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US20130072473 COMPOUNDS FOR TREATING PROTEIN FOLDING DISORDERS  
The present invention is directed to compounds of Formulae (I), (IIa-IIh), (IIIa-IIIe), (IVa-IVc), (Va-V1), (VIa-VII), (VII), (VIII) and (IX), pharmaceutical compositions thereof and methods of...
US20130053348 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS  
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin...
US20120135964 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS  
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin...
US20120065228 COMPOSITIONS AND METHODS FOR TREATING, CONTROLLING, REDUCING, OR AMELIORATING OCULAR INFLAMMATORY WITH LOWER RISK OF INCREASED INTRAOCULAR PRESSURE  
A composition for treating, controlling, reducing, or ameliorating inflammatory pain comprises a dissociated glucocorticoid receptor agonist (“DIGRA”), a prodrug thereof, a pharmaceutically...
US20140343095 Methods of Diagnosing and Treating Multiple Sclerosis  
Methods of using a 15-oxysterol, e.g., 15-ketocholestene (15-KE), 15-ketocholestane (15-KA), and/or 15-hydroxy-cholestene (15-HC), as a biomarker to monitor disease progression in multiple...
US20150057288 PEST CONTROL AGENTS FOR HONEYBEE PARASITIC PESTS, AND PEST CONTROL METHOD FOR HONEYBEE PARASITIC PESTS USING THE PEST CONTROL AGENTS  
A pest control method for honeybee parasitic pests has been found, which is highly safe to honeybees and demonstrates excellent pest control effects against honeybee parasitic pests by using a...
US20090075937 LHRH ANTAGONISTS FOR THE TREATMENT OF LOWER URINARY TRACT SYMPTOMS  
The present invention provides at least one LHRH antagonist for the treatment or prophylaxis of at least one lower urinary tract symptom in mammals which is to be administered in an intermediate...
US20120004261 MIF MODULATORS  
The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low...
US20140128428 COLD MENTHOL RECEPTOR ANTAGONISTS  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:...
US20070032521 Use of c-kit inhibitors for treating type II diabetes  
The present invention relates to a method for treating type II diabetes, comprising administering a compound capable of depleting mast cells to a human in need of such treatment. Such compounds...
US20100311728 Manipulation of brain CDP-diacylglycerol and uses thereof  
Provided herein methods of screening for potential antidepressant compounds effective to increase production of cellular CDP-diacylglycerol and synthesis of inositol phospholipid in...
US20110092514 COMPOUNDS WITH ANTI-CANCER ACTIVITY  
Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle...
US20080076773 Aminopiperidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes  
The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or...
US20070232647 Use of Ppar Agonists to Treat Ruminants  
The use of a PPAR agonist in the manufacture of a medicament to increase ruminant serum glucose concentrations, and preferably, the use for the palliative, prophylactic or curative treatment of...
US20100197661 Method of Treating Neurological Diseases and Disorders  
The present invention provides methods for treating neurological diseases and disorders. Compounds that replace or enhance the function of SMN or alleviate or reduce a phenotype of cells with low...
US20130296333 HEDGEHOG PATHWAY MODULATORS  
The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant...
US20110152282 HEDGEHOG PATHWAY MODULATORS  
The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant...
US20120135984 DUAL-ACTION INHBITORS AND METHODS OF USING SAME  
Provided are compounds, compositions, and methods for treating diseases and conditions wherein an inhibitor of a kinase, such as rho kinase (ROCK), and an inhibitor of one or more of the monoamine...
US20120225057 METHODS AND COMPOSITIONS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES  
Compounds of the present invention, alone and in combination with other active agents, find utility in the treatment of hyperproliferative diseases, mammalian cancers and especially human cancers...
US20110065138 Quantitative Method For Detecting Yessotoxins In Fishery Products On Based On The Activation That The Toxin Produces In Cellular Phosphodiesterases And Therapeutic Use Of This Activation  
The present invention relates to a quantitative method for detecting yessotoxins in fishery products based on the activation the toxin produces on cellular phosphodiesterases and the therapeutic...
US20060063702 Neuromedin U 2 receptor agonists and uses thereof  
This invention provides neuromedin U 2 receptor (NMU-2R) agonists. This invention further provides a method for screening and identification of said agonist. This invention also provides the core...
US20120101115 Compounds For Inducing Cellular Apoptosis  
The present invention provides isoquinoline, tetrahydroisoquinoline and tetrahydropyridopyrimidine compounds that induce cell death by apoptosis and uses of the compounds in medicine, especially...
US20060205761 Ccr-2 antagonists for treatment of neuropathic pain  
The invention is directed to methods of treating neuropathic pain and other neuropathic diseases and conditions with CCR-2 antagonists and pharmaceutical composition containing CCR-2 antagonists.
US20060194837 Tetrahydroisoquinoline compounds  
Certain tetrahydroisoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
US20130005756 METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS  
This invention is directed to methods of preventing or treating diseases or conditions of the lungs associated with excessive cell proliferation, remodeling, inflammation, vasoconstriction,...
US20130178457 CANNABINOID RECEPTOR MODULATORS  
Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the...
US20050096334 Use of substance P antagonists for the treatment of chronic fatigue syndrome and/or fibromyalgia and use of NK-1 receptor antagonists for the treatment of chronic fatigue syndrome  
The invention relates to the use of specific substance P antagonists, in particular, 1-acylpiperidine substance P antagonists, especially N-benzoyl-2-benzyl-4-(azanapthoyl-amino)-piperidines,...
US20130281485 BRIDGED BICYCLIC RHO KINASE INHIBITOR COMPOUNDS, COMPOSITIONS AND USE  
The present invention is directed to synthetic bridged bicyclic compounds that are inhibitors of rho-associated protein kinase. The present invention is also directed to pharmaceutical...
US20050014783 Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy  
The present invention is directed to a method for preventing or decreasing the incidence of or treating aneurysm or cardiac hypertrophy, comprising administering an effective amount of a...
US20060052315 Cb 1/cb 2 receptor ligands and their use in the treatment of pain  
Compounds of formula (I) or pharmaceutically acceptable salts thereof wherein Ar1?, Ar2?, R1?, R2?, n and X are as defined in the specifications well as salts and pharmaceutical compositions...
US20100324086 COMPOUNDS AND METHODS  
A compound of formula (1) as well as pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compound. The compound is useful for the treatment of disorder from...
US20060062829 Medical pad, and method for making and using  
A germicidal absorptive material for use in surgical packings, wound bandages, sanitary tampons and bed sore prevention and/or treatment uses is provided by a foam-like matrix of hydrophilic...
US20130172324 METHOD FOR TREATING CARDIOVASCULAR DISEASES USING RHO KINASE INHIBITOR COMPOUNDS  
This invention is directed to methods of preventing or treating diseases or conditions associated with excessive cell proliferation, remodeling, inflammation, and vasoconstriction. Particularly,...
US20070112012 Carbocyclic fused cyclic amines  
The invention is concerned with novel carbocyclyl fused cyclic amines of formula (I) wherein A, X1 to X3, Y1 to Y3, Z, R1, R2, m and n are as defined in the description and in the claims, as well...
US20060051314 Drug for prevention and/or treatment of constipation and sympton caused by constipation  
A medicament for preventive and/or therapeutic treatment of constipation and/or a symptom resulting from constipation which comprises magnesium polycarbophil as an active ingredient. The...
US20130029995 Substituted Bicyclic Aromatic Carboxamide and Urea Compounds as Vanilloid Receptor Ligands  
Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds, and a method of using these compounds in the...
US20060105939 Treatment of autism and similar disorders  
Methods of treating certain behavioral characteristics associated with autism are provided. Additionally, methods of treating disorders associated with repetitive behaviors, social deficits and/or...
US20060078555 Intraventricular hemorrhage thrombolysis  
The invention provides methods of treating intraventricular hemorrhage using thrombolytic agents.
US20050014676 Methods for delaying or inducing labor  
Disclosed herein are novel methods for preventing or delaying preterm uterine contractions in a pregnant mammal. Also disclosed are novel methods for inducing uterine contractions in a pregnant...
US20140315928 SUBSTITUTED AMIDE COMPOUNDS  
The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as...
US20120245163 TRPV1 Antagonists  
Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, wherein X1, X2, X3, X4, J, K, L, X5, X6, Rb, G2, and m are defined in the...
US20100048619 Cold Menthol Receptor Antagonists  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:...
US20060229294 Benzisothiazoles useful for treating or preventing HCV infection  
The present invention relates to benzisothiazoles and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use...
US20080293709 Novel 2-Amino-Heterocycles Useful in the Treatment of Abeta-Related Pathologies  
This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salts, compositions and methods of use. These novel compounds provide a...
US20070155652 Composition for regenerative treatment of cartilage disease  
A composition for regenerative treatment of cartilage disease, which comprises a PDE4 inhibitor as an active ingredient, specifically a composition comprising a PDE4 inhibitor and a biocompatible...
US20120269906 TREATMENT OF SUICIDAL IDEATION OR BEHAVIOR USING INHIBITORS OF NICOTINIC ACETYLCHOLINE RECEPTORS  
The invention concerns methods of treating suicidal ideation or behavior in a subject in need thereof, comprising decreasing endogenous nicotinic acetylcholine receptor (nAChR) activity in the...
US20090137594 Pentafluorosulphanyl-Substituted Compound And Its Use For Producing Medicaments  
The present invention relates to pentafluorosulphanyl-substituted compounds, methods for their production, medicaments containing such compounds and the use of such compounds for producing...
US20130096083 USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME  
The use of isoquinolones for preparing drugs, including novel isoquinolones as well as their synthesis method. In particular, isoquinolone derivatives used in the treatment of pathological...
US20050124533 Glucocorticoid blocking agents for increasing blood-brain barrier permeability stan-261con  
Glucocorticoid blockers, including glucocorticoid receptor antagonists, are effective to prevent glucocorticoid-induced decrease in permeability of the blood-brain barrier and to increase the...
US20130296363 QUINOLINE AND ISOQUINOLINE DERIVATIVES FOR USE AS JAK MODULATORS  
Provided herein are compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions...

Matches 1 - 50 out of 356 1 2 3 4 5 6 7 8 >