|
Match
|
Document |
Document Title |
|
|
US20090306130 |
NOVEL TETRAHYDRO-ISOQUINOLINES
The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic...
|
|
|
US20090298836 |
Thiadiazole modulators of PKB
The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the...
|
|
|
US20090298869 |
Crystalline pharmaceutical and methods of preparation and use thereof
Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses...
|
|
|
US20090298870 |
PODOPHYLLOTOXIN DERIVATIVES
4-O esters of podophyllotoxin and 4′-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and...
|
|
|
US20090291949 |
SUBSTITUTE ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS
A compound of Formula (I):
or a salt or solvate thereof, wherein:
One of R 1 and R 2 is H and the other represents —NHCONHR 4 , wherein R 4 represents
a phenyl or naphthyl...
|
|
|
US20090291978 |
Enzyme Inhibitors
Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein R 1 is a carboxylic acid group (—COOH), or an ester...
|
|
|
US20090274650 |
INHIBITORS OF ASPARTYL PROTEASE
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
|
|
|
US20090275609 |
Carboxamide Compounds and Methods for Using The Same
Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure
in which R 1 , R 2 , R 3 , R 4 , D, J, Z, T, p,...
|
|
|
US20090275608 |
Methods of diagnosing and treating parp-mediated diseases
Disclosed are methods of identifying a disease treatable with modulators of differentially expressed genes in a disease, including at least PARP modulators, by identifying the level of expression...
|
|
|
US20090275607 |
Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof
A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as κ-opioid receptor excitant in pain...
|
|
|
US20090270414 |
2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS
The invention relates to novel tetrahydro-1H-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects...
|
|
|
US20090264462 |
KAPPA OPIOID RECEPTOR LIGANDS
Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease...
|
|
|
US20090258069 |
Delivery of LFA-1 antagonists to the gastrointestinal system
The present invention provides compositions and methods for treating disorders and diseases by delivery of LFA-1 antagonists to the gastrointestinal system. Methods include delivery of LFA-1...
|
|
|
US20090247572 |
AGENT FOR TREATING ATRIAL FIBRILLATION
It is intended to provide an agent for treating atrial fibrillation, comprising an I f current inhibitor as an active ingredient. In the present invention, the means for resolution comprises an...
|
|
|
US20090247522 |
Hsp90 FAMILY PROTEIN INHIBITORS
The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I):
(wherein n represents an integer of 0...
|
|
|
US20090247573 |
(HETERO)ARYL CYCLOHEXANE DERIVATIVES
The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these...
|
|
|
US20090247574 |
3-AMINO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF METABOLIC DISORDERS
The present invention provides novel compounds represented by the general formula (I):
their pharmaceutically acceptable salts and their pharmaceutically acceptable solvates thereof, which are...
|
|
|
US20090239841 |
Diaryl Ureas as CB1 Antagonists
Compounds of Formula I are provided. In which the variables are as described herein. Such compounds may be used to modulate CB1 activity in vivo or in vitro, and are particularly useful in the...
|
|
|
US20090233930 |
Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia
This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a...
|
|
|
US20090227624 |
Oxazole and thiazole compounds as beta-catenin modulators and uses thereof
A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of β-cat oxazole and...
|
|
|
US20090221633 |
INHIBITORS OF AKT (PROTEIN KINASE B)
4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol or a pharmaceutically acceptable salt thereof or a hydrate of the compound or the salt thereof as Akt inhibitors that are antineoplastic...
|
|
|
US20090215764 |
Antimicrobial agents
Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or...
|
|
|
US20090203710 |
Novel piperidine derivative
Provided are a histamine-H3 receptor antagonist; and a preventive and/or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty...
|
|
|
US20090203734 |
F1F0-ATPASE INHIBITORS AND RELATED METHODS
The present invention relates to inhibitors of mitochondrial F 1 F 0 -ATPase, methods for their discovery, and their therapeutic use. In particular, the present invention provides the compound...
|
|
|
US20090203653 |
Compositions and Methods Using Apocynin Compounds and Nitric Oxide Donors
The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least...
|
|
|
US20090197862 |
2-AMINOPYRIDINE KINASE INHIBITORS
2-Aminopyridine compounds having the structure of Formula I, and pharmaceutically acceptable salts of these compounds. Compounds of Formula I inhibit the activity of tyrosine kinase enzymes in...
|
|
|
US20090192188 |
TETRAHYDROISOQUINOLINE DERIVATIVES
This invention relates to novel tetrahydroisoquinoline derivatives, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of...
|
|
|
US20090186905 |
ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE
The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R 1 , R 2 , R 3 and R 4 are defined herein. The invention also provides methods of using the compounds for...
|
|
|
US20090186869 |
Antiviral compounds
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and...
