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US20090298846 |
Indolo[3,2-c]quinoline Compounds
Indolo[3,2-c]quinoline compounds of formula (I) shown below. Each variable in this formula is defined herein. These compounds can be used to inhibit both growth of cancer cells and activity of...
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US20090269360 |
THERAPY
The invention relates to a method of inhibiting chemotherapy induced upregulation of Cathepsin S on the surface of tumour cells, the method comprising the administration of a Cathepsin S inhibitor...
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US20090269305 |
NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION
The embodiments provide compounds of the general Formulae I, II, III, IV, V, VI, VII, and X, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The...
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US20090264455 |
Androgen Receptor Modulator Compounds and Methods
Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions...
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US20090258064 |
COMPOSITIONS OF UCP INHIBITORS, FAS ANTIBODY, A FATTY ACID METABOLISM INHIBITOR AND/OR A GLUCOSE METABOLISM INHIBITOR
Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and/or Fas antibody or other inhibitor, or combination thereof, and a...
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US20090221623 |
Indole Alkaloid Derivatives Having Opioid Receptor Agonistic Effect, and Therapeutic Compositions and Methods Relating to Same
Indole alkaloid derivatives having an opioid receptor agonistic effect, their synthesis, and therapeutic compositions containing these derivatives, and methods of treating conditions with these...
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US20090203725 |
Androgen Receptor Modulator Compounds and Methods
Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors and/or modulate the amount of androgen receptors; and to methods for making and using...
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US20090197906 |
REVERSION OF MALIGNANT PHENOTYPE WITH 9-HYDROXY ELLIPTICINE DERIVATIVES
The invention relates to the use of 9-hydroxy ellipticine derivatives for the treatment of cancer. 9-hydroxy ellipticine derivatives may prove particularly useful for the treatment of metastatic...
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US20090170890 |
METHOHDS OF INHIBITING VIRAL INFECTION
A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one of the compounds of FGI-103 which are represented by 273, 365 and 510...
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US20090143374 |
Use of Compounds and Compositions for the Treatment of Amyloid Diseases
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, pharmaceutical compositions containing them, and their use in the treatment of amyloid...
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US20090143279 |
Methods and compositions for treating metabolic disorders
The present invention provides methods of treating of disorders characterized by defective mitochondrial activity. In particular compounds of the present invention can be used in the treatment...
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US20090136496 |
CHRONIC LYMPHOCYTIC LEUKEMIA PROGNOSIS AND TREATMENT
Provided herein are methods for identifying a subject afflicted with chronic lymphocytic leukemia who is responsive to treatment with a chemotherapeutic agent by detecting the presence or absence...
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US20090130229 |
Antitumor uses of compound
The use of an arylidene 2-indolinone derivative for treating tumors involving Met, PDGF-R, FGF-RI, FGF-R3 or Kit tyrosine kinases, or a Ret oncoprotein which includes a MEN2-associated mutation is...
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US20090105292 |
Glucocorticoid Receptor Modulator Compounds and Methods
Disclosed herein are compounds of Formula I:
and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof. Certain of such compounds are selective glucocorticoid receptor...
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US20090069277 |
Compounds and compositions for treating infection
Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.
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US20090060873 |
Novel synthetic triterpenoids and methods of use in the treatment and prevention of multiple scleroris
The present invention overcomes limitations of the prior art by providing new compounds and methods for the treatment of conditions, such as neurodegenerative diseases (e.g., multiple sclerosis),...
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US20090030027 |
Androgen Receptor Modulator Compounds and Methods
Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors, and to methods for making and using such compounds. Also provided are compositions...
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US20090030025 |
TRANS-FUSED CHROMENOISOQUINOLINES SYNTHESIS AND METHODS FOR USE
Optionally substituted chromenoisoquinolines and analogs and derivatives thereof are described herein. In addition, syntheses of these compounds are described herein. In addition, uses of these...
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US20090012107 |
Antiviral Compounds and Methods of Using Thereof
Disclosed herein are compounds which exhibit antiviral activity against a plurality of viruses belonging to different families such as Bornaviridae, Filoviridae, Paramyxoviridae, Rhabdoviridae,...
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US20090004173 |
Diagnosis and Treatment of Drug Resistant Leukemia
The present invention encompasses methods and compositions useful in the diagnosis and treatment of drug resistant leukemia. The invention provides a number of genes that are differentially...
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US20080306019 |
Dopamine Receptor Agonists in the Treatment and Prevention of Hiv-Induced Dementia
Provided herein is a method of protecting a neuron from dysfunction induced by an HIV neurotoxin, comprising contacting the cell with a therapeutically effective dose of a dopamine D1 receptor...
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US20080300225 |
PESTICIDAL FORMULATION CONTAINING OXYMATRINE OR MATRINE
Compositions and methods are provided for a water-soluble insecticidal or pesticidal comprising at least one alkaloid, particularly at least one tetracyclo-quinolizindine alkaloid derived from...
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US20080293693 |
Treatment or Prevention of Ovarian Hyperstimulation Syndrome (Ohss) Using a Dopamine Agonist
Disclosed herein is a method for preventing ovarian hyperstimulation syndrome in a subject by administering an effective amount of a dopamine agonist in a pharmaceutically acceptable carrier. Also...
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US20080279961 |
TELOMERE TARGETING AGENTS AS STEM CELLS DIRECTED TREATMENTS
It is demonstrated in the present invention that G-quadruplex ligands can be used to both shorten telomeres and inhibit telomerase by causing telomere uncapping. The invention relates to...
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US20080262015 |
Aryl imidazoles and their use as anti-cancer agents
Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods -of preparing the compounds and pharmaceutical compositions comprising the compounds alone...
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US20080260828 |
STABLE SOLID DISPERSION OF A DERIVATIVE OF VINCA ALKALOID AND PROCESS FOR MANUFACTURING IT
This invention relates to solid and stable dispersions of a hydrosoluble derivative of vinca alkaloids in at least one polyethyleneglycol with a molecular mass between 800 and 30,000.
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US20080221118 |
Tetrahydroquinoline Derivatives
Compounds of the formula I, in which s, k, I, W, R 1 , R 2 , R 3 , and U have the meanings indicated in claim 1 , can be employed, inter alia, for the treatment of tumours.
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US20080214576 |
Topoisomerase Inhibitors and Prodrugs
Compositions and methods for treating cancer and other hyperproliferatice disease conditions with topoisomerase inhibitors and their prodrugs are disclosed.
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US20080064712 |
Morphinan derivatives, the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof
The present invention relates to a class of morphinan compounds and quaternary ammonium salts thereof, substituted in Position 14, which may be used as highly active analgesics or also as opioid...
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US20080058365 |
Fused heterocyclic compounds
Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds...
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US20080051426 |
Indoloquinoline compounds as calcium channel blockers
Various calcium channel blockers and pharmaceutical compositions containing these compounds are disclosed. Calcium channel blockers are compounds capable of inhibiting calcium ion channels. Methods...
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US20080045538 |
Nitro and amino substituted topoisomerase agents
The invention provides compounds of formula I:
wherein R 1 -R 9 , W, and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention...
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US20080020973 |
Assays for identification of topoisomerase inhibitors
The instant invention provides a continuous spectroscopic assay for DNA topoisomerase activity. The invention further provides topoisomerase inhibitors and pharmaceutical compositions for the...
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