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US20130078284 PHARMACEUTICAL FORMULATIONS  
The present invention relates to oral formulations comprising an active agent comprising at least one of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, salts of...
US20120171262 PHARMACEUTICAL FORMULATIONS  
The present invention relates to oral formulations comprising an active agent comprising at least one of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, salts of...
US20120004262 PHENYLCYCLOPROPYLAMINE DERIVATIVES AND THEIR MEDICAL USE  
The present invention relates to phenylcyclopropylamine derivatives. In particular, pharmaceutical compositions comprising phenylcyclopropylamine derivatives are provided. The compounds of this...
US20140135325 NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING  
The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful...
US20110311613 TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS  
Described herein, are topical formulations for treating a dermatological disease, disorder, or condition. Topical formulations disclosed herein include a therapeutically-effective amount of a FLAP...
US20080153871 ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF  
The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description,...
US20120121723 Antimicrobial Compositions  
An antimicrobial composition, including a synergistic combination of three or more agents as an active ingredient. Each of the three or more potentiating agents can be selected from the following...
US20100041653 COMPOSITION AND METHODS FOR THE DESIGN AND DEVELOPMENT OF METALLO-ENZYME INHIBITORS  
The present disclosure provides compounds having the general structure A or pharmaceutically acceptable salts thereof: R—X (A) wherein R is an alkyl or aryl moiety comprising heterocyclic...
US20100239678 IONICALLY FUNCTIONALIZED NANODIAMONDS  
The present invention is directed to attaching drugs 11 and other functional groups to surfaces of nano-sized diamond particles (NDs) 20 to enhance their efficacy. The method involves hydrating a...
US20090298868 QUINOLINE COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF  
A method of identification of quinoline compounds (formula I) that modify melanin synthesis (melanogenesis), and the use of such compounds and compositions thereof to control (e.g., inhibit)...
US20110288161 METHODS FOR TREATMENT OF THIOL-CONTAINING COMPOUND DEFICIENT CONDITIONS  
Certain embodiments in the present invention provide for methods for therapy of lung diseases and other conditions such as infection are provided. In certain embodiments, the methods comprise one...
US20120189614 INHIBITORS OF FILOVIRUS ENTRY INTO HOST CELLS  
Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful...
US20130137721 6-AMINOISOQUINOLINE COMPOUNDS  
6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the...
US20120277185 Pesticidal Carboxamides  
To provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Carboxamides represented by the following Formula (I) and use thereof as pesticides and an animal...
US20090029949 GPCR Ligands Identified by Computational Modeling  
Disclosed are pharmacophores for developing and screening compounds having G-protein-coupled receptor antagonist activity, including LPA1, LPA2, LPA3 and S1P antagonists. These compositions have...
US20080159995 TREATMENT OF FIBROSIS  
The present invention relates to methods and compositions for treating fibrosis. In one aspect the invention provides the use of an agent capable of increasing the number of stem cells and/or...
US20130109713 ANTIMICROBIAL AGENTS  
The invention provides a compound of formula I:or a salt thereof, wherein R3-R8 and X and Y have any of the values described in the specification, as well as compositions comprising a compound of...
US20080200451 Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5  
Compounds of the formula (I), in which W, R, R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
US20090291980 TRIGLYCERIDE-LOWERING AGENT AND HYPERINSULINISM-AMELIORATING AGENT  
The present invention is directed to a triglyceride-lowering agent, exhibiting excellent triglyceride-lowering effect and a hyperinsulinemia-ameliorating agent. The triglyceride-lowering agent and...
US20100292229 TRYPHOSTIN-ANALOGS FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES  
The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. In general aspects, compounds of the present invention are tyrphostin-like in structure....
US20100150844 USE OF 8-QUINOLINOL AND ITS ANALOGS TO TARGET CANCER STEM CELLS  
8-quinolinol (8Q) and derivatives thereof for use in the treatment of proliferative diseases such as cancer, in particular slow metabolizing quiescent cancer stem cells.
US20130203727 NAPHT-2-YLACETIC ACID DERIVATIVES TO TREAT AIDS  
The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for...
US20110059991 Selective Insecticides Based on Anthranilic Acid Diamides and Safeners  
The present invention relates to the use of selective insecticidal compositions, characterized by an effective amount of an active compound combination comprising (a) (1) at least one...
US20100056483 METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF BONE LOSS  
Disclosed herein are methods and compositions for the treatment and prevention of bone loss. The methods comprise providing a therapeutically effective amount of at least one chelating agent to a...
US20090069373 Quinoline Acids  
This invention relates generally to quinoline-based modulators of Liver X receptors (LXRs) and related methods.
US20140134235 NOVEL BENZYLAMINE DERIVATIVES AND THEIR UTILITY AS CHOLESTEROL ESTER-TRANSFER PROTEIN INHIBITORS  
The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using...
US20100298205 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS RELATED TO GASTRIC ACID SECRETION  
A method comprising orally administering to a mammal a proton pump inhibitor, or a pharmaceutically acceptable prodrug thereof, and a compound which modulates the activity of the MRP2 or other...
