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US20050203119 Dihydropyridine compounds for treating or preventing metabolic disorders  
This invention relates to dihydropyridine compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein A2, R12, R13, R14, R15, R16, R17, R18,...
US20060194769 Small molecules that reduce fungal growth  
The present invention relates to methods for reducing the growth of a fungus with an anti-fungal small molecule. Methods for reducing fungal cell growth in a subject with an anti-fungal small...
US20090069623 METHODS AND COMPOSITIONS FOR TREATMENT OR PREVENTION OF RADIATION-INDUCED FIBROSIS  
The present invention comprises methods and compositions for the treatment or prevention of radiation-induced fibrosis. Methods and compositions for the inhibition of CTGF are disclosed herein....
US20130005767 THERAPEUTIC COMPOUNDS  
Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
US20120316167 SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES  
The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as...
US20130252990 STABLE PHARMACEUTICAL COMPOSITION AND METHODS OF USING SAME  
The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
US20130252989 STABLE PHARMACEUTICAL COMPOSITION AND METHODS OF USING SAME  
The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
US20140121238 TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS  
Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.
US20150209311 (R,R) FORMOTEROL IN COMBINATION WITH OTHER PHARMACOLOGICAL AGENTS  
This invention related to methods of treating, preventing and managing various pulmonary diseases or disorders using stereomerically pure (R,R)-formoterol in combination with other pharmacological...
US20070265278 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS  
The present invention is directed to a compound of Formula (XVI): (please replace Formula (I) with Formula (XVI) as shown below) wherein R, R2, R3, R4, R5, R6, R7 and n are as defined herein, or a...
US20100273777 Compounds for Modulating TRPV3 Function  
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
US20080194614 Combination of Organic Compounds  
The invention relates to a pharmaceutical combination comprising an HMG-Co-A reductase inhibitor, especially fluvastatinor pitavastatin or a pharmaceutically acceptable salt thereof and mTOR...
US20090124656 Heterocyclic Oxime Compounds a Process for Their Preparation and Pharmaceutical Compositions Containing Them  
Compounds of formula (I): wherein: R1, R2, R3, R4 and X are as defined in the description,A represents an alkylene chain as defined in the description,B represents an alkyl or alkenyl group...
US20110003795 Substituted Aromatic Carboxamide and Urea Derivatives as Vanilloid Receptor Ligands  
The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the...
US20080113975 THIOUREA COMPOUNDS  
This invention relates to thiourea compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.
US20150099015 Sorbic and Benzoic Acid and Derivatives Thereof Enhance the Activity of a Neuropharmaceutical  
Methods and compositions are provided for treating neuropsychiatric disorders such as schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia, and bipolar...
US20060257481 Sustained release formulation and dosing schedule of leukotriene synthesis inhibitor for human therapy  
The invention relates to improved materials and methods for therapy to inhibit production of leukotrienes, and all therapeutic applications thereof.
US20080242698 Organic Compounds  
The invention relates to novel diamines of the formula in which all variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their...
US20140296228 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION  
Compounds of formula I: wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
US20100311735 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION  
Compounds of formula I: wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
US20110077221 Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof  
This invention provides nuclear hormone receptor binding compounds, compositions comprising the same and methods of uses thereof in treating a variety of diseases or conditions in a subject,...
US20150175586 THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION  
This invention provides well defined 6-alkyl or hydroxyalkyl-1-naphthamide or quinoline compounds for treating glaucoma or ocular hypertension.
US20120015978 THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION  
This invention provides well defined 6-alkyl or hydroxyalkyl-1-naphthamide or quinoline compounds for treating glaucoma or ocular hypertension.
US20140288119 NOVEL MOLECULES THAT SELECTIVELY INHIBIT HISTONE DEACETYLASE 6 RELATIVE TO HISTONE DEACETYLASE 1  
This invention provides a compound having the structure: whereinR1 is H, halogen, —NR5R6, —NR5—C(═O)—R6, —NH—C(═O)—OR7, —OR7, —NO2, —CN, —SR7, —SO2R7, —CO2R7, CF3, —SOR7, —POR7, —C(═S)R7,...
US20100215775 USE OF C10-C14-ALKANEDIOLS IN THE PREPARATION OF A COMPOSITION FOR THE PROPHYLAXIS AND/OR TREATMENT OF MALASSEZIA-INDUCED DANDRUFF FORMATION  
The invention relates to the use of C10-C14-alkane-1,2-diols, in particular 1,2-decanediol, 1,2-dodecanediol and/or 1,2-tetradecanediol, in the preparation of a composition for the prophylaxis...
US20130324573 SUBSTITUTED 1, 2, 3, 4-TETRAHYDROQUINOLIN-7-YL CARBAMATES AS ACETYLCHOLINESTERASE INHIBITORS FOR TREATMENT OF ALZHEIMER'S DISEASE  
The present invention relates to novel substituted 1,2,3,4-tetrahydroquinolin-7-yl carbamates, their preparation, and use as therapeutic agents, particularly in the prevention or treatment of...
US20110111021 PHARMACEUTICAL PREPARATION  
The present invention provides a pharmaceutical preparation including a compartment containing a renin inhibitor as a pharmacologically active ingredient, and a compartment containing an HMG-CoA...
