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US20100069306 |
Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a...
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US20100069301 |
COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY
Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of...
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US20100062985 |
AGENTS AND METHODS FOR TREATING PAIN
The invention provides agents useful for treating pain. An exemplary agent comprises or consists of the a portion of a retroviral Tat protein. One such agent is the peptide Tat-NR2B9c. This peptide...
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US20100062984 |
FGF-23 POLYPEPTIDES
This document relates to FGF-23 polypeptides, FGF-23 polypeptide fragments, and methods for making and using such polypeptides and polypeptide fragments. For example, FGF-23 polypeptide fragments...
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US20100056446 |
NA+K+-ATPase-Specific Peptide Inhibitors/Activators of SRC and SRC Family Kinases
A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for...
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US20100056431 |
MEDICAL USES
The present invention provides the use of a polypeptide comprising an amino acid sequence according to SEQ ID NO: 1 (corresponding to the N-terminal 25 amino acid fragment of the human...
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US20100056456 |
Omega Conotoxins
The present invention relates to a method for increasing the binding reversibility of a ??-conotoxin to a N-type calcium channel, which comprises preparing a ??-conotoxin having a Ile and/or Ala...
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US20100055150 |
METHOD AND COMPOSITION FOR TREATMENT OF SKELETAL DYSPLASIAS
The present invention relates to a method for the treatment of skeletal dysplasia by administering to a patient a composition comprising a therapeutically effective amount of at least one C-type...
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US20100055164 |
SYNTHETIC LUNG SURFACTANT AND USE THEREOF
The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline...
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US20100056455 |
Therapies Which Act on Neuropeptide S Receptors
Compositions and methods that act on Neuropeptide S reseptors (NPSR) (also known as or ???TGR23??? or ???vasopressin receptor-related receptor 1 (VRR1)???) to cause desired effects in the bodies of...
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US20100056441 |
Method for Inhibiting Angiogenesis
The invention provides methods for inhibiting angiogenesis in an animal in need thereof. The invention also pro-vides methods for preventing tumor growth and metastasis in an animal comprising...
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US20100048462 |
TRUNCATED PTH PEPTIDES WITH A CYCLIC CONFORMATION
The present invention provides PTH peptides which are cyclised substitution analogues of the truncated PTH fragment PTH (1-17) and which preferably retain the desired or similar biological activity...
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US20100048464 |
Bioactive peptides identified in enzymatic hydrolyzates of milk caseins and method of obtaining same
The invention relates to the production of bioactive products that are derived from milk proteins for the production of bioactive milk products derived from milk proteins, particularly caseins. The...
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US20100048469 |
ANTIMICROBIAL PEPTIDES
There is provided at least one isolated antimicrobial peptide, wherein the peptide is a linear analog of hBD3 or a fragment thereof. In particular, there is provided a linear analog of hBD3 wherein...
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US20100048482 |
COMPOSITIONS AND METHODS FOR MODULATING EPSILON PROTEIN KINASE C-MEDIATED CYTOPROTECTION
Compositions and methods for reducing ischemic cell damage and treating mitochondrial disorders using therapeutic agents derived from the V2 domain of epsilon protein kinase C (PKC) are described.
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US20100047275 |
PEPTIDE SEQUENCES AND COMPOSITIONS
Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-6, or comprises two or more...
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US20100047333 |
Modified Peptides and Their Use for the Treatment of Autoimmune Diseases
Disclosed herein are a modified peptide, compositions containing the same and their use in the treatment of autoimmune diseases. The modified peptide is provided by a chemical modification of at...
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US20100041609 |
INTERLEUKIN-1 RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS OF TREATMENT
Peptides that are designed to inhibit the biological activity of the IL-1R type 1 receptor and inhibit IL-1R/IL-1RacP related cell signaling and biological activity are disclosed. Compositions...
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US20100040590 |
Tumor-associated peptides binding to human leukocyte antigen (HLA) class II molecules
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
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US20100041597 |
PEPTIDES TARGETED TO PROTEIN KINASE C ISOFORMS AND USES THEREOF
Peptides having a sequence of general formula (I), or the retro form thereof, and having an affinity for one or more mammalian protein kinase C-alpha isoforms are provided: X—[(HY—HB) n...
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US20100041604 |
NOVEL ANTIVIRAL PEPTIDES AGAINST INFLUENZA VIRUS
The present disclosure generally relates to peptides having antiviral properties. More particularly, the invention relates to peptides exhibiting activity against influenza viruses, to...
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US20100041612 |
Fragments of the Glucagon-Like Peptide-1 and Uses Thereof
GLP-1 fragments and derivatives thereof are able to interact with and activate the GLP-1 receptor GLP-1 fragments and derivatives thereof are used either alone or in combination with other...
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US20100040623 |
NEURITOGENIC AND NEURONAL SURVIVAL PROMOTING PEPTIDES DERIVED FROM THE FAMILY OF S-100 PROTEINS
The present invention relates to peptide fragments derived from proteins of the S-100 family promoting neural cell survival, differentiation and proliferation. The invention further relates to...
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US20100035816 |
MEDICAMENT COMPRISING A PEPTIDE EXTRACT OF AVOCADO, WHICH IS INTENDED FOR THE TREATMENT AND PREVENTION OF ILLNESSES THAT ARE LINKED TO AN IMMUNE SYSTEM DEFICIENCY OR OXIDATIVE STRESS OR SKIN AGEING OR DRY SKIN
The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose an/or perseitol, such as a water-soluble...
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US20100035820 |
AMIDATED DOPAMINE NEURON STIMULATING PEPTIDES FOR CNS DOPAMINERGIC UPREGULATION
The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides...
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US20100029570 |
PEPTIDE AND TREATMENT FOR HIV-1 INFECTION
A compound of the formula X 1 -M-SEQ ID NO:1, or a derivative thereof, is provided, wherein X 1 -M- represents an optional group comprising a protein transduction domain conjugated to the...
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US20100029571 |
NOVEL AND POWERFUL MHC-CLASS II PEPTIDES DERIVED FROM SURVIVIN
The present invention relates to peptides, nucleic acids, and cells for use in the immunotherapy of cancer. The present invention furthermore relates to survivin-derived tumor-associated cytotoxic...
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US20100029552 |
Peptide inhibitors of c-jun dimerization and uses thereof
The present invention provides a method for the screening of nucleic acid fragment expression libraries and selecting encoded peptides based upon their ability to modulate the activity of a target...
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US20100021510 |
NEURONAL EXOCYTOSIS INHIBITING PEPTIDES
The invention relates to peptides of general formula (I):
R 1 -AA-R 2 (I)
...
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US20100015150 |
Tdf-related compounds and analogs thereof
The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing,...
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US20100015197 |
AMPHIPHILIC PEPTIDES AND HYDROGEL MATRICES THEREOF FOR BONE REPAIR
The present invention relates to the field of tissue engineering and more specifically to amphiphilic peptides and peptide matrices thereof useful in vitro and in situ biomineralization and...
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US20100015136 |
CAMPTOTHECIN-PEPTIDE CONJUGATES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
The present invention relates to a novel compound of use in the improved delivery of therapeutic drug agents into target cells or tissues, composition comprising the same and uses thereof. The...
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US20100016225 |
CONJUGATES COMPRISED OF POLYMER AND HIV gp-41-DERIVED PEPTIDES AND THEIR USE IN THERAPY
Provided are conjugates comprising a polymer having operably bound thereto no less than two molecules of synthetic peptide derived from HIV gp41; methods of using these conjugates to inhibit...
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US20100016235 |
Inhibitors of Protein Phosphatase 1, GADD34 and Protein Phosphatase 1/GADD34 Complex, Preparation and Uses Thereof
The present invention relates to the use of a protein phosphatase inhibitor selected from an inhibitor of the catalytic subunit of the protein phosphatase 1 (PP1), an inhibitor of GADD34 and an...
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US20100009918 |
METHOD FOR THE ADMINISTRATION OF LIGANDS, AGONISTS OF LIGANDS OF THE TNF FAMILY WITH REDUCED TOXICITY
The present invention concerns the use of a multimerized form of ligands of the TNF family for the preparation of a medicament for injection into an appropriate cavity of the body, for the...
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US20100009921 |
PHARMACEUTICAL COMPOSITIONS AND METHODS FOR PEPTIDE TREATMENT
Disclosed are compositions and methods for treating a patient with a pharmaceutically active agent other than insulin selected from the group consisting of peptides, peptidomimetics, and proteins,...
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US20100009912 |
INSECTICIDAL EXTRACT FROM LEGUME PLANTS AND METHOD OF PREPARING THE SAME
The invention may be summarized as follows. The present invention provides insecticides comprised of naturally-occurring compounds, such as, for example, PA1b-related peptides and terpenoid...
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US20100009903 |
Methods for Promoting Wound Healing and/or Reducing Scar Formation
The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived...
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US20100009919 |
Apolipoprotein A1 Mimetics and Uses Thereof
The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also...
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US20100008965 |
BIOCOMPATIBLE MEDICAL PRODUCTS HAVING ENHANCED ANTI-THROMBOGENIC PROPERTIES
Described are medical products including a plurality of polypeptides having an amino acid sequence derived from fibronectin, and particularly those polypeptides having an amino acid sequence...
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US20100009920 |
TTK AS TUMOR MARKER AND THERAPEUTIC TARGET FOR LUNG CANCER
Disclosed herein is a method for determining kinase activity of TTK for EGFR and methods of screening for modulators of this kinase activity. Also disclosed are methods and pharmaceutical...
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US20100009907 |
Glucagon-Like Peptides and Uses Thereof
The present invention relates to non-mammalian Glucagon-like peptides (nmGLP-1), analogs thereof, related nucleic acids, and processes production of such peptides. The nmGLP-1 peptides and analogs...
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US20100008936 |
IL-16 antagonist peptides and DNA encoding the peptides
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The...
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US20100008919 |
COMPOSITIONS AND METHODS TO CONTROL ANGIOGENESIS WITH CUPREDOXINS
The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that...
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US20100003225 |
HSP60, HSP60 PEPTIDES AND T CELL VACCINES FOR IMMUNOMODULATION
The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention...
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US20090325883 |
Peptides Which Interact with Anti-Apoptotic Members of the BCL-2 Protein Family, and Uses
The invention lies within the field of seeking out and identifying new peptides which interact with anti-apoptotic members of the Bcl-2 protein family, by means of the two-hybrid system. The...
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US20090324633 |
Immunogens from Uropathogenic Escherichia Coli
Disclosed herein are various genes that can be included in immunogenic compositions specific for pathogenic E. coli strains. The genes are from uropathogenic strains but are absent from...
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US20090325869 |
SYNTHETIC REGULATORS OF FERRITIN PROTEIN NANOCAGE PORES AND METHODS OF USE THEREOF
The present invention provides synthetic regulators of ferritin pores, and compositions comprising the regulators. The regulators function to reduce ferritin demineralization rates. The regulators...
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US20090317428 |
Immunogenic T-Helper Epitopes From Human Tumour Antigens and Immunotherapeutic Methods Using Said Epitopes
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
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US20090318362 |
OLIGOMERIC COMPOUNDS FOR THE MODULATION OF SURVIVIN EXPRESSION
Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides,...
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