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US20140094465 Compounds as S-Nitrosoglutathione Reductase Inhibitors  
The present invention is directed to compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using...
US20100184707 ANTICONVULSIVE PHARMACEUTICAL COMPOSITIONS  
The use of a substance selected from the group consisting of taurine, a taurine precursor, a taurine metabolite, a taurine derivative, a taurine analog and a substance required for the taurine...
US20120142728 CHEMICAL COMPOUND AND ITS USE  
The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to...
US20110257085 Crystal Forms of Saxagliptin and Processes for Preparing Same  
Physical crystal structures of a compound of the formula I: are provided including the free base monohydrate thereof (form H-1) and the hydrochloric acid salt thereof, including hydrochloric acid...
US20110082119 PROPHYLACTIC/AMELIORATING OR THERAPEUTIC AGENT FOR NON-ALCOHOLIC STEATOHEPATITIS  
A highly safe and effective prophylactic/ameliorating or therapeutic agent for NACH and the method for using the same are provided. A prophylactic/ameliorating or therapeutic agent for NASH...
US20080119513 Sulfonamide Derivative Selectively Inhibiting Mmp-13  
It is considered that MMP-13 inhibitors contribute to the treatment or prevention against the diseases caused by or related to activity of MMP-13, especially osteoarthritis (OA). Therefore, the...
US20090280982 Quinolinylmethyl Compounds  
The present invention relates to novel biphenyl-4-sulfonicacid (quinolin-4-ylmethyl)-amide compounds of formula (I) wherein R1 and R2 are halogen, OH, CN, NH2, NO2, C1-C6-alkyl, C2-C6-alkenyl,...
US20110118307 Compositions and methods for the treatment of infectious diseases  
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the...
US20110224242 STYRLYQUINOLINES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC USES  
The present disclosure concerns new substituted styrylquinolines, the process of their preparation and their therapeutic uses as integrase inhibitors and/or for the treatment and/or prevention of HIV.
US20090281103 Renin Inhibitors  
The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also...
US20140323518 NOVEL ESTROGEN RECEPTOR LIGANDS  
Compounds of formula (I) or a pharmaceutically acceptable ester, amide, carbamate or salt thereof, including a salt of such an ester, amide or carbamate in which R1 to R9 have meanings as defined...
US20070099956 Nitrogen-containing heterocyclic derivatives having 2, 6-disubstituted styryl  
The invention provides a novel nitrogen-containing heterocyclic derivative having 2,6-disubstituted styryl and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition...
US20080004290 Anti-Cancer Agents  
The present invention provides compounds having the structural formula (I): and methods for the treatment of cancer using compounds of formula (I).
US20130059884 INHIBITOR OF THE DIFFERENTIATION OF T CELLS INTO TH1 CELLS  
The present invention is to provide an inhibitor that inhibits differentiation of T cells into Th1 cells. The inhibitor that inhibits differentiation of T cells into Th1 cells contains, as an...
US20070254875 Androgen Receptor Modulator Compounds and Methods  
Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators...
US20090264463 Inhibitors Of Protein Phosphatase-1 And Uses Thereof  
Inhibitors of Protein Phosphatase-1 have been shown to slow replication of HIV-1. Inhibitors of PP 1 and their use for treatment or prevention of HIV-1 infections are disclosed.
US20080269213 8-Hydroxyquinoline compounds and methods thereof  
The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder,...
US20120282353 METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS  
The present invention generally relates to the modulation of hypoxia-inducible factor (HIF) using the compounds and methods disclosed herein. These compounds and methods can be applied to the...
US20110306614 N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors  
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of...
US20140315857 N- (4 -QUINOLINYLMETHYL) SULFONAMIDE DERIVATIVES AND THEIR USE AS ANTHELMINTICS  
Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Q, A, R1, R2, R3 and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of...
US20080051384 ANTIVIRAL AGENTS  
Disclosed are compounds and compositions of Formula (I) and their uses for treating Flaviviridae family virus infections.
US20110166117 Novel Compounds  
The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for...
US20150148360 3,5,N-TRIHYDROXY-ALKANAMIDE AND DERIVATIVES: METHOD FOR MAKING SAME AND USE THEREOF  
The present invention provides novel compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and...
US20130096156 QUINOLINE DERIVATIVES AS FUNGICIDES  
Compounds of the general formula (I) wherein the substituents are as defined in claim 1, are useful as fungicides.
US20140031388 AKT INACTIVATION BY TOCOPHERYL DERIVATIVES  
Anticancer compounds according to formula I are described herein. wherein R1, R2, R3 and R4 are selected from H, CH3, OH, SH, OCH3, NHR′, halogen, CF3, N-linked pyrrolidine, and SO2NHR′, or any...
US20130210860 PROPHYLACTIC AND/OR THERAPEUTIC AGENT AGAINST LYMPHEDEMA  
Provided is a new prophylactic and/or therapeutic agent for lymphedema, for which until now there has been no effective means of treatment, and the prophylactic and/or therapeutic agent for...
