECTIONS  
Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein L is (CR13aR13b)t, CR14═CR14, C≡C, CR15aR15bX, XCR15aR15b, CO, O, S(O)p, NR5, CONR5, NR5CO, NR5SO2 or SO2NR5;X is O, S,...
US20050004167 Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases  
The invention relates to BCAT inhibitor compounds of formula (I) and use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as...
US20120214803 Novel Sulfonaminoquinoline Hepcidin Antagonists  
The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism...
US20070274922 Water Soluble Boronic Acid Fluorescent Reporter Compounds and Methods of Use Thereof  
Described herein are boronic acid fluorescent compounds and methods of use thereof.
US20050187244 Montelukast sodium polymorphs  
The present invention provides high crystallinity montelukast sodium, crystalline forms of montelukast sodium, and processes of preparing the same.
US20070197467 ZAFIRLUKAST COMPOSITIONS  
Intimate dispersions comprising zafirlukast and hydroxypropyl cellulose.
US20120196893 COMPOSITION, METHOD, SYSTEM AND KIT FOR OPTICAL ELECTROPHYSIOLOGY  
The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing...
US20080318957 POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF  
Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent...
US20090062279 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTI-ALZHEIMER AGENTS  
The invention is related to compound which comprises at least one radical C═Y, Y being O or S, and an oxidable and non protonable nitrogen atom N wherein the distance (d) between the at least one...
US20110027251 NOVEL USES FOR 4-PHENYLBUTYRATE (4PBA) AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS  
Novel uses for 4-phenylbutyrate (4PBA) and its pharmaceutically acceptable salts The use of 4PBA in the manufacture of a medicament useful to treat cognitive disorders in dementias coursing with...
US20090082372 Arylmethylene Substituted N-Acyl-Beta-Amino Alcohols  
The present invention relates to arylmethylene substituted N-Acyl-β-amino alcohols of the formula I in which Y is selected from the aryl or heteroaryl groups: and R1, R2, R3, R4, R5, Q, X and W...
US20140296236 QUINOLINES AS FGFR KINASE MODULATORS  
The invention relates to new quinoline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the...
US20080213396 Copper Lowering Treatment Of Cardiac Disease  
The present invention relates generally to the field of prophylaxis and therapy for cardiac fibrosis. In particular, the present invention is related to agents that can bind or complex copper, and...
US20110183962 SMOOTHENED ANTAGONISM FOR THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS  
The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g.,...
US20150094334 8-HYDROXY QUINOLINE DERIVATIVES  
The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a...
US20150025108 8-HYDROXY QUINOLINE DERIVATIVES  
The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a...
US20090124657 PHARMACEUTICAL COMPOSITIONS COMPRISING MONTELUKAST  
Pharmaceutical compositions comprising montelukast or pharmaceutically acceptable salts, solvates, polymorphs, enantiomers or mixtures thereof.
US20080280849 Synergic Combinations Comprising a Quinoline Compound and Other Hiv Infection Therapeutic Agents  
The invention relates to a combination comprising a quinoline compound or its sail, according to general formula (I) and at least one HIV infection therapeutic agent selected from the group...
US20070099919 Composition and synthesis of new reagents for inhibition of HIV replication  
The present invention provides compounds and compositions for inhibiting Vif and methods for treating viral infection, e.g., HIV infection.
US20130035312 CATHEPSIN CYSTEINE PROTEASE INHIBIORS  
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for...
US20150080328 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF MUSCULAR DISORDERS  
The present invention relates to compounds and compositions and their application as pharmaceuticals for treating, preventing, or reversing injury to skeletal or cardiac muscles, for treating or...
US20090030037 Sustained Release Formulation and Dosing Schedules of Leukotriene Synthesis Inhibitor for Human Therapy  
The invention relates to materials and methods for therapy to inhibit the production of leukotrienes, and therapeutic and prophylactic applications thereof.
US20110021461 COMBINATIONS TO IMPROVE ANIMAL HEALTH AND PERFORMANCE  
The present invention provides combinations of dietary supplements and methods of using of these combinations to improve the health and production performance of animals. In particular, the...
US20110281811 Use Of Leukotriene Inhibitors For Treating Lung Diseases In Prematurely Born Infants  
The invention relates to the use of at least one leukotriene inhibitor for preparing a pharmaceutical composition for the prophylaxis and/or treatment of lung diseases, more particularly of...
US20150209371 Methods and Compositions For Stimulating Neurogenesis and Inhibiting Neuronal Degeneration  
The present invention provides methods and compositions comprising compounds useful for stimulating neurogenesis. The methods and compositions comprising compounds are also useful for inhibiting...
US20110319391 METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION  
The present invention provides methods and compositions comprising compounds useful for stimulating neurogenesis. The methods and compositions comprising compounds are also useful for inhibiting...
US20070161622 Diamino alcohols and their use as renin inhibitor  
The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for...
US20130236468 BENZODIOXANE INHIBITORS OF LEUKOTRIENE PRODUCTION FOR COMBINATION THERAPY  
The present invention relates to a combination comprising compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein, and an additional active agent. The present invention also...
US20100233106 SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION  
The present invention relates to small molecule modulators of melanin expression and methods of making the small molecules. Also disclosed are methods of increasing pigmentation in a cell which...