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US20110033547 DEHYDRATED CHITOSAN NANOPARTICLES  
The present invention relates to dehydrated nanoparticles comprising chitosan and a nucleic acid. Preferably, the nucleic acid is a siRNA. Dehydrated nanoparticles of the invention have improved...
US20110172144 METHODS FOR INCREASING EXPRESSION OF SERCA2A IN CARDIAC MUSCLE  
The present invention relates to methods for augmenting SERCA2 mediated calcium ion transport into the sarcoplasmic reticulum of cardiac myocytes of a host. The method includes administering to...
US20150151002 TARGETED THERAPY FOR THE PREVENTION OF RESTENOSIS IN THE CARDIOVASCULAR SYSTEM  
Provided herein are compositions and methods for targeted drug delivery to prevent restenosis in the cardiovascular system. In particular, provided herein are nanoscale delivery vehicles for drugs...
US20150141321 COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY  
Provided are 9-base morpholino antisense compounds targeted to polyCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA, and related methods for treating myotonic...
US20140107013 COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY  
Provided are 9-base morpholino antisense compounds targeted to polyCUG repeats in the 3′UTR region of dystrophia myotonica protein kinase (DMPK) mRNA, and related methods for treating myotonic...
US20100330158 PROTEIN-ASSISTED DRUG DELIVERY SYSTEM FOR THE TARGETED ADMINISTRATION OF ACTIVE AGENTS  
The present invention provides a composition and prodrug for targeted drug delivery to the central nervous system of a patient. The inventive composition and prodrug include a pharmaceutically...
US20120309672 TREATMENT OF EXTRACELLULAR MATRIX TO REDUCE INFLAMMATION  
Pharmaceutical compositions are provided. The compositions comprise a compound comprising the hyaluronan-containing structure A-(low molecular weight hyaluronan domain)-B. The compositions also...
US20150250850 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HYPERLIPIDEMIA, FATTY LIVER, ATHEROSCLEROSIS AND OTHER DISORDERS ASSOCIATED WITH METABOLIC SYNDROME  
The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis,...
US20140044644 ANKYRIN G AND MODULATORS THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS  
The present invention generally relates to the technical field of medicine, in particular to the field of neurodegenerative, neurological and protein misfolding disorders such as amyloidosis. By...
US20110033468 Ophthalmic Drug Delivery System Containing Phospholipid and Cholesterol  
An ophthalmic drug delivery system that contains phospholipid and cholesterol for prolonging drug lifetime in the eyes.
US20130012426 Virion Derived Protein Nanoparticles For Delivering Diagnostic Or Therapeutic Agents For the Treatment of Psoriasis  
This invention relates to a transdermal delivery system for treating skin related diseases employing protein nanoparticles to deliver drugs to the keratinocytes and basal membrane cells for the...
US20110212160 CONFIGURABLE MICROSCOPIC MEDICAL PAYLOAD DELIVERY DEVICE TO DELIVER NUCLEAR SIGNALING PROTEINS TO SPECIFIC CELLS TO MANAGE DIABETES MELLITUS AND GENETIC DEFICIENCY DISORDERS  
The innovative treatment strategy described here utilizes configurable microscopic medical payload delivery devices to act as a transport vector to deliver nuclear signaling proteins to specific...
US20130095091 METHODS OF REGULATING UPTAKE AND TRANSCELLULAR TRANSPORT OF LEUKOCYTES AND THERAPEUTICS  
Methods for controlling and regulating engulfment, uptake and/or transcellular transport at a stage following initial engagement of an agent to the endothelium are provided, based on the...
US20150247839 CMPF AS A BIOMARKER FOR DIABETES AND ASSOCIATED METHODS  
Provided are methods for identifying or monitoring a subject having, or at risk of developing, impaired glucose homeostasis. Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) is shown to be a...
US20130288949 COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN  
The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such...
US20140038880 Compositions and Methods for Promoting Wound Healing and Tissue Regeneration  
Provided herein are compositions and methods for use in promoting wound healing and tissue regeneration following tissue injury in a subject.
