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US20090286760 |
Novel Compositions and Methods for Treating Hyperproliferative Diseases
The invention relates to a composition that includes a first agent selected including an agent that possesses anti-inflammatory activity or acetaminophen, phenacetin, tramadol and the like; a...
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US20090285786 |
METHOD TO MODULATE HEMATOPOIETIC STEM CELL GROWTH
The present invention provides for compositions and methods for modulating hematopoietic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease...
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US20090270332 |
GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS, METHODS OF DETECTION AND USES THEREOF
The present invention is based on the discovery of genetic polymorphisms that are associated with venous thrombosis. In particular, the present invention relates to nucleic acid molecules...
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US20090264385 |
STABILIZED COMPOSITIONS CONTAINING ALKALINE LABILE DRUGS
A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition...
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US20090263513 |
COSMETIC SKIN LIGHTENING FORMULATION
The present invention features novel cosmetic skin care compositions for lightening hyperpigmentation.
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US20090239832 |
DRUGS FOR CHRONIC PAIN
The present invention relates to nitrooxyderivatives or salts thereof having the following general formula (I):
R—NR 1c —(K) k0...
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US20090238763 |
HIGH PENETRATION COMPOSITIONS AND USES THEREOF
The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for non-steroidal anti-inflammatory agents...
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US20090233886 |
DERIVATIVES OF 4- OR 5-AMINOSALICYLIC ACID
The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients,...
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US20090220435 |
TIGHT JUNCTION MODULATING PEPTIDE COMPONENTS FOR ENHANCING MUCOSAL DELIVERY OF THERAPEUTIC AGENTS
Compounds and components including sequences for mucosal epithelial transport of an active agent are given. Tight junction modulating peptide components are described for use in transport and...
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US20090203766 |
vWF aptamer formulations and methods for use
The invention relates to the formulation, dosing, administration and use of an aptamer antagonist therapeutic that binds to von Willebrand Factor.
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US20090203656 |
Method for the Reduction of Dangerous Blood Sugar Levels
The present invention relates to a method and procedure for reducing immediate serum glucose levels without resort to drugs. Specifically, the invention discloses a regular regimen comprising...
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US20090202659 |
Modulation of Peripheral Clocks in Adipose Tissue
Genes encoding the transcription factors controlling the core circadian oscillator (BMAL, Clock, NPAS, Per) and their regulatory targets (Rev-erbα, Rev-erb) have been found in adipose tissue. The...
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US20090163451 |
METHODS FOR TREATING VISCERAL PAIN
The invention features methods of treating visceral pain in humans by administering an effective amount of a 5HT 1B or 5HT 1D receptor agonist, (e.g., a triptan). These methods can be used, for...
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US20090137527 |
Compositions and methods for modulating immune function
The invention relates to methods of modulating immune function, suppressing immune response, treating autoimmune diseases or autoimmune disorders, and treating diseases, sequelae or pathological...
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US20090131377 |
Combinations of Superoxide Dismutase Mimetics and Nonsteroidal Analgesic/Anti-Inflammatory Drugs
Combinations of synthetic low molecular weight catalysts for the dismutation of superoxide and Nonsteroidal Analgesic/Anti-Inflammatory Drugs (NSAIDs) are potent analgesics that are effective in...
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US20090131376 |
PROCESS FOR THE MODIFICATION OF THE SOLID STATE OF A COMPOUND AND CO-AMORPHOUS COMPOSITIONS PRODUCED WITH SAME
The invention provides a process for preparing non-crystalline organic compositions and non-crystalline, co-amorphous blends of organic compounds.
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US20090123567 |
BISBENZISOSELENAZOLONYL DERIVATIVES HAVING ANTINEOPLASTIC, ANTI-INFLAMMATORY AND ANTITHROMBOTIC ACTIVITIES AS WELL AS THEIR USE
The present invention relates to new bisbenzisoselenazolonyl derivatives of the following general formula (I), wherein R is C 4-5 -alkylene, and their pharmaceutically acceptable salts. The...
