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US20120101053 CATHEPSIN CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF VARIOUS DISEASES  
The present invention relates to compounds capable of inhibiting and/or decreasing the activity of one or more cathepsins, thereby treating and/or preventing various disease states associated with...
US20150239827 ARYLALKYLAMINE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS  
The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or...
US20120178749 NS1 PROTEIN INHIBITORS  
The present invention generally relates to compounds to treat viral infections and methods of their use. In particular, compounds of the present invention inhibit the activity of NS1 protein,...
US20080166310 Administration of 2-oxyacetamide compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting the depigmentation and/or bleaching thereof  
A regime or regimen for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for preventing and/or limiting the depigmentation and/or bleaching and/or for...
US20140088104 NOVEL SMALL-MOLECULES AS THERAPEUTICS  
The present invention provides compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful in...
US20130331411 COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS  
The invention relates to the use of a compound of Formula I for the treatment of protease-activated receptor mediated diseases by the administration of a compound of Formula I or a prodrug or...
US20070197585 Use of cysteinyl leukotriene 2 receptor antagonists  
The instant invention provides a method for treating and/or reducing the risk for atherosclerosis, pulmonary fibrosis and stroke, comprising administering an effective amount of a cysteinyl...
US20140364453 SALUBRINAL-DRIVEN ATTENUATION OF MALIGNANT PHENOTYPES OF 4T1 BREAST CANCER CELLS  
A method is disclosed for the in vivo treatment of a breast cancer tumor utilizing a therapeutically effective amount of an agent that inactivates the Rac1 GTPase and results in a reduction in...
US20140315944 SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS  
The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making...
US20130245037 Stabilization of Hypoxia Inducible Factor (HIF) Alpha  
The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating...
US20110166145 Stabilization of hypoxia inducible factor (HIF) alpha  
The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating...
US20130310420 STABLE FORMULATIONS OF PITAVASTATIN  
Disclosed is a pharmaceutical composition comprising pitavastatin, or its salt or ester and MgO, of which the aqueous solution or dispersion has pH of from 10 to 10.8. The composition has good...
US20110034424 METHOD FOR THE LONG TERM NSAID USE  
Provided is a method for the long term treatment of a condition or disease which is one of the indications for NSAID use in a human patient, which comprises administering to the patient a...
US20150210674 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION  
Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general...
US20120041023 SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION  
Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general...
US20130035328 ANTIVIRAL COMPOUNDS AND METHODS  
The invention relates to compounds having antiviral activity and methods utilizing the compounds to treat viral infections.
US20090075985 ARYL SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE  
Aryl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the...
US20100304966 Fungicidal Compounds, Method For the Production Thereof, And Use Thereof To Combat Damaging Fungi, And Agents Comprising The Same  
Compounds of the formula I in which the substituents have the meaning given in the description, processes for preparing these compounds, compositions comprising them and their use for controlling...
US20120245166 TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR SUCH  
Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for...
US20140364432 SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS  
The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX1 or OX2, or both; to pharmaceutical compositions and combinations comprising a...
US20080138350 PROCESS FOR USE OF FLUOROQUINOLONES TO REDUCE OR MODULATE INFLAMMATION DUE TO EYE DISEASE OR OPHTHALMIC SURGERY  
The present invention provides a safer and more effective way to treat ophthalmic disease and to perform ophthalmic surgeries while reducing the risk of vision loss due to the inflammatory...
US20110124614 Methods And Compositions For The Treatment of Autoimmune Disorders  
Methods and compositions are provided which confer protection against autoimmune diseases without triggering intracellular estrogen receptors. Such methods and compositions limit the side effects...
US20060069074 Genetic predictor of efficacy of anti-asthmatic agents for improving pulmonary function  
The present invention relates to methods for determining and predicting the efficacy of therapeutics for the treatment of an individual with asthma based on that individual's β2-adrenergic...
US20150119414 STATIN AND OMEGA 3 FATTY ACIDS FOR REDUCTION OF APOLIPOPROTEIN-B LEVELS  
A composition and a method of treatment utilizing a combination of statins (or HMG-CoA reductase inhibitors), a class of drug used to lower cholesterol levels by inhibiting the enzyme HMG-CoA...
US20130079310 STATIN AND OMEGA 3 FATTY ACIDS FOR REDUCTION OF APOLIPOPROTEIN-B LEVELS  
A composition and a method of treatment utilizing a combination of statins (or HMG-CoA reductase inhibitors), a class of drug used to lower cholesterol levels by inhibiting the enzyme HMG-CoA...
US20140073668 N-QUINOLIN-BENZENSULFONAMIDES AND RELATED COMPOUNDS FOR THE TREATMENT OF CANCER, AUTOIMMUNE DISORDERS AND INFLAMMATION  
The present invention relates to the NQBS class of molecules. It is based, at least in part, on the discovery that a representative group of compounds have been observed to inhibit nuclear...
US20140171445 TREATMENT AND PREVENTION OF DISEASES MEDIATED BY MICROORGANISMS VIA DRUG-MEDIATED MANIPULATION OF THE EICOSANOID BALANCE  
The invention provides a method of enhancing the efficacy of antibiotic treatment of tuberculosis, trypanosomiasis, leprosy, and leishmaniasis involving co-administering to a mammal undergoing...
