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US20130137601 LAMINAR LIBRARY SCREEN  
Described is a method of screening libraries of variant proteins produced in plant leaves using a plant viral vector to identify a gene of interest comprising, inoculating leaves with a library of...
US20130137600 LAMINAR LIBRARY SCREEN  
Described is a method of screening libraries of variant proteins produced in plant leaves using a plant viral vector to identify a gene of interest comprising, inoculating leaves with a library of...
US20110318344 Tumor Treatment  
The patent discloses the use of Hepatocellular Carcinoma Related Protein 1 (HCRP1) as a marker for the efficiency of an anti-EGFR antibody treatment of a tumour patient. If a tumour biopsy sample...
US20120302450 Bacterial Metastructure and Methods of Use  
The present invention provides a method of determining bacterial metastructure by integrating multiple genome-scale information yielded by high-throughput technologies. The metastructure constructs...
US20120004134 Diagnostic Assay For Source of Inflammation  
A method of diagnosing the source of local, acute inflammation has been developed based on the discovery that white cells have different patterns of gene expression, and therefore protein markers,...
US20120004121 Diagnostic Assay For Source of Inflammation  
A method of diagnosing the source of local, acute inflammation has been developed based on the discovery that white cells have different patterns of gene expression, and therefore protein markers,...
US20110201513 PROTEIN SPLICE VARIANT / ISOFORM DISCRIMINATION AND QUANTITATIVE MEASUREMENTS THEREOF  
The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a...
US20120129880 METHOD FOR DETERMINING SENSITIVITY TO IRINOTECAN AND USE THEREOF  
To provide a method for determining the sensitivity of a patient to irinotecan, SN-38, and/or a salt thereof, which method can determine the therapeutic response of the patient and to provide a...
US20110294681 METHODS FOR BREAST CANCER RISK ASSESSMENT  
The present invention relates to methods and systems for assessing the overall risk of a human female subject for developing a breast cancer phenotype. In particular, the present invention relates...
US20100331193 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination  
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are...
US20120094854 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PSYCHOTIC DISORDERS THROUGH THE IDENTIFICATION OF THE OLANZAPINE POOR RESPONSE PREDICTOR GENE SIGNATURE  
Methods and compositions relate to genetic markers of psychotic disorders, e.g., schizophrenia (SZ), are provided. For example, in certain aspects methods for determinations of a OPRP genetic...
US20100298164 STRUCTURE-BASED APPROACH TO DESIGN OF INHIBITORS OF PROTEIN-PROCESSIVITY FACTOR INTERACTIONS  
A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor...
US20130137753 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF BREAST CANCER  
Embodiments of the present disclosure relate to methods and compositions for the diagnosis and treatment of breast cancer. In some embodiments, the present disclosure relates to the use of Merlin,...
US20120302447 MOCK COMMUNITY FOR MEASURING PYROSEQUENCING ACCURACY AND METHOD OF MEASURING PYROSEQUENCING ACCURACY USING THE SAME  
The present invention describes a method of measurement of pyrosequencing accuracy by directly calculating sequence errors from FLX Titanium pyrosequencing using mock community, according to the...
US20130203814 Association of Rare Recurrent Genetic Variations to Attention-Deficit, Hyperactivity Disorder (ADHD) and Methods of Use Thereof for the Diagnosis and Treatment of the Same  
Compositions and methods for the detection and treatment of ADHD are provided.
US20140051585 METHODS AND COMPOSITIONS FOR REDUCING GENETIC LIBRARY CONTAMINATION  
Embodiments include methods, compositions, and kits for creating genetic libraries useful for massively parallel genetic sequencing. Some embodiments are directed to methods of preventing the...
US20100313290 MULTIPLEX ANALYSIS OF STACKED TRANSGENIC PROTEIN  
The invention relates to methods for multiplex analysis of complex protein samples from plants using mass spectroscopy. In some embodiments, the disclosure concerns methods for maintaining a...
US20110124657 METHOD FOR SCREENING OF 5HT7 RECEPTOR LIGANDS BASED ON A NEW PHARMACOPHORE MODEL AND A DESCRIPTOR'S PROFILE FILTER  
The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor; to a method for identifying them as 5-HT7 ligands, especially as agonists, by using a...
US20130202579 USE OF CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE-ALPHA (CCT-ALPHA) AS A BIOMARKER FOR CANCER PROGNOSIS  
It has previously been demonstrated that positive 8F1 immunohistochemistry is an indicator of a poor cancer prognosis and poor response to chemotherapy. The 8F1 antibody was generated by...
US20140113832 ENGINEERED THIOREDOXIN-LIKE FOLD PROTEINS  
The invention features compositions based on thioredoxin-like fold protein domains described as engineered thioredoxin-like fold proteins (ETRXs). These proteins include one or more artificially...
US20130209460 METHODS AND KITS USED IN IDENTIFYING GLIOBLASTOMA  
The invention encompasses methods and kits used in the identification of invasive glioblastoma based upon the expression of TROY. The methods and kits also allow prediction of disease outcome as...
US20110262426 METHODS AND KITS USED IN IDENTIFYING GLIOBLASTOMA  
The invention encompasses methods and kits used in the identification of invasive glioblastoma based upon the expression of TROY. The methods and kits also allow prediction of disease outcome as...
US20120277211 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PSYCHOTIC DISORDERS THROUGH THE IDENTIFICATION OF THE SULT4A1-1 HAPLOTYPE  
Methods and compositions that relate to genetic markers of psychotic disorders, e.g., schizophrenia (SZ), are provided. For example, in certain aspects methods for determinations of a SULT4A1-1...
US20110105466 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PSYCHOTIC DISORDERS THROUGH THE IDENTIFICATION OF THE SULT4A1-1 HAPLOTYPE  
Methods and compositions relate to genetic markers of psychotic disorders, e.g., schizophrenia (SZ), are provided. For example, in certain aspects methods for determinations of a SULT4A1-1...
US20130330333 TREATMENT OF ANGIOGENESIS DISORDERS  
This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.
US20120040848 MOLECULAR SIGNATURE OF LIVER TUMOR GRADE AND USE TO EVALUATE PROGNOSIS AND THERAPEUTIC REGIMEN  
The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a...
US20110183862 MOLECULAR SIGNATURE OF LIVER TUMOR GRADE AND USE TO EVALUATE PROGNOSIS AND THERAPEUTIC REGIMEN  
The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a...
US20130171069 NEUROTOXIC TARGET FOR AMYLOSPHEROID, METHOD AND MATERIAL FOR REDUCING THE NEUROTOXICITY OF AMYLOSPHEROID, AND USE THEREOF  
In one or a plurality of embodiments, there is provided a target molecule of amylospheroid, which is expressed in mature neurons and to which the amylospheroid binds to induce death of cells....
US20130267438 USE OF SPECIFIC GENES FOR THE PROGNOSIS OF LUNG CANCER AND THE CORRESPONDING PROGNOSIS METHOD  
At least 13 genes chosen among a set of 28 genes for carrying out a method for identifying at least 66% of patients of those having a survival rate of at most about 20% at 30 months, among a...
US20120178641 GLOBAL MAPPING OF PROTEIN-DNA INTERACTION BY DIGITAL GENOMIC FOOTPRINTING  
The present invention provides a method for globally mapping a genome for its protein-binding pattern. A computer system useful for this purpose is also described.
US20130072389 THERANOSTIC AND DIAGNOSTIC METHODS USING SPARC AND HSP90  
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. The molecular profiling can be used to provide a diagnosis, prognosis, or theranosis for the disease,...
US20110092569 Administration of Exogenous mi/siRNA  
Certain genes controlled by endogenous miRNA are actually upregulated upon the transfection of exogenous mi/siRNA. Based on this, methods of determining whether administration of mi/siRNA will have...
US20130149336 Methods for Screening Viral Like Particles and Identifying Neutralizing Epitopes and Related Vaccines, Constructs, and Libraries  
The invention is directed to methods of screening immunogenic viral like particles and related immunogenic compositions and diagnostic techniques. In one embodiment, the invention provides methods...
