Matches 1 - 50 out of 336 1 2 3 4 5 6 7 >


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US20100286150 LEVOSIMENDAN FOR USE IN TREATING CHRONIC VALVULAR DISEASE  
A method for the treatment of chronic valvular disease (CVD) in animals, particularly dogs, comprising administering to a subject in need thereof an effective amount of levosimendan or a...
US20110224128 METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY  
The invention features methods, compositions, and kits useful for the treatment of muscular dystrophy, e.g., Duchenne muscular dystrophy, in a patient.
US20140349969 COMPOUNDS AND METHODS FOR TREATING PAIN  
The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.
US20130252924 Compounds and Methods for Treating Pain  
The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.
US20080194567 Combination Treatment for Enhancing Diuresis  
A combination therapy for promoting diuresis in a patient comprises administering levosimendan or its active metabolite or any of their pharmaceutically acceptable salts in conjunction with a...
US20110263530 Aurora Kinase Modulators and Method of Use  
The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating...
US20110301166 METHOD FOR THE PREVENTION OF THROMBOEMBOLIC DISORDERS  
A method for the prevention of thrombotic, embolic and/or hemorrhagic disorders, such as cerebral infarction (stroke) or myocardial infarction, by administering levosimendan or its metabolite (II)...
US20050255096 Combination treatment for acute myocardial infarction  
A combination therapy for the treatment of acute myocardial infarction comprises administering a combination of a thrombolytic agent and levosimendan or a pharmaceutically acceptable salt thereof...
US20130090307 BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS  
The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present...
US20130085122 BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS  
The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present...
US20120108592 PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES  
A new class of salicylanilides is described. These compounds show strong activity against hepatitis viruses.
US20150025061 GABAA RECEPTOR ANTAGONISTS AFFECTING GANGLION CELL FUNCTION AND VISUAL ACUITY  
The present invention is directed to a method of enhancing visual acuity in a subject, comprising intravitreally administering to the subject in need of such enhancement, a therapeutically...
US20110263567 COMPOUNDS FOR INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) / VASCULAR ADHESION PROTEIN-1 (VAP-1) AND USES THEREOF FOR TREATMENT AND PREVENTION OF DISEASES  
The present invention relates to compounds of general formula (i) having an oxime moiety or a pharmaceutically acceptable salt, hydrate or solvate thereof and its use for inhibiting...
US20130303548 INDICATION FOR USE OF NIACIN (NICOTINIC ACID) FOR TREATMENT, PREVENTION AND REVERSAL OF FATTY LIVER DISEASE  
Niacin prevents and/or reverses the development of experimental hepatic steatosis, deposition of triglycerides in liver and serum of individuals, deposition of total cholesterol in liver and serum...
US20130079328 COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY  
The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R1,...
US20110152301 Compounds that Inhibit HIV Particle Formation  
The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and...
US20140038927 COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS  
The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present...
US20120058992 THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF ANGIOGENESIS  
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that...
US20120071483 THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF CELL STRESS RESPONSE  
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that...
US20130237545 PYRIDAZINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING COGNITIVE IMPAIRMENT  
This invention relates to pyridazine derivatives, compositions comprising therapeutically effective amounts of those pyridazine derivatives and methods of using those derivatives or compositions...
US20070191365 3,4,6-Substituted pyridazines for treating neuropathic pain and associated syndromes  
The present invention is directed to the use of 3,4,6-substituted pyridazines such as those characterized by structure I for treating conditions such as neuropathic pain among others.
US20150191454 MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO  
Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions...
US20110245251 MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO  
Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions...
US20080146543 Angiotensin II receptor antagonist for the prevention or treatment of systemic diseases in cats  
The present invention relates to a method of prophylaxis or treatment of systemic diseases in cats, wherein the method comprising administration of a therapeutically effective amount of...
US20070299064 Pesticidal Heterocyclic Dihaloallyl Compounds  
The invention relates to compounds of formula wherein Het, A1, A2, A3, A4, D, W, T, Q, Y, X1, X2, R1, R2, R3, R4, k and m are as defined hereinabove, and, where applicable, to possible E/Z...
US20120065165 COMPOSITIONS AND METHODS OF TREATING ENDOTHELIAL DISORDERS  
Compositions and methods of treating endothelial disorders, including: asthma, erectile dysfunction, pulmonary hypertension, cardiovascular disorders, and other disorders, using a synergistic...
US20100317665 Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death  
A novel class of pyridazine compositions and related methods of use.
US20050070529 Use of type 4 phosphodiesterase inhibitors in myocardial diseases  
The invention relates to the use of type 4 phosphodiesterase inhibitors to treat myocardial diseases.
