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US20140031368 SELECTIVE HDAC INHIBITORS  
This disclosure is related to compounds having the structure wherein Ar1, Ar2, R1-R6, Z, m, n, o, and p are defined herein. This disclosure also relates to pharmaceutical compositions comprising...
US20100130503 NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90  
The present invention relates to compounds of formula (I): wherein R1, R2, R2′, L, Het, p and p′ are as defined herein, compositions containing them, and their use as medicinal products.
US20080280932 COMPOSITIONS AND METHODS FOR TREATING VASCULAR, AUTOIMMUNE, AND INFLAMMATORY DISEASES  
The disclosure provides methods and compositions for the treatment of vascular, autoimmune and inflammatory diseases using a combination of an inosine monophosphate dehydrogenase (IMPDH) inhibitor...
US20110281898 PHENOXIACETIC ACID DERIVATIVES  
The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their...
US20100204195 Pharmaceutical Compositions and Process for Making Them  
Amorphous HMG CoA reductase inhibitors, especially amorphous atorvastatin, are described. Also described are pharmaceutical combinations comprising amorphous HMG CoA reductase inhibitors in...
US20090169583 Solid Adsorbates of Hydrophobic Drugs  
A solid pharmaceutical composition comprises a solid adsorbate comprising a hydrophobic drug, a lipophilic vehicle, and a porous substrate, wherein the hydrophobic drug and lipophilic vehicle are...
US20140128427 5-CARBAMOYL-ADAMANTAN-2-YL AMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND PREPARATION PROCESS THEREOF  
Provided are a novel derivative of 5-carbamoyl adamantan-2-yl amide or a pharmaceutically acceptable salt thereof, and a pharmaceutical use thereof for inhibiting the activity of...
US20150246885 CERTAIN CHEMICAL ENTITES, COMPOSITIONS, AND METHODS  
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
US20140128391 SELECTIVE HDAC1 AND HDAC2 INHIBITORS  
Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with HDAC activity,...
US20110092368 2,4,6-Phenyl-substituted cyclic ketoenols  
The present invention relates to novel 2,4,6-phenyl-substituted cyclic ketoenols of the formula (I) in which W, X, Y and CKE have the meanings given in the disclosure, to a plurality of processes...
US20130053333 Aminoquinoline Derivatives  
This invention relates to novel aminoquinoline derivatives of Formula (I) or Ia, or pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of...
US20100227884 AMIDE COMPOUNDS AND PLANT DISEASE CONTROLLING METHOD USING SAME  
The object of the present invention is to provide a compound having excellent controlling effect on plant diseases. An amide compound represented by the following formula (I) has excellent...
US20100137364 6-Aminoisoquinoline Compounds  
6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the...
US20090075978 SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS  
The present invention relates to substituted propiolic acid amides, to methods for the production thereof, to medicaments containing these compounds and to the use thereof for producing medicaments.
US20120028969 BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF  
The present invention provides compounds of formula (I); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for...
US20130289066 ANTI-ANGIOGENIC COMPOUND  
A styrylquinoline derivative of structure I or IV or a benzodioxol isoquinoline of structure II or III for use in the treatment of an angiogenesis-related disease or disorder. The invention also...
US20120029013 DERIVATIVES OF AMINOCYCLOBUTANE OR AMINOCYCLOBUTENE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICAL PRODUCTS  
The present invention concerns compounds of general formula (1), where in:—-a- is a single or double bond, Ar is an aromatic group, substituted or unsubstituted, R1 and R2 each independently or...
US20120004197 PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR ANEMIA COMPRISING TETRAHYDROQUINOLINE COMPOUND AS ACTIVE INGREDIENT  
Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed...
US20150126549 Inhibitors of the PP1/GADD34 Complex for the Treatment of a Condition Requiring an Immunosuppressive Activity  
The present invention relates to the general field of the treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as...
US20120251562 Inhibitors of the PP1/GADD34 Complex for the Treatment of a Condition Requiring an Immunosuppressive Activity  
The present invention relates to the general field of the treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as...
US20140322303 LIPOSOMAL CURCUMIN FOR TREATMENT OF DISEASES  
The present invention provides compositions and methods for the treatment of a human patient. The methods and compositions of the present invention include composition for the efficient loading of...
US20100222380 Modified Chalcone Compounds as Antimitotic Agents  
Antimitotic agents comprising a modified chalcone or modified chalcone derivative are disclosed. The modified chalcone or modified chalcone derivative compounds are of the general formula...
US20090118262 Non-Aqueous Water-Miscible Materials as Vehicles for Drug Delivery  
A pharmaceutical composition includes at least one pharmaceutical component having a low aqueous solubility and at least one non-aqueous water-miscible material. Such a pharmaceutical composition...
