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US20140105886 ASSOCIATION OF BIOMARKERS WITH PATIENT OUTCOME  
Glioblastoma multiforme (GBM) is an aggressive form of brain cancer. Biomarkers for GBM that provide prognostic and predictive information are useful because they provide the physician valuable...
US20130190340 Small-Molecule-Targeted Protein Degradation  
Certain aspects of the invention relate to compounds, compositions and methods that are useful for treating or preventing a disease in a subject by enhancing the degradation of a protein. In other...
US20110034495 Method of Modulating Stress-Activated Protein Kinase System  
A series of thieno[2,3-b]pyridin-6(7H)-one derivatives, substituted in the 2-position by a carbonyl- or sulfonyl-linked pyrrolidin-1-yl or related moiety, being inhibitors of p38 MAP kinase, are...
US20150209353 APPLICATION OF 5-HT6 RECEPTOR ANTAGONISTS FOR THE ALLEVIATION OF COGNITIVE DEFICITS OF DOWN SYNDROME  
Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists...
US20130210829 APPLICATION OF 5-HT6 RECEPTOR ANTAGONISTS FOR THE ALLEVIATION OF COGNITIVE DEFICITS OF DOWN SYNDROME  
Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists...
US20130022661 BIO-REMODABLE BONE AUGMENTATION DEVICE AND METHOD  
A bio-remodable augmentation device including an implantable member configured for maintaining space in a bone defect. The implantable member is formed from a bio-remodable composite having...
US20130216560 Lipidomic Biomarkers for Identification of High-Risk Coronary Artery Disease Patients  
The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a...
US20140073632 TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS  
Novel CFTR corrector compounds that are effective in rescuing halide efflux in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The...
US20150010638 Method for Improving Water Solubility of Slightly Soluble Substance  
It is an object of the present invention to provide a method for improving the solubility of a poorly-soluble substance, which is capable of increasing the solubility of substantially all...
US20110263601 METHODS OF TREATING ULCERATIVE COLITIS  
Methods are disclosed for treating ulcerative colitis and related diseases and disorders, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.
US20140256758 METHODS FOR REDUCING THE RISK OF AN ADVERSE TERIFLUNOMIDE AND ROSUVASTATIN INTERACTION IN MULTIPLE SCLEROSIS PATIENTS  
This invention relates to a method for managing the risk of an adverse interaction between teriflunomide and a substrate of breast cancer resistance protein (BCRP) and/or organic anion...
US20120114723 ONE STEP FIRE ANT CONTROL  
The present invention relates to a method for controlling fire ants with a single step application of a combination of a bait and a controlled release treatment composition, and to the novel...
US20110190327 METHOD FOR MODULATING GPR119 G PROTEIN-COUPLED RECEPTOR AND SELECTED COMPOUNDS  
A method of modulating the activity of the GPR119 G protein-coupled receptor comprising administering to a mammalian patient in need thereof a therapeutically effective amount of at least one...
US20120157420 TREATMENT AND PREVENTION OF SECONDARY INJURY AFTER TRAUMA OR DAMAGE TO THE CENTRAL NERVOUS SYSTEM  
A method of administering one or multiple medications to human patients with CNS injury through oral or parenteral (including transdermal, intravenous, subcutaneous, intramuscular) routes....
US20110201602 PROTEIN KINASE MODULATORS AND METHOD OF USE  
The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating...
US20110077261 PREVENTION OF HIV-INFECTION  
This invention relates to the use of a parenteral formulation comprising the NNRTI TMC278 for the long term prevention of HIV infection in a subject at risk of being infected by HIV, which...
US20120029001 METHOD OF TREATMENT OF NEPHROGENIC DIABETES INSIPIDUS  
Nephrogenic diabetes insipidus is treated with statins.
US20150023955 Treatment and Diagnosis of Melanoma  
The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
US20130065870 TREATMENT OF PAIN WITH TOPICAL DICLOFENAC  
The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide...
US20140309247 Systems And Methods For Detecting Scalp Follicular Inflammation In Humans  
Methods, processes, systems, and apparatuses are disclosed for detecting biomarkers associated with the inflammation response in the pilosebaceous unit of the human scalp using plucked human hair...
US20130261104 METHODS OF USE OF DIAZACARBAZOLES FOR TREATING CANCER  
Methods of use of compounds of formula (I) for treating cancer: wherein X, Y, X, R3, R5 and R6 are as defined herein.
US20140212488 ORAL TABLET FORMULATION CONSISTING OF IMMEDIATE RELEASE ROSUVASTATIN AND EXTENDED RELEASE METFORMIN  
A solid dosage product and formulation containing a fixed combination of rosuvastatin and metformin is provided here. In the formulation rosuvastatin is delivered immediately to the patient and...
US20120029003 GALECTIN-3 AND STATIN THERAPY  
Described herein are materials and methods for predicting and monitoring a heart failure patient's physiological response to treatment with a statin. More specifically, the present invention...
US20120156255 DRUG ELUTING PATCH FOR THE TREATMENT OF LOCALIZED TISSUE DISEASE OR DEFECT  
A polymeric matrix for delivery of an HMG CoA reductase inhibitor such as a statin to tissue such as cardiac tissue in need thereof for the treatment or prevention of a disease or defect such as...
US20140378445 METHODS FOR TREATING VASCULAR LEAK SYNDROME  
Disclosed are methods for treating Vascular Leak Syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, inflammatory bowel...
