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US20090275542 |
AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS
Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart...
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US20090215736 |
CASPASE INHIBITORS AND USES THEREOF
This invention provides caspase inhibitors of formula I:
wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; between R 3 and R 4 represents a...
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US20090209505 |
PRODRUGS OF HETEROARYL COMPOUNDS
The present invention provides hydrophobic prodrugs of bases, nucleosides, and nucleotides as well as methods of using the prodrugs as antiviral and anti-cancer chemotherapeutic agents.
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US20090202645 |
INTRASYNOVIAL FORMULATIONS OF STANOZOLOL
Disclosed are intrasynovial formulations comprising stanozolol and a suitable carrier.
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US20090197844 |
Demethylpenclomedine Analogs and Their Use as Anti-Cancer Agents
This disclosure concerns novel demethylpenclomedine analogs. Also disclosed are pharmaceutical compositions and methods for using such compositions to treat hyperproliferative disorders. In one...
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US20090186862 |
TREATMENT OF CYSTIC FIBROSIS
The present invention discloses a therapeutic target for the treatment of cystic fibrosis. It was found that inhibition of non-lysosomal glucosylceramidase (GBA2) sufficiently restores chloride...
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US20090156562 |
NOVEL COLORED SOLUTIONS OF INJECTABLE DRUGS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS
The invention is directed to pharmaceutical compositions comprising colored solutions, colored emulsions, or colored powders of injectable pharmaceuticals wherein said pharmaceuticals are selected...
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US20090149429 |
ANTIVIRAL COMPOUNDS
The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.
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US20090137541 |
Novel Series of Imidazolyl Substituted Steroidal and Indan-1-One Derivatives
The present invention provides a novel series of imidazolyl substituted steroidal and indan-1-one derivatives and salts thereof having the following general structural formulae (A and B)
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US20090131384 |
COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS
The invention provides novel compounds, methods for treating or preventing a condition related to ER-stress, e.g. hypercholesterolemia, atherosclerosis and related conditions, and pharmaceutical...
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US20090131383 |
Pharmaceutical compositions of a neuroactive steriod and methods of use thereof
The present invention relates to pharmaceutical compositions of the neuroactive steroid 3α-hydroxy-3β-methoxymethyl-21-(1′-imidazolyl)-5α-pregn
an-20-one or a pharmaceutically-acceptable salt...
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US20090124587 |
METHODS FOR TREATING CANCER USING 17alpha-HYDROXYLASE/C17,20-LYASE INHIBITORS
Methods for treating certain cancers in patients, such as mammals, using certain 17α-hydroxylase/C 17,20 -lyase inhibitors are discussed herein. More particularly, methods for treating cancers...
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US20090123522 |
Medicament Delivery Device and a Method of Medicament Delivery
A medicament delivery device and method of delivering a medicament is provided wherein the device is insertable into the uterine myometrium for the delivery of medicaments to the pelvic area and...
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US20090118248 |
3-Alpha-hydroxy 21-n-heteroaryl-pregnane derivatives for modulation of brain excitability and a process for the production thereof
The invention relates to a novel multi step process of making compounds of Formula I:
wherein R 1 is an alkoxy group and R 2 is an optionally substituted, N-attached heteroaryl. The hydrogen...
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US20090105202 |
Androsterone Derivatives and Method of Use thereof
The disclosure provides androsterone derivatives. The derivatives of the disclosure are useful in the treatment of androgen- and estrogen-associated diseases and disorders, including breast cancer.
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US20090069277 |
Compounds and compositions for treating infection
Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.
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US20090042846 |
Topical Delivery System for Phytosterols
This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne,...
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US20090042844 |
17ALPHA-SUBSTITUTED STEROIDS AS SYSTEMIC ANTIANDROGENS AND SELECTIVE ANDROGEN RECEPTOR MODULATORS
Compounds having the structure, their salts or N-oxide derivatives:
are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic...
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US20090028918 |
Gynecological pharmaceutics- containing microspherical vascular suppository of sodium alginate and its preparation method
The present invention relates to a kind of sodium alginate microsphere vascular embolus containing gynecological drug and its preparation. The preparation of it consists of the following steps:...
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US20090022671 |
TREATMENT METHODS
Disclosed are methods of treating rhinosinusitis of the upper airway passages in patients afflicted with said disease, which comprises administering at least once-a-day to the surfaces of said...
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US20080312201 |
Reduced Toxicity Methotrexate Formulations and Methods for Using the Same
Methods of using methotrexate (MTX) active agents in which reduced host toxicity is observed are provided. In the subject methods, an effective amount of an MTX active agent is administered to the...
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US20080293682 |
Novel Betulinic Acid Derivatives
The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH 2 ) CH 3 or CH(CH 3 ) 2 ; R 2 together with the adjacent carbonyl group forms a carboxylic acid,...
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US20080287408 |
ENDOMETRIOSIS TREATMENT
A pharmaceutical composition comprises at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to a vaginal mucosal surface, and comprises danazol in an...
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US20080280864 |
Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic...
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US20080255075 |
SUBSTITUTED ESTRATRIENE DERIVATIVES AS 17BETA HSD INHIBITORS
Substituted estratriene compounds of formula (I) useful in therapy, especially in the treatment or inhibition of a steroid hormone dependent disorder requiring the inhibition of a...
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US20080255074 |
Drug Combination Comprising A Selective Serotonin Reuptake Inhibitor And A Glucocorticoid Receptor Antagonist For The Treatment Of Depression
The invention provides for a combination comprising an amount of an SSRI, or a pharmaceutically acceptable salt or solvate thereof, and an amount of a GR antagonist, or a pharmaceutically...
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US20080249076 |
Pharmaceutical Compositions Comprising Danazol
A controlled release pharmaceutical comprising danazol has the property of slow release of danazol over an extended period of time and markedly increased bioavailability compared to commercially...
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US20080214514 |
Steroid derivatives of fullerenes
Described herein are steroid derivatives of fullerene moieties, for example fullerene derivatives in which cholesterol, or a cholesterol moiety, is attached via ester, amide, or ether bonds to one...
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US20080193499 |
Angiogenesis Inhibitors
Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound...
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US20080182830 |
Agent for Treatment and Prevention of Endometriosis and Uterine Adenomyosis
An object of the present invention is to provide an agent for use in the effective treatment and prevention of endometriosis and uterine adenomyosis. The present invention relates to an agent for...
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US20080167282 |
Use of Inhibitors of Steroid Activity for the Treatment of Substance Related Disorders
The invention concerns the use of one or more steroid activity inhibitors, namely androgens, such as, for example, testosterone, for the treatment of disorders related to, or resulting from use of,...
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US20080166301 |
Steroidal antiestrogens and antiandrogens and uses thereof
The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human,...
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US20080153789 |
TOPICAL ADMINISTRATION OF DANAZOL
Pharmaceutical preparations for topical or local administration of drugs directly to the skin for treatment of disorders of the subcutaneous fatty tissue, in particular in cases of cellulite, are...
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US20080146531 |
Therapeutically Active Triazoles and Their Use
Estratrien-triazoles corresponding to formula (I) (shown below) which are useful in therapy, especially for the treatment and/or prevention or inhibition of a steroid hormone dependent disorder,...
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US20080125403 |
Method of Treating Men with Metabolic and Anthropometric Disorders
A method of safely and specifically treating the combined metabolic disturbances of insulin resistance and visceral adiposity in male subject with visceral adiposity, metabolic syndrome (also known...
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US20080119443 |
Certain lithocholic acid analogues that inhibit sialyltransferase
Certain chemical entities chosen from compounds of Formula I:
and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof are described....
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US20080090791 |
Cystic fibrosis treatment methods
The invention relates to the use of compounds to ameliorate or treat an condition such as a cystic fibrosis, neutropenia or other exemplified conditions. Exemplary compounds that can be used...
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US20080085873 |
Disease treatment methods
The invention relates to the use of compounds to ameliorate or treat a condition such as a cystic fibrosis, neutropenia or other exemplified conditions. Exemplary compounds that can be used include...
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US20080058298 |
Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
The present invention makes available assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction...
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US20080051380 |
METHODS AND COMPOSITIONS FOR TREATING CANCER
Methods and compositions for treating cancer are described herein. More particularly, the methods for treating cancer comprise administering a 17α-hydroxylase/C 17,20 -lyase inhibitor, such as...
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US20080051323 |
Chloroquine drug compositions and methods for their synthesis
This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough...
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US20080021005 |
Pegylated Ion Channel Modulating Compounds
This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also...
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US20080019961 |
Hedgehog signaling pathway antagonist cancer treatment
The present invention provides methods and compositions for treating tumorigenic cells (e.g., mammary progenitor cancer cells), with hedgehog signaling pathway antagonists (e.g., Cyclopamine or...
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