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US20150182410 PNEUMATIC WRAP COMPRESSION TREATMENTS FOR VENOUS CONDITIONS  
A method of treatment of a condition such as deep vein thrombosis, arterial insufficiency, lymphedema, pulmonary embolism, and pain includes use of a pneumatic compression wrap, pump, and...
US20130259800 COMPOSITIONS AND METHODS FOR CANCER TREATMENT  
The invention described herein pertains to the use of oxazolidinone antibiotics, alone or in combination, in the treatment of cancer. In particular, the invention pertains to the treatment of...
US20140343046 USE OF SELECTIVE GABA A ALPHA 5 NEGATIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS  
The present invention relates to the pharmaceutical use of selective GABA A α5 negative allosteric modulators for the treatment, prevention and/or delay of progression of central nervous system...
US20120115839 USE OF SELECTIVE GABA A ALPHA 5 NEGATIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CONDITIONS  
The present invention relates to the pharmaceutical use of selective GABA A α5 negative allosteric modulators for the treatment, prevention and/or delay of progression of central nervous system...
US20150031697 METHOD FOR PREVENTING ULTRAVIOLET RADIATION-INDUCED CUTANEOUS DAMAGE AND DEVELOPMENT OF SQUAMOUS CELL CARCINOMAS  
Provided herein are methods of preventing skin cancer, where the methods comprise the step of administering an effective amount of at least one Hsp90 inhibitor to a subject at the risk of...
US20130131063 Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners  
The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with...
US20140288075 Isoxazole compound for the treatment of cancer  
The use of 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmeth yl-phenyl)-isoxazole-3-carboxylic acid ethylamide or a tautomer thereof or a pharmaceutically acceptable salt or a hydrate...
US20120214813 ISOXAZOLE COMPOUND FOR THE TREATMENT OF CANCER  
The use of 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmeth yl-phenyl)-isoxazole-3-carboxylic acid ethylamide or a tautomer thereof or a pharmaceutically acceptable salt or a hydrate...
US20120083496 ISOXAZOLE COMPOUND FOR THE TREATMENT OF CANCER  
The use of 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmeth yl-phenyl)-isoxazole-3-carboxylic acid ethylamide or a tautomer thereof or a pharmaceutically acceptable salt or a hydrate...
US20130143885 CHEMICAL INDUCERS OF NEUROGENESIS  
The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as...
US20110269762 METHODS FOR TREATING ATRIAL FIBRILLATION AND REDUCING STROKE RATE IN ATRIAL FIBRILLATION PATIENTS  
The subject invention provides methods for reducing stroke rate, methods for preventing atrial remodeling, and methods for reversing atrial remodeling by administering budiodarone to reduce atrial...
US20130129695 METHODS FOR TREATING OR INHIBITING INFECTION BY CLOSTRIDIUM DIFFICILE  
The invention provides methods for treating or inhibiting infection by Clostridium difficile in a subject in need of such treatment, comprising administering an effective amount of a compound...
US20110136779 METHODS FOR STROKE REDUCTION IN ATRIAL FIBRILLATION PATIENTS  
The subject invention provides methods for reducing stroke rate, methods for preventing atrial remodeling, and methods for reversing atrial remodeling by administering a multiple ion channel...
US20140128362 GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS AND STATIN RESPONSE, METHODS OF DETECTION AND USES THEREOF  
The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment (particularly for reducing the risk of venous...
US20140356322 Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase  
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are...
US20150030583 Methods of Treating Serosal Cancer  
The discovery of clonally pure populations of serosal cancer stem cells (CSCs) as well as methods of producing CSCs, culturing the CSCs and using them in screening assays, has lead to the...
US20120157457 COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION  
The present invention provides compositions and methods for inducing neuronal cell differentiation.
US20140094462 SONIC HEDGEHOG MODULATORS  
Sonic Hedgehog modulators and methods of use thereof are provided for.
US20110077250 COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR  
The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with...
US20110172234 METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS  
This invention describes a series of methods and compositions for prevention and treatment of diseases such as cancer. One aspect of the invention describes small molecule-based drugs that can be...
US20110092508 BIOMARKERS OF TUMOR PHARMACODYNAMIC RESPONSE  
The present invention provides novel biomarkers, and methods of using said biomarkers, for assessing the efficacy of a treatment regimen for treating cancer in a subject, particularly for treating...
US20120316148 Compositions and Methods for Modulating a Kinase  
The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade.
US20140256658 Antibiotic Conjugates  
The present invention describes antibiotic conjugates. These single drug entities are formed connecting one antibiotic with another antibiotic. Upon topical application to the eye, the conjugate...
US20140031275 METHODS OF ERADICATING BACTERIAL CELL POPULATIONS  
Disclosed herein are methods and compositions for the eradication of bacterial infections. In particular, methods and compositions are disclosed for the eradication of persister and slow growing...
US20120101101 THERAPEUTIC AGENT FOR MOTOR DISORDERS  
Provided are an agent for the treatment and/or prophylaxis of a movement disorder, the agent for the treatment and/or prophylaxis wherein the movement disorder is extrapyramidal syndrome, the...
US20100331330 METHODS AND COMPOSITIONS FOR TREATING ISCHEMIC STROKE  
A method of treating a cerebrovascular accident in a subject includes administering a therapeutically effective amount of at least one PPARγ agonist or a derivative thereof to the subject after...
US20110183953 SELECTIVE HETEROCYCLIC SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS  
Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such...
US20130196996 USE OF ISOXAZOLINE COMPOUNDS AND COMPOSITIONS IN BLADDER CANCER  
One embodiment provides a method, comprising treating or preventing at least one disease selected from the group consisting of bladder cancer, weight loss accompanying bladder cancer, bone pain...
US20110301149 COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES  
The present invention provides compounds which antagonize epsilon protein kinase C (PKCε). These compounds have a structural formula (Ia), (Ic) or (II). The present invention also provides...
US20150209275 Fast Dissolving Ocular Insert  
This invention relates to a pharmaceutical dosage form, particularly to a topical ocular pharmaceutical dosage form comprising a polymeric matrix of polyethylene oxide block copolymer, preferably...
US20140343062 METHOD OF TREATING A VIRAL INFECTION USING ELVITEGRAVIR COMBINATIONS  
The invention includes methods, compositions, and kits useful for treating a viral infection by coadministering...
US20110172233 SONIC HEDGEHOG MODULATORS  
The present invention relates to relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule...
US20110130402 HETEROAROMATIC GLUCOKINASE ACTIVATORS  
The present invention describes 2,3-di-substituted N-heteroaromatic propionamides, wherein the substitution at the 3-position is an optionally substituted phenyl ring and the substitution at the...
US20120122870 Treatment Of Ischemia-Reperfusion Injury  
Ischemia-reperfusion injury remains a primary cause of morbidity and mortality in individuals who experience disruption of normal blood flow to one or more major organs. For example, there are no...
US20100210650 ISOXAZOLE COMPOUND FOR THE TREATMENT OF CANCER  
The use of 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmeth yl-phenyl)-isoxazole-3-carboxylic acid ethylamide or a tautomer thereof or a pharmaceutically acceptable salt or a hydrate...
US20120178713 PHENYL SULPHONAMIDES AS MODULATORS OF ION CHANNELS  
The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the...
US20080027052 METHODS FOR TREATING CYSTIC KIDNEY DISEASE  
The present invention relates to methods for treating or preventing cystic kidney diseases or disorders using calcimimetics and pharmaceutically acceptable salts of these compounds. Various...
US20150158830 CYCLIC PROTEIN TYROSINE KINASE INHIBITORS  
Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated...
US20140206691 CYCLIC PROTEIN TYROSINE KINASE INHIBITORS  
Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated...
US20130324537 GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS  
The present invention relates to guanidine compounds of the general formula I corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable...
US20110237589 GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS  
The present invention relates to guanidine compounds of the general formula I corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable...
US20120108571 SUBSTITUTED PHENOXY N-ALKYLATED THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS  
The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not...
US20120214735 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATIONS  
Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment,...
US20100310493 ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND MEDICINAL APPLICATION  
Acetamide derivatives, their stereoisomers, tautomers, prodrugs, pharmaceutically acceptable salts, polymorphs, solvates and formulations thereof for the prophylaxis, management, treatment,...
US20140343063 METHOD OF TREATING A VIRAL INFECTION USING ELVITEGRAVIR COMBINATIONS  
The invention includes methods, compositions, and kits useful for treating a viral infection by administering...
US20110319415 Susceptibility to HSP90-Inhibitors  
The present invention relates to a method of selecting (a) cell(s), (a) tissue(s) or (a) cell culture(s) with susceptibility to an HSP90 inhibitor. Also a method for determining the responsiveness...
US20150080399 ATAZANAVIR SULFATE FORMULATIONS WITH IMPROVED pH EFFECT  
Disclosed are compressed tablets containing atazanavir sulfate and an acidifying agent, optionally with another active agent, e.g., anti-HIV agents, and optionally with precipitation retardant...
US20130203759 ATAZANAVIR SULFATE FORMULATIONS WITH IMPROVED pH EFFECT  
Disclosed are compressed tablets containing atazanavir sulfate and an acidifying agent, optionally with another active agent, e.g., anti-HIV agents, and optionally with precipitation retardant...
US20130096124 5-ARYL ISOXAZOLINES FOR CONTROLLING PESTS  
The present invention relates to new isoxazoline compounds of formula wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the...
US20130158028 USE OF STIMULATORS AND ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING SICKLE-CELL ANEMIA AND CONSERVING BLOOD SUBSTITUTES  
The present invention relates to the novel use of stimulators and activators of soluble guanylate cyclase for the treatment of sickle cell anemia and for the preservation of blood substitutes. The...