US20130090261 Device for Determining or Studying the State of Stimulation of the Natural Defences of Plants or Portions of Plants  
The present invention relates to a device for determining or studying the state of stimulation of the natural defenses of plants or plant portions, which plants advantageously belong to the...
US20110301059 Biomarkers For Human Papilloma Virus-Associated Cancers  
Cervical cancer cells and HPV+ head and neck cancer cells express three testis-specific genes not normally expressed in somatic cells: testicular cell adhesion molecule 1 (TCAM1), synaptonemal...
US20140100188 PHENOTYPING TUMOR-INFILTRATING LEUKOCYTES  
The present disclosure relates to an immune signature of tumor infiltrating leukocytes. In particular, the disclosure provides methods and kits for determining the immune signature of tumor...
US20120329878 PHENOTYPING TUMOR-INFILTRATING LEUKOCYTES  
The present disclosure relates to an immune signature of tumor infiltrating leukocytes. In particular, the disclosure provides methods and kits for determining the immune signature of tumor...
US20130130925 TOOL FOR DIAGNOSIS AND PROGNOSIS OF MATURE B-CELL NEOPLASMS  
The present invention provides a microarray useful as a tool in the diagnosis and/or prognosis of certain types of cancers, particularly mature B-cell neoplasms. The microarray can include a...
US20120225796 TOOL FOR DIAGNOSIS AND PROGNOSIS OF MATURE B-CELL NEOPLASMS  
The present invention provides a microarray useful as a tool in the diagnosis and/or prognosis of certain types of cancers, particularly mature B-cell neoplasms. The microarray can include a...
US20110160079 TOOL FOR DIAGNOSIS AND PROGNOSIS OF MATURE B-CELL NEOPLASMS  
The present invention provides a microarray useful as a tool in the diagnosis and/or prognosis of certain types of cancers, particularly mature B-cell neoplasms. The microarray can include a...
US20120027766 METHODS AND MEANS FOR TREATMENT OF OSTEOARTHRITIS  
The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically, the invention relates to methods and...
US20130116135 Methods, Kits and Reagents for Diagnosing, Alding Diagnosis and/or Monitoring Progression of a Neurological Disorder  
The present inventors have identified a panel of biomarkers present in a biological sample of an individual (e.g. blood, including serum or plasma) whose concentrations or levels are altered in...
US20120329671 METHODS OF IDENTIFYING OBM MODULATORS  
Novel proteins and polypeptides binding to osteoclastogenesis inhibitory factor (OCIF) (OCIF-binding molecules, OBMs) and nucleic acids encoding these proteins and polypeptides are provided....
US20110077283 MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES  
The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation,...
US20130274129 TAL-EFFECTOR ASSEMBLY PLATFORM, CUSTOMIZED SERVICES, KITS AND ASSAYS  
The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional...
US20120258074 Systems, Models and Methods for Identifying and Evaluating Skin-Active Agents Effective for Treating Dandruff/Seborrheic Dermatitis  
Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for...
US20140024552 COMPOSITIONS AND METHODS FOR DIAGNOSING OVARIAN CANCER  
The invention provides methods and compositions for distinguishing ovarian cancer from a benign pelvic mass using two or more of the following biomarkers: IL-6, MMP9, tPA, IGFBP2, MMP7, Tenascin,...
US20130079243 Fibronectin Type III Repeat Based Protein Scaffolds with Alternative Binding Surfaces  
Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors,...
US20110059074 Knowledge-Based Proliferation Signatures and Methods of Use  
The present invention provides methods and compositions for predicting patient responses to cancer treatment using a proliferation gene signature. These methods can comprise measuring in a...
US20130266557 METHODS FOR TREATMENT OF A SARCOMA USING AN EPIMETABOLIC SHIFTER (COENZYME Q10)  
Methods and formulations for treating a sarcoma in humans using an epimetabolic shifter, such as Coenzyme Q10, a building block of CoQ10, a derivative of CoQ10, an analog of CoQ10, a metabolite of...