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US20090286827 |
NOVEL BI-ARYL AMINES
The present invention relates to novel bi-aryl amines of formula (I) and to pharmaceutically acceptable prodrugs, salts, solvates, hydrates, and N-oxides thereof and to pharmaceutical compositions...
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US20090286800 |
Glucokinase Activators
Compounds are provided for use with glucokinase that comprise the formula:
wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of...
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US20090281115 |
INHIBITORS OF C-KIT AND USES THEREOF
Compounds and methods useful as inhibitors of c-Kit are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of c-Kit and processes for...
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US20090281075 |
ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS
A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKCθ inhibitors, and their methods of use are disclosed. The genus is represented by the formula I:
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US20090275573 |
Imidazolidinone Derivatives as 11B-HSD1 Inhibitors
Compounds of formula
as well as pharmaceutically acceptable salts and esters thereof, wherein A and R 1 to R 4 have the significance given in claim 1 can be used in the form of...
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US20090275572 |
FAB I INHIBITORS
Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections.
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US20090270443 |
1-AMINO IMIDAZO-CONTAINING COMPOUNDS AND METHODS
Imidazo-containing compounds (e.g., imidazonaphthyridines, imidazopyridines) with an amino substituent at the 1-position, pharmaceutical compositions containing the compounds and methods of use of...
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US20090270431 |
Cyclopentenol Nucleoside Compounds Intermediates for their Synthesis and Methods of Treating Viral Infections
The present invention relates to compounds according to the structure (I), Where B is formula (Ia), formula (Ib) or formula (Ic); A is H, OR 2 or halogen (F, Cl, Br, I, preferably F or Br, more...
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US20090270412 |
PYRIDO[3,4-B]INDOLES AND METHODS OF USE
This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions...
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US20090270376 |
HETEROCYCLIC JANUS KINASE 3 INHIBITORS
The present invention provides a compound of formula (I) having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various...
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US20090270370 |
FUSED HETEROCYCLIC COMPOUNDS
Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
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US20090270369 |
BICYCLOAMINE DERIVATIVES
Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various...
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US20090264442 |
PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS
The invention relates to compounds of formula I
having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions...
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US20090264425 |
CHEMICAL COMPOUNDS
This invention relates to biaryl ether derivatives of formula (I)
wherein R 1 , R 3 , R 4 , X, W, Y and m are defined in the description, and to compositions containing them and the uses of such...
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US20090258897 |
Substituted benzimidazoles
Disclosed herein are substituted benzimidazole-based proton pump modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
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US20090258874 |
PYRAZOLO-HETEROARYL COMPOUNDS
A compound of formula I
wherein the groups R1-R4, X and Y are as defined in the specification, useful to treat TNF-Alpha and IL-1 mediated diseases.
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US20090258866 |
CGRP Receptor Antagonists
The disclosure generally relates to the novel compounds of formula I, including their salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and...
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US20090258856 |
IMIDAZOPYRIDAZINONE AND IMIDAZOPYRIDONE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula
wherein Y and R 1 to R 4 are defined as in claim 1 , the tautomers, enantiomers,...
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US20090253738 |
TRIAZOLOPYRIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
The present invention discloses triazolopyridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I:
The compounds are useful in treating and/or...
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US20090253737 |
CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and...
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US20090247571 |
Certain Chemical Entities, Compositions and Methods
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and...
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US20090247570 |
PHARMACEUTICALS
The present invention relates to the use of a CCR5 antagonist in an HIV infected patient to enhance their immune reconstitution and so treat to HIV related opportunistic conditions resulting from...
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US20090247517 |
COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of...
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US20090247507 |
Enzyme Inhibitors
Compounds of formula (I), are aurora kinase inhibitors: wherein X is —N—, —CH2—N—, —CH2—CH—, or —CH—; R1 is a radical of formula (IA) wherein Z is —CH2—, —NH—, -0-,...
