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US20090286826 |
PHARMACEUTICAL COMPOSITIONS HAVING CARBOXYVINYL POLYMER AND POVIDONE POLYMER
The present invention is directed to pharmaceutical compositions, such as ophthalmic gels. The compositions typically include a carboxyvinyl polymer. A povidone polymer is also typically included...
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US20090286767 |
SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES
Substituted quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the...
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US20090281120 |
BICYCLIC HETEROCYCLIC COMPOUND
A compound represented by the formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof:
wherein X, Y, and W each independently represent a carbon atom or a...
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US20090275577 |
IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS
Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable...
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US20090275563 |
Combination of 5-HT7 Receptor Antagonist and Serotonin Reuptake Inhibitor Therapy
Patients suffering from serotonin-mediated diseases or conditions, such as depression, may be treated by administering an effective combined amount of a 5-HT7 receptor antagonist and a serotonin...
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US20090275550 |
Pyridyl Amide T-Type Calcium Channel Antagonists
The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which...
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US20090275537 |
Certain chemical entities, compositions, and methods
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin...
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US20090274674 |
Heterocyclic Oxime Compounds, Process for Their Preparation and Pharmaceutical Compositions Containing Them
Compounds of formula (I):
wherein:
X represents a hydrogen or halogen atom or an alkyl group, R 1 , R 2 , R 3 and R 4 are as defined in the description, A represents an alkylene chain...
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US20090270444 |
1,7-Naphthyridines
There are provided according to the invention novel compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof,
wherein:
R 1 is phenyl which may be unsubstituted or...
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US20090270412 |
PYRIDO[3,4-B]INDOLES AND METHODS OF USE
This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions...
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US20090270406 |
Combination Therapy for the Treatment of Urinary Frequency, Urinary Urgency and Urinary Incontinence
This invention concerns compositions for the treatment of urinary frequency, urinary urgency and urinary incontinence comprising...
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US20090270376 |
HETEROCYCLIC JANUS KINASE 3 INHIBITORS
The present invention provides a compound of formula (I) having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various...
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US20090270374 |
DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES
Bicyclic nitrogen containing compounds and their use as antibacterials.
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US20090270370 |
FUSED HETEROCYCLIC COMPOUNDS
Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
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US20090264459 |
Organic Compounds
Compounds of formula (I) in free or a pharmaceutically acceptable salt form, wherein X 1 , L and Q have the meanings as indicated in the specification, are useful for treating obstructive or...
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US20090264414 |
Amide Derivatives and Pharmaceutical Use Thereof
The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a...
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US20090264399 |
HETEROCYCLIC JANUS KINASE 3 INHIBITORS
The invention relates to compound of the formula (I) or its salt, wherein —R 1 , —R 2 , —R 3 , —R 4 , —R 5 , -M-, —X— and —Y═ are as defined in the description, their use of as,...
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US20090263393 |
Methods of using(+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4 -oxo-1-(2-thiazolyl)- 1,8-naphthyridine-3-carboxylic acid for treatment of cancer
Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure...
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US20090258868 |
HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS
Disclosed are compounds of the formula I
or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein
W is a bond, —C(═S)—, —S(O)—, —S(O) 2...
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US20090258861 |
Tetrahydronaphthyridine Derivatives
The present invention relates to tetrahydronaphthyridine derivatives of the general formula (I):
or of the general formula (I′)
in which A and R 1 are as defined within, and to processes...
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US20090258070 |
Topical LFA-1 antagonists for use in localized treatment of immune related disorders
This invention provides specifically formulated LFA-1 antagonists or pharmaceutically acceptable salts thereof that are suitable for topical delivery. In particular, the LFA-1 antagonists are...
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US20090258069 |
Delivery of LFA-1 antagonists to the gastrointestinal system
The present invention provides compositions and methods for treating disorders and diseases by delivery of LFA-1 antagonists to the gastrointestinal system. Methods include delivery of LFA-1...
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US20090253736 |
AZAINDOLE DERIVATIVES AS CFTR MODULATORS
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”),...
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US20090253735 |
2-ARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
The present invention is related to a compound of formula (I)
wherein R 1 , R 2 , R 3 and R 4 are as defined herein, or an addition salt of an cid thereof, the pharmaceutical composition and...
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US20090253689 |
Organic Compounds
New compounds of the Formula (I):
for the treatment of non-insulin-dependent diabetes mellitus.
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US20090253679 |
NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7
The present invention relates to imidazolone derivatives of formula (I)
to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives,...
