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US20090286798 |
FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
Novel[1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following:
The compounds may be prepared as pharmaceutical...
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US20090286797 |
Novel Quinoxaline Derivatives and Their Medical Use
This invention relates to novel quinoxaline derivatives having medical utility, to use of the quinoxaline derivatives of the invention for the manufacture of a medicament, to pharmaceutical...
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US20090286791 |
Amide Compounds
The present invention provides compounds represented by the formula (Ia):
the formula (Ib):
the formula (Ic):
and the formula (Id):
wherein each symbol is as defined in the specification....
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US20090286768 |
SUBSTITUTED IMIDAZOPYR- AND IMIDAZOTRI-AZINES
Fused pyridine-based bicyclic compounds having the structure of Formula I, as defined herein, pharmaceutically acceptable salts thereof, preparation, compositions, and disease treatment therewith....
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US20090281108 |
PRENATAL DIETARY SUPPLEMENT
The present invention relates to a prenatal dietary supplement comprising at least one omega-3 fatty acid, at least one omega-6 fatty acid; folic acid; lutein; and at least one proanthocyanidin.
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US20090281086 |
2 -OXYHETEROARYLAMIDE DERIVATIVES AS PARP INHIBITORS
A compound of the formula (I): and pharmaceutically acceptable salts thereof, wherein: HetA is a C 5 arylene group, wherein the two substituent groups are on adjacent ring atoms, and where the...
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US20090281083 |
Combination Product
There is provided a combination product comprising: (A) BH 4 , a functional derivative or biosynthetic precursor thereof, or a pharmaceutically-acceptable derivative of BH 4 or its derivative or...
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US20090280115 |
Dihydropteridinones in the Treatment of Respiratory Diseases
The present invention relates to the use of dihydropteridinones of formula 1
wherein the groups X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 have the meanings given in the claims and...
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US20090275586 |
HETEROCYCLIC INHIBITORS OF PDE4
The present invention is directed to potent and selective heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as...
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US20090275537 |
Certain chemical entities, compositions, and methods
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin...
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US20090270405 |
QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may...
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US20090270404 |
OXYMETHYLENE ARYL COMPOUNDS AND USES THEREOF
Use of oxymethylene aryl GPR119 agonists and DPP IV inhibitors for the treatment of diabetic diseases, including Type II diabetes and other diseases associated with poor glycemic control are provided.
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US20090270403 |
NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVE AND ITS MEDICAL USE
This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a...
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US20090270402 |
Novel triazolopyridazines
The present invention is directed to novel compounds of formula (I)
wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be...
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US20090270401 |
USE OF A DIHYDROIMIDAZOPYRAZOINE DERIVATIVE FOR TREATING OR PREVENTING PAIN
The invention relates to the use of...
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US20090270400 |
PAINKILLING ASSOCIATION COMPRISING A DIHYDROIMIDAZOPYRAZINE DERIVATIVE
The invention relates to a product comprising (1R)-1-[(({2R)-2-amino-3-[(8S)-8-(cyclohexylmethyl) -2-phenyl-5,6-dihydroimidazo...
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US20090270397 |
Methods and compositions for the treatment of cancers, such as melanomas and gliomas
A method of potentiating the efficacy of an antineoplastic agent such as temozolomide, comprises the administration of an antifolate agent as defined herein. Also disclosed are compositions,...
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US20090270379 |
QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
The present invention is directed to quinolone derivatives, useful as antimicrobial compounds, pharmaceutical compositions comprising said derivatives and the use of said derivatives and...
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US20090270374 |
DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES
Bicyclic nitrogen containing compounds and their use as antibacterials.
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US20090269409 |
PHARMACEUTICAL COMPOSITIONS COMPRISING ESZOPICLONE
Pharmaceutical compositions comprising eszopiclone, including its pharmaceutically acceptable salts, hydrates, clathrates, solvates, polymorphs, and mixtures thereof. The invention also relates to...
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US20090264476 |
CB-1 receptor modulator formulations
Described herein are solid, stable pharmaceutical formulations of cannabinoid receptor inverse agonists, such as taranabant, and processes of making such formulations. Additionally, described...
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US20090264436 |
CB-1 receptor modulator formulations
Described herein are solid, stable pharmaceutical formulations of cannabinoid receptor inverse agonists, such as taranabant, and processes of making such formulations. Additionally, described...
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US20090264435 |
Novel Aryl- and Heteroarylpiperazines
Novel aryl- and heteroarylpiperazines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these...
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US20090264405 |
Cetp Inhibitors
Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or...
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US20090263397 |
Combination anti-cancer therapy
The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to said patient simultaneously or sequentially a therapeutically effective...
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US20090263320 |
Peptide-Based Compounds
The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
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US20090258881 |
ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT
The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives...
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US20090258880 |
Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions
Substituted tetrahydropyrrolopyrazine compounds corresponding to formula I
a process for producing such compounds; and a method of using such compounds to treat or inhibit various disorders or...
