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US20090312327 |
PYRROLIDINE DERIVATIVES AS NK2 RECEPTOR ANTAGONISTS
The present invention relates to compounds of formula I
wherein R 1 , R 2 , R 3 , Ar and n are as defined herein and pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers...
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US20090306075 |
CHEMICAL COMPOUNDS
Compounds of formula (I):
wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are...
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US20090306059 |
CYCLIC AMINE DERIVATIVE HAVING SUBSTITUTED ALKYL GROUP
A compound having the general formula (I), pharmacologically acceptable salts thereof or prodrugs thereof:
[wherein R 1 represents a hydrogen atom, a C1-C6 alkyl group which may be substituted,...
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US20090298828 |
Alkoxyalkyl-Substituted Cyclic Keto-Enols
The invention relates to new alkoxyalkyl-substituted cyclic ketoenols of the formula (I)
in which A, B, D, G, W, X, Y and Z have the definitions indicated above,
to a number of processes and...
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US20090298829 |
MELANOCORTIN RECEPTOR AGONISTS
The present invention relates to a compound of the following formula 1, pharmaceutically acceptable salt and isomer thereof effective as agonist of melanocortin receptor, and an agonistic...
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US20090286786 |
Compounds having a 4-pyridylalkylthio group as a substituent
A compound having the following formula [I] or a pharmaceutically acceptable salt thereof:
wherein A is benzene or an aromatic five-membered heterocycle which optionally is fused with a...
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US20090286787 |
SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS
A compound comprising
or a pharmaceutically acceptable salt thereof, or a prodrug thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related...
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US20090286788 |
Active agent combinations with insecticidal and acaricidal properties
The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing
(a) cyclic ketoenols having the formula
in which the...
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US20090285887 |
Pharmaceutical Composition Comprising A Plurality of Mini-Tablets Comprising A Factor XA Inhibitor
A modified release pharmaceutical composition for oral administration comprising plural mini-tablets, comprising a therapeutically effective amount of a Factor Xa inhibitor within a matrix of...
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US20090281074 |
DRUG COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING THROMBOSIS OR EMBOLISM
Drug compositions containing a substituted diamine compound represented by formula (1):
Q 1 -Q 2 -r-N(R 1 )-Q 3 -N(R 2 ) ...
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US20090275581 |
RENIN INHIBITORS
Disclosed are compounds according to Formula I:
wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the...
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US20090275556 |
Aryl sulfonamides useful as inhibitors of chemokine receptor activity
The present invention provides compounds of general formula I:
or a pharmaceutically acceptable salt thereof, wherein R 1 , X, Z, R 2 , X 1 , Ar, n, R 3 and R 4 are defined generally and in...
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US20090275550 |
Pyridyl Amide T-Type Calcium Channel Antagonists
The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which...
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US20090270360 |
DICARBOXAMIDE DERIVATIVES
The invention is concerned with novel dicarboxamide derivatives of formula (I)
wherein A, B, R c , D and E are as defined in the description and in the claims, as well as physiologically...
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US20090270359 |
SUBSTITUTED PYRAZOLE DERIVATIVES
The present invention provides a novel pyrazole derivative and an androgen receptor antagonist containing the derivative. The present invention provides a compound represented by the formula (I′)...
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US20090270451 |
Piperdine Glycine Transporter Inhibitors
The present invention is directed to piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with...
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US20090270392 |
SUBSTITUTED GAMMA LACTAMS AS THERAPEUTIC AGENTS
Therapeutic compounds, compositions, medicaments, and methods are disclosed herein.
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US20090270365 |
BENZAMIDE DERIVATIVE OR SALT THEREOF
There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine,...
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US20090270394 |
CYCLYLAMINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type and/or T-type calcium channel activity are disclosed....
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US20090270393 |
Iminopyridine Derivatives and Use Thereof
The present invention aims to provide an iminopyridine derivative compound having an α 1D adrenergic receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of...
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US20090270382 |
Soluble epoxide hydrolase inhibitors
Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for...
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US20090264428 |
Renin Inhibitors
Described are compounds of the formula (I) which are orally active and bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated...
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US20090263353 |
Novel Sulphonylpyrroles as Inhibitors of Hdac S Novel Sulphonylpyrroles
Compounds of a certain formula I,
in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.
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US20090253688 |
Semicarbazide derivatives as kinase inhibitors
The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the...
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US20090247521 |
SOLUBLE EPOXIDE HYDROLASE INHIBITORS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION
The present invention generally relates to methods useful for a therapy using a class of urea or amide compounds and related compositions, wherein the compound is a soluble epoxide hydrolase...
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US20090247522 |
Hsp90 FAMILY PROTEIN INHIBITORS
The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoyl compound represented by general formula (I):
(wherein n represents an integer of 0...
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US20090233900 |
2-AMINOBENZAMIDE DERIVATIVE
To provide a novel and excellent agent for treating or preventing nociceptive pain, neuropathic pain, cancer pain, headache, bladder function disorder and the like, based on the inhibitory action...
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US20090233896 |
Inhibitors of checkpoint kinases
The instant invention provides for compounds which comprise substituted pyridyl aminothiazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory...
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US20090227585 |
SUBSTITUTED N-HETEROCYCLE DERIVATIVES AND METHODS OF THEIR USE
The present invention is directed to substituted N-heterocycle derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions...
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US20090221555 |
FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS
The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , A 1 , A 2 , A 3 , A 4 , and A 5 , are as...
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US20090221578 |
Organic Compounds
There are provided according to the invention compounds of formula (I)
in free or salt form, wherein
R 1 , R 2 , R 4 , R 5 , R 6 , D, X, W, m and n are as described in the specification,...
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US20090221577 |
COMPOUNDS HAVING MORPHOLINYL AND PIPERIDINYL GROUPS FOR USE AS GLYT1 INHIBITORS
The invention provides a compound of formula (I) or a salt or solvate thereof:
wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , n and Ar are as defined in the specification, and uses...
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US20090215775 |
Sulphonamido-Substituted Cyclohexyl Sulphones for Treatment of Cancer
Compounds of formula (I) are disclosed for treatment of cancer.
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US20090215776 |
Organic compounds
Compounds of formula I
in free or salt or solvate form, where T 1 , T 2 , X, R a , R b , R 8 and R 9 have the meanings as indicated in the specification, are useful for treating inflammatory...
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US20090209538 |
THERAPEUTIC SUBSTITUTED LACTAMS
Herein are described compounds having a structure
or a pharmaceutically acceptable salt thereof, wherein Y, A, and B are as described. Methods, compositions, and medicaments related thereto are...
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US20090203696 |
Aryl- and Heteroaryl-Ethyl-Acylguanidine Derivatives, Their Preparation and Their Application in Therapeutics
Disclosed are compounds according to formula (I):
wherein A, Q, X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. The disclosure also relates to pharmaceutical...
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US20090203694 |
INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE
The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions...
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US20090203675 |
Sulfonyl Semicarbazides, Semicarbazides and Ureas, Pharmaceutical Compositions Thereof, and Methods for Treating Hemorrhagic Fever Viruses, Including Infections Associated with Arena Viruses
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically...
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US20090196906 |
Kinase inhibitors
The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate,...
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US20090196912 |
Pyridinylamines
Described are pyridinylamines and pharmaceutically acceptable salts thereof, the use of these pyridinylamines for the prophylaxis and/or treatment of various diseases such as infectious diseases,...
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US20090197884 |
Compounds Useful as Antagonists of CCR2
The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the...
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US20090192158 |
Methods for Treating or Preventing Neoplasias
The present invention is directed to a method for treating or preventing a neoplasia in a human patient in need of such treatment comprising administering to the patient a compound that inhibits...
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US20090186894 |
N-Substituted-Heterocycloalkyloxybenzamide Compounds and Methods of Use
The present invention provides N-substituted-heterocycloalkyloxybenzamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment of the invention is a compound having...
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US20090181956 |
Hydrazide Compound and Pesticidal Use of the Same
A hydrazide compound represented by the formula (1):
has excellent pesticidal activity.
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US20090176781 |
Acetylenic Heteroaryl Compounds
This invention relates to compounds of the general formula:
in which the variable groups are as defined herein, and to their preparation and use.
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US20090170829 |
Carboxamide, Sulfonamide and Amine Compounds and Methods for Using The Same
Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure
in which R 1 , R 2 , R 4...
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US20090163497 |
Compounds Useful as Antagonists of CCR2
The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R 1 are defined generally and in subsets herein. Compounds of...
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US20090156571 |
BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
The present invention discloses novel compounds of Formula I: possessing 11 β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention...
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US20090156465 |
DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS
The present invention relates to β-amino acid derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological...
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US20090149461 |
METHOD OF TREATING CANCER
Methods of treating cancer using...
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