US20060211729 Combination of anticholinergics and leukotriene receptor antagonists for the treatment of respiratory diseases  
Pharmaceutical compositions comprising an anticholinergic and at least one leukotriene inhibitor for treatment of respiratory diseases, including allergic rhinitis, bronchial asthma, COPD and...
US20140031389 SCREENING METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES  
The present invention relates to screening methods and pharmaceutical compositions for the treatment of inflammatory bowel disease. More particularly, the present invention relates to a method for...
US20130157947 COMPOUNDS FOR STEM CELL DIFFERENTIATION  
Small molecule compounds and methods for stem cell differentiation are provided herein. An example of a class of compounds that may be used to practice the methods disclosed herein is represented...
US20110124681 TOPICAL AND INJECTABLE FORMULATIONS COMPRISING LEUKOTRIENE RECEPTOR ANTAGONIST AND USES THEREOF  
Methods of treating, preventing, reducing the occurrence of, or slowing progression of folliculitis, partial or full hair loss, thinning of the hair, changes in the texture of hair, graying or...
US20120294826 METHODS, KITS AND COMPOSITIONS FOR AMELIORATING ADVERSE EFFECTS ASSOCIATED WITH TRANSFUSION OF AGED RED BLOOD CELLS  
The present invention provides, inter alia, methods for ameliorating an adverse effect in a patient caused by an acute transfusion into the patient of a composition containing aged red blood cells...
US20140170213 CAPSULE FORMULATION COMPRISING MONTELUKAST AND LEVOCETIRIZINE  
Disclosed is a capsule formulation for preventing or treating allergic rhinitis and asthma, which comprises two separate layers of: (1) a Montelukast layer comprising montelukast or a...
US20110021560 Compositions And Methods For Regulating Chondrocyte Proliferation In Bone Disorders  
The present invention is related to the field of cartilage physiology, repair, and regeneration. In particular, the invention contemplates a treatment for bone healing disorders, especially those...
US20070232648 MODULATORS OF THE GLUCOCORTICOID RECEPTOR AND METHOD  
Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such...
US20130274215 PHARMACEUTICAL COMPOSITIONS TO TREAT FIBROSIS  
The present invention provides methods for the prevention, treatment and/or amelioration of fibrosis or fibrotic conditions. The present invention further provides small molecule inhibitors of...
US20150152061 Method of Preparation of Pitavastatin and Pharmaceutical Acceptable Salts Thereof  
The present invention discloses a compound, which is alkali or alkaline earth metal salts of pitavastatin, wherein the alkali or earth metal comprise one or more of magnesium, zinc, potassium,...
US20130059885 Method For Preparation Of Pitavastatin and Pharmaceutical Acceptable Salts Thereof  
The present invention discloses a compound, which is alkali or alkaline earth metal salts of pitavastatin, wherein the alkali or earth metal comprise one or more of magnesium, zinc, potassium,...
US20120022102 METHOD FOR PREPARATION OF PITAVASTATIN AND ITS PHARMACEUTICAL ACCEPTABLE SALTS THEREOF  
The present invention discloses a compound, which is alkali or alkaline earth metal salts of pitavastatin, wherein the alkali or earth metal comprise one or more of magnesium, zinc, potassium,...
US20080118591 Bactericidal Formulations  
The invention relates to bactericidal formulations that come into contact with human body, particularly wash formulations including liquid soaps, comprising perfume ingredients active against...
US20150183800 GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO  
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the...
US20140024665 GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO  
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the...
US20140378507 VITAMIN D RECEPTOR AGONISTS AND USES THEREOF  
This invention features vitamin D receptor agonists, and their use in treating bone disorders, cardiovascular disease, hyperparathyroidism, immune disorders, proliferative disease, renal disease,...
US20080254053 Protocol for treatment of diabetes  
A method and composition for reducing highly sensitive C-reactive protein is provided for the treatment of Type I and Type II diabetes which is achieved through the daily administration of a...
US20130058904 Method and system for treatment of biological tissue  
A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component...
US20130123225 INHIBITION OF BACTERIAL BIOFILMS WITH ARYL CARBAMATES  
Disclosure is provided for carbamate compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods...
US20080182872 USE OF ER-BETA SELECTIVE LIGANDS FOR TREATING ACUTE LUNG INJURIES  
The present invention provides a method of treating acute lung injuries, such as acute lung injury induced by peritonitis during sepsis, acute lung injury induced by intravenous bacteremia during...
US20080096917 I-Alkynyl-2-Aryloxyalkylamides And Their Use As Fungicides  
Compounds of the formula wherein the substituents are as defined in the claims, are useful as fungicides.
US20140080788 NOVEL BICYCLIC NITROGEN CONTAINING HETEROARYL TGR5 RECEPTOR MODULATORS  
Novel compounds of Formula I:or an enantiomer, diastereomer, tautomer, prodrug or salt thereof, wherein m, Q, T, U, V, ring A, X, Y, R3, R4, R4a, R5a, R5b, R5c, R5d, R5e, R6a, R6b, and R6c are...
US20100056570 FUNGICIDES  
Compounds of the general formula wherein the substituents are as defined in claim (1), are useful as fungicides.