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US20130136794 HETEROARYL (ALKYL) DITHIOCARBAMATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF  
Heteroaryl(alkyl)dithiocarbamate compounds represented by general formula (I) or their pharmaceutically acceptable salts, their preparing methods, and their uses for preparing antitumor medicines...
US20080267886 Combinations of Glycopyrrolate and Beta2 Adrenoceptor Agonists  
A medicament comprising, separately or together (A) glycopyrrolate; and (B) either a compound of formula I in free or salt or solvate form, wherein W, Rx, Ry, R1, R2, R3, R4, R5, R6 and R7 have...
US20140378459 GUANIDINOBENZOIC ACID COMPOUND  
[Problem] Provided is a compound which is useful as an agent for preventing and/or treating renal diseases. [Means for Solution]The present inventors have conducted extensive studies on compounds...
US20130123180 FAST DISSOLVING PHARMACEUTICAL COMPOSITION  
The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises inulin.
US20110189274 Stable Pharmaceutical Compositions Of Montelukast Or Its Salts Or Solvates Or Hydrates  
A stable pharmaceutical composition includes a therapeutically effective amount of montelukast or its pharmaceutically acceptable salts, solvates or hydrates and a blend which includes...
US20120058945 NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM  
Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload...
US20140371266 Mono Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors  
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a...
US20070299096 Treating Learning Deficits With Inhibitors of Hmg CoA Reductase  
The disclosure provides methods of treating cognitive disorders by administering a HMG CoA reductase inhibitor. Cognitive deficits treatable with the inhibitor compound include those associated...
US20140286944 Methods of Treating Cardiovascular Diseases and Predicting the Efficacy of Exercise Therapy  
Methods of treating a subject having a cardiovascular disease, selecting a therapy for a subject having a cardiovascular disease, identifying a subject having a cardiovascular disease that will...
US20140303150 INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES  
The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is...
US20130150393 Statin Bioavailability Enhancement Delivery Composition  
A composition for increasing the bioavailability of a statin active pharmaceutical ingredient (“API”) in humans and animals, wherein that composition includes a statin API selected from the group...
US20120322727 Pharmaceutical Compositions for Intranasal Administration for the Treatment of Neurodegenerative Disorders  
In one embodiment of the invention, a pharmaceutical composition for intranasal administration comprises insulin, dimethyl sulfoxide and at least one pharmaceutically acceptable excipient. In...
US20130158036 N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS  
Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are...
US20130023513 Methods and Compositions for Treating Cardiovascular Disorders  
The invention generally relates to methods of treating a patient having, and/or at risk of, cardiovascular or cerebrovascular disorders. Such methods may include administering a MetAP2 inhibitor...
US20110086023 COMBINATION ANTIHISTAMINE MEDICATION  
The invention provides a topical pharmaceutical composition for application to the nasal or ocular mucosa which comprises (1) a pharmaceutical excipient suitable for topical administration, (2) a...
US20080119463 4-Anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (AML)  
The claimed invention is directed to a method of treating, inhibiting, or preventing acute myelogenous leukemia, also called acute myeloid leukemia (AML), using 4-anilino-3-quinolinecarbonitriles.
US20130150358 THERAMUTEIN MODULATORS  
This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and...
US20140031390 PITAVASTATIN-CONTAINING PREPARATION AND METHOD FOR PRODUCING SAME  
The present invention provides a pitavastatin-containing preparation containing pitavastatin or a pharmacologically acceptable salt thereof and at least one kind of a basic additive selected from...
US20080311221 LEWIS ACID AND OIL-SOLUBLE HYBRID PESTICIDE CONCENTRATE THAT SPONTANEOUSLY FORMS A WATER-BASED MICROEMULSION  
A chemically and physically stable, transparent, hybrid pesticide concentrate is provided for preparation of a water-based microemulsion formulation. The pesticides preferably comprise an...
US20090233963 METHODS TO DETERMINE SUCEPTIBILITY TO TREATMENT WITH LEUKOTRIENE MODIFIERS  
The present invention provides a method of determining the susceptibility of a subject to treatment with a leukotriene modifier by determining the subject's cysteinyl leukotriene (CysLT) level and...
US20150150798 FAST DISSOLVING PHARMACEUTICAL COMPOSITION  
The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises levan.
US20130310319 FAST DISSOLVING PHARMACEUTICAL COMPOSITION  
The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises levan.
US20130123179 FAST DISSOLVING PHARMACEUTICAL COMPOSITION  
The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises levan.
US20110263498 METHOD AND COMPOSITION FOR ENHANCEMENT OF MALE ERECTILE FUNCTION  
A pharmaceutical composition for enhancing male erectile function comprising an erectile function-enhancing amount of an insulin-like growth factor selected from the group consisting of IGF-1...
US20060040981 Use of phosphodiesterase-4 inhibitors as enhancers of cognition  
The present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of a phosphodiesterase-4 inhibitor. In...
US20130225621 SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEIN  
In one aspect, the invention relates to substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of...
US20110288110 METHODS FOR TREATING DISORDERS ASSOCIATED WITH HYPERLIPIDEMIA IN A MAMMAL  
The invention is directed to methods for treating hyperlipidemia in a mammal. The methods involve combination therapies using a microsomal triglyceride transfer protein (MTP) inhibitor (for...