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US20090258879 |
METHOD FOR TREATING CANCER, RHEUMATOID ARTHRITIS AND OTHER MEDICAL DISEASES BY UTILIZING MODIFIED VIRUS VIRIONS TO INSERT MEDICATIONS INTO TARGETED CELLS
A safer, more effective treatment of many medical diseases may be approached by a method utilizing modified viruses as vehicles to transport medically therapeutic drug molecules to specific cells...
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US20090258877 |
TRIAZOLOTRIAZINES AND TRIAZOLOPYRAZINES AND THEIR USE
The invention relates to substituted triazolotriazines and triazolopyrazines and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or...
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US20090258862 |
Niacin receptor agonists, compositions containing such compounds and methods of treatment
Compounds of the formula (I): as well as pharmaceutically acceptable salts and solvates are disclosed. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL,...
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US20090258854 |
Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical...
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US20090257984 |
ANTIFUNGAL COMPOSITIONS CONTAINING THE ENDOPHYTE FUNGUS ALTERNARIA ALTERNATA AND OR ITS METABOLITES, AS ANTAGONIST AGENTS OF PLASMOPARA VITICOLA
The present invention relates to compositions containing the fungus Alternaria alternata and/or the secondary metabolites thereof, which belong to the family of the diketopiperazines (DKPs), for...
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US20090253706 |
Methods and Compositions for the Treatment of Rheumatoid Arthritis and Other Inflammatory Diseases
Compositions and methods for the treatment of inflammatory diseases are disclosed.
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US20090247532 |
Crystalline polymorph of sitagliptin phosphate and its preparation
The present invention is directed to a novel polymorph form of crystalline sitagliptin phosphate, named as Form V herein. The present invention further provides processes for preparations of Form...
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US20090247499 |
SULFONYLATED PIPERAZINES AS CANNABINOID-1 RECEPTOR MODULATORS
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases...
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US20090239856 |
Use of Pyrrolopyridine Compounds for Activating PPAR Receptors and Treatment of Conditions Involving Such Receptors
A method of activating PPAR receptors in a subject, said method comprising administering to said subject an effective PPAR receptor activating amount of a pyrrolopyridine compound corresponding to...
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US20090239836 |
Multifunctional Ophthalmic Compositions
An multifunctional ophthalmic composition includes a nonionic oxygen-containing polymer and a surfactant. The composition can be used to treat or control ophthalmic diseases, conditions, or...
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US20090238828 |
Combinations for the Treatment of Diseases involving Cell Proliferation
Disclosed are pharmaceutical compositions for the treatment of diseases which involve cell proliferation. Also disclosed are methods for the treatment of said diseases, comprising co-administration...
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US20090238757 |
Methods and Compositions for Administering Therapeutic and Diagnostic Agents
Methods and compositions are described for targeting therapeutic and diagnostic molecules to particular types of cells using targeting antibodies or other targeting moeities.
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US20090233935 |
Methods for Fabrication of Antimicrobial Surfaces
A method for rendering a carboxyl-containing polymer surface resistant to microbial growth, the method comprising: (i) reacting the carboxyl-containing polymer surface with a metal borohydride in a...
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US20090227579 |
Pteridine Derivatives and their Use as Cathespin Inhibitors
The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F,...
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US20090227539 |
Boron compounds useful in bnct
The present invention relates to novel boron comprising compounds, to pharmaceutical compositions comprising said compounds, to the therapeutic use of said compounds, and to a process for...
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US20090221595 |
Crystalline form of sitagliptin
A Sitagliptin crystalline form characterized by PXRD pattern having any 5 peaks selected from the group consisting of 7.4, 11.5, 16.7, 17.7, 18.9, 24.1, 24.5, 27.0, 28.5 and 28.8±0.2 degrees...
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US20090221594 |
STABLE PHARMACEUTICAL COMPOSITIONS OF 5, 10 METHYLENETRAHYDROFOLATE
The invention provides a stable lyophilized composition of 5,10 methylenetetrahydrofolate suitable for use in the treatment of cancer and other therapies. The composition comprises 5,10-MTHF in...
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US20090221593 |
TRIAZOLE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS
The present invention relates to novel compounds of formula (I) or a salt thereof:
wherein:
G is a 5- or 6-membered heteroaromatic group, or is a 9- or 10-membered bicyclic heteroaromatic...
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US20090221592 |
Dodecylsulfate Salt Of A Dipeptidyl Peptidase-Iv Inhibitor
The dodecylsulfate salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo
[4,3-a]pyrazin-7(8H)-yl]- 1 -(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl...
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US20090221591 |
Selective Inhibitors of Human Corticosteroid Synthases
The invention relates to compounds for selectively inhibiting human corticosteroid synthases CYP1 1 B1 and CYP1 1 B2, and to the production and use thereof for treating hypercortisolism, diabetes...
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US20090221587 |
NOVEL INSECTICIDES
Compounds of formula (I), wherein the substituents are as defined in claim ( 1 ), and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I)...
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US20090221562 |
NOVEL OPIOID ANTAGONISTS
Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.
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