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US20090042900 |
2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY
2,4-Diaminoquinazolines of formula (I)
are provided herein and are useful for treating spinal muscular atrophy (SMA).
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US20080090802 |
QUINAZOLINONE AND ISOQUINOLINONE ACETAMIDE DERIVATIVES
Disclosed herein are quinazolinone derivatives of formula I,
or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in...
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US20080058312 |
Modulators of hepatocyte growth factor/c-Met activity
This invention is directed to compounds and compositions that have biological properties useful for modulating HGF/SF activity. In certain embodiments, said compounds and compositions may be used...
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US20080051414 |
Protein Kinase Inhibitors
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following...
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US20080038357 |
Inhalation Powder Containing the CGRP antagonist BIBN4096 and Process for the Preparation Thereof
The invention relates to an inhalation powder for treating migraine, containing the CGRP antagonist 1-[N 2...
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US20080032965 |
Method for enhancing cognitive function
Pharmaceutical compositions and compositions are provided for treating cognitive disorders using synergistically effective amounts of 5-HT 1A receptor antagonists and cognition enhancers.
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US20080027069 |
Quinazoline compounds
The invention relates to compounds of the formula (I): wherein ring C is as defined herein, for example indolyl, indazolyl or azaindolyl; Z is —O—, —NH— or —S—; n is 0-5; m is 0-3; R 1 ...
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US20080026077 |
METHODS AND COMPOSITIONS OF GENE DELIVERY AGENTS FOR SYSTEMIC AND LOCAL THERAPY
A method is provided for the delivery of a therapeutic to epithelial cells through the use of a bile acid conjugated to a peptide, the peptide being ionically charged at physiological pH. The...
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US20080020041 |
Enteric Coated Compositions that Release Active Ingredient(s) in Gastric Fluid and Intestinal Fluid
Embodiments of a pharmaceutical formulation comprising an enteric material are disclosed. The embodiments release at least a portion of an active ingredient upon contacting gastric fluid. The...
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US20080015182 |
Potent PARP Inhibitors
The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I),
their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of...
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US20080004248 |
17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES
In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical...
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