US20140179693 METHODS FOR TREATING VASCULAR LEAK SYNDROME  
Disclosed are methods for treating Vascular Leak Syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, inflammatory bowel...
US20140066458 METHODS FOR TREATING VASCULAR LEAK SYNDROME  
Disclosed are methods for treating Vascular Leak Syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, irritable bowel...
US20130281410 METHODS FOR THE TREATMENT OF PSYCHIATRIC DISORDERS  
The invention provides methods for the treatment of major depressive disorder in male subjects and methods for the treatment of psychiatric disorders at high altitudes by administering one or more...
US20120055076 SYSTEMS AND METHODS FOR PEST CONTROL  
Systems and methods for controlling one or more types of pests include the use of one or more freestanding pesticidal baits positioned at a location below and/or adjacent to one or more foundation...
US20110245283 Methods for predicting the response to statins  
The invention provides methods for optimizing therapeutic efficacy for treating hypercholesterolemia in a subject having a cardiovascular disease (CVD), comprising (a) determining subject...
US20120121540 Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections  
Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
US20110190239 BMI-1 PROTEIN EXPRESSION MODULATORS  
The compounds, pharmaceutical compositions, and methods of using such compounds or compositions thereof described herein are useful for treating a disease modulated by B-cell specific Moloney...
US20140037647 MOLECULAR SUBTYPING, PROGNOSIS AND TREATMENT OF PROSTATE CANCER  
Disclosed herein are new prognostic molecular markers for prostate cancer. More specifically, the invention has identified that overexpression or amplification of at least one of AURKA or MYCN...
US20130210771 METHODS AND COMPOSITIONS FOR TREATING CANCERS  
This invention provides a combination of antagonists of the hedgehog signaling pathway with a BCR-ABL inhibitor. The combination of the present invention may be used for treating cancers known to...
US20120165355 METHODS AND COMPOSITIONS FOR TREATING CANCERS  
This invention provides a combination of antagonists of the hedgehog signaling pathway with a BCR-ABL inhibitor. The combination of the present invention may be used for treating cancers known to...
US20120107401 OSTEOCONDUCTIVE MATRICES COMPRISING STATINS AND METHODS OF USING THE SAME  
Osteoconductive matrices and methods are provided that have one or more statins disposed therein. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for...
US20110195962 USE OF MULTI-PHARMACOPHORE COMPOUNDS TO TREAT NASAL DISORDERS  
Compositions and methods for treating nasal disorders associated with nasal inflammation using a multipharmacophoric agent (MPA) that can prevent the production and/or release of at least one or...
US20110301186 USE OF HAPTOGLOBIN GENOTYPING IN DIAGNOSIS AND TREATMENT OF CARDIOVASCULAR DISEASE  
This invention is directed to methods and compositions for the treatment of cardiovascular disorders. Specifically, the invention is directed to compositions comprising vitamin E, statins and/or...
US20130310340 METHOD OF TREATING MUSCULAR DEGRADATION  
A method for treating muscular deterioration is disclosed. Also disclosed are embodiments of a compound, and compositions comprising the compound, for inhibiting muscular deterioriation, including...
US20120329760 RNASE 7 AS A MARKER FOR INFECTION  
Methods of identifying a subject having a urinary tract infection using RNase 7 are described. The methods include providing a test sample of urine from the subject, determining the level of RNase...
US20130252987 METHOD OF REGULATING PLASMA LIPOPROTEINS  
A method of modulating the level of lipoproteins in human cells comprising the step of inhibiting resistin in the cells or cellular environment. The method is useful to treat cardiovascular disease.
US20110091565 METHOD OF FORMING NON-IMMUNOGENIC HYDROPHOBIC PROTEIN NANOPARTICLES AND USES THEREFOR  
Methods are described for producing non-immunogenic nanoparticles from protein sources by controlling the pH in a nanoprecipitation process. The nanoparticles that are produced by the disclosed...
US20110118292 METHOD OF TREATING ATHEROSCLEROSIS, DYSLIPIDEMIAS AND RELATED CONDITIONS  
A method of treating atherosclerosis is disclosed wherein nicotinic acid or another nicotinic acid receptor agonist is administered to the patient in combination with a DP receptor antagonist. The...
US20140371251 METHOD OF INHIBITING DYRK1B  
The present invention relates to a DYRK1B inhibitor for use in the treatment of cancer, wherein in said cancer and/or in cells of said cancer the hedgehog signaling pathway is activated, and in...
US20130276352 BAIT MATERIALS, PEST MONITORING DEVICES AND OTHER PEST CONTROL DEVICES THAT INCLUDE POLYURETHANE FOAM  
A termite bait includes a plurality of cellulosic food material pieces palatable to termites embedded within a water resistant polyurethane foam matrix. Another termite bait includes a plurality...
US20110046126 Use of 2,4-Pyrimidinediamines For the Treatment of Atherosclerosis  
Novel methods and compositions for the prevention and treatment of all forms of atherosclerosis with 2,4-pyrimidinediamine compounds are described. Also disclosed is the coating of prosthetic...
US20140045840 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR  
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described...
US20110112127 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR  
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described...
US20130195997 FUNGICIDAL MIXTURES  
The invention relates to a method of controlling fungi and spores and to compositions suitable for this purpose and their use. The compositions according to the invention comprise trifloxystrobin,...
US20140066430 AURORA KINASE MODULATORS AND METHOD OF USE  
The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating...