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US20140127168 Polypeptide  
The invention relates to a polypeptide, a corresponding nucleic acid molecule, a construct and/or vector and/or cell comprising such nucleic acid molecule and/or a composition comprising said...
US20070249524 High affinity ligands bind to clostridium difficile toxin A  
Glycans are identified which have high affinity for C. difficile toxin A. They share one of two saccharide backbones and may have additional side chains. The backbones are galactose-β1-3...
US20070134303 Protective and therapeutic article  
An antimicrobial protective article is described. The article has a first, outer surface that is coated at least partially with an antimicrobial agent containing polyhexamethylene biguanide...
US20140073559 Antibiotic Compositions for the Treatment of Gram Negative Infections  
Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a...
US20090263389 Use of TGF-Beta Antagonists to Treat or to Prevent Chronic Transplant Rejection  
Effective use of a TGF-β antagonist to treat or to prevent loss of transplant function is described herein. Use of a TGF-β antagonist is demonstrated to effectively prevent loss of organ function...
US20110305682 Compositions and Methods for Treating S. Pneumonia Infection  
The present invention relates to novel compounds that are useful for inhibition and prevention of pathogen cell adhesion and cell adhesion-mediated pathologies. This invention also relates to...
US20140162937 POLYMYXIN DERIVATIVES AND USES THEREOF  
The present invention relates to a polymyxin derivative and to a combination product comprising at least two such derivatives. The invention further relates to a method for treating, alleviating...
US20070207953 Host Defense Factor X (HDFX)  
The present invention relates to compositions and methods useful in medical prophylaxis and treatment of a mammalian subject before and after exposure of the subject to potentially lethal...
US20050123583 Medical use of reuterin  
Use of reuterin, a naturally occurring β-hydroxypropinoaldehyde, in the manufacture of a biocompatible implant is disclosed, which involves crosslinking an amine-containing biological material...
US20130045267 METHODS OF USING AGENTS THAT MODULATE CLAUDIN EXPRESSION  
Methods are provided for modulating expression of claudin-1 and/or claudin-23, for purposes of regulating formation of tight junctions in keratinocytes or other types of cells such as antigen...
US20110311591 Antimicrobial Coating  
A substrate (100) comprising a sol-gel derived coating (101). The coating, is chemically bonded to the substrate (100) and is derived from a polysiloxane to form a network of silicon-carbon and...
US20120021036 COMPOSITE NANOSTRUCTURES AND METHODS FOR MAKING AND USING THEM  
The invention provides nanostructures or products of manufacture for use as ex vivo or in vivo composition (e.g., a drug, or a therapeutic, diagnostic or imaging reagent) delivery vehicles. In one...
US20120255071 MUTANT BACILLUS THURINGIENSIS CRY GENES AND METHODS OF USE  
The invention provides nucleic acids obtained from strains of Bacillus thuringiensis encoding δ-endotoxins having pesticidal activity against insect pests including Lepidoptera. Particular...
US20060159665 Seed tear resistant scaffold  
A seeded tear resistant scaffold comprising a biocompatible, tear resistant substrate, a biocompatible biodegradable material and optionally cells.
US20050186260 Medicated gel foam and method of use  
A method and improved foam structure for use in vacuum assisted closure therapy comprising an open cell foam structure coated with a therapeutic agent.
US20100022458 METHODS FOR TREATING ACUTE ACOUSTIC TRAUMA  
The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition includes compounds which...
US20120316105 Polymyxin Derivates Useful As Antibacterial Agents  
The present invention provides a new class of polymyxin derivates useful for treating bacterial infections, especially Gram-negative infections, that have reduced renal cytotoxicity.
US20150094255 Lectin Conjugates for Mucin Hydration  
The invention provides, inter alia, conjugates of a hydratable polymer (such as PEG, polyethylene glycol) and a lectin (such as wheat germ agglutinin, WGA), compositions comprising these...
US20150038406 PHARMACEUTICAL FORMULATIONS OF TRANEXAMIC ACID AND THEIR USE  
The present invention relates to pharmaceutical formulations comprising tranexamic acid, kits thereof, and methods for treating bleeding by local administration.
US20060198886 Medicament having coated methenamine combined with acidifier  
A solid pharmaceutical medicament has a coated methenamine compound in combination with an urinary acidifier.
US20120114742 Polymer Conjugates with Decreased Antigenicity, Methods of Preparation and Uses Thereof  
Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof),...
US20130184201 Cyclodepsipeptides with Antineoplastic Activity and Methods of Using to Inhibit Cancer and Microbial Growth  
The present invention is directed to cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity, preferably Kitastatin 1. The present invention is further directed to methods...
US20140287987 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES  
The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to...
US20120065125 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES  
The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to...
US20100130408 USE OF MODIFIED CYCLOSPORINS  
Disclosed are non-immunosuppressive cyclophilin-binding cyclosporine having useful properties in the prevention or treatment of liver diseases.
US20070129288 Antibacterial amide macrocycles  
The invention relates to antibacterial amide macrocycles, to methods for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of...
US20100152100 ACCELERATED THERAPY  
The present invention encompasses the surprising finding that romidepsin can safely be administered to humans on an accelerated dosing schedule.
US20130338059 Methods for Differentiating Between Disease States  
This disclosure relates to methods for differentiating between mammals having active and latent Tuberculosis disease, by determining the percentage of polyfunctional CD4+ T-cells expressing...
US20120237593 Formulations of Guanylate Cyclase C Agonists and Methods of Use  
The invention provides low-dose formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use. The formulations of the invention can be administered either alone or in...
US20070093416 Human beta-defensin secretion promoter  
The present invention provides a human β-defensin secretion promoter that can be used in various forms, such as external preparation, internal preparation, food, etc., and promotes human...
US20140274878 AMINOTHIAZOLES AND THEIR USES  
The present application describes organic compounds of Formula (I) and pharmaceutical compositions thereof, and their use for the treatment, prevention and/or amelioration of diseases,...
US20090176701 Anti-microbial agents that interact with the complement system  
Anti-microbial therapeutic agents that act via a novel method to treat infection are compounds which may comprise a peptide with natural or non-natural amino acids, or a small molecule. The agent...
US20060003944 Bacterial efflux pump inhibitors and methods of treating bacterial infections  
This invention relates to the field of antimicrobial agents and more specifically it relates to Efflux Pump Inhibitor (EPI) compounds to be co-administered with antimicrobial agents for the...
US20110033487 VACCINES AND DIAGNOSTICS FOR THE EHRLICHIOSES  
The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In...
US20100203100 ANTIMICROBIAL ACCESSORY FOR AN IMPLANTABLE MEDICAL DEVICE  
An antimicrobial accessory may include a pressure sensitive adhesive and an antimicrobial mixed in the pressure sensitive adhesive. In some examples, an antimicrobial accessory may include at...
US20090068250 Bioresorbable and biocompatible compounds for surgical use  
A bioresorbable and biocompatible compound for surgical use is composed of functionalized collagen cross-linked with a glycosaminoglycan.
US20120177720 MULTI-LAYER WOUND DRESSINGS  
A wound dressing includes one or more layers containing a first anti-microbial agent and optionally at least one of: a chelating agent, a second anti-microbial agent, a zinc-containing agent, a...
US20100119519 OPHTHALMIC DRUG DELIVERY SYSTEM AND METHOD  
An ocular device comprising a delivery body configured for implanting within the capsular bag of a patient's eye, the delivery body containing an ocular therapeutic agent, the delivery body having...
US20070173438 [PSI[CH2NH]PG4] glycopeptide antibiotic analogs  
[ψ[CH2NH]PG4] glycopeptide antibiotic analogs are reengineered forms of glycopeptides that exhibit antimicrobial activity against both wild type and glycopeptide antibiotic resistant strains of...
US20050042202 Compositions for and methods of treating and preventing sirs/sepsis  
The present invention relates to methods of inhibiting the immune response underlying sepsis, to methods of preventing sepsis, to methods of treating sepsis and to pharmaceutical compositions...
US20080139450 Antimicrobial Compositions and Uses Thereof  
The present invention includes compositions for preventing growth and proliferation of biofilm embedded microorganisms comprising: (a) a cationic polypeptide and (b) a bis-guanide or a salt...
US20110021418 ENRICHED HAPTOGLOBIN POLYMERS FOR THE TREATMENT OF DISEASE  
Haptoglobin (Hp) removes cell-free Hemoglobin (Hb), with different physiological effects depending on the particular Hp polymer. We propose that material enriched for alpha 1 chain Hp polymeric...
US20100327008 LIQUID FOR EJECTION AND METHOD FOR EJECTING BIO-SPECIMEN  
A liquid for ejection includes a bio-specimen, and at least one kind of first compounds expressed by Formula (1), wherein, in Formula (1), m≧8, and 8≦n≦18.
US20050107303 Health feed  
The present invention relates to a method of promoting immunoglobulin A secretion in the mucosal membranes of non-human animals. The method comprises administering a foodstuff comprising glutamine...
US20120021033 DISPERSIN B POLYNUCLEOTIDES AND METHODS OF PRODUCING RECOMBINANT DspB POLYPEPTIDES  
Isolated nucleic acid sequences and amino acid sequences for soluble, β-N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm...
US20100191040 Manipulation of ovarian primordial follicles  
Methods are provided for activating dormant ovarian primordial follicles in a mammal to promote development to preovulatory follicles.
US20050163817 Biomatrix structural containment and fixation systems and methods of use thereof  
The containment and fixation system of the present invention generally includes a biomatix sleeve, biomatrix particles or combinations thereof made of a biomatrix material. The biomatrix material...
US20060093553 Cd26-based therapies for cancers and immune disease  
Therapeutic methods comprising administering a composition comprising CD26 thereof in conjunction with chemotherapeutic agents or radiotherapeutic agents for the prevention and treatment of...
US20050129687 Use of inhibitors of PACAP receptor activity for treatment of overactive bladder and pelvic floor pain syndrome  
The present invention relates to the use of inhibitors of PACAP receptor activity for the treatment of pelvic floor pain syndrome and overactive bladder.
US20150190461 DOSING INSTRUCTIONS FOR ENDOTOXIN-BINDING LIPOPEPTIDES  
The invention relates to an endotoxin-binding lipopeptide selected from the group consisting of polymyxins, polymyxin derivatives, polymyxin analogues, prodrugs thereof and pharmaceutically...