|
|
|
US20090176798 |
New compounds III
The present application relates to new compounds of formula (I),
to pharmaceutical compositions comprising the compounds, to processes for their preparation, and to the use of the compounds as...
|
|
|
US20090170857 |
Method for healing a wound using a direct vasodilator
A method for healing a wound comprising the step of topically administering a wound healing composition to a wounded area, wherein the wound healing composition comprises a first medicament...
|
|
|
US20090170895 |
S1P3 RECEPTOR ANTAGONIST
The present invention relates to a medicine, and more particularly to novel arylamidrazone derivatives having an antagonistic action against S1P 3 receptors and a medicine containing thereof as an...
|
|
|
US20090163497 |
Compounds Useful as Antagonists of CCR2
The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R 1 are defined generally and in subsets herein. Compounds of...
|
|
|
US20090162420 |
Matrix-Controlled Transdermal System Comprising Salts of ACE Inhibitor Dicarboxylic Acids
The invention relates to a salt of an ACE inhibitor dicarboxylic acid with an organic amine and/or an alkali compound, a transdermal therapeutic system comprising the salt, and a method of...
|
|
|
US20090155176 |
Compositions and methods for treatment of diabetic retinopathy
The present invention provides compounds and methods for the treatment of diabetic retinopathy. In particular, LFA-1 antagonists are described herein to be used in the treatment of diabetic...
|
|
|
US20090143372 |
CHEMICAL COMPOUNDS
The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I:
where R1, R2, R3, U and V are defined below and to...
|
|
|
US20090143423 |
SOLID DISPERSION PRODUCT CONTAINING N-ARYL UREA-BASED COMPOUND
A solid dispersion product comprising at least one N-aryl urea-based pharmaceutically active agent or an agent of related structural type is obtained by a) preparing a liquid mixture containing the...
|
|
|
US20090137566 |
Substituted Piperdines as Renin Inhibitors
The invention relates to substituted 3,4- or higher substituted piperididine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that...
|
|
|
US20090131444 |
Aminopiperidine Quinolines and Their Azaisosteric Analogues with Antibacterial Activity
The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their...
|
|
|
US20090105187 |
METHODS OF TREATING LENTIVIRUS INFECTION
The present invention provides methods of identifying agents that reduce a level of active APOBEC3C in a cell. The present invention provides agents that reduce a level of active APOBEC3C in a...
|
|
|
US20090105278 |
Selective inhibitors of human corticosteroid syntheses
The invention relates to compounds for selectively inhibiting human corticosteroid syntheses CYP11B1 and CYP11B2, to the production thereof and to their use for treating hypercortisolism and...
|
|
|
US20090105231 |
AMIDE DERIVATIVES AS ROCK INHIBITORS
This invention relates to novel amide derivatives and salts thereof. More particularly, it relates to novel amide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical...
|
|
|
US20090105275 |
PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE
The present invention relates to compounds of Formula I as shown below, wherein the definitions of Het, R 0 , R 1 R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are provided in the...
|
|
|
US20090099221 |
PYRIDYL-AND PYRIMIDINYL-SUBSTITUTED PYRROLE-, THIOPHENE-AND FURANE-DERIVATIVES AS KINASE INHIBITORS
The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the specification....
|
|
|
US20090099158 |
TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
Certain substituted tetrahydroisoquinoline compounds are histamine H 3 receptor modulators useful in the treatment of histamine H 3 receptor-mediated diseases.
|
|
|
US20090099229 |
Isoquinolines as IGF-1R Inhibitors
Compounds of the formula (I):
were synthesized. In at least one embodiment, they were found to down-regulate or inhibit the expression or function of the IGF-1 receptor.
|
|
|
US20090093493 |
1-PHENYLALCOXY-2-BETA-PHENYLETHYL DERIVATIVES AS P-GLYCOPROTEIN (P-GP) INHIBITORS USEFUL IN DRUG RESISTANCE EVENTS
The invention relates to a new class of compounds, which are 1-phenylalcoxy-2-β-phenylethyl derivatives, as P-glycoprotein (P-GP) inhibitors. These compounds are useful in drug resistance events....
|
|
|
US20090088429 |
Isoquinoline Derivatives
The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I)
useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase...
|
|
|
US20090088438 |
NEW TYROSINE DERIVATIVES AS PPARy MODULATORS
Compounds of general formula I,
and the salts and solvates thereof, wherein R1 represents the radical 2-benzoylphenylamino; R2 represents —(CH 2 ) s —N(COR3)-A-J-T or —(CH 2 ) s...
|
|
|
US20090082393 |
New addition salts of angiotensin-converting enzyme inhibitors with no donor acids, a process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I):
(A) m ·(B) n (I)
wherein A represents an...
|