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US20090264396 |
17Alpha, 21-Dihydroxypregnene esters as antiandrogenic agents
17α,21-Dihydroxypregna-4,9-diene-3,20-dione and 17α,21-dihydroxypregna-4-ene-3,20-dione 17 and/or 21 esters of having remarkable antiandrogenic activity, and the processes for the preparation...
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US20090263459 |
METHODS AND COMPOSITIONS FOR TREATING INTERVERTEBRAL DISC HERNIATIONS
Methods and compositions are provided for treating an intervertebral disc herniation by local administration of one or more biodegradable drug depots comprising a therapeutically effective amount...
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US20090246281 |
Soft steroid compositions for use in dry powder inhalers
A medicament and a method of producing a medicament are disclosed. The medicament contains a soft steroid and is suitable for administration via a dry powder inhaler.
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US20090239836 |
Multifunctional Ophthalmic Compositions
An multifunctional ophthalmic composition includes a nonionic oxygen-containing polymer and a surfactant. The composition can be used to treat or control ophthalmic diseases, conditions, or...
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US20090239835 |
STABILIZATION OF GLUCOCORTICOID ESTERS WITH ACIDS
The invention relates to nonaqueous pharmaceutical preparations comprising a glucocorticoid ester and an acid, and to the stabilization of glucocorticoid esters in such preparations by acids.
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US20090233892 |
Topical Compositions Comprising Hydrocortisone Butyrate
The present invention generally relates to a a topical composition, such as a dermatological cream, containing the corticosteroid compound hydrocortisone butyrate.
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US20090227551 |
Therapeutic Uses of Steroidal Compounds
A steroid derivative compound of formula (I) in which: one of R 1 and R 2 is hydroxy and the Vehicle other is hydrogen; or R 1 and R 2 together represent oxo; R 3 is hydrogen or hydroxy; and...
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US20090214443 |
METHOD FOR RETARDING SYSTEMIC DELIVERY RATE FOR EASILY ABSORBABLE ACTIVE AGENTS
Drugs such as hormones, which are easily absorbable through the stratum corneum into the vascular network, are administered to the skin of a patient in an absorption retarding matrix material,...
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US20090208493 |
Compounds and methods for the selective inhibition of ABCB1, ABCC1 and ABCG2 transporters and the treatment of cancers, especially drug resistant cancers and high throughput flow cytometry assay to detect selective inhibitors
Compounds disclosed which inhibit ABCB1 transporter protein are useful for treating diseases in which ABCB1 transporter protein mediates the disease state, including numerous cancers, including...
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US20090202611 |
COMPOSITE SELF-COHERED WEB MATERIALS
The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting...
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US20090176754 |
Crystalline Form of the Compound A-348441
There is provided a hemihydrate of (3β, 5β, 7α, 12α)-7,12-dihydroxy-3-{2-[{4-[17β-hydroxy-3-oxo-17α-prop-
1-ynylestra-4,9-dien-11β-yl]phenyl}(methyl)amino]ethoxy}cho
lan-24-oic acid in a...
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US20090169624 |
Nano-emulsion technology for drug elution
Embodiments of the invention provide to apparatuses and media used in drug elution studies and methods for making and using them. One embodiment of the invention is a drug elution method that can...
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US20090169587 |
Chronotherapeutic dosage forms
A chronotherapeutic pharmaceutical formulation comprising a core containing an active agent (e.g., a drug) and a surfactant and a delayed release compression coating comprising a natural or...
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US20090149434 |
FORMULATIONS WITH IMPROVED BIOAVAILABILITY, COMPRISING A STEROID DERIVATIVE AND A POLYGLYCOLYSED GLYCERIDE
Compositions comprising a polyglycolysed glyceride, such as GELUCIRE, and a steroid related compound are provided.
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US20090137543 |
METHOD AND COMPOUNDS FOR MODULATING INSULIN PRODUCTION
The present invention provides screening methods for the detection of agents that affect various aspects of β-cell biology, particularly insulin gene expression. Screening methods are also...
