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US20090286736 |
ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF
The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides...
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US20090286735 |
METHOD FOR ADMINISTERING GLP-1 MOLECULES
The invention relates to formulations that demonstrate the feasibility of oral absorption comprising glucose-like peptide-1 compounds and specified delivery agents, and to methods of stimulating...
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US20090286734 |
Pharmaceutical Use of Alpha Antigen or Alpha Antigen Gene
The α antigen-encoding gene and the α antigen protein suppress the production of interleukin-4 etc., improve the Th2 type cytokine-dominant state, and furthermore inhibit various conditions of...
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US20090286733 |
LONG-ACTING VETERINARY POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME
A polypeptide and polynucleotides comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a non-human peptide-of-interest are disclosed. Pharmaceutical...
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US20090286732 |
COMPOUNDS FOR DELIVERY OF THERAPEUTIC AND IMAGING MOIETIES TO NERVE CELLS
The invention features compounds of the general formula:
B-L-M
where B is a...
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US20090286731 |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF XEROSTOMIA
Methods for the treatment of xerostomia are described, hi particular, the present invention takes advantage of the inventors' observation that xerostomia is caused by induction of apoptosis, and...
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US20090286730 |
REMEDIES FOR ISCHEMIA
The present invention relates to uses and methods of parathyroid hormone (PTH), preferably PTH (1-34), and/or parathyroid hormone-related peptide (PTHrP), preferably PTHrP (1-34), for recruiting...
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US20090286729 |
Epidermal Growth Factor Receptor Antagonists and Methods of Use
The present invention features epidermal growth factor receptor (EGFR) antagonists. These EGFR antagonists are polypeptide variants of ligands of EGFR. The EGFR ligand polypeptide variants of the...
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US20090286728 |
Tooth root formation promoting factors and method for promotion of tooth root formation
The present invention provides a tooth root formation promoting factor and a method for promotion of tooth root formation, which can promote tooth root formation and which are useful in various...
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US20090286727 |
DP-78-Like Nanobodies
The present invention relates to Nanobodies® that have a high degree of sequence homology with human variable domain sequences from the V H 4 class and in particular with human DP-78 sequences,...
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US20090286726 |
USE OF THE LONG PENTRAXIN PTX3 FOR THE PREVENTION OR TREATMENT OF VIRAL DISEASES
It is described the use of the long pentraxin PTX3 (PTX3) or one of its functional derivatives, for the preparation of a medicament for the prevention or treatment of viral diseases and/or for...
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US20090286725 |
PEPTIDES AND DERIVATIVES THEREOF, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION
Peptides and peptide derivatives of the following general Formula I:
(SEQ ID NO: 15) (I) H 2 N-GHRPX 1 X 2 X 3 X 4 X 5 X 6 X 7 X 8 PX 9 X 10 X 11 PX 12 PPPX 13 X 14 X 15 X 16 GYR-X 17 ,
...
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US20090286724 |
AGGREGABLE GLP-1 ANALOGUE AND SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION
The present invention provides a GLP-1 analogue having a high association-aggregability or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition to be used for preventing or...
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US20090286723 |
Hybrid Polypeptides with Selectable Properties
The present invention relates generally to novel, selectable hybrid polypeptides useful as agents for the treatment and prevention of metabolic diseases and disorders which can be alleviated by...
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US20090286722 |
Analogs of Gastric Inhibitory Polypeptide as a Treatment for Age Related Decreased Pancreatic Beta Cell Function
Peptide analogues and methods are provided for treating age-related symptoms of decreased pancreatic beta-cell function, including glucose intolerance, type 2 diabetes, beta-cell glucose...
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US20090286721 |
TARGETED PLASMINOGEN ACTIVATOR FUSION PROTEINS AS THROMOBOLYTIC AGENTS
This invention relates to novel fusion proteins, comprising a targeting protein and a plasminogen activator, preferably an antibody that binds to P-selectin, operably linked to the plasminogen...
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US20090286719 |
MODIFICATION OF CUPREDOXIN DERIVED PEPTIDES AND METHODS OF USE THEREOF
The present invention provides modified cupredoxin derived peptides with pharmacologic activity that have improved pharmacokinetic properties, and methods to use them to treat mammals suffering...
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US20090285880 |
DRIED RECONSTITUTED VESICLE FORMATION FOR PHARMACEUTICAL APPLICATION
The present invention relates to dried reconstituted vesicle (DRV) compositions and water based formulations thereof, which contain one or more therapeutic agents (e.g. hydrophilic protein). More...
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US20090285874 |
Implantable Devices For Accelerated Healing
Implantable devices (e.g., stent) having a protein patterning or bioactive patterning for accelerated healing and method of forming and using the same are provided.
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US20090285846 |
MUTANTS OF CHOLESTEROL-DEPENDENT CYTOLYSINS AND USES THEREOF
Mutants of cholesterol-dependent cytolysins comprising at least one amino acid substitution in at least one of Loop 1, Loop 2, or Loop 3 of Domain 4, nucleic acids encoding such polypeptide...
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US20090285838 |
USE OF SOLUBLE CD164 IN INFLAMMATION AND AUTOIMMUNE DISORDERS
The present invention relates to novel therapeutic uses of soluble proteins comprising the extracellular region of human CD164, in particular for treating inflammatory and/or autoimmune disorders.
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US20090285825 |
NOVEL SNAKE TOXIN
This invention is in the field of snake venom and the invention provides a novel snake toxin protein and nucleic acids encoding the same. Also, provided are various uses and compositions based on...
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US20090285798 |
CD4 MIMIC PEPTIDES AND THEIR USES
An isolated peptide comprising the sequence (I): TPA-Asn-Leu-His-Phe-Cys-Gln-Leu-Xaa a -Cys-Lys-Ser-Leu-Gly-Leu-Leu-Gly-Arg-Cys-Xaa b -Xaa c -Xaa d -Xaa e -Cys-Ala-Cys-Val-NH 2 , wherein: TPA...
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US20090285785 |
External Agent for Treatment of Skin Ulcer
[Problems] To provide a novel external agent for treatment of skin ulcer which has an excellent healing effect on intractable skin ulcer such as bedsore, diabetic skin ulcer and ischemic skin...
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US20090285771 |
Methods and compositions for needleless delivery of macromolecules
Methods and compositions for needleless delivery of macromolecules to the bloodstream of a subject are provided herein. In one aspect, the invention provides a delivery construct, comprising a...
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US20090285770 |
Topical Compositions for Promoting Homeostasis of the Skin
The invention relates in particular to a composition for topical application to the skin, comprising, in a physiologically acceptable medium, at least one peptide increasing the expression of...
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US20090285762 |
IMAGING METHODS AND COMPOSITIONS COMPRISING FLUORESCENT DYES ASSOCIATED WITH VIRAL COMPONENTS FOR NERVE IMAGING
Disclosed herein are compositions and methods for imaging nerve cells. The composition comprises a fluorescent dye; and a viral component selected from a neurotropic, replication-defective virus, a...
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US20090282495 |
NEUROTROPHIC FACTOR MANF AND USES THEREOF
The present invention generally relates to the field of treatment of neuronal disorders and more particularly to neurotrophic factor MANF and uses thereof. The present invention provides a...
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US20090281040 |
Methods For Treating Endoplasmic Reticulum (ER) Stress Disorders
The present invention provides methods for treating ER stress disorders and for identifying compounds for treating ER stress disorders.
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US20090281039 |
SATIETY INDUCING PRODUCTS AND A METHOD OF THEIR PRODUCTION
The invention relates to a food product inducing satiety with the aim of contributing to weight management. The product contains as its essential ingredients viscous soluble dietary fibre or other...
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US20090281038 |
Phylloplanins Inhibition of Microbial Growth on Organic Materials
The present invention relates to plant proteins produced by a plant's epidermal layer that contribute to the innate pest/disease resistance of the plant (“phylloplanins’), compositions...
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US20090281037 |
Method of Reducing Injury to Mammalian Cells
A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to the neuron an effective inhibiting...
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US20090281036 |
FUSION PEPTIDE FOR INHIBITING INTERACTION OF NEURONAL NMDA RECEPTOR (NMDAR) AND NMDAR INTERACTING PROTEINS
The present invention provides a fusion peptide comprising at least a component (I), wherein component (I) comprises a transporter peptide, and a component (II), selected from a peptide inhibiting...
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US20090281035 |
Soluble Heterodimeric Receptors and Uses Thereof
Soluble versions of heterodimeric receptors, e.g., CD94/NKG2 receptors, and methods of producing and using such constructs, are described. The constructs comprise soluble fragments of, each...
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US20090281034 |
Microencapsulation and sustained release of biologically active polypeptides
The invention relates to compositions and methods for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible...
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US20090281033 |
Control of radiation injury
The invention relates to the field of drug development against acute radiation injury caused by exposure to high-energy electromagnetic waves (X-rays, gamma rays) or particles (alpha particles,...
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US20090281032 |
Modified CCK peptides
The invention concerns a peptide based on biologically active CCK-8. The peptide has improved characteristics for the treatment of at least one of obesity and type 2 diabetes and has the structure:...
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US20090281031 |
Methods and Compositions Related to Improving Properties of Pharmacological Agents Targeting Nervous System
Disclosed are compositions and methods related to improving pharmacological properties of bioactive compounds targeting nervous system.
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US20090281030 |
Genes Associated with Macular Degeneration
Identification of variant genes correlated with age related macular degeneration, such as variant LOC387715, variant SYNPR and variant PDGFC; methods of identifying or aiding in identifying...
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US20090281029 |
LACTOFERRIN COMPLEX AND METHOD OF PRODUCING THE SAME
A biologically active complex of lactoferrin with a branched non-peptide hydrophilic polymer, one example of which is represented by the following formula [I]:
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US20090281028 |
OSK1 peptide analogs and pharmaceutical compositions
Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition...
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US20090281027 |
MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES
The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot...
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US20090281026 |
Use of BiP or a Variant, Homologue, Derivative or Fragment Thereof in the Manufacture of a Medicament for the Prevention or Treatment of Bone Loss or Bone Resorption
The present invention relates to the use of BiP or a variant, homologue, derivative or fragment thereof in the manufacture of a medicament for the prevention or treatment of bone loss or bone...
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US20090281025 |
INHIBITION OF TUMOR GROWTH AND METASTASIS BY ATF2-DERIVED PEPTIDES
The present invention relates to novel therapies for cancer and, in particular, to therapies that are particularly suited to tumor cells resistant to other types of therapies, such as radiation...
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US20090281024 |
Compositions Comprising Receptor-Associated Protein (RAP) Variants Specific for CR-Containing Proteins and Uses Thereof
The present invention relates generally to receptor-selective variants of the low-density lipoprotein receptor-associated protein (RAP) and compositions thereof, methods of generating such variants...
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US20090281023 |
Mixtures Of Calcitonin Drug-Oligomer Conjugates And Methods Of Use In Pain Treatment
A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower...
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US20090280192 |
METHOD FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE
Disclosed is a method for treating or preventing Alzheimer's disease by restricting the level of metabolizable carbohydrate in the diet and/or administering to the patient an effective amount of an...
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US20090280190 |
ANTI-ANGIOGENIC PEPTIDES FROM THE N-TERMINUS OF ENDOSTATIN
Provided herein are anti-angiogenic comprising the N-terminal end of endostatin, nucleic acids encoding the same, pharmaceutical preparations comprising an effective amount of the peptide and...
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US20090280182 |
Devices for the treatment of wounds and methods and kits therefor
Interpenetrating network hydrogels are described that may be incorporated into wound dressings and/or in implants. The properties of the interpenetrating network hydrogel may be tuned to control an...
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US20090280161 |
Thin Film Multilocular Structure Made of Collagen, Member for Tissue Regeneration Containing The Same, and Method for Producing The Same
The present invention provides a new structure made of collagen for improving promotion of nerve tissue regeneration, curing and regeneration of a defective part of a soft biological tissue and so...
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