US20140031338 INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES  
The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
US20110275643 AROYLQUINOLINE COMPOUNDS  
A serious of nitro heterocyclic derivatives including a structure of formula (I) are provided. In formula (I), P, Q and R1 to R8 are defined in the specification. The derivatives disclosed in the...
US20090163543 Histone Deacetylase Inhibitors and Methods of Use Thereof  
One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for...
US20140256619 USE OF AVERMECTIN DERIVATIVE FOR INCREASING BIOAVAILABILITY AND EFFICACY OF MACROCYLIC LACTONES  
The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) wherein: (i) R1...
US20070259887 INHIBITORS OF POLYQ-AGGREGATION  
Compounds of formula I, wherein R1, R2, R3, R4 and R5 have the meanings as given in claim 1, and their pharmaceutically tolerable derivatives, solvates and stereoisomers and their use for the...
US20140336221 Antibiotic and Anti-Parasitic Agents that Modulate Class II Fructose 1, 6-Bisphosphate Aldolase  
This invention provides a family of compounds that inhibit Class II fructose 1,6-bisphosphate aldolase (FBA), which is implicated in the pathogenic activity of a broad range of bacterial and...
US20120283249 Novel compounds which have a protective activity with respect to the action of toxins and of viruses with an intracellular mode of action  
The subject matter of the present invention is novel families of compounds which are aromatic amine, imine, aminoadamantane and benzodiazepine derivatives, medicaments comprising same and the use...
US20070244153 Diamine Derivative, Process of Preparation Thereof, and Fungicide Comprising Diamine Derivative as an Active Ingredient  
It is an object of the invention to provide a novel fungicide which exhibits a wide controlling spectrum against pathogens of various crops, and solves the toleration problem. The diamine...
US20110021540 Bis-(Sulfonylamino) Derivatives in Therapy 066  
The invention provides compounds of formula wherein R1, R3, L1, L2, G1, G2, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically...
US20100204244 AGENTS FOR TREATMENT OF DIABETIC RETINOPATHY AND DRUSEN FORMATION IN MACULAR DEGENERATION  
Agents that stimulate nuclear translocation of Nrf2 protein and the subsequent increases in gene products that detoxify and eliminate cytotoxic metabolites are provided in a method for treating...
US20140271923 Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions  
Patients inflicted with various clustering chronic diseases require treatment with multiple drugs having distinct mechanisms of action. Accordingly, patients with multiple conditions suffer from...
US20090215819 ANTI-INFECTIVE AND IMMUNOMODULATORY COMPOUNDS  
The present invention provides pharmaceutical compositions and methods that include the use of anti-infective compounds that potentiate the host-immune response or limit or prevent the expression...
US20080261945 Compounds Having Activity at Nk3 Receptor and Uses Thereof in Medicine  
The present invention relates to compounds of formula (I), a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein R1 is phenyl optionally substituted by 1, 2 or 3 halogen atoms...
US20070244117 Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof  
The invention relates to compounds of general formula I wherein D, E, F, G, W, Y, R1, A, R9, X, B, R8 are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof,...
US20070191425 Solifenacin-containing composition  
To provide a novel method for producing a composition comprising solifenacin or a salt thereof, and a composition comprising solifenacin or a salt thereof as produced by the method, wherein an...
US20090239841 Diaryl Ureas as CB1 Antagonists  
Compounds of Formula I are provided. In which the variables are as described herein. Such compounds may be used to modulate CB1 activity in vivo or in vitro, and are particularly useful in the...
US20100247485 FORMULATIONS AND DEVICES FOR DELIVERING COMPOUNDS TO ARTHROPODS AND MICROORGANISMS WITHIN ARTHOPODS  
Described herein are formulations and devices for delivering compounds to arthropods and microorganisms within the arthropods. The formulations are generally composed of a sugar and the compound,...
US20140350045 PHENOXYISOBUTYRIC ACID COMPOUNDS AND METHOD OF SYNTHESIS  
The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced...
US20080132503 Inhibitors of Histone Deacetylase  
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
US20080027098 Derivatives of alpha-phenylthiocarboxylic and alpha-phenyloxy-carboxylic acids useful for the treatment of diseases responding to PPARalpha activation  
Formula (I) compounds are described in which the substituents have the meanings described in the text, and which are useful for the treatment of diseases responding to PPARαactivation, such as...
US20100120856 Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers  
The invention relates to compounds of the animated hydroxyquinoline type capable of preventing the migration of metastases or tumoral cells. Such compounds are useful for treating cancers.
US20140275165 COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY  
The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's...
US20120064099 COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY  
The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's...
US20080214605 Alkyl Sulfoxide Quinolines as Nk-3 Receptor Ligands  
Compounds of Formula I wherein R1, A, R2, R3, R4, R5, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing...