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US20120058949 Methods of Treating Neurological Disorders  
The present invention provides methods of treating epilepsy and other neurological disorders. The methods generally involve administering to an individual in need thereof an effective amount of an...
US20110311651 CARDENOLIDES FOR THE TREATMENT OF OCULAR CANCER  
The instant invention provides methods of using a class of compounds known as cardenolides in the treatment of proliferative diseases such as cancer. In particular, the instant invention provides...
US20100324004 Method for Treating Diabetes  
This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
US20130035321 COMPOUNDS FOR THE TREATMENT OF OCULAR CANCER  
In one aspect, the instant invention provides novel compounds and pharmaceutical compositions useful for treating proliferative diseases such as cancer. In another aspect, the invention provides...
US20120003261 DIGOXIN-LIKE FUNGAL GLYCOSIDE WITH CYTOTOXIC PROPERTIES: NOVEL ASSAY AND APPLICATIONS  
The present invention provides methods of isolating cytotoxic metabolites from a fungus, and specific metabolites obtained from such methods. The present invention also provides methods of...
US20120004204 Methods for treating sexual dysfunction while decreasing cardiovascular risk  
Methods for treating female sexual dysfunction are provided. In particular, methods for treating a woman having HSDD by administering to the woman a therapeutically effective amount of an...
US20130324508 BIOMARKER FOR PROSTATE CANCER AND METHOD OF USING THE SAME  
The present invention relates to a biomarker for characterizing prostate cancer and method of using the same. More particularly, the invention relates to method of using a membrane-associated C...
US20130143850 METHODS AND COMPOSITIONS FOR STIMULATING REEPITHELIALISATION DURING WOUND HEALING  
The present invention relates to methods and compositions for stimulating reepithelialisation during wound healing. More particularly, the present invention relates to a mmeralocorticoid receptor...
US20150157647 METHODS AND COMPOSITIONS RELATED TO ACUTE RESPIRATORY DISTRESS SYNDROME  
Certain embodiments are directed to methods of identifying patients with ARDS by detecting elevated levels of marinobufagenin (MBG) and treating the same with anti-MBG agents.
US20110319351 TREATING CANCER WITH CARDIAC GLYCOSIDES  
The invention provides methods to treat cancer with cardiac glycosides.
US20140011755 Cardiac Glycosides for Treating Autoimmune Disease  
The invention provides methods for treating inflammatory and autoimmune diseases by administering to the subject an effective amount of a cardiac glycoside, where the dose is effective to suppress...
US20140256694 STEROID ANTIBIOTIC CONJUGATES  
The present invention describes steroid antibiotic conjugates. These single drug entities are formed connecting a steroid moiety and two same antibiotics moieties, or a steroid moiety and two...
US20150099712 METHOD AND COMPOUNDS FOR INHIBITING THE MCM COMPLEX AND THEIR APPLICATION IN CANCER TREATMENT  
A method for treating cancer by using an agent which is capable of inhibiting the functionality of the MCM complex, a heterohexameric ring formed from six subunits, in the process of DNA...
US20140249120 NEUROACTIVE 13, 17-SUBSTITUTED STEROIDS AS MODULATORS FOR GABA TYPE-A RECEPTORS  
The present disclosure is generally directed to neuroactive 13,17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic,...
US20140256612 ANTIBIOTIC CONJUGATES DIRECTLY LINKED WITH STEROID DRUGS  
The present invention describes novel single drug entities, formed by direct linkage of an antibiotic to a steroidal drug. Upon topical application to the eye, the conjugate would undergo...
US20110053878 ACID-SENSITIVE LINKERS FOR DRUG DELIVERY  
The invention is in general directed to acid-sensitive linkers, and methods of use thereof, such as, for example, in drug delivery methods.
US20130040921 ANTICANCER STEROIDAL LACTONES UNSATURATED IN POSITION 7 (8)  
A compound of general formula (I), wherein R1-R17 and the ------ line take various meanings for use in the treatment of cancer.
US20140128356 Na/K-ATPase Ligand  
Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described.
US20110104066 PROPHYLACTIC/THERAPEUTIC AGENTS FOR LIFESTYLE-RELATED DISEASES  
Disclosed is a method for the screening of a compound having an activity to selectively modulate an androgen receptor. The method comprises the steps of: contacting a substance to be tested with a...
US20150246944 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS  
Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
US20130123224 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS  
Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
US20120053162 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS  
Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
US20110201584 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS  
Chemical entities that are bufalin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
US20110105423 COMPOUNDS THAT MODULATE NEGATIVE-SENSE, SINGLE-STRANDED RNA VIRUS REPLICATION AND USES THEREOF  
The present invention relates to compounds that modulate the replication of negative-sense, single-stranded RNA viruses, such as influenza virus, and the use of such compounds. The invention...
US20130345186 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS  
Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.
US20120196842 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS  
Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.
US20070265194 Agents for the treatment of viral infections  
The invention relates to methods of treating a hepatitus virus infection by administering a therapeutically effective amount of a proteasome inhibitor and a pharmaceutically acceptable carrier to...
US20120077788 USE OF TELOCINOBUFAGIN AS AN ANALGESIC IN THE TREATMENT OF ACUTE AND CHRONIC PAINS; PHARMACEUTICAL COMPOSITION CONTAINING TELOCINOBUFAGIN AND ITS USE  
The present invention is directed to the use of telocinobufagin, or its pharmaceutically acceptable derivatives, in the manufacture of a medicament for the treatment or prevention of acute and...
US20140221327 Method of Diagnosing and Therapeutically Treating a Patient for a Traumatic Brain Injury  
Known or suspected traumatic brain injuries may be treated therapeutically by administering a therapeutically effective dose of resibufogenin. A preferred method for determining if a patient has a...
US20140056851 METHODS FOR MANAGING WEIGHT LOSS AND BODY MASS  
The invention provides methods for promoting weight loss by an animal, promoting weight loss by an animal while preventing or minimizing loss of lean body mass by the animal preventing a reduction...
US20080188449 Treatment of Conditions Caused By Calcium Abnormalities  
In certain aspects, the invention relates to use of PKD2 agonists, such as triptolide and triptolide derivatives, to regulate calcium release. In other aspects, the invention relates to use of...
US20110178052 9-ALPHA ESTRATRIENE DERIVATIVES AS ER-BETA SELECTIVE LIGANDS FOR THE PREVENTION AND TREATMENT OF INTESTINAL CANCER  
Use of 9α-estra-1,3,5(10)-triene derivatives of formula (I) for the prevention and treatment of intestinal cancer, in particular adenoma and adenocarcinoma of the duodenum, ileum, colon, and rectum.
US20070066580 Novel aldosterone antagonists and uses thereof  
The present invention relates to novel compounds that are aldosterone receptor antagonists, to pharmaceutical compositions containing the aldosterone receptor antagonists, and to methods of...
US20090023666 Modulators of Hypoxia Inducible Factor-1 and Related Uses  
The invention features compounds of formulas I or II: and pharmaceutically acceptable salts and prodrugs thereof, as well methods for modulating the effects of local and systemic hypoxic events...
US20100285064 ADJUVANT COMPOSITION FOR VACCINE  
The present invention provides a Withania somnifera fraction rich in withanolides and a vaccine comprising a “Withania somnifera fraction” as an adjuvant.
US20140088056 CARDIAC GLYCOSIDES ARE POTENT INHIBITORS OF INTERFERON-BETA GENE EXPRESSION  
The invention provides for a method of inhibiting interferon-beta gene expression and/or reducing the level of interferon-beta in a cell by contacting the cell with a Na+, Ca2+, or K+ ion-channel...
US20090226513 Na/K-ATpase Ligand  
This process relates to a pharmaceutical composition of an Na-K-ATPase ligand which will stimulate Na/K-ATPase signaling in a pharmaceutically acceptable vehicle. In one embodiment, the...
US20140357608 TACCALONOLIDE MICROTUBULE STABILIZERS  
The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.
US20060199790 Use of 3-methoxy-pregnenolone in the production of a medicament for treating neurodegenerative diseases  
The invention relates to a novel use of derivatives of neurosteroids, particularly pregnenolone, for the treatment of acute or chronic lesions of the nervous system, especially certain...
US20080233189 Pharmaceutical Tablets Comprising Two or More Unitary Segments  
Accurate means of dosing with a compressed, segmented pharmaceutical tablet, and tablettes formed from said tablets, is disclosed.
US20120128733 PHARMACEUTICAL COMPOSITIONS COMPRISING ACTIVE DRUGS, CONTRACEPTIVE KITS COMPRISING ACTIVE DRUGS, AND METHODS OF ADMINISTERING THE SAME  
The present invention relates to pharmaceutical compositions and kits comprising pharmaceutical compositions, and methods for administering pharmaceutical compositions comprising active...
US20110243892 Y-SHAPE BRANCHED HYDROPHILIC POLYMER DERIVATIVES, THEIR PREPARATION METHODS, CONJUGATES OF THE DERIVATIVES AND DRUG MOLECULES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE CONJUGATES  
The present invention relates to Y-shape branched PEG derivatives of formulae (I) to (IV). The present invention also relates to conjugates of these Y-shape derivatives and drug molecules,...
US20050070515 Compounds  
Compounds capable of providing a therapeutic effect at a target site within a human or animal body with reduced systemic potency to said body are identified by comparing the susceptibility to...
US20100120704 Cardiac glycosides to treat cystic fibrosis and other IL-8 dependent disorders  
A method of inhibiting the secretion of IL-8 and other pro-inflammatory cytokines from cells secreting elevated levels of these compounds is provided. The method includes contacting the cell with...
US20100249082 MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES  
The invention features compounds of formula (I): and pharmaceutically acceptable salts and prodrugs thereof, as well methods for modulating the effects of local and systemic hypoxic events using...
US20100093651 Artemisinin Derivatives  
This disclosure provides improved derivatives of artemisinin; pharamaceutical compositions containing these compounds; methods for preparing these compounds and compositions; methods of using...
US20120252772 Cucurbitane-Triterpenoid Compounds, Pharmaceutical Composition, Use and Preparation Method Thereof  
Disclosed is a cucurbitane-triterpenoid compound for activating estrogen receptor activity, and a pharmaceutical composition, use and preparation method thereof. The cucurbitane-triterpenoid...
US20120258923 BIOACTIVITY COMPOSITION OF Reevesia formosana  
A series cardenolide derivatives including structure of formula I from the root of Reevesia formosana have provided. In formula (1) and (2), where R3, R5, R10 and R16 are as defined in the...
US20120108559 RECEPTOR ACTIVATOR OF THE RANK RECEPTOR COMPLEX INHIBITOR  
Methods and pharmaceutical compositions utilizing compounds of Formula II: for inhibiting osteoclastogenesis and the activity of osteoclasts in patients.
US20130005696 BUFADIENOLIDE DERIVATIVES, PREPARING PROCESS THEREOF, COMPOSITION COMPRISING THE SAME AND THE USE THEREOF  
The present invention provides a class of bufadienolide derivatives representing by the following formula I or pharmaceutically acceptable salts thereof, the preparing process thereof,...

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