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US20110117055 |
Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds
Provided herein are hepatitis C virus entry inhibitor oxoacetamide compounds, pharmaceutical compositions thereof, and methods for their use in treatment or prevention of hepatitis C virus...
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US20110178062 |
INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
Certain substituted indole and benzothiophene compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
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US20110251176 |
PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is a thiazolyl,...
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US20090185975 |
DIAGNOSTIC PROBE FOR CONFORMATION DISEASE
The invention provides a probe compound useful for early diagnosis of conformation disease, a composition and a kit comprising it for diagnosis for conformation disease, and a medical composition...
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US20110071115 |
PHARMACEUTICALLY USEFUL HETEROCYCLE-SUBSTITUTED LACTAMS
The invention provides compounds that inhibit CK2 and/or Pim kinases and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders...
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US20120094974 |
SMOOTHENED RECEPTOR MODULATORS
The present invention relates, in general, to the Smoothened receptor and, in particular, to a method of modulating Smoothened receptor activity and to compounds and compositions suitable for use...
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US20110177999 |
Therapeutic Combinations Useful in Treating CFTR Related Diseases
The present invention relates to therapeutic combinations and kits useful in treating CFTR-related diseases, such as cystic fibrosis.
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US20110105456 |
3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
The present invention relates to certain 3-phenyl-pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds...
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US20110207715 |
Disubstituted Azepan Orexin Receptor Antagonists
The present invention is directed to disubstituted azepan and oxazepan amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological...
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US20120053164 |
CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases...
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US20110124621 |
BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS
A compound of formula I or a pharmaceutically acceptable salt thereof in which R1, R2, R3, R4 and m are as described in the specification for use in the treatment of obesity and/or diabetes.
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US20100022512 |
COMPOSITIONS OF CHK1 INHIBITORS AND CYCLODEXTRIN
Compositions containing at least one Chk1 inhibitor and at lease one cyclodextrin are disclosed. Also disclosed are methods of treating a cancer or potentiating a cancer treatment with a...
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US20110021493 |
SUBSTITUTED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF
This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making...
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US20100305097 |
N-BENZYL-4-METHYLENEAMINO-3-HYDROXY-2-PYRIDONES
Compounds of Formula (I) are effective in the treatment of a microbial infection.
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US20100305096 |
BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE
Formula I (Ia and Ib) compounds wherein (i) X1 is N and X2 is S, (ii) X1 is CR7 and X2 is S, (iii) X1 is N and X2 is NR2, or (iv) X1 is CR7 and X2 is O, including stereoisomers, tautomers,...
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US20090186870 |
Therapeutic Agents - 802
A compound of formula I or a pharmaceutically acceptable salt thereof in which R1, R2, R3, R4 and m are as described in the specification for use in the treatment of obesity and/or diabetes.
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US20110118230 |
DIAZACARBAZOLES AND METHODS OF USE
The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus...
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US20110172207 |
SUBSTITUTED PYRAZOLAMIDES AND THEIR USE
The present invention relates to novel substituted pyrazolamides, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture...
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US20100249088 |
AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF
[Object] To provide a therapeutic and/or prophylactic agent for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including...
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US20120028958 |
5-ALKYNYL-PYRIMIDINES
The present invention encompasses compounds of general formula (1) whereinR1 to R4 R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or...
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US20120028952 |
5-ALKYNYL-PYRIMIDINES
The present invention encompasses compounds of general formula (1) whereinR1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal...
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US20110294779 |
NOVEL IMIDAZOPYRIDINES
The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, as well as physiologically...
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US20110071128 |
NOVEL IMIDAZOPYRIDINES
The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, as well as physiologically...
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US20110092481 |
QUINOLINE OR ISOQUINOLINE SUBSTITUTED P2X7 ANTAGONISTS
The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing...
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US20110086840 |
N-7 SUBSTITUTED PURINE AND PYRAZOLOPYRIMINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
The present invention relates to compounds of Formula I: wherein R1, R2, R3, A1, A2, A3, A4, Y1 and Y2 and D have the meaning described herein. The present invention also relates to pharmaceutical...
