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US20100298348 Method of Decreasing Ubiquitylated Protein Levels  
The present invention provides a method of decreasing the level of ubiquitylated protein in a subject, the method comprising administering a heterocyclic compound disclosed herein or a...
US20130115286 ORAL ADMINISTRATION FORMS FOR CONTROLLED RELEASE OF RIFAMPICIN FOR THE TREATMENT OF BACTERIAL INFECTIONS AND INFLAMMATORY DISEASES OF THE GASTROINTESTINAL TRACT  
Oral administration forms are described for the controlled release of an antibiotic selected from the group consisting of rifampicin, rifabutin, rifapentine, rifalazil and mixtures thereof, for...
US20140343046 USE OF SELECTIVE GABA A ALPHA 5 NEGATIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS  
The present invention relates to the pharmaceutical use of selective GABA A α5 negative allosteric modulators for the treatment, prevention and/or delay of progression of central nervous system...
US20110086818 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS  
The invention features methods, compositions, and kits for selective inhibition of pain-and itch sensing neurons (nociceptors and pruriceptors) by drug molecules of small molecule weight, while...
US20110003822 P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN  
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or...
US20110136844 METHODS FOR INHIBITING DYRK1A TO TREAT CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS  
Compositions and methods for treating, preventing and/or delaying the onset and/or the development of diseases and disorders of the central nervous system are disclosed. The present disclosure...
US20150182516 DRUG DELIVERY SYSTEMS AND METHODS FOR TREATMENT OF BLADDER DYSFUNCTION OR DISORDER USING TROSPIUM  
Methods, devices, and medicaments that include trospium are provided for use in the treatment of bladder dysfunction by locally administering the trospium into the bladder to achieve a sustained...
US20130203794 COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER  
The present invention relates to compounds for modulating sonic hedgehog signaling and preventing or treating cancer.
US20130261104 METHODS OF USE OF DIAZACARBAZOLES FOR TREATING CANCER  
Methods of use of compounds of formula (I) for treating cancer: wherein X, Y, X, R3, R5 and R6 are as defined herein.
US20130210771 METHODS AND COMPOSITIONS FOR TREATING CANCERS  
This invention provides a combination of antagonists of the hedgehog signaling pathway with a BCR-ABL inhibitor. The combination of the present invention may be used for treating cancers known to...
US20130072511 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES  
Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
US20110003839 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES  
A hydantoin compound useful for the prevention or treatment of hyperproliferative diseases or disorders.
US20110244051 PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT OF OVERACTIVE BLADDER  
Disclosed herein are pharmaceutical compositions comprising a plurality of first beads each comprising: a core; a first layer comprising pilocarpine or a pharmaceutically acceptable salt thereof;...
US20150157656 Method for Treatment of Castration-Resistant Prostate Cancer  
Castrate resistant prostate cancer cell lines exhibiting resistance to the androgen-receptor antagonist enzaluatamide overexpress one or both of IGFBP-2 or IGFBP-5 when compared to non-resistant...
US20140228333 METHODS FOR INHIBITING MUSCLE ATROPHY  
In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression...
US20110195987 TREATMENT WITH CHOLINERGIC AGONISTS  
Methods of treating disorders with cholinergic agonists for example, muscarinic receptor agonists such as pilocarpine and cevimeline are provided. In particular, methods of treating and/or...
US20150246904 Opioid Receptor Ligands And Methods Of Using And Making Same  
This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
US20130331408 Opioid Receptor Ligands and Methods of Using and Making Same  
This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
US20120245181 OPIOID RECEPTOR LIGANDS AND METHODS OF USING AND MAKING SAME  
This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
US20110112102 METHOD OF TREATING CANCER USING A NEUROPEPTIDE Y 5R (NP Y5R) ANTAGONIST  
The present invention relates to methods for treating cancer by administering a therapeutically effective amount of compound of formula (I), such as selective NPY5R antagonist MK-0557...
US20140235593 SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES  
In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoqui noline-4-carboxamides; synthetic methods for making the compounds;...
US20110015220 MIXED ORL1/MU-AGONISTS FOR THE TREATMENT OF PAIN  
The invention relates to the use of compounds which exhibit an affinity for the μ-opioid receptor of at least 100 nM (Ki value, human) and an affinity for the ORL-1 receptor, wherein the ratio...
US20140128352 COMPOUNDS AND METHODS FOR MODULATING MITOCHONDRIAL METABOLISM AND REACTIVE OXYGEN SPECIES PRODUCTION  
Compounds that modulate mitochondrial reactive oxygen species (ROS) production are provided. The compounds may modulate ROS production at defined sites without also altering energy production....
US20120035200 GRISEOFULVIN ANALOGUES FOR THE TREATMENT OF CANCER BY INHIBITION OF CENTROSOMAL CLUSTERING  
The invention relates to compounds of the formula (I), where the symbols have the meaning given in the specification, for use in a method for treating cancer, to use of these compounds for the...
US20120263676 COMPOSITIONS, METHODS AND KITS RELATING TO HER-2 CLEAVAGE  
The present invention relates to compositions, methods and kits based on the ADAM-mediated cleavage of Her-2. The present invention also relates to treatments for cancer, and in particular, breast...
US20140135305 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY  
The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene,...
US20110086833 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY  
The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene,...
US20140234402 Intravenous Infusion of Curcumin and a Calcium Channel Blocker  
Compositions and methods for treating systemic diseases by intravenous administration of formulations of synthesized curcumin (diferuloylmethane) and concomitantly a calcium channel blocker to...
US20120129833 CYCLIC KETOENOLS FOR THERAPY  
The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and...
US20120214809 Aminoindane Compounds and Use Thereof in Treating Pain  
The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by...
US20140288110 PPAR MODULATORS  
1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and...
US20110178112 PPAR Modulators  
1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and...
US20140206693 COMPOSITIONS AND METHODS FOR TREATING COLON CANCER  
Certain embodiments are directed to methods of treating a pathophysiological state or symptoms thereof resulting from aldose reductase-mediated signaling in a cytotoxic pathway using an aldose...
US20120029006 Cis-tetrahydro-spiro(cyclohexane-1,1'-pyrido[3,4-b]indole)-4-amine Compounds  
Cis-tetrahydro-spiro(cyclohexane-1,1′-pyrido[3,4-b]indole)-4 -amine compounds which act on the nociceptin/ORL-1 receptor system as well as on the μ-opioid receptor system and which are...
US20120322719 METHODS OF TREATMENT OF FATTY LIVER DISEASE BY PHARMACOLOGICAL ACTIVATION OF CHOLINERGIC PATHWAYS  
A method of treating a fatty liver disease in a subject. The method comprises administering to the subject an effective amount of a cholinergic pathway stimulating agent, wherein the fatty liver...
US20130089607 ONCE DAILY TROSPIUM CHLORIDE TREATMENT METHOD  
A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum...
US20140155369 PREVENTIVES/REMEDIES FOR STRESS URINARY INCONTINENCE AND METHOD OF SCREENING THE SAME  
An agent for the prophylaxis or treatment of stress urinary incontinence, which contains a substance that activates a serotonin 5-HT2C receptor, an agent for the prophylaxis or treatment of stress...
US20130203793 Protection and Treatment Against Influenza Infection  
Method and composition for protection and treatment against influenza viral infection by modulating the activity of at least one essential host signaling pathways, including the Hedgehog (Hh), the...
US20060217405 Interstitial cystitis treatment  
An anti-muscarinic agent exemplified by trospium is administered by intravesicular instillation into the bladder and used to treat interstitial cystitis. The instilled medication does not interact...
US20120245153 MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
US20140051702 Use of Aminoindane Compounds in Treating Overactive Bladder and Interstitial Cystitis  
The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the...
US20110245286 TREATMENT OF INFLAMMATION USING ALPHA 7 RECEPTOR-BINDING AGONISTS  
Methods of inhibiting release of a proinflammatory cytokine from a macrophage are provided. The methods comprise treating the macrophage with a cholinergic agonist in an amount sufficient to...
US20120316148 Compositions and Methods for Modulating a Kinase  
The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade.
US20150126496 DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDERS  
The invention relates to methods for diagnosis and treatment of autism spectrum disorders, particularly for autism spectrum disorders characterized by increased head size (circumference) and...
US20150148318 METHOD FOR INHIBITING GROWTH OF CANCER CELLS  
A method of inhibiting the growth of cancer cells is disclosed in which cancer cells that contain an enhanced amount relative to non-cancerous cells of one or more of phosphorylated mTOR, Akt1,...
US20110008333 METHODS OF INHIBITING UNWANTED CELL PROLIFERATION USING HEDGEHOG ANTAGONISTS  
The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog...
US20110003808 OCTAHYDROQUINOLIZINES FOR ANTIDIABETIC TREATMENT  
This invention relates to novel octahydroquinolizines for treatment or prevention of diabetes mellitus and its complications, for treatment or prevention of hyperlipidemia, for treatment of...
US20140378430 Heterocyclic Compounds and Methods of Their Use  
The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to pyrrolidine and azetidine...
US20110044991 METHODS AND COMPOSITIONS FOR TREATING LYMPHOMA AND MYELOMA  
This invention relates to the use of antagonists of the hedgehog signaling pathway to induce apoptosis of lymphoma and myeloma cells and to treat subjects suffering from various forms of lymphoma...
US20130191933 METHODS OF TREATING PAIN AND MORPHINE TOLERANCE VIA MODULATION OF HEDGEHOG SIGNALLING PATHWAY  
Described herein are methods of treating nociception by administering to a subject in need thereof a therapeutic amount of one or more compounds which modulate the Hedgehog signaling pathway.