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US20110150775 GENOMIC APPROACHES TO FETAL TREATMENT AND DIAGNOSIS  
The present invention provides systems for developing and/or testing therapies for prenatal diseases and conditions including Down Syndrome. The present invention also provides diagnostic methods...
US20140303133 Markers of Triple-Negative Breast Cancer And Uses Thereof  
In one aspect provided herein are methods of determining a triple negative breast cancer (TNBC) subtype in an individual in need thereof comprising determining expression of one or more genes in...
US20150031697 METHOD FOR PREVENTING ULTRAVIOLET RADIATION-INDUCED CUTANEOUS DAMAGE AND DEVELOPMENT OF SQUAMOUS CELL CARCINOMAS  
Provided herein are methods of preventing skin cancer, where the methods comprise the step of administering an effective amount of at least one Hsp90 inhibitor to a subject at the risk of...
US20140127287 LIPOSOME-ENCAPSULATED HYDROGELS FOR USE IN A DRUG DELIVERY SYSTEM  
Drug delivery systems including a lipogel are disclosed. The lipogels allow for high drug loading and sustained release of drug molecules. Also disclosed are methods of making the drug delivery...
US20080255079 Therapeutic Use of Nefopam and Analogues Thereof  
Nefopam or an analogue thereof is useful in the treatment of a syndrome characterized by chronic pain and fatigue.
US20110160175 18,21-Didesoxymacbecin Derivatives for the Treatment of Cancer  
The present invention relates to macbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and...
US20140248270 METHOD FOR TOPICAL TREATMENT OF TAR-RESPONSIVE DERMATOLOGICAL DISORDERS  
A method of treating a tar-responsive dermatological disorder includes topically applying an anhydrous tar composition to skin of a mammal, preferably a human, that is involved with the disorder,...
US20110123488 Method of Treatment for Cancers Associated with Elevated HER2 Levels  
Novel methods of treating proliferative disorders characterized by elevated Her-2, and the patient is then administered an effective amount of an HSP90 inhibitor.
US20150158832 COMPOUNDS AND METHODS OF TREATING CANCER  
Presented herein inter alia are novel compounds and methods of using the same for the treatment of cancers.
US20130210771 METHODS AND COMPOSITIONS FOR TREATING CANCERS  
This invention provides a combination of antagonists of the hedgehog signaling pathway with a BCR-ABL inhibitor. The combination of the present invention may be used for treating cancers known to...
US20110118298 COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF CANCER  
Described herein are compositions, kits, and methods for determining whether subjects having cancer(s) are likely to respond to treatment with an HSP90 inhibitor, as a single agent or in...
US20110015168 METHODS FOR INCREASING LEVELS OF HUMAN FETAL HEMOGLOBIN  
The invention provides methods for increasing the level of human fetal hemoglobin in a subject or cell in need thereof. The methods can be used with subjects suffering from a β-chain...
US20110301186 USE OF HAPTOGLOBIN GENOTYPING IN DIAGNOSIS AND TREATMENT OF CARDIOVASCULAR DISEASE  
This invention is directed to methods and compositions for the treatment of cardiovascular disorders. Specifically, the invention is directed to compositions comprising vitamin E, statins and/or...
US20130244992 Method of Inhibiting AB-Type Bacterial Toxins and Treatment for Associated Diseases  
Disclosed herein are compounds useful in inhibiting the action of AB-type bacterial toxins such as cholera, traveler's diarrhea, enterohemorrhagic diarrhea caused by E. coli O157:H7 and pertussis...
US20120198576 METHODS FOR MAKING EMBRYONIC CELLS, EMBRYOS, AND ANIMALS SENSITIZED TO STRESS  
Embodiments of the invention are based upon the discovery that exposure of cleavage-stage embryos to a stress inducer, e.g. heat shock or chemical, renders the exposed embryos more sensitive to a...
US20110177002 CYLIC POLYAMINES FOR BINDING PHOSPHATIDYLSERINE  
The invention pertains to a compound for detecting cell death. According to the invention, the compound comprises a cyclic polyamine unit for the complexation of a bi- or trivalent metal ion. The...
US20130281423 METHODS AND COMPOSITIONS FOR AMELIORATING PANCREATIC CANCER  
Embodiments of the present invention include methods and compositions for ameliorating cancer. Some embodiments include methods and compositions for ameliorating pancreatic cancer targeting the...
US20110256235 COMPOSITIONS AND METHODS RELATING TO PREVENTION OF CHEMOTHERAPY-INDUCED ALOPECIA  
The present invention relates to a method for protecting a human patient or a mammalian animal to be subjected to chemotherapy treatment of a tumor not residing in the scalp of the patient or the...
US20110020270 TREATMENT AND PROPHYLAXIS  
This invention discloses the use of an E-selectin antagonist and a mobilizer of hematopoietic stem cells or progenitor cells in methods and compositions for treating or preventing...
US20110281814 METHODS AND COMPOSITIONS FOR TREATING BREAST CANCER  
The invention relates to methods and compositions for treating a subject afflicted with breast cancer using a CX-CR4 antagonist and optionally in combination with a chemotherapeutic agent.
US20110245265 CXCR4 ANTAGONISTS FOR KIDNEY INJURY  
Methods to treat or prevent acute kidney injury and chronic kidney injury in subjects using CXCR4 antagonists are disclosed.
US20110091452 4,5-Dihydromacbecin Derivatives and Their Use in the Treatment of Cancer or B-Cell Malignancies  
The present invention relates to 4,5-dihydromacbecin analogues to the formula (IA) or (IB), or a pharmaceutically acceptable salt there of: wherein: R1 represents H or CONH2 that are useful, e.g....
US20150065945 SPINAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS  
Methods for treating a patient using therapeutic spinal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to...
US20140148398 METHODS OF TREATING GIARDIASIS  
Compounds useful for the treatment of giardiasis are described.
US20130101553 INDUCING INACTIVATION OF FIBROGENIC MYOFIBROBLASTS  
Provided are methods of treating fibrotic conditions in a subject and diagnostic methods for determining fibrosis and appropriate treatments for the fibrosis by the identification of specific...
US20140219952 METHODS OF TREATMENT USING STEM CELL MOBILIZERS  
The present invention relates to the field of stem cells. In one aspect, the present invention provides methods of treating a subject with acute liver injury comprising administering to the...
US20060040905 Formulation of nefopam and its use in the treatment of pain  
(+)-Nefopam is formulated for intranasal administration, for use in the treatment of pain.
US20120141491 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCERS AND PATHOGENIC INFECTIONS  
The subject application provides small compounds that are able to increase/enhance autophagy in various cells. These compounds are useful in augmenting existing treatments of various cancers,...
US20140105824 Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods  
Provided herein are diagnostic methods for identifying subjects susceptible to treatment with a hypoxia-activated agent, and related methods. Also provided herein are methods of monitoring...
US20110207814 Combination Therapy for Breast Cancer Treatment  
The present invention provides a novel treatment which features immune therapy in the context of the functions of MSCs as a novel approach to breast cancer treatment. By identifying and...
US20120022026 METHOD OF TREATING CANCER  
The present invention relates to a method of treating or preventing hyperproliferative disease in a body tissue of a subject, comprising the steps of administering to a subject in need thereof a...
US20150111918 IMMUNE SYSTEM NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS  
Methods for treating a patient using therapeutic immune system neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed...
US20130273009 METHODS TO MOBILIZE PROGENITOR/STEM CELLS  
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the...
US20140193376 COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT  
The present embodiments provide for combinations of modulators that increase hematopoietic stem cell engraftment or increase mobilization in vivo. Methods and compositions for modulating the...
US20120058056 TREATMENT OF CUTANEOUS HEMANGIOMA  
This invention concerns a method of treating hemangiomas with a beta blocker by applying the beta blocker onto the hemangiomas directly. The invention also concerns a combination therapy by using...
US20150148318 METHOD FOR INHIBITING GROWTH OF CANCER CELLS  
A method of inhibiting the growth of cancer cells is disclosed in which cancer cells that contain an enhanced amount relative to non-cancerous cells of one or more of phosphorylated mTOR, Akt1,...
US20100190705 Suppression of glial fibrillary acidic protein  
Provided herein are methods of decreasing glial fibrillary acidic protein (GFAP) levels in a cell. Such methods include administering an effective amount of a GFAP lowering compound to the cell....
US20140350041 Methods and Compositions for Treating a Disease Condition in a Subject  
Methods for treating a disease condition in a subject are provided. The subject methods are characterizing by enhancing at least one symptom of the disease condition in a manner effective to cause...
US20110223255 IMPLANTABLE PRODUCTS COMPRISING NANOPARTICLES  
The present disclosure relates to nanoparticle-containing implantable and preferably biodegradable medical products and their use for the thermotherapeutic after-treatment after surgical removal...
US20120264802 PHOTOSENSITIZERS FOR TARGETED PHOTODYNAMIC THERAPY  
The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.
US20110206638 COMPOSITIONS AND METHODS FOR REDUCING THE MUTATION RATE OF VIRUSES  
The disclosure provides compositions and methods for reducing the mutation rate of a virus, such as an RNA virus or a DNA virus, in a cell infected with the virus by, in one aspect, contacting the...
US20140086901 Inhibition of Post-Radiation Tumor Growth  
Compositions and methods for inhibiting the growth of solid tumors following radiation treatment are described. The compositions and methods target matrix metalloproteinases and bone...
US20110091486 INHIBITION OF POST-RADIATION TUMOR GROWTH  
Compositions and methods for inhibiting the growth of solid tumors following radiation treatment are described. The compositions and methods target matrix metalloproteinases and bone...
US20110070244 METHODS FOR THE TREATMENT OF MULTIPLE MYELOMA  
Methods for treating multiple myeloma with inhibitors of CXCR4, such as AMD3100 and anti-CXCR4 antibodies, are described. The decreased expression of CXCR4 on multiple myeloma cells according to...
US20140056952 METHODS AND COATINGS FOR TREATING BIOFILMS  
Methods of treating or reducing biofilms, treating a biofilm-related disorder, and preventing biofilm formation using polyamines is described.
US20060110448 Combination of a macrolide and a local anesthetic for the treatment of dermatological diseases  
Synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a local anaesthetic such as lidocaine, polidocanol or prilocaine are...
US20120082623 SHH Regulation and Methods Thereof  
The invention provides for methods of upregulating endogenous GDNF by inhibiting Shh signaling. The invention further provides a method for increasing the production of cholinergic neurons and...
US20080200442 Compositions and Methods for Treating, Reducing, Ameliorating, or Preventing Infections of the Ear or Upper Respiratory Tract  
Compositions for treating, reducing, ameliorating, or preventing infection of an ear or upper respiratory tract comprise a fluroquinolone having Formula I, II, or III. Methods for treating,...
US20110257145 METHOD OF TREATING NEUROLOGICAL DISEASES  
A method of treating neurological diseases, like Alzheimer's Disease by administering a compound that activates protein kinase C and inhibits histone deacetylases to an individual suffering from...
US20150239824 BRANCHED OR MACROCYCLIC POLYAMINES AND USES THEREOF  
The present invention relates to synthetic polyamines and their polyammonium derivatives and their use as a pharmacological or biological research tool or as a therapeutic agent.