US20060287318 Method for treating glaucoma III B  
Provided, among other things, is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure...
US20140357614 Diamino-Pyridine, Pyrimidine, and Pyrazine Modulators of the Histamine H4 Receptor  
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders,...
US20110092474 Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor  
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders,...
US20060063774 Phosphodiesterase inhibitor compounds and nitric oxide donors  
The invention provides phosphodiesterase inhibitors and/or nitric oxide donors that are useful in treating male impotence, female sexual dysfunction and anal diseases.
US20140213598 SUBSTITUTED CYANOANILINE COMPOUNDS, PREPARATION AND USE THEREOF  
Disclosed is a substituted cyanoaniline compound or a salt thereof, wherein the compound has a structure represented by General Formula I. The compound of General Formula I has broad-spectrum...
US20090306081 Solid Dosage Formulations of Hydralazine Compounds and Nitric Oxide Donor Compounds  
The invention provides solid dosage formulations, methods of making and using the formulations comprising at least one hydralazine compound or a pharmaceutically acceptable salt thereof, and at...
US20130029999 MYOSIN LIGHT CHAIN KINASE INHIBITOR COMPOUNDS, COMPOSITIONS AND RELATED METHODS OF USE  
Pyridazinyl compounds, compositions and related methods of use.
US20070191373 Heterocyclic compounds for use in the treatment of viral infections  
6-substituted-3-substituted-3H-furo[2,3-d]pyrimidin-2-one and 6-substituted-2-substituted-furo[2,3-d]pyrimidine novel compounds are useful in the treatment of viral infection, in particular...
US20150224105 HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES  
The present invention is directed to triazolopyrimidine, phenylpyrimidine, pyridopyridazine, and pyridotriazine compounds which are microtubule-stabilizing compounds and their use in the treatment...
US20090137609 VITAMIN D-LIKE COMPOUND  
The present invention provides a compound represented by the following general formula (I): or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing such a compound,...
US20120270836 THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER'S DISEASE  
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial...
US20120028988 USE OF PYRIDAZINONE COMPOUND FOR CONTROL OF HARMFUL ARTHROPOD PESTS  
Since a pyridazinone compound shown by formula (I) has an activity for controlling arthropod pests, the pyridazinone compound is effective for a use for controlling arthropod pests.
US20110065686 CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES  
Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the...
US20100190731 METHODS FOR TREATING ACUTE MYOCARDIAL INFARCTIONS AND ASSOCIATED DISORDERS  
The invention relates to methods of treating patients who have suffered an acute myocardial infarction (AMI) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs...
US20050065154 Treatment of migraine accompanied by nausea with a combination of cyclooxygenase-2 selective inhibitors and anti-nausea agents  
The present invention is related to the treatment or prevention of migraine accompanied by nausea or vomiting with a combination of a cyclooxygenase-2 selective inhibitor and an anti-nausea agent.
US20070219201 COMBINATION OF ATOMOXETINE AND A 5HT1A RECEPTOR AGONIST FOR TREATING ADHD AND OTHER DISORDERS  
This invention relates to combinations of atomoxetine, and a 5HT1A receptor agonists, kits containing such combinations, pharmaceutical compositions comprising such combinations, and methods of...
US20110269715 ABNORMAL CANNABIDIOLS AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE  
The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular...
US20100077512 Pyridazin-4-ylmethyl-sulfonamides used as Fungicides and Against Arthropods  
The present invention relates to novel pyridazin-4-ylmethyl-sulfonamide compounds (I) and to their N-oxides, their agriculturally acceptable salts and their veterinarily acceptable salts and also...
US20050004124 THERAPIES RELATING TO COMBINATIONS OF ALDOSE REDUCTASE INHIBITORS AND CYCLOOXYGENASE-2 INHIBITORS  
This invention relates to pharmaceutical compositions and kits comprising pyridazinone compounds and cyclooxygenase-2 inhibitors, therapeutic methods of treatment or prevention of certain...
US20070232586 Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof  
A compound having an inhibitory activity against cysteine protease, represented by formula (I): (wherein ring X is a heterocyclic group which may contain 1 to 4 hetero atoms selected from an...
US20130059848 CANNABINOID-2 AGONISTS  
The present specification discloses cannabinoid-2 agonists, compositions comprising such cannabinoid-2 agonists, and methods of treating an individual suffering from a disease by administering...
US20100004247 COMBINATION COMPRISING A MEK INHIBITOR AND AN AURORA KINASE INHIBITOR 188  
The present invention relates to a therapeutic combination comprising a MEK inhibitor and an Aurora kinase inhibitor, and to methods for the production of an anti-cancer effect in a patient, which...

Matches 1 - 50 out of 336 1 2 3 4 5 6 7 >