US20150216930 CYSTINOSIN REPLACEMENT FACTOR  
The present invention provides compositions and methods for providing factor replacement therapy. In particular, the present invention provides replacement therapy for subjects suffering from...
US20110150894 METHODS OF MODULATING ANGIOGENESIS VIA TRPV4  
The present invention relates to methods of inhibiting capillary endothelial (CE) cell migration, the formation of CE networks and angiogenesis, and uses thereof for the purpose of treating...
US20140037554 CUPREDOXIN DERIVED TRANSPORT AGENTS AND METHODS OF USE THEREOF  
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains...
US20130011338 CUPREDOXIN DERIVED TRANSPORT AGENTS AND METHODS OF USE THEREOF  
The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains...
US20150004220 RLIP76 AS A MEDICAL CHEMICAL COUNTERMEASURE  
Provided herein are methods of preventing or reducing the effects of exposure to a mustard compound. The methods include the steps of contacting cells exposed to a mustard compound or at risk of...
US20130295115 COMPOSITIONS AND METHODS FOR TREATING ALPHAVIRUS INFECTION  
Provided herein are compositions and methods for treating a disease or disorder associated with an alphavirus infection. Specifically, the invention relates to administering a Natural...
US20150038401 CARRIER FOR TARGETING NERVE CELLS  
The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically...
US20120172283 METHODS AND COMPOSITIONS FOR TARGETED DRUG DELIVERY  
Disclosed are Drug Delivery Molecules (DDMs) which both facilitate functional imaging, as by PET, MRI or SPECT, and create a biological effect and methods of their use. These DDMs which are...
US20110223204 TREATMENT OF PAIN WITH GAP JUNCTION MODULATION COMPOUNDS  
The present invention relates to delivery, including transdermal delivery, of a therapeutically effective amount of a compound useful for modulating gap junction formation and function, including...
US20110098211 MUTEINS WITH TEAR LIPOCALIN HAVING AFFINITY TO HUMAN C-MET RECEPTOR TYROSINE KINASE AND METHODS FOR OBTAINING THE SAME  
The present invention relates to novel muteins derived from human tear lipocalin having affinity to human c-Met receptor tyrosin kinase (c-Met). The invention also refers to a corresponding...
US20140241993 FLUORESCENT CHLOROTOXIN CONJUGATE AND METHOD FOR INTRA-OPERATIVE VISUALIZATION OF CANCER  
A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for...
US20140045741 Method Of Treating An Ocular Disease And Compositions Effective For Treating An Ocular Disease  
Methods and compositions are provided for treating an ocular disease in a subject in need thereof by increasing the bioavailability of a drug in the subject's eye. In one aspect, the ocular...
US20110209248 NOVEL SUGAR TRANSPORTERS  
A novel class of transporter protein, referred to as SWEET, GLUE or Glü, is disclosed. These transporters provide a novel system for the transportation of sugars across membranes within a cell and...
US20150133362 COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION  
Aspects of the invention provide methods for selecting a candidate oligonucleotide for activating expression of a target gene. Further aspects of the invention provide methods of selecting a set...
US20110091467 COMPOSITIONS AND METHODS FOR MODULATING DOPAMINE NEUROTRANSMISSION  
The present invention provides for diagnosis or treatment of neurological or neuropsychiatric disorders involving abnormal dopamine neurotransmission. Methods and agents are provided for...
US20140287983 ANTISENSE COMPOSITIONS AND METHODS FOR MODULATING CONTACT HYPERSENSITIVITY OR CONTACT DERMATITIS  
Provided are methods and compositions, including topical compositions, for inducing tolerance to a sensitizing agent known to provoke contact hypersensitivity in a subject. Included are methods of...
US20140348754 Method of Delivering Therapeutics and Imaging Agents to the Brain by Nanoparticles that Cross the Blood Brain Barrier  
Described herein are methods of delivering a nanoparticle to the brain of a subject by administering to the subject a nanoparticle having a nanoparticle core and a targeting agent. A variety of...
