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US20110160162 PRODRUGS OF A2B ADENOSINE RECEPTOR ANTAGONISTS  
Disclosed are prodrugs of A2B adenosine receptor antagonists, and their use in treating mammals for various disease states.
US20150056277 DRUG DELIVERY SYSTEM  
The invention relates to a time controlled, immediate release drug delivery system for oral administration of a first active ingredient to a subject in need thereof. The invention additionally...
US20120276152 SYSTEMS AND METHODS OF USING ZINC-CHELATOR TO TREAT MYOCARDIAL INFARCTION  
Methods and systems for treating an infarct by delivery of zinc chelator to modulate tissue.
US20130072498 TRANSDERMAL DELIVERY OF BENEFICIAL SUBSTANCES EFFECTED BY A HOSTILE BIOPHYSICAL ENVIRONMENT  
The present invention generally relates to the transdermal delivery of substances and, in some embodiments, to the transdermal delivery of beneficial substances by a hostile biophysical...
US20140178473 SOLID DOSAGE FORM  
There is provided a solid dosage form adapted for the release of a biologically active material in the oral cavity wherein the dosage form includes at least one biologically active material, and...
US20150254433 Methods and Models for Determining Likelihood of Cancer Drug Treatment Success Utilizing Predictor Biomarkers, and Methods of Diagnosing and Treating Cancer Using the Biomarkers  
A method of identifying one or more biomarkers associated with one or more drugs effective to stop or repress proliferation of cancer cells, and a system for predicting effectiveness of the same....
US20140155397 EMT SIGNATURES AND PREDICTIVE MARKERS AND METHOD OF USING THE SAME  
EMT signatures and markers useful for characterizing the status of epithelial cancers and for predicting drug responses in patients having non-small cell lung cancer are provided together with...
US20130143894 ORAL SPRAY FORMULATIONS AD METHODS FOR ADMINISTRATION OF SILDENAFIL  
The present disclosure is directed to chemically-stable and pharmaceutically-acceptable sildenafil oral spray formulations for the treatment of male erectile dysfunction, wherein the oral spray...
US20130131028 METHODS FOR TREATMENT OF SLEEP-RELATED BREATHING DISORDERS  
Described herein are methods for modulation of the activity of the carotid body that afford therapeutic benefit for sleep-related breathing disorders and related conditions.
US20120053182 METHODS OF ALLEVIATING OR TREATING SIGNS AND/OR SYMPTOMS ASSOCIATED WITH MODERATE TO SEVERE PARKINSON'S DISEASE  
The present invention provides a method for alleviating motor complications and motor indications in a patient suffering from moderate to severe Parkinson's disease by administering a composition...
US20150164899 INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN  
This invention is directed to the treatment of pain by inhibiting adaptor associated kinase 1 (AAK1). Numerous AAK1 inhibitors are disclosed.
US20140066452 TRANSDERMAL DELIVERY OF BENEFICIAL SUBSTANCES EFFECTED BY A HOSTILE BIOPHYSICAL ENVIRONMENT  
The present invention generally relates to the transdermal delivery of substances and, in some embodiments, to the transdermal delivery of beneficial substances by a hostile biophysical...
US20120039913 Selective Histamine H4 Receptor Antagonists for the Treatment of Vestibular Disorders  
The invention relates to Histamine H4 receptor antagonists or inhibitors of Histamine H4 receptor gene expression for the treatment and/or the prevention of vestibular disorders.
US20110217262 Treatment of Ocular Surface Disorders by Increasing Conjunctival Vascular Permeability  
A method of treating an ocular surface disorder in a subject in need of such treatment is provided. The method includes exposing conjunctival tissue of the subject to an effective amount of a...
US20110033506 COMBINATION DOSAGE FORM OF LOW-DOSE MODAFINIL AND LOW-DOSE SILDENAFIL  
Modified release formulations comprising at least one of modafinil and sildenafil, and combinations thereof, and a time-controlled delivery system coating.
US20110160222 MODULATORS OF GLUCOSE HOMEOSTASIS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS  
Aryl 119 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
US20120232089 METHOD OF TREATING AN ANXIETY DISORDER  
Anxiety disorders, such as panic disorder, agoraphobia, obsessive-compulsive disorder, social phobia, post-traumatic stress disorder, generalized anxiety disorder, specific phobia, or the like,...
US20150250791 COMBINING SILDENAFIL WITH CAFFEINE IN AN ORAL DISINTEGRATING DOSAGE FORM  
Pharmaceutical compositions and formulations are provided herein comprising a phosphodiesterase type 5 inhibitor, such as sildenafil citrate; and, an adenosine receptor (A1, A2A, A2B, and A3...
US20140080838 Methods for Treatment of Lymphomas with Mutations in Cell Cycle Genes  
The present disclosure identifies a novel subtype of follicular lymphoma (FL) characterized by dysregulation of the cyclin/CDK/RB proliferative pathway. This subtype of FL is associated with...
US20120027723 TAURINE OR TAURINE-LIKE SUBSTANCES FOR THE PREVENTION AND TREATMENT OF A DISEASE ASSOCIATED WITH RETINAL GANGLION CELL DEGENERATION  
The present invention relates to taurine or taurine-like substances for the prevention and treatment of a disease associated with retinal ganglion cell degeneration. More particularly the...
US20150051216 ORAL SPRAY FORMULATIONS AND METHODS FOR ADMINISTRATION OF SILDENAFIL  
The present disclosure is directed to chemically-stable and pharmaceutically acceptable sildenafil oral spray formulations for the treatment of diseases such as pulmonary arterial hypertension...
