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US20080085866 METALLO-DESFERRIOXAMINE COMPLEXES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS  
Methods for treating a bacterial infection by using a metallo-desferrioxamine complex.
US20140256614 COMPOSITIONS AND METHODS FOR AUGMENTING PERMEABILITY BARRIERS  
Compositions and methods for activating MK2, augmenting permeability barriers, such as epithelial and/or endothelial barriers, and treating diseases, conditions, disorders, and/or injuries...
US20130280223 FUNCTIONALIZED TISSUE MATRICES  
Disclosed herein are tissue treatment products that have been bound to at least one chelating agent. Also disclosed are tissue treatment products that have been functionalized with at least one...
US20150224129 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE PROPHYLACTIC TREATMENT OF BACTERIAL SUPERINFECTIONS POST-INFLUENZA WITH INVARIANT NKT CELL AGONISTS  
The present invention relates to methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with iNKT cell agonists.
US20140038882 Stable Pexiganan Formulation  
The invention provides chemically and physically stable topical formulations of pexiganan, and methods of preparing the same.
US20110003001 BISMUTH-THIOLS AS ANTISEPTICS FOR EPITHELIAL TISSUES, ACUTE AND CHRONIC WOUNDS, BACTERIAL BIOFILMS AND OTHER INDICATIONS  
Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and/or a wound or epithelial tissue surface that...
US20140037634 REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ╬▒CD3 proliferation of T cells in vitro. A...
US20110206674 Yersinia SPP. Polypeptides and Methods of Use  
The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and...
US20140050777 Liposomal Formulations of Polymyxin and Uses Thereof  
The present invention provides novel liposomal formulations of polymyxin B and pharmaceutical compositions thereof useful for the treatment of bacterial infections. The liposomal formulation...
US20130203652 DIFFOCINS AND METHODS OF USE THEREOF  
This disclosure relates to the discovery and isolation of the entire cluster of genes encoding R-type high molecular weight bacteriocins that specifically kill Clostridium difficile bacteria,...
US20110160124 ANTIMICROBIAL PROTEIN COMPOSITIONS AND PRODUCTION THEREFOR FROM MARINE BACTERIA  
Several bacterial species were isolated from marine segment obtained from seabed sediment at depths exceeding 1700 feet. At least four of the bacteria produced a compound that showed antibacterial...
US20110046039 POST-EXPOSURE PROPHYLAXIS AND TREATMENT OF INFECTIONS  
The invention provides methods and materials for identifying agents for preventing and/or treating anthrax and similar diseases. Embodiments provide strains and model systems for studying...
US20110104180 NEW VACCINE FOR THE TREATMENT OF MYCOBACTERIUM RELATED DISORDERS  
The invention relates to genes and proteins involved in the sporulation of Mycobacteria and the use thereof in the technical fields of immunology and medicine. A vaccine comprising spore forming...
US20150147281 CARIES RISK TEST FOR PREDICTING AND ASSESSING THE RISK OF DISEASE  
Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole...
US20140274876 CARIES RISK TEST FOR PREDICTING AND ASSESSING THE RISK OF DISEASE  
Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole...
US20110293566 DIFFOCIN AND METHODS OF USE THEREOF  
This disclosure relates to the discovery and isolation of the entire cluster of genes encoding R-type high molecular weight bacteriocins that specifically kill Clostridium difficile bacteria,...
US20130157932 NGAL AND URINARY TRACT INFECTION  
In some embodiments, the present invention is directed to compositions and methods for the treatment and prevention of urinary tract infections (UTIs) and urosepsis. In some embodiments, the...
US20120184484 LACTOFERRIN AND BRAIN HEALTH AND DEVELOPMENT IN INFANTS  
The present invention relates generally to the field of brain development and brain health. One embodiment of the present invention relates to a composition that can be used for the treatment or...
US20130196900 ENHANCEMENT OF INNATE RESISTANCE TO INFECTION  
The present invention provides compounds and compositions that enhance the innate immune system. The present invention comprises methods of preventing, treating or ameliorating an infectious...
US20110130326 DEFENSINS FOR TREATMENT OF INFECTIVE ENDOCARDITIS  
The present invention relates to methods for treating infective endocarditis, such as bacterial endocarditis, with defensin polypeptides.
US20120213732 TARGETED DELIVERY OF ANTIVIRAL COMPOUNDS THROUGH HEMOGLOBIN BIOCONJUGATES  
This invention relates to targeted delivery of anti-viral compounds through protein bioconjugation. More particularly, it relates to an anti-viral compound conjugated to a protein, such as...
US20110020375 STROMAL CELL-DERIVED FACTOR-1 POLYPEPTIDES, POLYNUCLEOTIDES, MODULATORS THEREOF AND METHODS OF USE  
Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also...
US20150140186 CLOSTRIDIUM BOTULINUM CONTROL IN MIDLY PROCESSED REFRIGERATED FOOD PRODUCTS  
The protection of low-acid, high moisture and/or high water activity processed food products against outgrowth of Clostridium botulinum. It was surprisingly found that combinations of propionic...
US20120135037 FLAGELLIN FUSION PROTEINS AND CONJUGATES COMPRISING PNEUMOCOCCUS ANTIGENS AND METHODS OF USING THE SAME  
The present invention is based, in part, on flagellin adjuvant used to enhance immune responses directed against Streptococcus pneumoniae, in particular, to enhance immune responses to polypeptide...
US20140170124 METHODS AND USES OF A MODIFIED CECROPIN FOR TREATING ENDOPARASITIC AND BACTERIAL INFECTIONS  
The present disclosure provides a modified cecropin protein comprising a cecropin or a variant thereof fused to a hydrophilic tail lacking a C-terminal glycine. The present disclosure also...