US20150246063 ATX MODULATING AGENTS  
Compounds of formula (I) can modulate the activity of autotaxin (ATX).
US20060111368 Phosphodiesterase inhibitor  
[wherein n represents an integer of from 1 to 4, R1 represents substituted or unsubstituted lower alkyl, —C(═Y)R9 or the like, R2 represents a hydrogen atom, substituted or unsubstituted lower...
US20060094755 Novel quinoline-based metal chelators as antiviral agents  
This invention relates to novel quinoline-based divalent metal ion chelating ligands of Formula I, wherein A or B are independently —CR7R8, or —CH(R9)CH(R10). X is hydrogen, C1-C10 alkyl; —OH, or...
US20080312270 COMPOUNDS AND METHODS USEFUL FOR TREATING ASTHMA AND ALLERGIC INFLAMMATION  
Compounds, compositions and methods that are useful in the treatment of inflammatory and immune-related diseases and conditions are provided herein. In particular, the invention provides compounds...
US20060281739 Compositions and methods for treatment of eye disorders  
The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the...
US20120004218 NOVEL TETRAHYDRO-QUINOLINE DERIVATIVES  
A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These...
US20100216837 GLYCINE TRANSPORT INHIBITORS  
The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in...
US20070244103 Novel Compounds Having an Anti-Bacterial Activity  
The present invention describes novel anti-bacterial compounds of formula (I). Q-A-R3 (I) These compounds are, amongst others, of interest as inhibitors of DNA gyrase.
US20070185126 Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing Them  
The present invention relates to novel 1,3-dihydroindol-2-one (oxindole) derivatives of the formula (I) in which A, R3, R4, R5 R6 and R7 are defined according to claim 1, and to medicaments...
US20120316259 Process For The Co-Encapsulation Of Biocidally Active Compounds In Clay Minerals Functionalized By Nitrogen Compounds  
This invention relates to a process for the co-encapsulation of biocidally active ingredients in a clay mineral, the process comprising the step of bringing the clay mineral into contact with a...
US20090298872 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROIDAL RECEPTORS AND CALCIUM CHANNEL ACTIVITIES  
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorder associated with the activation...
US20100215774 FILM COMPRISING NITROGLYCERIN  
The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of nitroglycerin and/or other...
US20100197684 SUBSTITUTED HETEROCYCLIC COMPOUNDS  
The present invention relates to novel heterocyclic compounds and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular...
US20070037830 2-Adamantyl derivatives as p2X7 receptor antagonists.  
The invention provides compounds of formula (I) or a pharmaceutically acceptable salt or solvate or pro-drug thereof, wherein A, B, X, n and m have the meanings as defined in the specification....
US20150111886 NOVEL ADAMANTYL DERIVATIVES AS CANNABINOID RECEPTOR 2 AGONISTS  
The invention relates to a compound of formula (I) wherein A1, R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
US20080262033 4-Phenyl-5-Oxo-1,4,5,6,7,8- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility  
The present invention- relates to 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives having the general Formula (I) wherein the substituents are defined as in the description, or a...
US20110021528 NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS  
The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore...
US20100130545 BRIDGED SIX-MEMBERED RING COMPOUNDS  
The invention relates to compounds of formula (I), wherein R1, R2, R1a, R2a, R3, R4, A, B, X, W and n are as defined in the description, and pharmaceutically acceptable salts of such compounds....
US20070129361 LACTAM-CONTAINING DIAMINOALKYL, Beta-AMINOACIDS, Alpha-AMINOACIDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS  
The present application describes lactam-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof of Formula I: P-M-M1 I or pharmaceutically acceptable salt forms thereof,...
US20100160371 INHIBITION OF P38 KINASE ACTIVITY BY ARYL UREAS  
This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical...
US20090018133 Novel Adamantane Derivatives  
The invention provides compounds of formula (I), in which m, A, R1 and Ar have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing...
US20150218100 ANTI-ANGIOGENIC COMPOUNDS  
(E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.
US20070299105 2-Cyanopropanoic Acid Amide and Ester Derivatives and Methods of Their Use  
This invention provides compounds of formula I or a pharmaceutically acceptable salt thereof that are useful for the treatment of the inflammatory component of diseases and are particularly useful...
US20100222338 BETA-SECRETASE MODULATORS AND METHODS OF USE  
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including...
US20090029855 Quinoline Derivatives and Their Use as Pesticides  
This invention relates to quinoline derivatives of formula I wherein R1, R2, R3 are each independently halogen, hydroxy, cyano, amino, nitro, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl,...
US20080234233 MEDICAMENT FOR TREATMENT OF NEURODEGENERATIVE DISEASES  
A medicament for preventive and/or therapeutic treatment of neurodegenerative diseases such as Alzheimer's disease or the like which comprises as an active ingredient a substance selected from the...
US20140024608 INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF  
The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention...