|
Match
|
Document |
Document Title |
|
|
US20090298861 |
Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
The invention provides compounds of formula (I) wherein m, R 1 , n, R 2 , q, p, X, Y, R 3 , R 4 , t and, R 5 are as defined in the specification, processes for their preparation, pharmaceutical...
|
|
|
US20090298810 |
IL-8 Receptor Antagonists
This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (II-8).
|
|
|
US20090298808 |
INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The...
|
|
|
US20090291963 |
SUBSTITUTED INDOLES
Substituted indoles of the formula (I) and physiologically acceptable derivatives and salts thereof, in which R 1 , D, E, R 12 , p, X 1 , E, G, X 2 and Z are as defined in claim 1 , exhibit...
|
|
|
US20090291946 |
LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The...
|
|
|
US20090286822 |
Treatment of psoriasis and of other skin disorders associated with inhibition of differentiation of epidermal cells
This invention concerns the use of cyclopamine, a naturally occurring steroidal alkaloid known for over thirty years, for the treatment of psoriasis and achievement of rapid clearance of the...
|
|
|
US20090281133 |
Heterocyclic antiviral compounds
This invention relates to piperidine derivatives of formula I wherein R 1 , R 2 and R 3 are as defined herein useful in the treatment of a variety of disorders, including those in which the...
|
|
|
US20090281081 |
CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an...
|
|
|
US20090281080 |
Spirohydantoin Tricyclic CGRP Receptor Antagonists
Compounds of formula I:
(wherein variables A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , B 1 , B 2 , B 3 , B 4 , D 1 , D 2 , E 1 , E 2 , E 3 , E 4 , E 5 , G 1 , G 2 , R 6 , T, U, V, W, X, Y and Z...
|
|
|
US20090275602 |
Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's...
|
|
|
US20090275560 |
ORGANIC COMPOUNDS
The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those...
|
|
|
US20090270436 |
SPIROCHROMANON DERIVATIVES
The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of benzene, pyrazole, isoxazole, pyridine,...
|
|
|
US20090270435 |
Spiroketone Acetyl-CoA Carboxylase Inhibitors
The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are as described herein;...
|
|
|
US20090270405 |
QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may...
|
|
|
US20090270375 |
SPIRO ANTIBIOTIC DERIVATIVES
The invention relates to compounds of formula (I) wherein R 1 represents H, alkyl, alkoxy, cyano or halogen; one of U and X represents CH or N and the other represents CH, or, in the case of U,...
|
|
|
US20090270360 |
DICARBOXAMIDE DERIVATIVES
The invention is concerned with novel dicarboxamide derivatives of formula (I)
wherein A, B, R c , D and E are as defined in the description and in the claims, as well as physiologically...
|
|
|
US20090264410 |
THERAPEUTIC COMPOUNDS AND USES THEREOF
Compounds of formula (I) are described herein
The compounds can be used, for example, to modulate growth hormone secretagogue receptor (GHS-R). In some instances, the compounds can be used to...
|
|
|
US20090264403 |
NOVEL AZACYCLYL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their...
|
|
|
US20090258871 |
Aza-Substituted Spiro Derivatives
A compound of the following formula (I) or its pharmaceutically-acceptable salt is provided:
[wherein X, Y, Z and W each independently represent a methine group or a nitrogen atom, provided that...
|
|
|
US20090258857 |
CHEMICAL COMPOUNDS
The present invention encompasses compounds of general formula (1) wherein R 1 , M 1 , L 1 and Q are defined as in claim 1 , which are suitable for the treatment of diseases characterised by...
|
|
|
US20090253727 |
NOCICEPTIN ANALOGS
A compound of the having the general formula (I) or general formula (II):
wherein
Z, A, B, C, R 1 , R 2 , Q, W, and n are as described herein.
|
|
|
US20090253726 |
TRI-, TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVE
A quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria,...
|
|
|
US20090253725 |
ACETYL CoA CARBOXYLASE INHIBITORS
The present invention relates to acetyl coenzyme-A carboxylase (“ACC”) inhibiting compounds of the formula
wherein the variables are as defined herein. In particular, the present invention...
|
|
|
US20090247561 |
SUBSTITUTED SPIROCYCLIC CYCLOHEXANE DERIVATIVES
The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these...
|
|
|
US20090247560 |
Diaryl ketimine derivative
Provided is a compound of a formula (I):
[wherein R 1a and R 1b are the same or different, representing a hydrogen atom, etc.; R 2a and R 2b are the same or different, representing a...
|
|
|
US20090247534 |
NEW COMPOUNDS
The present invention provides organic compounds of the following structure;
A-L1-B-C-D-L2-E
|
|
|
US20090247514 |
Spirolactam aryl cgrp receptor antagonists
Compounds of formula I:
(wherein variables A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , E 1 , E 2 , E 3 , E 4 , E 5 , G 1 , G 2 , J and K are as described herein) which are antagonists of CGRP...
|
|
|
US20090247505 |
SPIRO(5.5)UNDECANE DERIVATIVES
The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these...
|
|
|
US20090239890 |
SPIRO SUBSTITUTED CYCLOPROPANE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
A compound of the Formula I:
or a pharmaceutically acceptable salt, solvate or isomer thereof, can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE,...
|
|
|
US20090239889 |
Spiroindolinone Derivatives
There are provided compounds of the general formulas
wherein W, X, Y, R 1 , R 2 , R 3 , and R 4 are as described herein. The compounds exhibit anticancer activity.
|
|
|
US20090239870 |
Spirohydantoin Aryl Cgrp Receptor Antagonists
Compounds of formula I:
(wherein variables A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , B, E 1 , E 2 , E 3 , E 4 , E 5 , G 1 , G 2 and R 6 are as described herein) which are antagonists of CGRP...
|
|
|
US20090239849 |
Aryl-Fused Spirocyclic Compounds
The present invention relates to a novel class of aryl-fused spirocyclic compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal...
|
|
|
US20090233953 |
ANTAGONISTS OF THE VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF
The present invention is directed to compounds of formula (I)
wherein variables X 1 , X 2 , Y, R 1a , R 1b , R 2a , R 2 , A 1 , A 2 , A 3 , and A 4 are as defined in the description, and...
|
|
|
US20090233952 |
SUBSTITUTED CYCLOALKENE DERIVATIVE
[Object] To provide a substituted cycloalkene derivative having an action to suppress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to...
|
|
|
US20090227614 |
Modulators of Muscarinic Receptors
The present invention relates to modulators of muscarnic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating...
|
|
|
US20090227613 |
Novel 3-Aza-Spiro[5.5]Undecane Derivatives and Their Use As Monoamine Neurotransmitter Re-Uptake Inhibitors
This invention relates to novel 3-aza-spiro[5.5]undecane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds...
|
|
|
US20090221554 |
METHOD OF TREATING COGNITIVE IMPAIRMENT
Disclosed is an method of treating cognitive impairment, including administering to a subject in need thereof a combination of a therapeutic agent for neurodegenerative disease and a...
|
|
|
US20090215807 |
Novel Diazaspiroalkanes and Their Use for Treatment of CCR8 Mediated Diseases
The invention provides compounds of general formula. [Chemical formula should be inserted here. Please see paper copy] (II) wherein R and R 1 are as defined in the specification, processes for...
|
|
|
US20090209568 |
Spiro [Benzopyran] or Spiro [Benzofuran] Derivatives Which Inhibit the Sigma Receptor
The present invention relates to compounds having pharmacological activity towards the sigma (σ) receptor, and more particularly to spiro[benzopyran] or spiro[benzofuran] derivatives, to processes...
|
|
|
US20090209566 |
Spirocyclic Compounds
The present invention relates to a novel class of substituted spirocyclic compounds, represented by the following structural Formula: I Wherein A, B and D are independently selected from CR 1 2 ,...
|
|
|
US20090203721 |
USE OF SIRAMESINE IN THE TREATMENT OF CANCER
The present invention relates to the treatment of cancer. In particular, the invention provides pharmaceutical compositions comprising siramesine for the treatment of cancer. The invention further...
|
|
|
US20090203694 |
INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE
The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions...
|
|
|
US20090197904 |
Sulphamides for Treatment of Cancer
Bridged bicyclic sulphamides of formula (I) are disclosed for treatment of cancer.
|
|
|
US20090192182 |
COMPOUND HAVING ACIDIC GROUP WHICH MAY BE PROTECTED, AND USE THEREOF
A compound represented by general formula (I):
a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification. The compound of the present...
|
|
|
US20090186901 |
CHEMICAL COMPOUNDS
The present invention relates to new heterocyclic compounds of general formula (1) wherein the groups R 1 to R 7 , k, X and Y have the meanings given in the claims and specification, the isomers...
|
|
|
US20090181997 |
THERAPEUTIC CANCER TREATMENTS
The invention is directed to use of hedgehog inhibitors in conjunction with chemotherapy in treating cancers, and preventing relapses thereby.
|
|
|
US20090181996 |
SUBSTITUTED QUINOLONES III
The invention relates to substituted quinolones and to methods for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases,...
|
|
|
US20090176815 |
Novel Tricyclic Spiropiperidine Compounds, Their Synthesis and Their Uses as Modulators of Chemokine Receptor Activity
Compounds of formula (I) wherein R 1 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 10 are as defined in the specification, are described. The present invention also relates to pharmaceutical composition...
|
|
|
US20090176775 |
DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE
The present invention is related to a compound of formula (I):
wherein i, j, n, o, p, q, r, R 1a , R 1b , R 1c , R 1d , R 2a , R 2b , R 2c , R 2d , R 3a , R 3b and R 4 are as defined herein,...
|
|
|
US20090176757 |
Bicyclic Spirohydantoin CGRP Receptor Antagonists
Compounds of formula I:
(wherein variables A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , B, E 1 , E 2 , E 3 , E 4 , E 5 , G 1 , G 2 and R 6 are as described herein) which are antagonists of CGRP...
|