US20080255189 HEPATITIS C VIRUS INHIBITORS  
A compound of the following formula: in which R1, R2, R3, U, V, T, W, X, Y, Z, m, n, p, x, y, and z are as defined herein. Also disclosed are (1) a pharmaceutical composition containing such a...
US20060276505 Acylhydrazine P2X7 antagonists and uses thereof  
The present invention discloses a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein D, A, m, n, Rx and Ry are defined in the description. The present...
US20130023528 PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE  
Compounds for inhibiting hypoxia inducible factor (HIF) prolyl-4-hydroxylases (PHDs) having the general formula (1). Methods of using these and related compounds for treating a patient having a...
US20090233962 Amide derivative and insecticide containing the same  
The present invention is to provide a compound represented by the general formula (1) exhibiting a high insecticidal effect and an insecticide comprising the compound as an active ingredient. The...
US20110046177 THERAPEUTIC QUINOLINE AND NAPHTHALENE DERIVATIVES  
Disclosed herein is a stable compound having a structure formula (I): therapeutic methods, compositions, and medicaments related thereto are also disclosed.
US20070049559 Preparations comprising arylazine substituted with a carbonylic moiety to increase the activity of Gelatinase A in ocular cells  
Preparations for controlling intraocular pressure in the eye comprise as an active compound, arylazine substituted with a carbonylic moiety, which compound is capable of effecting a...
US20120095042 Organic Compounds Having Cooling Properties  
Provided are compounds of formula (I) whereinm is 0, 1 or 2;RI is a mono- or bicyclic heterocyclic ring system including one, two or three heteroatoms selected from nitrogen, sulphur and oxygen;R2...
US20120122784 NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF  
The invention relates to novel calcium-sensing receptor (CaSR) modulating substituted cyclopentylene compounds represented in formula I and derivatives thereof, to said compounds for use as a...
US20100004244 USE OF CB2 RECEPTOR AGONISTS FOR PROMOTING NEUROGENESIS  
The present invention relates to ligands of the peripheral cannabinoid receptor CB2, especially (+)-α-pinene derivatives, and to pharmaceutical compositions thereof, which are useful for...
US20070037848 Treatment of neurological conditions  
The present invention relates generally to the treatment of conditions and/or disorders associated with or exacerbated by oxidative stress and which have symptoms including cognitive impairment...
US20110052556 PHARMACEUTICAL COMPOSITION COMPRISING RACETAM AND CARNITINE AND PROCESS FOR ITS PREPARATION  
The present invention refers to a pharmaceutical composition comprising racetam and carnitine. Said pharmaceutical composition may further comprise coenzyme Q10 and/or agent associated with...
US20100010026 STATIN AND OMEGA-3 FATTY ACIDS FOR REDUCTION OF APO-B LEVELS  
Methods of utilizing a combined administration or a unit dosage of a combination of an HMG-CoA inhibitor and omega-3 fatty acids for the reduction of apolipoprotein-B levels. The methods are...
US20120178717 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS  
The present invention relates to substituted 4-qinolinemethanols and pharmaceutical compositions thereof and methods of using the same for treating of malaria, tuberculosis, and other infectious...
US20130096138 NOVEL THIOUREA OR UREA DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING AIDS, CONTAINING SAME AS ACTIVE INGREDIENT  
Disclosed are novel thiourea or urea derivatives inhibitory of HIV activity. Also provided are a method for preparing the thiourea or urea derivatives, and a pharmaceutical composition for the...
US20130123300 UREA COMPOUNDS AND USE THEREOF FOR INHIBITING APOPTOSIS  
A compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, is provided. Also, a composition containing a compound of Formula I, or an isomer, pharmaceutically...
US20130012536 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS  
The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are...
US20090318496 PREPARATION CONTAINING FIBRATE AGENT AND PROCESS FOR PRODUCING THE SAME  
A preparation (pharmaceutical composition) reducing a concentration of a free fatty acid and/or fibrinogen in the blood is prepared. The preparation contains a statin agent comprising at least a...
US20140309257 TOPOISOMERASE INHIBITORS AND METHODS OF MAKING AND USE AS THERAPEUTIC AGENTS  
The invention provides methods of inhibiting the growth or metastasis of cancer in a mammal by inhibiting TopoIIa in the mammal. The invention also provides small molecule inhibitors of TopoIIa...
US20150148376 NOVEL 5-AMINOTETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS AND THEIR USE  
The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases,...
US20140031391 Novel 5-aminotetrahydroquinoline-2-carboxylic acids and their use  
The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases,...
US20140107155 SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS  
The present invention relates to sodium channel inhibitors of Formula (I): in which R1, R2, R3, R4, R5, X, Y, and Z are as defined herein, and to their use in the treatment of various disease...
US20130102632 SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS  
The present invention relates to sodium channel inhibitors of Formula (I): in which R1, R2, R3, R4, R5, X, Y, and Z are as defined herein, and to their use in the treatment of various disease...
US20110178092 HIV-1 Protease Inhibitors  
Described are novel protease inhibitors and methods for using said protease inhibitors in the treatment of human immunodeficiency virus (HIV) infection.