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US20090239899 |
Triazolopyridinylsulfanyl Derivatives As P38 Map Kinase Inhibitors
A compound of formula (I), or a pharmaceutical acceptable salt and/or solvate (including hydrate) thereof;
and the use of a compound of formula (I) in the treatment of a TNF-mediated disease,...
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US20090233960 |
Kinase Inhibitors
The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I, II, or III or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or...
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US20090232844 |
IMMUNOPOTENTIATING COMPOUNDS
The invention provides novel compositions comprising Imidazopyridine compounds. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of...
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US20090227616 |
INHIBITORS OF AKT ACTIVITY
Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
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US20090227578 |
Azabenzimidazole Derivatives, Their Manufacture and Use as Anti-Cancer Agents
Objects of the present invention are the compounds of formula I
their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the...
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US20090221632 |
Bicyclo-Pyrazoles and Pharmaceutical Compositions Comprising Them
Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.
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US20090221631 |
IMIDAZOPYRIDINONES
The invention relates to imidazopyridinones, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. By...
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US20090221611 |
Fused Triazole Tachykinin Receptor Antagonists
The present invention is directed to certain fused triazole compounds which are useful as neurokinin-1 (NK-I) receptor antagonists, and inhibitors of tachykinin and in particular substance P- The...
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US20090215818 |
THIOZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS
Invented is a method of inhibiting the activity/function of PI3 kinases using thiozolidinedione derivatives. Also invented is a method of treating one or more disease states selected from:...
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US20090215817 |
Novel Triazolopyridine Compounds for the Treatment of Inflammation
This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally...
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US20090209578 |
CHEMICAL COMPOUNDS
The present invention provides compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , Het and m are as defined in the description. The compounds of the present invention are modulators,...
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US20090209577 |
Novel Triazolopyridine Compounds
This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally...
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US20090209540 |
Novel Biaryl Benzolmidazole Derivatives and Pharmaceutical Composition Comprising The Same
Disclosed are biaryl benzoimidazole derivatives. They have an inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further...
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US20090208456 |
Imidazo[4,5-d]pyrimidines, their uses and methods of preparation
The present invention relates to pharmaceutical compositions for the treatment of prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyrimidine having the...
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US20090203732 |
Thiazolones for Use as P13 Kinase Inhibitors
Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune...
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US20090203730 |
BICYCLIC PPAT INHIBITORS AS ANTIBACTERIAL AGENTS
Disclosed are compounds of Formula I, pharmaceutical compositions comprising Formula I and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT...
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US20090203687 |
FUSED RING HETEROCYCLE KINASE MODULATORS
The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
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US20090203678 |
PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PROTOZOAN PARASITIC DISEASES
The present invention relates to the use of a Rho/ROCK/PI3K/Akt pathway modulator for the manufacture of a medicament intended for the prevention or the treatment of pathologies associated with an...
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US20090203677 |
Dual Pharmacophores - PDE4-Muscarinic Antagonistics
The present invention relates to novel compounds of Formula (I)
and their use in the treatment of respiratory diseases, including anti-inflammatory and allergic diseases such as chronic...
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US20090203668 |
TRIAZOLOPYRIDINE 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing...
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US20090203657 |
Dual Pharmacophores - PDE4-Muscarinic Antagonistics
The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof,
pharmaceutical compositions and their use as dual chromaphores having...
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US20090197911 |
LONIDAMINE ANALOGUES AND TREATMENT OF POLYCYSTIC KIDNEY DISEASE
Lonidamine derivatives can be useful in methods of treating, inhibiting, and/or preventing polycystic kidney disease (PKD). Accordingly, lonidamine derivatives can be administered in a...
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US20090197910 |
NOVEL VIRAL REPLICATION INHIBITORS
The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one benzimidazole conjugates derivative...
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US20090197889 |
SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES
This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine,...
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US20090197871 |
Dual Pharmacophores - PDE4-Muscarinic Antagonistics
The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as...
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US20090197823 |
ALISKIREN MODULATION OF NEUROGENESIS
The disclosure provides compositions and methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis by use of a renin...
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