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US20090247547 |
HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B
The present teachings relate to compounds of Formula I:
and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R 1 , R 2 , R 3 , Y, Z, and are as defined...
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US20090246198 |
MAPK/ERK KINASE INHIBITORS AND METHODS OF USE THEREOF
Compounds of the following formula are provided:
wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such...
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US20090239898 |
FURTHER THERAPEUTIC USE OF ZOLPIDEM
An imidazo[1,2-a] pyridine-3-acetamide such as zolpidem is useful in the treatment of a condition of the brain which has a lesion and exhibits diaschisis/dormant cells at the contralateral and...
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US20090239897 |
NOVEL COMPOUNDS
Novel substituted 1,5,7-trisubstituted-1,8-napthyridin-2(1H)-one compounds; 1,5,7 trisubstituted-1,6-napthyridine-2-(1H)-one compounds and 1,5,7-trisubstituted quinoline-2(1H)-one compounds,...
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US20090239896 |
AZAINDOLE COMPOUNDS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS
Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention...
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US20090239866 |
PEPTIDE DEFORMYLASE INHIBITORS
Novel PDF inhibitors and novel methods for their use are provided.
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US20090239856 |
Use of Pyrrolopyridine Compounds for Activating PPAR Receptors and Treatment of Conditions Involving Such Receptors
A method of activating PPAR receptors in a subject, said method comprising administering to said subject an effective PPAR receptor activating amount of a pyrrolopyridine compound corresponding to...
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US20090239853 |
Fused heterocycle derivative
A fused heterocycle derivative represented by the general formula (I):
(wherein R 1 represents optionally substituted lower alkyl, or the like; R 2 represents an optionally substituted...
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US20090239836 |
Multifunctional Ophthalmic Compositions
An multifunctional ophthalmic composition includes a nonionic oxygen-containing polymer and a surfactant. The composition can be used to treat or control ophthalmic diseases, conditions, or...
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US20090233960 |
Kinase Inhibitors
The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I, II, or III or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or...
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US20090233956 |
NOVEL PYRROLO(2,3-b) PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS
Novel compounds of formula (I):
or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions...
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US20090233955 |
1H-Pyrrolo[2,3-B]Pyridnes
Derivatives of pyrrolo[2,3-b]pyridine which are useful as SGK-1 kinase inhibitors are described herein. The invention described herein also describes pharmaceutical compositions containing...
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US20090233945 |
NEW COMPOUNDS 834
This invention relates to novel compounds having the structural formula I below:
and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a...
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US20090227622 |
IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS
The present invention provides compounds that are inhibitors of VEGF-R2 of the formula: (I) and methods of using these compounds.
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US20090227621 |
Naphthyridine derivatives having inhibitory activity against hiv integrase
[Problems to be Solved] To provide a novel compound having antiviral activity, especially inhibitory activity against HIV integrase, a pharmaceutical composition, especially anti-HIV drug,...
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US20090221629 |
Method for antagonizing MIF activity
Methods of antagonizing MIF activity using ibudilast are described. Also described are methods of screening for MIF antagonists. These agents can be used for treating addictions, including drug and...
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US20090221564 |
Heterocyclic Compounds and Their Use in the Treatment of Cardiovascular Disease
Heterocyclic compounds of the formula (I) are provided: wherein ring A, ring B, R 1 , R 2 , R 3 , R 4 , Y, m, n and q are as identified herein. R 1 is in particular amidino. The invention further...
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US20090215818 |
THIOZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS
Invented is a method of inhibiting the activity/function of PI3 kinases using thiozolidinedione derivatives. Also invented is a method of treating one or more disease states selected from:...
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US20090215816 |
Imidazo(1,2-a)Pyridine Derivatives Useful as Peptide Deformylase (PDF) Inhibitors
The present invention relates to compounds of formula (I). These compounds are a novel type of peptide deformylase (PDF) inhibitors, and are therefore of great interest especially as new antibiotics.
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US20090215771 |
JNK INHIBITORS
The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in...
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US20090215747 |
HETEROCYCLIC COMPOUNDS AS INHIBITORS OF BETA-LACTAMASES
This invention discloses and claims methods for inhibiting bacterial β-lactamases and treating bacterial infections by inhibiting bacterial β-lactamases in man or an animal comprising...
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US20090209575 |
Method for treating neuropathic pain and associated syndromes
The present invention is directed to the use of ibudilast for treating neuropathic pain.
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US20090209574 |
FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS
The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The...
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US20090209573 |
COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from...
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