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US20090123552 |
SPHEROIDS PREPARED FROM AN ISOLATED ACTIVE PRINCIPLE OF VEGETABLE ORIGIN AND A SOLUTION OF VEGETABLE ORIGIN CONTAINING THE ACTIVE PRINCIPLE OR A PRECURSOR THEREOF
The invention relates to spheroids which are obtained using a method comprising the following steps consisting in: supplying an active principle of vegetable origin in an isolated form; supplying a...
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US20090111778 |
2-Keto-Oxazoles as Modulators of Fatty Acid Amide Hydrolase
Certain 2-keto-oxazole compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states,...
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US20090111777 |
Jelly Composition
It is intended to provide a composition having at least one effect among the following effects; a plurality of medicinal ingredients can be taken as one preparation and the convenience for patients...
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US20090105197 |
Use of Sodium Channel Blocking Compounds and Aspirin in Manufacturing Drugs for Producing Analgesia Synergistically in Mammals
This invention relates to the use of combinations of a sodium channel blocking compound that binds to an SSI or SS2 site of extracellular region of a sodium channel alpha subunit, and aspirin in...
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US20090098201 |
Composition and Method for Treatment and Prevention of Atherosclerosis
This invention relates to an oral composition for treatment or prevention of atherosclerosis comprising a low-dose aspirin and a low-dose of statin wherein the aspirin and statin are in a...
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US20090098200 |
COMPOSITIONS COMPRISING LIPOPHILIC ACTIVE COMPOUNDS AND METHOD FOR THEIR PREPARATION
Compositions are provided comprising a lipophilic active compound, e.g., a human or veterinary drug or a nutraceutical, interwoven with a polymeric matrix formed by two or more polymers, wherein...
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US20090082316 |
Composition and Method Of Stabilized Sensitive Ingredient
The present invention comprises a method of achieving ingredient stabilization in a composition comprising the steps of: combining a pregelatinized starch with at least one sensitive ingredient;...
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US20090081291 |
Sustained Release Dosage Forms For Delivery of Agents to an Oral Cavity of a User
Aspects of the invention include a sustained release dosage form that can be administered to an oral cavity, e.g., the mouth. In certain embodiments, the sustained release dosage form is formulated...
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US20090062241 |
Highly porous, fast-disintegrating solid dosage form and its way of manufacturing comprising the preparation of a powder and a freezedrying step
The invention relates to a method of manufacture of fast-disintegrating solid dosage forms, characterized in that one or more structure building components in mixed solid powder form are dosed into...
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US20090060873 |
Novel synthetic triterpenoids and methods of use in the treatment and prevention of multiple scleroris
The present invention overcomes limitations of the prior art by providing new compounds and methods for the treatment of conditions, such as neurodegenerative diseases (e.g., multiple sclerosis),...
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US20090042842 |
Analogues of cilostazol
This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides...
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US20090041923 |
MEDICAL DEVICE HAVING A LUBRICIOUS COATING WITH A HYDROPHILIC COMPOUND IN AN INTERLOCKING NETWORK
A medical device having a lubricious coating on at least a section of the medical device, and a method of coating a medical device, the lubricious coating being a network of a hydrophilic compound...
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US20090023692 |
COMPOSITIONS FOR INHIBITING AND PREVENTING VASCULAR OCCLUSION CONTAINING NUTRITIONAL SUPPLEMENTS
Compositions for inhibiting vascular occlusion in humans comprising aspirin for inhibiting vascular occlusion which further contain nutritional supplements are disclosed. The compositions are...
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US20090017003 |
THIOSULFONATE ANTI-INFLAMMATORY AGENTS
The present invention relates to novel thiosulfonates derivatives. The present invention also provides methods for preventing, treating and/or reducing inflammation-associated diseases in the...
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US20090004290 |
RED YEAST RICE COMPOUND FOR CANCER CHEMOPREVENTION
The invention concerns a composition containing red yeast rice and other components, as a chemopreventative agent to reduce the risk of cancer.
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US20080287403 |
USE OF INHIBITORS OF THE RENIN-ANGIOTENSIN SYSTEM IN THE PREVENTION OF CARDIOVASCULAR EVENTS
Use of an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with an other antihypertensive, a cholesterol lowering agent, a diuretic...
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US20080286327 |
THOMBOLYSIS AND CHRONIC ANTICOAGULATION THERAPY
Method and systems of treating a patient with at least one of a myocardial infarction, a stroke, and a pulmonary embolism include providing a stimulator coupled to at least one electrode and a...
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US20080279843 |
Method For Improving Insulin Sensitivity By Administering an Inhibitor of Antitrypsin
Methods of delaying the onset or treating the progression of Type 2 diabetes in subjects that have increased blood levels of an inflammation marker protein. In one embodiment, the method includes...
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US20080268025 |
Compositions Useful for Preventing Pain and Soreness Resulting from Exercise and Methods of Use
Provided are beverages containing one or more anti-inflammatory agents, derivatives thereof, prodrugs thereof, salts thereof, or combinations thereof. Additional components include, but are not...
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US20080254036 |
COMBINATION ANTICOAGULANT THERAPY WITH A COMPOUND THAT ACTS AS A FACTOR XA INHIBITOR
The present invention is directed to methods of using combination therapies containing [2-({4-[(dimethylamino)iminomethyl]phenyl}carbonylamino)-5-m
ethoxyphenyl]-N-(5-chloro(2-pyridyl))carboxamide...
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US20080242645 |
COSMETIC COMPOSITION
The invention relates to a composition containing, preferably in a physiologically acceptable medium, at least one xanthine base or a plant extract containing it, at least one polyurethane powder,...
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US20080242644 |
Factor Viia Inhibitor
The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these...
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US20080242643 |
Nitric Oxide Releasing Prodrugs of Diaryl-2-(5H)-Furanones as Cyclooxygenase-2 Inhibitors
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases. Formula...
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US20080234237 |
QUINOLONE AND TETRAHYDROQUINOLONE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY
The present invention features quinolones, tetrahydroquinolines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide...
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US20080234236 |
REDUCTION OF ADVERSE EVENTS AFTER PERCUTANEOUS INTERVENTION BY USE OF A THROMBIN RECEPTOR ANTAGONIST
Disclosed are methods of preventing adverse clinical events in a patient undergoing a percutaneous coronary intervention procedure or a peripheral percutaneous interventional procedure comprising...
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US20080233206 |
COMPOSITIONS AND METHODS FOR ANTI-INFLAMMATORY TREATMENTS
The present invention relates to an improved method for treating a wide range of inflammatory disorders by administering a tetracycline compound together with an effective inhibitor of tetracycline...
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US20080206219 |
Novel Indications for Transforming Growth Factor-Beta Regulators
Methods, compounds and compositions for the modulation of TGF-β are disclosed wherein the vascular permeability in a subject is altered. The compounds can be antagonists or agonists, and can be...
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US20080194527 |
COMPOSITIONS AND COMBINATIONS 2
Compositions and methods for preventing, inhibiting or treating a disorder associated with the loss of normal adult tissue architecture are provided.
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US20080188402 |
NOVEL HETEROCYCLIC COMPOUNDS, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN MEDICINE
The present invention relates to novel substituted pyrrole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically...
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US20080175831 |
NEUROPROTECTION BY BLOOD FLOW STABILIZATION
A treatment is disclosed for alleviation or prevention of abnormal blood flow to various organs such as the eye, brain, kidneys, heart, feet and other tissues of organs with fine vascular networks...
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US20080166407 |
Solid oral formulations for combination therapy
Multifunctional, single, bilayer, and trilayer coated tablets for combination therapy are formed wherein the bioactive agents responsible for the therapeutic multifunctionality are present as a...
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US20080145446 |
Multi-purpose hand and/or skin cleaner, sanitizer, drug delivery and exercise system
By providing a reusable support base or carrier which is constructed for being easily held by the user in the person's hand, and incorporating additives, therapeutic agents and/or medicinal...
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US20080114057 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS OF THE MUCOSAE, SKIN AND THE EYE
The present invention relates to compositions comprising a proanthocyanidin, as well as methods for using such compositions in the treatment of an inflammatory condition of the skin including, but...
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