US20140357550 Pharmaceutical Composition for Treatment of Acute Toxic Conditions  
A pharmaceutical composition for treatment of acute toxic conditions relates to the field of medicine, particularly to nanotechnology and toxicology, and can be used for prophylaxis and therapy of...
US20110171232 METHODS OF TREATING AUTOIMMUNE DISEASES CAUSED BY SMALL INTESTINAL BACTERIAL OVERGROWTH  
Disclosed is a method of diagnosing autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, which involves detecting the presence of small intestinal bacterial overgrowth...
US20110038809 Growth control of oral and superficial microorganisms using gallium compounds  
The present invention provides methods for treating or preventing diseases and disorders caused by iron-dependent pathogenic microorganisms, such as bacteria, fungi, and parasites, by applying a...
US20130303437 ANTIMICROBIAL THERAPY FOR BACTERIAL INFECTIONS  
The disclosure provides a molecular genetic approach of targeted mutagenesis and heterologous expression, coupled with in vitro and in vivo models of bacterial pathogenesis, to demonstrate that...
US20140294925 FORMULATIONS COMBINING RAMOPLANIN AND RHAMNOLIPIDS FOR COMBATING BACTERIAL INFECTION  
Provided herein are methods of treating a superbug infection in a subject that include administering to the subject a therapeutically effective dose of ramoplanin in combination with a...
US20150210757 POLYPEPTIDES AND IMMUNIZING COMPOSITIONS CONTAINING GRAM POSITIVE POLYPEPTIDES AND METHODS OF USE  
The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and...
US20130288952 Polypeptides and Immunizing Compositions Containing Gram Positive Polypeptides and Methods of Use  
The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and...
US20110124551 FORMULATIONS OF DAPTOMYCIN  
Long term storage stable daptomycin-containing compositions are disclosed. The compositions include a pharmacologically acceptable fluid including daptomycin or a pharmaceutically acceptable salt...
US20130108682 WOUND CARE PRODUCT COMPRISING A CATHELICIDIN POLYPEPTIDE  
The present invention provides a wound care product comprising a wound care material and a polypeptide having wound care properties. In one embodiment, the wound care material comprises or...
US20140256617 In Situ Forming Hydrogel and Method Using Same  
A hydrogel (I), comprising a polymer backbone wherein an aqueous solution of the hydrogel comprises a first lower critical solution temperature, and wherein the hydrogel is configured to be...
US20130251689 KERATIN COMPOSITIONS FOR TREATMENT OF BONE DEFICIENCY OR INJURY  
A bone graft composition is described, with one or more of: (a) keratose; (b) kerateine; (c) optionally, particulate filler; (d) optionally, an antibiotic; and (e) water or saline. The composition...
US20130137630 FORMULATIONS FOR INFUSION OF TYPE B LANTIBIOTICS  
Described is a A liquid colloidal pharmaceutical formulation of a type B lantibiotic for infusion or direct injection comprising a type B lantibiotic or a salt thereof, an isotonic aqueous...
US20110002888 Albumin Fusion Proteins  
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors...
US20120070449 METHODS OF TREATING INFLAMMATION  
A method of treating an inflammation in a subject in need thereof is disclosed. The method comprising administering to the subject an agent capable of down-regulating an activity or expression of...
US20150132310 METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS  
The present invention relates to methods of treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection a subject that involves administering a...
US20120289452 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING NECROSIS  
A method for treating and/or preventing cell necrosis and diseases associated therewith, comprising the inhibition of one or more elastase enzymes within said cells.
US20110236367 RAT CATHESPIN DIPEPTIDYL PEPTIDASE I (DPPI): CRYSTAL STRUCTURE AND ITS USES  
The present invention relates to structural studies of dipeptidyl peptidase I (DPPI) proteins, modified dipeptidyl peptidase I (DPPI) proteins and DPPI co-complexes. Included in the present...
US20140051625 Bone Targeted Therapeutics and Methods of Making and Using the Same  
The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such analogs in the treatment of bone cancer,...
US20150018268 MULTIVALENT SYNTHETIC COMPOUNDS AS ANTIBIOTIC TREATMENT  
The present invention relates to the use of a multivalent synthetic compound, which is significantly more resistant to at least one protease than a standard peptide bond, for preparing a...
US20140356457 NOVEL MEANS AND METHODS FOR THE TREATMENT OF HEARING LOSS AND PHANTOM HEARING  
This invention relates to a method of identifying a modulator of an NADPH oxidase, whereby said modulator is suitable as a lead compound and/or as a medicament for the treatment and/or prevention...
US20110002877 PTEN Inhibitors Treat Neutropenia-Associated Pneumonia  
Neutropenia-associated pneumonia is treated with a therapeutically effective amount of a small-molecule PTEN inhibitor. The method may further include detecting a resultant alleviation of the...
US20120141467 Ascorbic acid to treat chronic obstructive lung diseases and non-Hodgkin's lymphoma  
Provided herein is a method for treating a tracheo-bronchial-alveolar tract disease in a subject in need thereof, the method comprising the step of administering to a subject in need of such...
US20120238998 Octanoate-reduced Human Albumin  
A method is described that improves the transport properties of albumin produced on an industrial scale, wherein the albumin is mixed, during the production process, with substances that saturate...
US20110034371 L. CASEI RHAMNOSUS SECRETED FACTORS AND USE THEREOF  
The present invention relates to a composition for inhibiting gastrointestinal inflammation comprising an effective amount of Lactoacillus casei rhamnosus secreted factors 5 to 30K fraction.
US20110152176 AGR-MEDIATED INHIBITION AND DISPERSAL OF BIOFILMS  
The present invention involves the use of activators of bacterial agr quoroum-sensing systems to block, inhibit or reverse biofilm formation. The biofilm may be located on an industrial or medical...