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US20090270396 |
THERAPEUTIC COMPOUNDS
Compounds comprising
or a pharmaceutically acceptable salt or a prodrug thereof,
are disclosed, wherein J 1 , J 2 , U 1 , B, Y, and A are as described.
Methods, compositions, and medicaments...
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US20090238773 |
Use of Morpholino Compounds for the Treatment of Halitosis
Use of a morpholino compound having the general formula (I) wherein R 1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R...
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US20090163487 |
N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of...
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US20090105218 |
CRTH2 Receptor Ligands For Therapeutic Use
Compounds of formula (I) are useful in the treatment of disease responsive to modulation of CRTH2 receptor activity, wherein: A represents a carboxyl group —COOH, or a carboxyl bioisostere; L1 is...
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US20090082353 |
TREATMENT OF EPILEPSY WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS
The present invention provides new method of treatment of epilepsy with non-imidazole alkylamine derivatives that constitute antagonists of the H3-receptors of histamine.
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US20090082328 |
Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity
This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating...
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US20090023735 |
Sulphonamide Derivatives
The invention relates to sulphonamide derivatives of formula (I), where R C is selected from a group consisting of dialkylamino, NO 2 , CN, aminocarbonyl, monoalkylaminocarbonyl,...
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US20090018103 |
Diaminoalkane Aspartic Protease Inhibitors
Diaminoalkanes of Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases...
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US20090017102 |
Enhancing transdermal delivery of opiod antagonists and agonistis using codrugs links to bupropion or hydroxybupropion
The present invention is directed to novel codrugs comprising bupropion or hydroxybupropion and an opioid antagonist or an opioid agonist joined together by chemical bonding. The codrugs provide a...
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US20080317806 |
Antiparasitic Compounds
A compound of Formula (A), wherein R 1 is C 1 -C 5 alkyl, C 3 -C 6 branched alkyl, C 4 -C 7 cycloalkyl, C 8 -C 12 fused or bridged polycycloalkyl, or heterocyclic ring, where any of the...
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US20080317883 |
METHODS FOR TREATING DEPRESSION
The present invention is a method for the treatment of depression comprising administering to a subject in need thereof a therapeutically effective amount of one or more carbamate compounds of...
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US20080287443 |
Treatment of Subgingival Pocket Infections
Use of a morpholino compound having the general formula (I) wherein R1 is a straight or branched alkyl group containing (8) to (16) carbon atoms at the 2- or 3-position of the morpholino ring, and...
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US20080269222 |
Use of Delmopinol in the Treatment of Acne
The present invention relates to the use of a morpholino compound having the general formula: (I) wherein R 1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or...
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US20080221106 |
Arylamine Ketones, Their Preparation Methods, The Pharmaceutical Composition Containing Them And Their Use
Disclosed Arylamine ketones of formula (I), their preparation methods, the pharmaceutical compositions containing them and their use in preventing and/or treating the diseases related to the...
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US20080206309 |
ANTAGONISTS OF PROSTAGLANDIN RECEPTORS EP2 AND/OR EP4 FOR THE TREATMENT OF DYSMENORRHEA AND MENORRHAGIA
A method of treating menorrhagia and/or dysmenorrhoea in a patient the method comprising administering to the patient an antagonist of a prostaglandin EP2 and/or EP4 receptor. Preferably the...
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US20080188476 |
METHOD FOR TREATING OBESITY
The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide...
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US20080167311 |
Prostaglandin Prodrugs
Novel compounds, and therapeutic methods, compositions and medicament related thereto are disclosed herein.
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US20080161308 |
Hydroxyphenol Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Them, And Therapeutic Uses Thereof
Compounds of the formula (I): in which A, R 1 , R 2 , X, Y and Z are defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of...
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US20080153826 |
SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE
The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions...
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US20080096883 |
Trifluoromethyl substituted benzamides as kinase inhibitors
The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals,...
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US20080096876 |
PHENYLALKYNES
Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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US20080032960 |
PI3 kinase antagonists
The present invention provides novel PI3-Kinase antagonists and methods of use thereof.
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US20080021021 |
Preventive And/Or Remedy For Lower Urinary Tract Diseases Containing Ep4 Agonist
(1) A preventive and/or a remedy for lower urinary tract diseases such as inflammation in the lower urinary tract, cystitis (interstitial cystitis, etc.) and urethritis; (2) an agent for improving...
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US20080020028 |
TRANSDERMAL DOSAGE FORM COMPRISING AN ACTIVE AGENT AND A SALT AND A FREE-BASE FORM OF AN ADVERSE AGENT
This invention relates to a tamper-resistant transdermal dosage form comprising an active agent, such as an opioid, or a pharmaceutically acceptable salt thereof, a free base of an adverse agent,...
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