US20100310663 PHARMACEUTICAL COMPOSITIONS COMPRISING NANOPARTICLES AND A RESUSPENDING MATERIAL  
A pharmaceutical composition comprises nanoparticles comprising a poorly water-soluble drug and a poorly aqueous soluble polymer, and a resuspending material selected from the group consisting of...
US20130345231 ANTICANCER THERAPEUTIC AGENTS  
The invention described herein pertains to anticancer therapeutic agents that exhibit preferential cytotoxicity to malignant cells that express a cancer specific isoform of proliferating cell...
US20090149496 INHIBITORS OF THE TASK-1 AND TASK-3 ION CHANNEL  
The invention relates to the use of Kv1.5 inhibitors for the therapy or prophylaxis of respiratory disorders, sleep-related respiratory disorders, central and obstructive sleep apneas, upper...
US20120329797 SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS  
The present invention provides secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal...
US20090209564 Glucagon Receptor Antagonist Compounds, Compositions Containing Such Compounds And Methods Of Use  
Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also...
US20110301193 METHODS AND COMPOSITIONS OF TARGETED DRUG DEVELOPMENT  
Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain...
US20130085159 COMPOUNDS DERIVED FROM ARTESUNATE, PREPARATION PROCESS, PHARMACEUTICAL COMPOSITION AND USE OF THE RESPECTIVE MEDICINE  
The present invention refers to new compounds represented by the general formula (I) where X is represented by the general formula (II) and Y is represented by the general formula (III). The...
US20120129887 COMPOUNDS DERIVED FROM ARTESUNATE, PREPARATION PROCESS, PHARMACEUTICAL COMPOSITION AND USE OF THE RESPECTIVE MEDICINE  
The present invention refers to new compounds represented by the general formula (I) where X is represented by the general formula (II) and Y is represented by the general formula (III). The...
US20130102609 BIARYL OXYACETIC ACID COMPOUNDS  
The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin. The compounds...
US20110071176 PHARMACEUTICAL COMPOSITION COMPRISING OMEGA-3 FATTY ACID AND HYDROXY-DERIVATIVE OF A STATIN AND METHODS OF USING SAME  
In various embodiments, the present invention provides compositions and methods for treating and/or preventing a cardiovascular-related disease in subject in need thereof.
US20100305080 Novel Crystalline Salts of Montelukast  
The present application relates to crystalline 1,2-ethanedisulfonic acid salt and N,N′-dibenzylethylenediamine salt of montelukast. The salts are useful as therapeutic agents for the treatment of...
US20120165370 QUINOLINE DERIVATIVES AS ANTI-CANCER AGENTS  
Quinoline derivatives showing anticancer activities against cancer cell lines of hepatocellular carcinoma (Hep3B), lung carcinoma (A549), esophageal squamous cell carcinoma (HKESC-1, HKESC-4 and...
US20130337015 C-Met Modulator Pharmaceutical Compositions  
Pharmaceutical compositions and unit dosage forms comprising Compound I are disclosed.
US20070281968 Compounds Derived From Artesunate, Preparation Process, Pharmaceutical Composition And Use Of The Respective Medicine  
The present invention refers to new compounds derived from artesunate salts with quinolines represented by the general formula (I) where X is represented by the general formula (II) and Y is...
US20130345154 Gap Junction-Enhancing Agents for Treatment of Necrotizing Enterocolitis and Inflammatory Bowel Disease  
The present invention relates to methods of reducing the risk of occurrence of, and/or treating, necrotizing enterocolitis (“NEC”) or inflammatory bowel disease (“IBD”) comprising administering,...
US20130237563 NOVEL POLYMORPHS OF PITAVASTATIN CALCIUM  
The present invention provides a solid of pitavastatin tert-butyl ester and process for its preparation. The present invention also provides a novel crystalline form of pitavastatin calcium,...
US20140142107 ANTIFUNGAL AGENTS AND USES THEREOF  
Antimicrobial agents, compositions that include the agent(s) and use(s) thereof are provided. Also disclosed are screening assays for identifying antimicrobial agents.
US20080207673 Method for Treating Cancer, Coronary, Inflammatory and Macular Disease, Combining the Modulation of Zinc-and/or Copper Dependent Proteins  
A method for treating diseases selected among cancer, coronary disease, inflammatory disease and macular disease by chelation therapy is disclosed.
US20120251616 Tocopherols, Tocotrienols, Other Chroman and Side Chain Derivatives and Uses Thereof  
The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl,...
US20080287399 Substituted Aminopyridines and Uses Thereof  
This invention relates to novel compounds having the structural formula (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a...
US20140107153 THERAPEUTIC QUINOLINE AND NAPHTHALENE DERIVATIVES  
Disclosed herein is a stable compound having a structure: therapeutic methods, compositions, and medicaments related thereto are also disclosed.
US20110118260 GLUCOCORTICOID RECEPTOR AGONIST COMPRISING 2,2,4-TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVES HAVING SUBSTITUTED OXY GROUP  
The present invention is related to glucocorticoid receptor agonists comprised of a compound represented by formula (1) which is 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivative or a salt...
US20080026018 Administration of coumarin, butylated hydroxyanisole and ethoxyquine for the treatment of canities  
At least one compound selected from among coumarin and/or derivative thereof, butylated hydroxyanisole, ethoxyquine and mixtures thereof, and admixtures thereof with other active agents selected...