US20090105300 AMINE LINKED MODULATORS OF y-SECRETASE  
The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, Y, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of...
US20130296300 QUINOLINES AND AZA-QUINOLINES AS CRTH2 RECEPTOR MODULATORS  
The invention provides certain quinolines and aza-quinolines of the Formula (I), and their pharmaceutically acceptable salts, wherein E, J1, Ja, Jb, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q...
US20070225325 Solid Forms of Montelukast Acid  
Differing forms of 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)-phenyl)-3-(2 -(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopro pane acetic acid and methods for synthesizing same.
US20130287688 NOVEL COMPOSITIONS AND USES OF ANTI-HYPERTENSION AGENTS FOR CANCER THERAPY  
Methods and compositions for improving the delivery and/or efficacy of a therapy (e.g., a cancer therapy) are disclosed. In one embodiment, methods and compositions for treating or preventing a...
US20120142634 Method of Treating Cancer with a Combination of a Proteasome Inhibitor and Salubrinal  
The disclosure provides methods for treating or preventing a cancerous condition, such as multiple myeloma, by administering a therapeutically effective combination of a proteasome inhibitor and...
US20050113410 Pharmaceutical salts of zafirlukast  
Zafirlukast, a leukotriene receptor antagonist, converts to a less bioavailable form in the presence of water. The present invention relates to crystalline forms of zafirlukast including salts and...
US20070071754 Method to ameliorate inflammation  
Administering to a patient a concentration of at least one anti-inflammatory agent and bevacizumab at a concentration sufficient to reduce fluid leakage from new vessels associated with angiogenesis.
US20110144127 AGENTS FOR TREATMENT OF GLAUCOMATOUS RETINOPATHY AND OPTIC NEUROPATHY  
Agents that stimulate nuclear translocation of Nrf2 protein and the subsequent increases in gene products that detoxify and eliminate cytotoxic metabolites are provided in a method for treating...
US20080146553 Antibiotic compostions and methods for using same  
Compositions including a quinolone component in an amount effective as an antibiotic when the composition is placed in a mammalian eye, and a carrier component in an amount effective to act as a...
US20120039958 COMPOSITIONS AND METHODS FOR TREATMENT OF TAUPATHY  
Provided are electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) comprising an ionic aqueous solution of charge-stabilized oxygen-containing...
US20120009253 PREPARATIONS FOR THE APPLICATION OF ANTI-INFLAMMATORY, ESPECIALLY ANTISEPTIC AGENTS AND/OR AGENTS PROMOTING THE HEALING OF WOUNDS OF THE LOWER RESPIRATORY TRACT  
Use of an anti-inflammatory agent such as povidone iodine for the preparation of a pharmaceutical composition for the treatment of diseases of the lower respiratory tract which are susceptible to...
US20110294848 SMALL MOLECULE INHIBITORS OF BOTULINUM NEUROTOXINS  
The invention provides potent quinolinol-based BoNT/A small-molecule inhibitors of botulinum neurotoxins, in particular of Clostridium botulinum serotype A neurotoxins. The invention also provides...
US20140194439 METHODS OF TARGETED DRUG DEVELOPMENT  
Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain...
US20080200499 Selective Insecticides and/or Acaricides Based on Substituted Cyclic Dicarbonyl Compounds and Safeners  
The present invention relates to the use of selective insecticidal and/or acaricidal compositions, characterized in that they comprise an effective amount of an active compound combination...
US20140255517 MANAGING POST-TRAUMATIC STRESS DISORDER  
In certain embodiments, the disclosure relates to methods of treating or preventing posttraumatic stress disorder comprising administering a pharmaceutical composition comprising effective amount...
US20130064892 CELLULOSIC GEL MATERIAL AS A PHARMACEUTICAL EXCIPIENT  
A method of making a pharmaceutical tablet comprises (a) combining (i) an aqueous networked cellulose gel with (ii) filler and (iii) an active agent to form a mixture thereof; (b) casting the...
US20110105477 COMPOSITIONS AND METHODS RELATING TO HIV PROTEASE INHIBITION  
The present invention relates to HIV protease, and methods for inhibiting the function of HIV protease. In particular, present invention provides compounds that inhibit or block the biological...
US20150094330 COMPOUNDS AND METHODS FOR SKIN REPAIR  
The invention provides compositions and methods for wound healing and scar reduction. The compositions and methods of the invention include at least one EP4 agonist set forth herein. Wounds and or...
US20130052190 CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions  
The present invention provides a method for the treatment of allergic and inflammatory diseases or conditions by administering a compound of Formula (I). The invention provides a method of...
US20110237538 TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES  
Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone...
US20110319445 HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS  
Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described....
US20100120848 STABLE PHARMACEUTICAL FORMULATIONS OF MONTELUKAST SODIUM  
The invention encompasses stable pharmaceutical compositions comprising montelukast or salts thereof and methods of preparing the same.
US20070244152 Use of an Nk3 Antagonist for the Treatment of Bipolar Disorders  
This invention relates to the use of the NK3 receptor antagonist talnetant [(S)—(−)—N-(α-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-car boxamide] for treating bipolar disorder.