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US20090291925 |
Bioactive polymeric liquid formulations of absorbable, segmented aliphatic polyurethane compositions
Bioactive liquid formulations are formed of combinations of absorbable, segmented aliphatic polyurethane compositions and liquid polyether for use as vehicles for the controlled release of at least...
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US20090281068 |
POLYLACTIDE COMPOSITIONS AND USES THEREOF
The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.
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US20090258842 |
7-Phenyl-Substituted Tetracycline Compounds
7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are...
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US20090253660 |
Minocycline Compounds and Methods of Use Thereof
Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an...
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US20090232899 |
Mucoadhesive nanocomposite delivery system
A nanocomposite delivery system uses chitosan as a mucoadhesive material encapsulated in a surface modified network of colloidal nanoporous nanoparticles, such as silica, or other colloid-forming...
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US20090221533 |
METHOD OF TREATING FATTY LIVER DISEASE
The present invention relates to a method for treating a fatty liver disease or disorder in a patient in need thereof. The method comprises administering at least one matrix metalloproteinase...
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US20090176747 |
TETRACYCLINE COMPOUNDS AND METHODS OF TREATMENT
The instant invention is directed towards tetracycline compositions, and methods of inhibiting Tdp1 activity, and methods of treating Tdp1-associated disorders.
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US20090155326 |
LAYERED DRUG DELIVERY POLYMER MONOFILAMENT FIBERS
The present invention is directed generally to a layered polymeric monofilament fiber drug delivery device, where each layer of the device can contain a different polymer, drug, additive, or any...
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US20090137533 |
Convenience Kit for Eyelid Treatment
The present invention offers an eyelid treatment kit used for convenient combination therapy for improving overall eyelid hygiene while also providing for adjunctive eyelid therapy. The eyelid...
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US20090136568 |
Tabletting process
A process for producing a compressed solid dosage form containing an active ingredient. The process includes a step of preparing core elements containing the active ingredient. Optionally the core...
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US20090124583 |
7-N-substituted phenyl tetracycline compounds
7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
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US20090118240 |
LOCAL TREATMENT OF NEUROFIBROMAS
A method for treating a neurofibroma, e.g. dermal neurofibroma, a subdermal neurofibroma, or a superficial plexiform neurofibroma, in a subject in need of such treatment is disclosed. The method...
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US20090111776 |
Novel tetracycline derivatives as antibacterial agents
In accordance with one aspect, the present invention provides a compound of general formula (I), its stereoisomers thereof and/or its pharmaceutically acceptable salts thereof, which have...
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US20090104121 |
Multi-subunit biological complexes for treatment of plaque-associated diseases
Provided herein are methods and compositions for the in vitro formation of multi subunit biological platforms. The biological platforms may be used to screen chemical or biological compounds, in...
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US20090098203 |
Mucoadhesive Tetracycline Formulations
Mucositis is treated and/or prevented by administrating to a patient a formulation containing a tetracycline and at least one cationic polymer and/or mucoadhesive material. The tetracycline may be...
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US20090054312 |
SMIPs: Small molecule inhibitors of p27 depletion in cancers and other proliferative diseases
Methods are provided for screening for SMIPs (small molecule inhibitors of p27 depletion). The SMIPs thus identified are useful for treating cancers and other proliferative diseases.
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US20090053149 |
SURFACTANT-BASED ANTIMICROBIAL SOLUTION FOR INHALATION
A surfactant can be added, safely and effectively, to a drug solution containing any antimicrobial agent, such as an antibiotic like tobramycin, that is suitable for administration to the lungs via...
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US20090042821 |
STABLE DOSAGE FORMS OF SPIRO AND DISPIRO 1,2,4-TRIOXOLANE ANTIMALARIALS
The field of the invention relates to stable dosage forms comprising spiro or dispiro 1,2,4-trioxolane antimalarials, or their pharmaceutically acceptable salts, prodrugs and analogues, and...
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US20090010908 |
Materials and Methods for Diagnosis and Treatment of Chronic Fatigue Syndrome
The invention relates to materials and methods for diagnosis and treatment of chronic fatigue syndrome/myalgic encephalitis. A number of genes are identified which are expressed at abnormal levels...
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US20080318910 |
Controlled-Release Oral Dosage Form
A controlled-release oral dosage form suitable for administration to a mammal. The dosage form comprises a drug and an organic acid or a salt thereof. The dosage form releases no more than 60% the...
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US20080312194 |
Methods and compositions for normalizing meibomian gland secretions
The present invention provides non-aqueous compositions for normalizing meibomian gland secretions, and methods of use thereof. The present invention further provides compositions and methods for...
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US20080312193 |
Substituted Tetracycline Compounds for Treatment of Inflammatory Skin Disorders
Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.
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US20080305186 |
Method and Composition for the Treatment of Cardiac Hypertrophy
The present invention includes compositions and methods treat a patient suffering from one or more symptoms of cardiac hypertrophy, hypertension and/or ischemia by administering a pharmaceutically...
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US20080287401 |
Methods for Synthesizing and Purifying Aminoalkyl Tetracycline Compounds
Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
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US20080274184 |
Ecm-Based Graft Material
This invention is directed to graft materials comprising an extracellular matrix (ECM) and therapeutic agents. This invention is also directed to methods of using the graft materials for healing of...
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US20080269175 |
INCREASED DRUG LOADING CAPACITY OF POLYMERIC MATERIAL
A method includes (i) contacting a polymeric material with a first solvent to produce a pre-extracted polymeric material, and (ii) contacting the pre-extracted material with a solution comprising...
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US20080268547 |
Systems and Methods for Indicating Oxidation of Consumer Products
The present invention relates to systems and methods using colorimetric indicators of oxidation in consumer products. In particular, betalains are used as oxidation indicators in food,...
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US20080249072 |
Use of Low Dose Chemically Modified Tetracylines to Reduce Inflammatory Mediators
The invention is a method for reducing the production of inflammatory mediators, and/or treating conditions characterized by increased levels of inflammatory mediators, in a mammal in need thereof,...
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US20080248124 |
Process for producing pharmaceutical composition
The present invention relates to a process for producing a pharmaceutical composition which can stably contain an active ingredient unstable against water and can sustained-release such the active...
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US20080241212 |
Biodegradable, Polymer Coverings for Breast Implants
A biodegradable, flexible covering for a breast implant is provided which comprises one or more biodegradable polymer layers dimensioned and shaped to cover at least a portion of the breast...
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US20080241197 |
MINOCYCLINE DOSAGE FORMS FOR THE TREATMENT OF ACNE
Minocycline oral dosage forms containing a controlled release carrier are useful for the treatment of acne.
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US20080233206 |
COMPOSITIONS AND METHODS FOR ANTI-INFLAMMATORY TREATMENTS
The present invention relates to an improved method for treating a wide range of inflammatory disorders by administering a tetracycline compound together with an effective inhibitor of tetracycline...
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US20080233151 |
Use of non-antibacterial tetracycline analogs and formulations thereof for the treatment of bacterial exotoxins
The invention relates to methods for protecting and/or treating a mammal at risk of acquiring a condition associated with bacteria that produce a calmodulin exotoxin, a metalloproteinase exotoxin,...
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US20080220079 |
SUSTAINED RELEASE COMPOSITIONS USING WAX-LIKE MATERIALS
Sustained release spherical or non-spherical pellets comprising (a) an active ingredient (b) a wax-like agent, and (c) a spheronizing agent are provided. Oral dosage forms comprising said pellets...
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US20080220003 |
C5a Receptor Antagonists
The present invention is related to a compound, preferably a C5a receptor antagonist, having the following structure, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17,...
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US20080214510 |
Methods and compositions for treating meibomian gland disease
A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the...
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US20080207569 |
Methods for the treatment of liver diseases
Provided herein are methods for treatment of a liver disease by administering a matrix metalloproteinase inhibitor. Also provided are methods for reducing liver damage associated with a liver...
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US20080206293 |
Absorbent substrate with a non-leaching antimicrobial activity and a controlled-release bioactive agent.
This invention relates to antimicrobial wound dressings having a non-leaching antimicrobial activity, releasable antimicrobial and antiprotease agents, and a controlled-release bioactive agent such...
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US20080188445 |
TETRACYCLINE COMPOSITIONS FOR TOPICAL ADMINISTRATION
Multi-part pharmaceutical formulations containing tetracycline for topical administration, as well as methods of making and administering the same, are disclosed.
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US20080182827 |
METHOD FOR THE TREATMENT OF ACNE
A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen.
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US20080182826 |
METHOD FOR THE TREATMENT OF ACNE
A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen.
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US20080182825 |
METHOD FOR THE TREATMENT OF ACNE
A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen.
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US20080181945 |
METHOD FOR THE TREATMENT OF ACNE
A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen.
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US20080171727 |
METHODS OF TREATING ACNE
A method of treating acne in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat acne but has substantially...
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US20080167273 |
7,8 And 9-substituted tetracycline compounds
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
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US20080160007 |
Diagnosis and treatment of cancer related to human dormancy
New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways....
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US20080139517 |
Methods of treating age associated memory impairment (AAMI), mild cognitive impairment (MCI), and dementias with cell cycle inhibitors
Therapeutic methods for treatment of age associated memory impairment (AAMI), mild cognitive impairment (MCI), Alzheimer's disease (AD), cerebrovascular dementia (CVD), and related...
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US20080132978 |
OUTER EYELID HEAT AND PRESSURE TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION
A method of treating meibomian gland dysfunction. Heat is applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the...
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US20080102127 |
HYBRID LIPID-POLYMER NANOPARTICULATE DELIVERY COMPOSITION
The invention relates to a nanoparticulate colloidal delivery vehicle comprising a biodegradable polymer in combination with a hydrophobic lipid component. Variation of the lipid and polymer types...
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US20080090789 |
Tigecycline crystalline forms and processes for preparation thereof
The present invention relates to solid crystalline Tigecycline, and crystalline forms thereof.
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