US20150258080 THERAPEUTIC COMBINATIONS WITH ESTROGEN RECEPTOR MODULATORS  
Described herein are therapeutic combinations with estrogen receptor modulators for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
US20120203147 VASODILATOR-ENHANCED CARDIOPULMONARY RESUSCITATION  
A method for increasing blood flow to vital organs during cardiopulmonary resuscitation of a person experiencing a cardiac arrest may include performing standard or active compression...
US20140037622 HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS  
Methods of treating a head and neck cancer are disclosed.
US20140128390 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR  
Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions...
US20130123264 COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY BOWEL DISORDERS AND INTESTINAL CANCERS  
Compositions and formulations useful for treating inflammatory bowel diseases, intestinal cancers, and improving the integrity of the luminal surface of the gastrointestinal tract are disclosed....
US20110039859 SUSCEPTIBILITY TO BONE DAMAGE  
In one aspect, the present invention provides methods for determining susceptibility to bone damage in a subject. In some embodiments, the methods comprise screening for polymorphisms in the MTHFR...
US20100305102 HETEROCYCLE-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES  
The invention relates to new dihydrothienopyrimidinesulphoxides of formula 1, as well as pharmacologically acceptable salts thereof, wherein X is SO or SO2, but preferably SO, and whereinR3...
US20140148465 Compositions and Methods to Improve Treatment of Medical Conditions Using D-Cycloserine  
The invention describes methods and compositions for alleviating medical afflictions for which anxiety may cause or exacerbate the affliction. A subject suffering from the affliction is treated...
US20140171440 Methods of Increasing Liver Proliferation  
The present invention is directed to methods of enhancing liver repair after injury, resection or transplantation using antagonists of the bone morphogenetic protein (BMP) signaling pathway in the...
US20130274268 NEW BICYCLIC COMPOUND FOR MODULATING G PROTEIN-COUPLED RECEPTORS  
The present invention relates to a bicyclic compound for modulating G protein-coupled receptors. The inventive compound provides preventing or treating a disease associated with the modulation of...
US20140275071 SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF  
Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
US20130331389 Methods and Compositions for Cardiomyocyte Replenishment by Endogenous and Progenitor Stem Cells  
Disclosed herein are methods and compositions for replenishing injured and/or damaged cardiomyocytes in a subject by inducing, increasing, and/or enhancing the differentiation of endogenous stem...
US20130059836 PYRAZOLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER  
Compound of Formula (I): are described, along with pharmaceutically acceptable salts thereof, compositions containing the same, and methods of use thereof in the treatment of cancer.
US20140194403 METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS  
Provided herein are methods for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal, which comprises administering to said mammal in need...
US20120321637 COMBINATION CANCER THERAPY WITH HERV INHIBITION  
Embodiments are directed to compositions and methods related combination therapy with HERV inhibition.
US20140135312 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES  
The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one...
US20130184285 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES  
The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one...
US20110152244 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES  
The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one...
US20050119272 Use of phosphodiesterase antagonists to treat insulin resistance  
There is provided the use of a phosphodiesterase antagonist to reduce insulin resistance, and to amplify the effect of nitric oxide on skeletal muscle insulin-mediated glucose uptake in a mammal....
US20150105374 Substituted annellated pyrimidines and use thereof  
The present application relates to novel substituted annellated pyrimidines, methods for production thereof, use thereof alone or in combinations for treating and/or preventing diseases and use...
US20130338137 Substituted annellated pyrimidines and use thereof  
The present application relates to novel substituted annellated pyrimidines, methods for production thereof, use thereof alone or in combinations for treating and/or preventing diseases and use...
US20150126494 NON-RETINOID ANTAGONISTS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND STARGARDT DISEASE  
A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in mammals afflicted therewith, comprising administering to the mammal an effective amount of a...
US20130217696 METHODS FOR THE TREATMENT OF ERECTILE DYSFUNCTION USING FISPEMIFENE  
A method of treatment of erectile dysfunction (ED) comprises the step of administering fispemifene to a subject in need thereof in an amount effective to raise the subject's testosterone level....
US20130303543 PROTECTION OF RENAL TISSUES FROM ISCHEMIA THROUGH INHIBITION OF THE PROLIFERATIVE KINASES CDK4 AND CDK6  
The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the presently disclosed subject matter...
US20140005154 6,7-Dihydrothieno[3,2-d]pyrimidine for the Treatment of Inflammatory Diseases  
The invention relates to new dihydrothienopyrimidine of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein X is...
US20130059824 METHODS FOR TREATING MILD COGNITIVE IMPAIRMENT  
Provided herein are PAK inhibitors. Also provided herein are compositions and methods for treating an individual suffering from Mild Cognitive Impairment.
US20110009353 TARGETING CDK4 AND CDK6 IN CANCER THERAPY  
The invention involves methods of inhibiting the cancer cell cycle to make cancer cells more susceptible to chemotherapeutic agents. In particular, inhibition of CDK4 and/or CDK6 inhibits cell...
US20140378452 Treatment of Neurodegenerative Diseases Through Inhibition of HSP90  
Treatment of neurodegenerative diseases is achieved using small molecule purine scaffold compounds that inhibit Hsp90 and that possess the ability to cross the blood-brain barrier or are other...
US20070004744 Prophylaxis and/or treatment of portal hypertension  
The invention provides a medication for the prophylaxis and/or therapy against diseases or complications in connection with portal hypertension, particularly against bleeding complications.