|
Match
|
Document |
Document Title |
|
|
US20090264415 |
PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR MEDICAL TREATMENT
This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable...
|
|
|
US20080108616 |
COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated...
|
|
|
US20080108568 |
COMPOUNDS FOR IMPROVING LEARNING AND MEMORY
The present invention provides a method for improving learning and memory in a subject by administering a therapeutically effective amount of a compound of Formula I:
or of Formula II:
or...
|
|
|
US20080096882 |
Dihydrothienopyrimidines for the Treatment of Inflammatory Diseases
The invention relates to new dihydrothienopyrimidine of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof,
wherein...
|
|
|
US20080096868 |
1,4 Substituted Pyrazolopyrimidines as Kinase Inhibitors
The invention relates to 1,4-substituted pyrazolopyrimidine compounds of the formula I,
pharmaceuticals comprising a 1,4-substituted pyrazolopyrimidine compound, the use of a 1,4-substituted...
|
|
|
US20080095718 |
METHODS AND COMPOSITIONS FOR TREATING ERECTILE DYSFUNCTION
Methods are provided for increasing libido and/or treating erectile dysfunction in a man. The methods include the administration of a formulation testosterone alone, another fast-acting drug to...
|
|
|
US20080085887 |
PYRIDO [4,3-d] PYRIMIDIN-4 (3H) -ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS
The present invention is directed to novel pyrido[4,3-d]pyrimidin-4(3H)-one derivatives and pharmaceutically acceptable salts thereof of structural formula I
wherein the variables R 1 , R 2 ,...
|
|
|
US20080076776 |
Therapeutic compounds
Compounds of formula (I) below are disclosed. Their use as medicaments is described, in particular for the treatment of pain or inflammation:
wherein:
when X═Y=Z=OH, R 1 is OCH 2 CF 2 CF...
|
|
|
US20080070914 |
5-Membered Annelated Heterocyclic Pyrimidines As Kinase Inhibitors
This invention comprises the novel compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , Q 1 , Q 2 , X 1 , X 2 , Y and Z have defined meanings, having cell cycle kinase...
|
|
|
US20080070896 |
Pyrimidine Derivative Condensed with a Non-Aromatic Ring
There are provided new pyrimidine derivatives condensed with a non-aromatic ring selected from dihydrothiophene, dihydrofuran, cycloalkane moiety, and the like or pharmaceutically acceptable salts...
|
|
|
US20080058341 |
AZAINDAZOLE COMPOUNDS AND METHODS OF USE
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in...
|
|
|
US20080058326 |
SUBSTITUTED PYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME
The invention relates to substituted pyrazolopyridines according to the general formula (I):
in which A, B, D, E, R a , R 1 , R 2 , R 3 , R 4 , R 5 and q are as defined in the claims, and...
|
|
|
US20080051414 |
Protein Kinase Inhibitors
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following...
|
|
|
US20080051387 |
TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES
Tetrahydropyrido[3,4-d]pyrimidines and related analogues are provided, of the formula:
in which variables are as described herein, as are methods for their preparation and use. Such compounds...
|
|
|
US20080045528 |
6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING
Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of...
|
|
|
US20080039446 |
Substituted isoindoles and their use
The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I),
a method for the production of these compounds, pharmaceutical compositions containing them, and...
|
|
|
US20080039441 |
MODIFIED RELEASE FORMULATIONS OF A BUPROPION SALT
The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of...
|
|
|
US20080032970 |
Amide Derivatives of 7-Amino-3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents
The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their...
|
|
|
US20080032933 |
Type V Phosphodiesterase Inhibitors and Natriuretic Polypeptides
This document provides methods and materials related to PDE V inhibitors, natriuretic polypeptides, and combinations thereof. For example, compositions containing one or more PDE V inhibitors in...
|
|
|
US20080021037 |
ISETHIONATE SALT OF A SELECTIVE CDK4 INHIBITOR
Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-
2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent...
|
|
|
US20080009498 |
Phosphodiesterase inhibitors and nitric oxide donors, compositions and methods of use
The invention provides novel compositions containing at least one phosphodiesterase inhibitor, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels...
|