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US20090281139 |
MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS
The present invention relates generally to novel macrocycles of Formula (I):
or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables...
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US20090275610 |
TRICYCLIC OPIOID MODULATORS
The invention is directed to compounds of Formula (I) useful as delta and mu opioid receptor modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and...
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US20090275537 |
Certain chemical entities, compositions, and methods
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin...
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US20090233961 |
TARTRATE DERIVATIVES FOR USE AS COAGULATION FACTOR IXA INHIBITORS
The invention relates to the compounds of formula I
having antithrombotic activity which especially inhibits blood clotting factor IXa, to methods for producing the same and to the use thereof...
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US20090233949 |
ISOSERINE DERIVATIVES FOR USE AS COAGULATION FACTOR IXA INHIBITORS
The invention relates to the compounds of formula (I)
having antithrombotic activity which especially inhibit blood clotting factor IXa, to methods for producing the same and to the use thereof...
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US20090221564 |
Heterocyclic Compounds and Their Use in the Treatment of Cardiovascular Disease
Heterocyclic compounds of the formula (I) are provided: wherein ring A, ring B, R 1 , R 2 , R 3 , R 4 , Y, m, n and q are as identified herein. R 1 is in particular amidino. The invention further...
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US20090209528 |
SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS
The present invention relates to substituted tetrahydroisoquinoline compounds of general formula (I), a process for their preparation, medicaments comprising said substituted tetrahydroisoquinoline...
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US20090203769 |
Modulation of the integrin-linked kinase signaling pathway provides beneficial human cardiac hypertrophy and post myocardial infarction remodeling
Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process for mediating a...
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US20090203678 |
PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PROTOZOAN PARASITIC DISEASES
The present invention relates to the use of a Rho/ROCK/PI3K/Akt pathway modulator for the manufacture of a medicament intended for the prevention or the treatment of pathologies associated with an...
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US20090192189 |
TREATMENT OF CANCERS EXPRESSING P95 ERBB2
The truncated ErbB2 receptor (p95 ErbB2 ) is shown to differ from the full-length ErbB2 receptor in its association with other ErbB receptors. The truncated receptor preferentially associated with...
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US20090186917 |
6-And 7-amino isoquinoline compounds and methods for making and using the same
6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and...
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US20090137594 |
Pentafluorosulphanyl-Substituted Compound And Its Use For Producing Medicaments
The present invention relates to pentafluorosulphanyl-substituted compounds, methods for their production, medicaments containing such compounds and the use of such compounds for producing...
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US20090118327 |
SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM
The present invention relates to compounds useful in the prevention or treatment of various disorders such as acute or chronic renal failure, for impairments of biliary function, for respiratory...
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US20090088429 |
Isoquinoline Derivatives
The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I)
useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase...
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US20090075937 |
LHRH ANTAGONISTS FOR THE TREATMENT OF LOWER URINARY TRACT SYMPTOMS
The present invention provides at least one LHRH antagonist for the treatment or prophylaxis of at least one lower urinary tract symptom in mammals which is to be administered in an intermediate...
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US20090029987 |
Pharmaceutical Compositions for the Prevention and Treatment of Complex Diseases and Their Delivery by Insertable Medical Devices
The present invention relates to polyphenol-like compounds that are useful for inhibiting VCAM-1 expression, MCP-1 expression and/or SMC proliferation in a mammal. The disclosed compounds are...
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US20080293735 |
Therapeutic treatment for metabolic syndrome, type 2 diabetes, obesity, or prediabetes
The present invention is directed to a method for treating a patient suffering from the metabolic syndrome, Type 2 diabetes, obesity, or prediabetes, comprising the step of increasing the ratio of...
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US20080293709 |
Novel 2-Amino-Heterocycles Useful in the Treatment of Abeta-Related Pathologies
This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salts, compositions and methods of use. These novel compounds provide a...
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US20080234268 |
Bis-aryl amide derivatives and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as c-Met mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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US20080214524 |
FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR
Compounds of formula (I)
are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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US20080200458 |
Methods and compositions for the treatment of body composition disorders
This invention relates to methods of treating, managing and preventing body composition disorders, and to compounds and pharmaceutical compositions useful in such methods.
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US20080194580 |
Inhibition Of Raf Kinase Using Quinolyl, Isoquinolyl Or Pyridyl Ureas
This invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in...
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US20080194557 |
Methods and compositions for the treatment of pain, inflammation and cancer
This invention relates to methods of treating, managing and preventing pain, inflammation, cancer, and ocular diseases and disorders, and to compounds and pharmaceutical compositions useful in such...
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US20080187928 |
METHODS FOR ENHANCING EXERCISE PERFORMANCE
Disclosed herein are methods for enhancing one or more effects of exercise in a subject by administering a PPARδ agonist (e.g., GW1516) to the subject in combination with an exercise program. Also...
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US20080182871 |
5, 6, or 7-Substituted - 3-(hetero) arylisoquinolinamine derivatives and therapeutic use thereof
The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and...
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US20080167340 |
6-Aminoisoquinoline Compounds
6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the...
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US20080166357 |
Diagnostics and Therapeutics for Diseases Associated with Dipeptidyl-Peptidase 6 (Dpp6)
The invention provides a human DPP6 which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, gastroenterological diseases, cancer, hematological...
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US20080160552 |
Methods and Compounds for Treating Inflammation
The invention relates in embodiments to methods for identifying compounds that inhibit phosphorylation of GD-1, to compositions comprising such inhibitors, including pharmaceutical compositions,...
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US20080153812 |
NOVEL COMPOUNDS
There is provided a compound of formula (I):
or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a...
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US20080145849 |
Methods for diagnosing and treating neuroendocrine cancer
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods...
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US20080113340 |
Diagnosis and treatment of cervical cancer
In certain aspects, the invention relates to methods of diagnosing cervical cancer by using a combination of certain biomarkers such as hTERT, IGFBP-3, transferrin receptor, beta-catenin, Myc-HPV...
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US20080113016 |
Method for Prevention or Treatment of Inflammatory Disease
Methods are provided for prevention or treatment of inflammatory disease in a mammal by administering an inhibitor of mitogen activated (MAP) kinase system to the mammal in a therapeutic amount to...
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US20080103127 |
METHODS FOR TREATING DISRUPTIVE BEHAVIOR DISORDERS
The present invention is a method for the treatment of Disruptive Behavior Disorders including both Conduct Disorder and Oppositional Defiant Disorder comprising administering to a subject in need...
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US20080096913 |
PPAR active compounds
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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US20080090826 |
Muscarinic modulators
The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic...
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US20080090808 |
Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction
The present invention provides compositions and methods for preventing, treating or reversing neuronal dysfunction in a mammal resulting from exposure to organophosphate nerve agents,...
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US20080081803 |
Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
The present invention is directed to compounds of the formula I:
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X, n and the broken lines are as defined herein which are useful as...
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US20080081078 |
Prevention of Cell Proliferation by Inhibiting Myosin Light Chain Kinase
Methods of using compounds having certain inhibitory effect to treat cancer are disclosed. More specifically, methods of using myosin light chain kinase inhibitor (MLCK) to treat cancer are...
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US20080076773 |
Aminopiperidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes
The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or...
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US20080070935 |
Isoquinoline, Quinazoline and Phthalazine Derivatives
Disclosed are compounds and pharmaceutically acceptable salts of Formula I
wherein R 0 , R 5 , R 6 , R 7 , n, Q 1 -Q 5 , Y, and X 1 -X 3 are as defined herein. Compounds of Formula I are...
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US20080039443 |
Manipulation of brain CDP-diacylglycerol and uses thereof
Provided herein methods of screening for potential antidepressant compounds effective to increase production of cellular CDP-diacylglycerol and synthesis of inositol phospholipid in...
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US20080021034 |
Compositions and methods for modulating gated ion channels
The present invention relates to compositions and methods to modulate the activity of gated ion channels.
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US20080009450 |
Genipin derivatives and uses thereof
Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin...
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