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US20090118702 |
Treatment Medium Delivery Device and Methods for Delivery of Such Treatment Mediums to the Eye Using such a Delivery Device
Featured are devices for delivering a treatment medium to an eye as well as methods related thereto. Such devices and methods allow a desired amount of the treatment medium to be delivered in a...
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US20090118253 |
COMPOSITIONS AND METHODS FOR TREATING DYSFUNCTIONAL UTERINE BLEEDING
The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention concerns methods of treating dysfunctional...
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US20090111781 |
Use of Cymipristone Type Compounds in Aids Treatment
This invention refers to use of cymipristone type compounds of formula (I), salt or solvate thereof in preparation of medicament for treating AIDS. Cymipristone type compounds are a new type...
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US20090104132 |
Topical anti-inflammatory compositions comprising O/W emulsions containing pro-penetrating glycols
Topically applicable compositions in the form of oil-in-water emulsions contain a pro-penetrating system including at least one glycol and at least one additional pro-penetrating agent, a suitable...
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US20090104125 |
Stable liquid desoximethasone compositions with reduced oxidized impurity
The present invention relates to a stable liquid formulation comprising desoximetasone, isopropyl myristate, a C 2 -C 4 alcohol and a stabilizing agent. Specifically, the present invention...
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US20090082314 |
Targeting Prodrugs for the Treatment of Gastrointestinal Diseases
Provided herein are compounds, compositions and methods for decreasing NFκB DNA-binding activity in a patient comprising administering of a therapeutically effective amount of a compound or...
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US20090075962 |
GROWTH STIMULANT COMPOSITIONS
An improved weight and growth stimulant for domesticated animals such as cattle, pigs and sheep is comprised of an anabolic agent that is subcutaneously administered in the form of a dual release...
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US20090074707 |
Shaped body and method for production of said body
Water-dispersible or water-soluble polymers, particularly those of the family of compounds comprising the poloxamers or the polyesters or amphiphilic agents (emulsifiers), and also lipophilic...
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US20090054388 |
NOVEL 11 BETA-HYDROXYANDROSTA-4-ENE-3-ONES
The invention provides 11β-hydroxyandrosta-4-ene-3-one compounds of Formula I, or physiologically acceptable salts or solvates thereof:
wherein R 4 represents a moiety selected from a group...
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US20090054387 |
Method for preparing 4-[17beta-methoxy-17alpha-methoxymethyl-3-oxestra-4,9-dien-11beta-yl]benzaldehyde (E)-oxime (asoprisnil)
The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-
yl]benzaldehyde (E)-oxime (asoprisnil) on the...
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US20090029959 |
Antiglucocorticoid Therapy for the Prevention of Neurological Damage in Premature Infants
This invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for preventing neurological damage associated with glucocorticoid...
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US20090028918 |
Gynecological pharmaceutics- containing microspherical vascular suppository of sodium alginate and its preparation method
The present invention relates to a kind of sodium alginate microsphere vascular embolus containing gynecological drug and its preparation. The preparation of it consists of the following steps:...
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US20090028824 |
SYSTEMS AND METHODS FOR DELIVERING DRUGS
A patch pump device generally includes at least one fluid source, a fluid communicator, and an electrochemical actuator. The fluid communicator is in fluid communication with the fluid source. The...
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US20090022671 |
TREATMENT METHODS
Disclosed are methods of treating rhinosinusitis of the upper airway passages in patients afflicted with said disease, which comprises administering at least once-a-day to the surfaces of said...
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US20090010908 |
Materials and Methods for Diagnosis and Treatment of Chronic Fatigue Syndrome
The invention relates to materials and methods for diagnosis and treatment of chronic fatigue syndrome/myalgic encephalitis. A number of genes are identified which are expressed at abnormal levels...
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US20080317844 |
Pharmaceutical Delivery Systems for Hydrophobic Drugs and Compositions Compositions Comprising Same
A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising...
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US20080317805 |
LOCALLY ADMINISTRATED LOW DOSES OF CORTICOSTEROIDS
This invention provides for using a locally delivered low dose of a corticosteroid to treat pain caused by any inflammatory disease including sciatica, herniated disc, stenosis, mylopathy, low back...
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US20080306039 |
Loteprednol Etabonate Aqueous Suspension
An aqueous suspension containing loteprednol etabonate wherein sedimented particles are detached easily from the container and adhesion of sedimented particles to the container and block formation...
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US20080279950 |
NANO-PARTICLES COMPRISING CUCURBITURIL DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND PROCESS FOR THE PREPARATION THEREOF
Provided are nanoparticles prepared by the aggregation of cucurbituril derivatives and having a particle size of 1 to 1,000 nm, a pharmaceutical composition in which a pharmaceutically active...
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US20080269181 |
METHODS FOR TREATING A POSTERIOR SEGMENT OF AN EYE
Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include corticosteroid...
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US20080249075 |
C11 Modified Retrosteroids as Progesterone Receptor Modulator Compounds
Retrosteroidal compounds corresponding to formula I, representing progesterone receptor modulators, and their production, and pharmaceutical preparations containing these compounds. These compounds...
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US20080242646 |
Split dose corticosteroid therapy
The invention features methods, compositions, and kits for split dose corticosteroid therapy for the treatment musculoskeletal disorders, periodontal disease, and immunoinflammatory disorders.
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US20080194468 |
TRANSPORTER-ENHANCED CORTICOSTEROID ACTIVITY AND METHODS AND COMPOSITIONS FOR TREATING DRY EYE
Methods and compositions for enhancing the activity and/or duration of action of loteprednol etabonate and other soft anti-inflammatory steroids of the haloalkyl...
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US20080166413 |
Topical pharmaceutical formulations and methods of treatment
In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a...
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US20080145406 |
DEVICES AND METHODS FOR OPHTHALMIC DRUG DELIVERY
Disclosed are ophthalmic drug-delivery devices, comprising a body having a proximal end and a distal end, wherein the body includes a styrene elastomer matrix and a drug in contact with the matrix....
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US20080125407 |
METHOD FOR PREPARATION OF FLUTICASONE PROPIONATE
Taught is a method for preparing S-fluoromethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17Î
±-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate (fluticasone propionate). The present method...
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US20080124395 |
FORMULATIONS AND DEVICES FOR TREATMENT OR PREVENTION OF NEURAL ISCHEMIC DAMAGE
A formulation is provided for treatment or prevention of neural ischemic damage, or for treatment of stroke, hemorrhage, trauma, epilepsy, tumor, or any disease of the brain, the formulation...
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US20080119448 |
Methods of treating an ocular allergy with low dose dexamethasone
The present invention is directed to a method of treating an ocular allergy with a composition comprising a low dose of dexamethasone. In some embodiments, the present invention is directed to a...
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US20080107736 |
Pharmaceutically Active Nanosuspensions
The present disclosure is directed at a pharmaceutically active nanoparticle suspension that may be optically clear. Such suspensions may be formed by selective dissolution of a pharmaceutically...
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US20080096852 |
USE OF OCULOSURFACE SELECTIVE GLUCOCORTICOID IN THE TREATMENT OF DRY EYE
Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of...
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US20080089939 |
Dermastick thickened ointment
Provided is a solid stick topical composition containing a corticosteroid. The solid stick also contains petrolatum, wax, propyleneglycol and emulsifier. The solid stick is contained in a...
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US20080051377 |
Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof
The present invention is directed to monophasic pharmaceutical compositions comprising a conjugated estrogen and a hydrophilic or lipophilic excipient. The present invention is also directed to...
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US20080050434 |
Novel Composition for Topical Delivery
Pharmaceutical composition for topical administration comprising of at least one active ingredient, its salts, esters, hydrates or derivatives; a gelator system consisting of a fiend of...
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US20080025991 |
Use of Aromatase Inhibitors for Treatment of Ectopic Pregnancy
Following a diagnosis of ectopic pregnancy, at least one aromatase inhibitor, is administered to a patient, either alone or in combination with other aromatase inhibitors or therapeutic agents or...
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US20080003276 |
Use of Liposomal Glucocorticoids for Treating Inflammatory States
The present invention provides the use of a glucocorticoid (GC) or of a GC derivative encapsulated in a liposome for the preparation of a pharmaceutical composition for the treatment of an...
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