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US20090286733 |
LONG-ACTING VETERINARY POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical...
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US20090286715 |
Pharmaceutical Composition
A pharmaceutical composition comprising: (A) a continuous liquid phase; (B) liquid droplets dispersed in said continuous phase; (C) a pharmaceutically-active compound; (D) an enhancer as described...
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US20090286714 |
Novel molecules of the card-related protein family and uses thereof
Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides...
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US20090286713 |
Collagen Receptor I-Domain Binding Modulators
The present invention relates to a refined and detailed molecular model of the α2⊕1 integrin I-domain, especially the MIDAS and to the use of such a model for designing novel integrin...
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US20090285895 |
Pharmaceutical Formulation for Regulating the Timed Release of Biologically Active Compounds Based on a Polymer Matrix
A formulation containing a biologically active compound having a structure with hydrogen bonding sites is blended with a polymer having a structure with complementary hydrogen bonding sites, the...
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US20090285880 |
DRIED RECONSTITUTED VESICLE FORMATION FOR PHARMACEUTICAL APPLICATION
The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More...
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US20090285874 |
Implantable Devices For Accelerated Healing
Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
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US20090285863 |
Coating Composition Comprising Starch
The present invention provides a coating composition comprising an aqueous medium and, dispersed therein, starch and a film-forming agent which controls swelling of the starch by the aqueous...
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US20090285780 |
PEG LINKER COMPOUNDS AND BIOLOGICALLY ACTIVE CONJUGATES THEREOF
PEG linker compounds and biologically active conjugates thereof having mixed functional group linkages attached to at least one PEG moeity, and a coupling group for attaching a biologically active...
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US20090285771 |
Methods and compositions for needleless delivery of macromolecules
Methods and compositions for needleless delivery of macromolecules to the bloodstream of a subject are provided herein. In one aspect, the invention provides a delivery construct, comprising a...
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US20090285770 |
Topical Compositions for Promoting Homeostasis of the Skin
The invention relates in particular to a composition for topical application to the skin, comprising, in a physiologically acceptable medium, at least one peptide increasing the expression of...
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US20090285750 |
AGENT, COMPOSITION AND METHOD
The present application relates to agents, compositions and methods for use in medicine. In particular, the application relates to an agent comprising a binding moiety capable of selectively...
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US20090281044 |
ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME
The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate...
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US20090281041 |
ANTIVIRAL CELL-PENETRATING PEPTIDES
Disclosed herein are cell penetrating peptides useful as treatment for Human Immunodeficiency Virus.
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US20090281020 |
Pharmaceutical Compositions Comprising Dextran With A Molecular Weight Of 1.0-100 KDA And Processes For Their Preparation
A solid or semisolid implant obtainable by providing a liquid composition comprising an aqueous solution of dextran with molecular weight of 1.0-100 kDa and introducing the liquid composition into...
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US20090281019 |
COMPOSITIONS AND METHODS FOR TREATING ATRIAL FIBRILLATION
The present invention provides compositions and methods for treating heart conditions. In particular, the present invention provides compositions and methods that block G protein coupled receptor...
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US20090280169 |
Compositions of peptides and processes of preparation thereof
The present invention provides composition of comprising a therapeutically effective amount of at least one peptide, polypeptide, analog or derivative thereof and a sufficient amount of at least...
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US20090280152 |
Tropoelastin for Promoting Endothelial Cell Adhesion or Migration
The invention provides methods, compositions, and devices for promoting adhesion or migration of endothelial cells.
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US20090280113 |
TARGET FOR REGULATING MULTIPLE SCLEROSIS
Methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). Methods are also provided for screening for...
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US20090280110 |
Cell Model for Alzheimer's Disease Pathology
The present invention encompasses compositions and methods for studying in cell culture the pathologic changes associated with Alzheimer's disease. The present invention further relates to methods...
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US20090280078 |
Cosmetic composition to accelerate repair of functional wrinkles
A cosmetic composition consists of a combination of peptides that regenerate the dermal matrix and a rapid acting muscle relaxant derived from the extract of the plant, Acmella oleracea . By...
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US20090280058 |
Delivery Of Double-Stranded RNA Into The Central Nervous System
The present invention provides for compositions and methods for in vivo delivery of a cell-permeable complex to cells of the central nervous system, wherein the cell-permeable complex decreases the...
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US20090275503 |
DIASTEREOMERIC PEPTIDES FOR MODULATING T CELL IMMUNITY
The present invention provides diastereomeric peptides derived from the T Cell Receptor alpha Transmembrane Domain, and lipophilic conjugates thereof, which peptides and conjugates are effective in...
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US20090275502 |
METHODS AND COMPOSITIONS FOR ENHANCING DEVELOPMENTAL POTENTIAL OF OOCYTES AND PREIMPLANTATION EMBRYOS
The invention relates to compositions and methods for enhancing the developmental potential of oocytes or preimplantation embryos by modulating mitochondrial-associated proteins and/or genomic...
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US20090275496 |
Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods
The instant invention provides methods for the detection and quantitation of complex peptide mixtures in tissue samples and functional readouts of the results of administration of such complex...
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US20090275495 |
METHODS AND COMPOSITIONS RELATING TO ALZHEIMER'S DISEASE
Methods and compositions relating to Alzheimer's disease are provided, including proteins that are differentially expressed in Alzheimer's disease as compared to the normal state. Further provided...
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US20090274737 |
IMPLANT COMPRISING A SURFACE OF REDUCED THROMBOGENICITY
An implant for a human or animal body, comprising a surface having reduced thrombogenic properties, whose surface has a wetting angle of Θ, where Θ≦80°. Also disclosed is a method for...
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US20090274703 |
Methods of treating inflammation using IL-17 antagonists
Aspects of the present invention provide methods for treating diseases associated with IL-17 mediated inflammatory or immunoregulatory reactions.
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US20090274687 |
ATTENUATION OF HYPOXIA INDUCED CARDIOVASCULAR DISORDERS
Blockade of stromal derived factor-1 (SDF-1), a stem cell mobilizer and/or its receptor, chemokine receptor 4 (CXCR4) attenuates and reverses hypoxia-induced cardiopulmonary remodeling in vivo....
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US20090274677 |
ANTIOXIDANT FOR USE IN COSMETIC, MEDICATED AND PHARMACEUTICAL PREPARATIONS
The invention provides the use a 2,2-dimethyl chroman as a SOD mimetic in a cosmetic preparation. Cosmetic preparations comprising a 2,2-dimethyl chroman as a SOD mimetic are described, as well as...
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US20090274626 |
TARGETING TNF-alpha CONVERTING ENZYME(TACE)- DEPENDENT GROWTH FACTOR SHEDDING IN CANCER THERAPY
The invention provides methods for modulating tumor cell proliferation by contacting cells (e.g. tumor cells) with a TACE inhibitor and a compound that inhibits EGFR tyrosine kinase, whereby the...
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US20090270334 |
NEURONAL DIFFERENTIATION INHIBITOR PEPTIDE AND USE THEREOF
Disclosed is a neuronal differentiation inhibitor which comprises at least one peptide capable of inhibiting or controlling the neuronal differentiation of at least one cell capable of being...
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US20090270308 |
Controlled release implantable dispensing device and method
A dispensing device having a polymer which is combined with a therapeutic agent in the form of a microparticle or nanoparticle which is “hyper-compressed” to form a controlled release...
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US20090269406 |
Therapeutic uses of biocompatible biogel compositions
The present invention relates to biocompatible biogel compositions and methods of drug delivery. The biocompatible biogel is a physical polymer matrix formed via affinity interactions between its...
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US20090269385 |
COMPOSITE IMPLANTS FOR PROMOTING BONE REGENERATION AND AUGMENTATION AND METHODS FOR THEIR PREPARATION AND USE
Collagen based matrices cross-linked by a reducing sugar(s) are used for preparing composite matrices, implants and scaffolds. The composite matrices may have at least two layers including reducing...
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US20090269342 |
Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to...
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US20090269283 |
METHOD AND PRODUCT FOR LOCATING AN INTERNAL BLEEDING SITE
A method is provided for localizing an internal bleeding site whereby a protein or other factor involved in the clotting process is complexed to an imaging agent and injected into a patient...
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US20090263474 |
Methods for Treating Autoimmune Diseases in a Subject and In Vitro Diagnostic Assays
The invention provides a method for treating an autoimmune disease in a subject by administering an interferon antagonist and a Flt3 ligand (Flt3L) antagonist. The invention also provides...
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US20090263408 |
FORMULATION AND PRESENTATION OF MEDICAMENTS
A medicament package ( 10,30 ) comprises a vessel ( 12,32 ) adapted to hold a quantity of a liquid vehicle. The vessel ( 12,32 ) has an opening formed therein, to which opening is bonded a...
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US20090263407 |
Cationic Lipids and Uses Thereof
Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
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US20090258816 |
USE OF GPCR AGONISTS TO DELAY PROGRESSION OF DIABETES
The present invention is directed to the use of G-protein coupled receptor agonists for the treatment of beta-cell degeneration.
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US20090258815 |
ANTIVIRAL PEPTIDE AND ANTIVIRAL AGENT
Disclosed is an antiviral agent comprising a non-naturally occurring, artificially synthesized peptide as the main ingredient. The antiviral agent comprises an antiviral peptide, wherein the...
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US20090258814 |
Method for treating a synucleinopathy
The present invention relates to methods for restoring fast axonal transport in a cell which expresses a pathological synuclein protein and for treating a synucleinopathy using a Protein Kinase C...
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US20090258058 |
NOVEL SILICONE FILM FORMER FOR DELIVERY OF ACTIVES
The invention provides: a film-forming composition comprising a) a saccharide-siloxane copolymer; b) a crosslinking agent; c) one or more active/inactive ingredients; and d) optionally, a solvent,...
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US20090258030 |
Materials and Methods for Improving Livestock Productivity
The subject invention provides methods for improving livestock health. In specific embodiments, the invention provides methods for accelerating and/or augmenting livestock growth; improving...
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US20090258028 |
Methods Of Forming Coatings For Implantable Medical Devices For Controlled Release Of A Peptide And A Hydrophobic Drug
This invention is generally related to methods of forming coatings for implantable medical devices, such as drug delivery vascular stents. The methods are for forming coatings to control the...
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US20090258005 |
Therapeutic compositions and methods
The present application provides novel binding proteins, including human binding proteins that specifically bind to the human ErbB2.
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US20090257954 |
Development of a simple animal model for infection by viruses and other obligate intracellular parasites
The present invention provides methods for studying pathogenesis of mammalian viruses. In particular, the present invention provides a nonhuman animal model system for studying disease mechanisms...
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US20090257950 |
Membrane Scaffold Proteins
The membrane scaffold proteins (MSP) of the present invention assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles which preserve native structure and...
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US20090255003 |
Diagnostic and therapeutic target SLC39A11 proteins for neurodegenerative diseases
The present invention discloses a dysregulation of the SLC39A11 gene and the protein products thereof in Alzheimer's disease patients. Based on this finding, the invention provides methods for...
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