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US20150232517 MUTANT FRAGMENTS OF OspA AND METHODS AND USES RELATING THERETO  
The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use...
US20140010835 MUTANT FRAGMENTS OF OspA AND METHODS AND USES RELATING THERETO  
The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use...
US20100092543 Dimpled adhering troche for use on teeth or orthodontic braces  
A dissolving oral adhering disc with a dimple on at least one side to improve adhesion to hard convex surfaces in the mouth, including teeth, orthodontic braces, and gums (keratinized gingiva)....
US20110143992 Methods and Compositions Related to GHS-R Antagonists  
Disclosed herein are methods and compositions related to GHS-R antagonists.
US20120172285 METHODS AND COMPOSITIONS FOR SPECIFIC MODULATION OF MCL-1  
A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for...
US20110038880 PARASPORIN-1 RECEPTOR AND USE THEREOF  
The receptor of parasporin-1 has been found to be beclin-1. Based on the finding, the present invention provides a method of determining the sensitivity of a cell to parasporin-1, comprising...
US20140329740 ANTI-INFECTIVE HYDROXY-PHENYL-BENZOATES AND METHODS OF USE  
The invention provides a method for preventing or treating a disease caused by an extracellular microorganism, said method comprising systemically administering to a subject in need thereof a...
US20120040888 ANTI-INFECTIVE HYDROXY-PHENYL-BENZOATES AND METHODS OF USE  
The invention provides a method for preventing or treating a disease caused by an extracellular microorganism, said method comprising systemically administering to a subject in need thereof a...
US20110212051 VARIANTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR AND USE THEREOF  
Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer,...
US20110039764 THERAPEUTIC COMPOSITION FOR BONE INFECTIOUS DISEASE  
A biodegradable composition containing an antibiotic or a physiologically active substance for use in surgical treatment of infection. A highly safe and biocompatible composition showing...
US20140294851 CLEAVABLE DRUG CONJUGATES, COMPOSITIONS THEREOF AND METHODS OF USE  
Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.
US20100291172 Sterile Autologous, Allogenic or Xenogenic Implant and the Method of its Production  
The subject of the invention is a sterile, dehydrated acellular implant, which during its rehydration by water or bodily fluids displays anisotropic expansion and can act as a substrate for...
US20150126435 PRIMERS, ASSAYS AND METHODS FOR DETECTING AN E. COLI SUBTYPE  
Disclosed are primers, probes, and single nucleotide polymorphisms (SNP) specific to a distinct subclones of the E. coli sequence type 131 (ST131). Also disclosed are methods and assay kits useful...
US20090075891 Methods and dressings for sealing internal injuries  
Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal...
US20130252881 Transcription Factor Decoys  
Decoy nucleic acid sequences comprising a sequence encoding all or part of a binding site for bacterial sigN alternative sigma54 factor are described. Uses of the decoys in antibacterial complexes...
US20130017203 METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS  
The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E...
US20140256612 ANTIBIOTIC CONJUGATES DIRECTLY LINKED WITH STEROID DRUGS  
The present invention describes novel single drug entities, formed by direct linkage of an antibiotic to a steroidal drug. Upon topical application to the eye, the conjugate would undergo...
US20110236306 COMPOSITIONS AND METHODS FOR THE REMOVAL OF BIOFILMS  
This invention provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an...
US20140315788 METHODS FOR IMPROVING HEART FUNCTION  
The present invention encompasses combination comprising a plurality of amino acids, formulations thereof for use in humans and animals, as well as methods for increasing muscle protein synthesis,...
US20120196791 COMBINATION THERAPIES USING ANTIBACTERIAL AMINOGLYCOSIDE COMPOUNDS  
Methods for treating a bacterial infection in a mammal in need thereof, and compositions related thereto, are disclosed, the methods comprising administering to the mammal an effective amount of...
US20150204845 PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS  
Perforin-2 (P2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, Mycobacteria smegmatis, M. avium, Salmonellae, MRSA (drug...
US20050220886 Modulators of the Notch signalling pathway and uses thereof in medical treatment  
A method is disclosed for therapeutic modulation of Notch signalling by administering a construct comprising a multiplicity of bond, linked or immobilised modulators of Notch signalling.
US20130172236 METHODS FOR EXTRACTING PLATELETS AND COMPOSITIONS OBTAINED THEREFROM  
This invention provides methods for extracting platelets, compositions obtained therefore, and methods for using the same.
US20110257078 ANTIBACTERIAL COMBINATION THERAPY FOR THE TREATMENT OF GRAM POSITIVE BACTERIAL INFECTIONS  
There is described a composition comprising a therapeutically active imidazole, and derivatives thereof, and an agent active on a bacterial cell surface selected from the group consisting of one...
US20080020975 Galanin Receptors and Brain Injury  
There is provided the use of a GALR2-specific agonist in the preparation of a medicament for the prevention or treatment of brain injury, damage or disease, wherein the brain injury or damage is...
US20120165246 Method of Diagnosis of Infection by Mycobacteria and Reagents Therefor  
The present invention provides a method of specifically detecting the presence of one or more Mycobacteria of the M. tuberculosis complex, said method comprising detecting ilvC nucleic acid of one...
US20060013889 Colostrum-based treatment for irritable bowel syndrome  
A method for prophylactically treating irritable bowel syndrome in a mammal through the administration of a colostral composition like bovine colostrum is provided, although other forms of...
US20090214464 COMPOUNDS FOR FLAVIVIRIDAE TREATMENT  
Disclosed are non-immunosuppressive cyclophilin-binding cyclosporins, e.g. of formula I, Ia or II as defined herein, having useful properties in the prevention or treatment of Flaviviridae...
US20060093597 Methods of treating involuntary facial spasms and facial wrinkles  
The invention describes antibiotics, muscle relaxants and plant extracts that have neuromuscular blockade effects as well as methods of use thereof. These compounds can be used in the same...
US20130231275 AMINIOTHIAZOLES AND THEIR USES  
The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases particularly bacterial infections.
US20090156484 Use of Transferrins for Treating Destructive Inflammation of Mucous Membrane  
Use of at least one transferrin, preferably lactoferrin, for preventing and/or treating destructive inflammation affecting mucous membranes, optionally associated with states of hypoferremia...
US20110262412 BACTERIOCIN BASED METHODS TO CONTROL LACTIC ACID BACTERIAL GROWTH  
The present invention relates to compositions and methods for protection against bacterial contamination. The invention provides bactericidal yeast expressing bacteriocin proteins and methods of...
US20080035141 AEROSOLIZED THERAPY KIT  
A comprehensive aerosol therapy for administration to a patient in need of treatment is provided. More particularly, the aerosol therapy kit provides a seamless conduit for a patient to receive...
US20070020219 Method for promoting hair growth  
A method is provided of promoting hair growth in a subject includes applying to the skin of the subject a composition including lactoferrin in an amount effective for at least one of proliferating...
US20100056443 RADIOPHARMACEUTICAL TO BE USED IN DISTINCTION BETWEEN INFLAMMATIONS AND INFECTIONS IN ORTHOPAEDIC IMPLANTS  
The present invention relates to a radio-pharmaceutical to be used in distinction between inflammations and infections in orthopaedic implants, containing one or more radiomarked human recombinant...
US20130129621 Integrin Receptor Antagonists and Their Methods of Use  
Compounds comprising R-G-Cysteic Acid (i.e., R-G-NH—CH(CH2—SO3H)COOH or Arg-Gly-NH—CH(CH2—SO3H)COOH) and derivatives thereof, including pharmaceutically acceptable salts, hydrates, stereoisomers,...
US20100173842 VACCINE FOR STAPHYLOCOCCAL INFECTIONS  
The invention relates to a method of preparation and use of a polypeptide vaccine formulation for prevention and control of Staphylococci mediated infections in human, bovine and other mammals,...
US20110033492 VACCINES FOR BRUCELLOSIS  
A polypeptide selected from the group consisting of BMEII0923, BMEI0411, a protective fragment of BMEII0923 and BMEI0411 and immunologically active variants of BMEII0923 and BMEIO411, which...
US20140023762 Antimicrobial Composition  
The present invention describes a process to preserve a water-containing product such as a foodstuff, which comprises adding natamycin and nisin to the product, whereby at least 90% (w/v) of...
US20090148543 Method for protecting humans against superficial vasodilator flush syndrome,  
Methods for protection of a human from SVFS comprise the administration of a flavonoid compound of the basic structures 2-phenyl-4H-1-benzopyran or 2-phenyl-4-keto-1-benzopyran or glycosides...
US20140243255 TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS  
The technology described herein relates to treatments for tuberculosis which target the ClpP1P2 protease complex, including ClpC1. Further embodiments relate to assays and screens for modulators...
US20140296134 METHODS AND USES FOR METABOLIC PROFILING FOR CLOSTRIDIUM DIFFICILE INFECTION  
Embodiments include methods for generating a metabolite profile of a stool sample and methods of assessing the status of a subject using the metabolic profile derived from a stool sample.
US20120028799 GROWTH ENHANCEMENT AND CONTROL OF BACTERIAL AND FUNGAL PLANT DISEASES WITH STREPTOMYCES SCOPULIRIDIS  
Methods of controlling plant diseases mediated by bacterial or fungal plant pathogens. The method comprises providing Streptomyces scopuliridis strain RB72 or an isolated protein or polypeptide...
US20110020355 TREATMENT AND PREVENTION OF GARDNERELLA VAGINALIS INFECTIONS  
The present invention is drawn to the nucleic and amino acid sequences encoding vaginolysin (VLY) toxin from Gardnerella vaginalis, and biologically active fragments and variants thereof. The...
US20100196478 PROTEIN MATRIX MATERIALS, DEVICES AND METHODS OF MAKING AND USING THEREOF  
The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to...
US20100210510 ORAL LACTOFERRIN IN THE TREATMENT OF SEPSIS  
The present invention relates to methods of treating prophylactically or therapeutically bacteremia, sepsis, septic shock or related conditions such as ARDS by administering orally a composition...
US20050075277 Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects  
The present invention relates to a use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects or subjects whose immune systems are expected to be...
US20110190199 Combination Therapy for Tuberculosis  
The present invention relates to methods of treating tuberculosis, including multi-drug resistant varieties and latent tuberculosis. More particularly, the present invention relates to a method of...
US20120034239 PROTEINS WITH IMPROVED SOLUBILITY AND METHODS FOR PRODUCING AND USING SAME  
A method is provided for improving the solubility of proteins, for example, bacterial toxins. In one embodiment, solubility is improved by introducing point mutations that replace cysteine...
US20100068253 BLEOMYCIN PREPARATION FOR USE AGAINST SKIN TUMOURS  
A preparation for use against skin tumours, which preparation has a semi-solid consistency for enabling the preparation to be applied to and remain on a patient's skin during treatment of a tumour...