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US20120046270 |
PYRIMIDO [5,4-D] PYRIMIDINE DERIVATIVES FOR THE INHIBITION OF TYROSINE KINASES
The present invention encompasses compounds of general formula (1), wherein the groups R1 to R4, X1, X2, X3, X4, X5, Q, L1 and L2 are defined as in claim 1, which are suitable for the treatment of...
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US20120035151 |
SUBSTITUTED DIHYDROPYRAZOLONES AND THEIR USE
The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the...
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US20110160182 |
PYRAZINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS
Pyrazine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of...
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US20110245232 |
NOVEL SMALL MOLECULE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS I
The present invention relates to small molecule potentiators of metabotropic receptors, in particular of the mGlu2 receptor. The present invention also relates to the use of these compounds for the...
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US20110144090 |
COMPOUNDS AND METHODS OF USE THEREOF
Indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.
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US20110098275 |
5-ALKYNYL-PYRIDINES
The present invention encompasses compounds of general formula (1) wherein R1 to R4, m and n are defined as in the specification, which are suitable for the treatment of diseases characterised by...
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US20110306588 |
HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS
Heteroaryloxyheterocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by...
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US20110275612 |
ALPHA-SUBSTITUTED N-SULFONYL GYLCINE AMIDES ANTAGONISTS OF CCR10, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR USING THEM
Disclosed is a compound of formula (I). Wherein R1, R2Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound...
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US20110098276 |
OXYCARBAMOYL COMPOUNDS AND THE USE THEREOF
The invention relates to oxycarbamoyl compounds of Formula I: The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade...
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US20110269705 |
QUINOLONE COMPOUND AND PHARMACEUTICAL COMPOSITION
The present invention provides a quinolone compound that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the...
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US20100069357 |
PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK...
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US20110172203 |
Substituted Imidazopyridinyl-Aminopyridine Compounds
The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions...
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US20100324021 |
(DIHYDRO)IMIDAZOISO[5,1-A]QUINOLINES
The invention relates to imidazoiso[5,1-a]quinoline and 5,6-dihydro-imidazoiso[5,1-a]quinoline derivatives according to general Formula I or a pharmaceutically acceptable salt thereof. The...
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US20100221445 |
O-DESMETHYLVENLAFAXINE AND BAZEDOXIFENE COMBINATION PRODUCT AND USES THEREOF
A combination product containing at least two active compounds, O-desmethylvenlafaxine or a pharmaceutically acceptable salt thereof and bazedoxifene or a pharmaceutically acceptable salt thereof...
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US20110251177 |
2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES
The present disclosure provides biologically active 2,4-pyrimidinediamine compounds of formulae (I) and (II): and salts thereof, compositions comprising these compounds, and methods of using these...
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US20090269420 |
SUBSTITUTED DIHYDROPYRAZOLONES AND THEIR USE
The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the...
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US20100009964 |
Compounds Which Modulate The CB2 Receptor
Compounds of formula (I) are disclosed. Compounds according to the and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
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US20100298288 |
CETP INHIBITORS DERIVED FROM BENZOXAZOLE ARYLAMIDES
Compounds having the structure of Formula I1 including pharmaceutically acceptable salts of the compounds, are potent CETP (cholesterol ester transfer protein) inhibitors, and are useful for...
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US20100099662 |
HYDRAZONE DERIVATIVE
A hydrazone derivative of formula [I]: wherein Ring A is aryl or heteroaryl, Ring T is heteroaryl or heterocycle, R1 and R2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl, etc.,...
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US20110312939 |
NEW CHEMICAL COMPOUNDS
The present invention relates to new compounds of general formula (I), wherein the groups R1 to R3, X1, X2, X3 and L1 are defined as in claim 1, which are suitable for the treatment of diseases...
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US20110195951 |
DIAZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE
The invention relates to diazaindole derivatives represented by the general formula (I): where A, E, G, R1, R2, R3 and R4 are defined herein, or pharmaceutically acceptable salts thereof, their use...
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US20120077801 |
Chemical Compounds 637
The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment...
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US20100056494 |
PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES
The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with...
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US20090264409 |
Bicyclic Heterocyclic p-38 Kinase Inhibitors
Provided are bicyclic heterocycle-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the c...
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US20110152240 |
PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS
The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds. These compounds and compositions are useful for treating...
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