US20150024030 PROTECTION AGAINST AND TREATMENT OF IONIZING RADIATION  
Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and...
US20120010123 METHODS OF TREATING METABOLIC DISORDERS AND CARDIOVASCULAR DISEASES  
A method of treating an LCN13-related condition is provided comprising administering to a patient in need thereof a therapeutically effective amount of a lipocalin or a physiologically active...
US20100297120 APROTININ-LIKE POLYPEPTIDES FOR DELIVERING AGENTS CONJUGATED THERETO TO TISSUES  
Based on our identification of a polypeptide (Angiopep-7) that is efficiently transported to cells such as liver, lung, kidney, spleen, and muscle, the invention provides polypeptides, conjugates...
US20140286863 Complexation of Fatty Acid-Conjugated Molecules with Albumin  
The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a...
US20080032928 Treatment of mucus hypersecretion  
The present invention relates to treatment of mucus hypersecretion, to compositions therfor and manufacture of those compositions. The present invention relates particularly, though not...
US20110028384 RAP VARIANTS FOR DRUG DELIVERY  
The present invention relates to stabilized RAP variants and methods of use thereof. Conjugates of stabilized RAP variants to therapeutic compounds and stabilized RAP fusion proteins comprising...
US20110172143 METHOD OF MODULATING CELL SURVIVAL AND REAGENTS USEFUL FOR SAME  
The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival...
US20140329737 Development of Novel Macromolecule Transduction Domain with Improved Cell Permeability and Method for Using Same  
The present invention relates to an improved macromolecule transduction domain (MTD), which facilitates permeating the cell membrane of a biologically active molecule, having enhanced cell...
US20150119316 ANTISENSE COMPOSITION AND METHOD FOR TREATING MUSCLE ATROPHY  
A method and compound for treating skeletal muscle mass deficiency in a human subject are disclosed. The composition is an oligomer of morpholino subunits and phosphorus-containing intersubunit...
US20100209443 Vaccine for the Prevention of Breast Cancer Relapse  
The invention features methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, E75, with the effect of inducing and maintaining...
US20120020878 FUSOGENIC PROPERTIES OF SAPOSIN C AND RELATED PROTEINS AND PEPTIDES FOR APPLICATION TO TRANSMEMBRANE DRUG DELIVERY SYSTEMS  
The present invention comprises a method for delivering pharmaceutical and/or imaging agents within and/or through the dermal, mucosal and other cellular membranes, and across the blood-brain...
US20150133363 GLUT-1 AS A RECEPTOR FOR HTLV ENVELOPES AND ITS USES  
The present application relates to polypeptides derived from the soluble part of the glycoprotein of the enveloped virus of Primate T-cell leukemia virus (PTLV), or fragments or variants thereof...
US20150086620 LIPOSOMES FOR PROTECTION AGAINST TOXIC COMPOUNDS  
Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and...
US20140010864 LIPOSOMES FOR PROTECTION AGAINST TOXIC COMPOUNDS  
Methods of preparing a proteoliposome comprise the step of contacting a liposome with an effective portion of RalBP1 to create a proteoliposome. RalBP1 is effective for the protection and...
US20100098752 Materials and Methods for Delivering Antioxidants into the Skin  
Compositions and methods for administering one or more antioxidants to a human subject have been developed. The antioxidant-containing lipid vesicles of the invention provide a delivery system for...
US20150246950 Chimeric Dystrophin-VSV-G Protein to Treat Dystrophinopathies  
A chimeric protein that is a fusion construct of a series of functional domains is used to deliver a therapeutic agent to a human subject suffering from disease. In some embodiments, the chimeric...
US20070219134 LYMPHATIC ZIP CODES IN TUMORS AND PRE-MALIGNANT LESIONS  
Disclosed herein are compositions and methods for and involving selectively targeting tumor lymphatics.

Matches 1 - 50 out of 364 1 2 3 4 5 6 7 8 >