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US20130023439 Method and Kit for Determining Sensitivity to Decitabine Treatment  
The present invention is a gene expression panel of chemotherapeutic drug-resistant cancer stem cells comprising RIN1, SOX15 and TLR4. In one embodiment the cancer stem cells are testicular cancer...
US20110177054 USE OF ENDO-LYSOSOMAL SYSTEM AND SECRETED VESICLES (EXOSOME-LIKE) IN TREATMENTS AND DIAGNOSTICS BASED ON SMALL RNA AND EXPERIMENTAL STUDY OF SMALL RNA  
The present invention relates to a method for determining the delivery rates and/or efficiency of a siRNA, miRNA or related molecule to target organs or cells, a kit and the use of proteins or...
US20120122707 HIGH THROUGHPUT APPROACH TO FORMULATION USING PRE-DESIGNED FORMULATION PLATES  
System and methods provide formulation using pre-designed formulation plates for rapidly formulating proteins and peptides, wherein proteins are added to a plurality of wells in the plate; means...
US20110224086 Methods and Algorithms for Selecting Polynucleotides For Synthetic Assembly  
The present invention relates to methods and algorithms for identifying, synthesizing and co-assembling combinatorial libraries of polynucleotide variants.
US20110301041 Modified Proteins and Methods of Making and Using Same  
Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example,...
US20140086899 DIAGNOSTIC AND PROGNOSTIC ASSAY FOR A CONDITION OR EVENT OF THE VASCULAR SYSTEM  
The present disclosure relates generally to the field of diagnostic and prognostic assays for a condition or event of a vascular system such as the cerebrovascular system. An assay is taught herein...
US20120201837 USE OF EIF3M FOR THE DIAGNOSIS AND TREATMENT OF CANCER  
Disclosed are a cancer marker-detecting composition comprising an agent for measuring an mRNA or protein expression level of eIF3m, a cancer diagnosis kit comprising the same, a method for...
US20140005059 BIOMARKERS FOR CANCER  
The instant invention provides methods and compositions for the diagnosis and treatment of cancer. The invention also provides method and compositions for determining if a subject is, or is at risk...
US20140162254 BREAST TUMOUR GRADING  
We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from...
US20110020317 BREAST TUMOUR GRADING  
We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from...
US20100331201 PROTEIN BIOCHIP FOR THE DIFFERENTIAL SCREENING OF PROTEIN-PROTEIN INTERACTIONS  
The present invention relates to a system of protein binders containing at least one protein binder presented in at least one native form and at least one non-native form and its use including a...
US20130195870 ERBB3 Mutations In Cancer  
The present invention concerns somatic ErbB3 mutations in cancer including methods of identifying, diagnosing, and prognosing ErbB3 cancers, as well as methods of treating cancer, including certain...
US20110160070 COPD BIOMARKER SIGNATURES  
The present invention relates to methods of detecting differentially expressed protein expression indicative of COPD in a test sample. The detection of circulating levels of proteins within an...
US20140179538 MUTATIONS IN PANCREATIC NEOPLASMS  
To help reveal the pathogenesis of these lesions, we purified the DNA from Intraductal Papillary Mucinous Neoplasm (IPMN) cyst fluids from 19 patients and searched for mutations in 169 genes...
US20120028816 METHODS AND SYSTEMS FOR SCREENING FOR AND DIAGNOSING DNA METHYLATION ASSOCIATED WITH AUTISM SPECTRUM DISORDERS  
Methods and systems for population screening and diagnostics are provided. In particular methods and systems for population screening of individuals for genetic disorders due to alterations in DNA...
US20130316014 METHODS FOR PREDICTING PROGNOSIS OF A SUBJECT WITH A MYELOID MALIGNANCY  
One aspect of the present disclosure includes a method for predicting the prognosis of a subject with a myeloid malignancy. One step of the method includes obtaining a biological sample from the...
US20120329661 Isotope Labeling-Assisted Quantification (iLAQ) of Biological Compounds  
The present invention relates to a plurality of isotopically labeled compounds (“tag isotopomers”) and individual labeled compounds, which are useful for labeling samples of analytes, such as bio...
US20140228224 SPECIFIC ALLELES IMPORTANT FOR ETHANOL TOLERANCE  
The present disclosure relates to the identification of a QTL associated with high ethanol tolerance in Saccharomyces spp. More specifically, it relates to specific alleles of MKT1 and APJ1...
US20110287968 Methylation Assay  
The present invention discloses a method of generating subsets of methylation specific markers from a set, having diagnostic power for various diseases, e.g. cancer of thyroid, breast, colon, or...
US20140171337 METHODS AND DEVICES FOR ASSESSING RISK OF FEMALE INFERTILITY  
The invention generally relates to methods and devices for assessing risk of female infertility. In certain aspects, methods of the invention involve obtaining a sample, conducting an assay on at...
US20110166040 COMPOSITIONS FOR USE IN IDENTIFICATION OF STRAINS OF E. COLI O157:H7  
The present invention relates generally to strain typing of Escherichia coli O157:H7, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular...
US20100323922 siRNA targeting TATA box binding protein (TBP)-associated factor (TAF1)  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
US20120128651 ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) BIOMARKERS  
The present invention concerns the use of biomarkers for acute lymphoblastic leukemia (ALL) to prognose or evaluate a patient with ALL who is Ph+. Methods and compositions are provided that concern...
US20120277999 METHODS, KITS AND ARRAYS FOR SCREENING FOR, PREDICTING AND IDENTIFYING DONORS FOR HEMATOPOIETIC CELL TRANSPLANTATION, AND PREDICTING RISK OF HEMATOPOIETIC CELL TRANSPLANT (HCT) TO INDUCE GRAFT VS. HOST DISEASE (GVHD)  
The invention relates to predicting or determining risk of a hematopoietic cell transplant (HCT) from a donor to induce Graft vs. Host Disease (GVHD) in a HCT recipient; to classifying HCT from a...
US20120172247 Method for measuring glycoprotein, method for examining liver disease, reagent for quantitative determination of glycoprotein, and glycan-marker glycoprotein as an index for clinical conditions of liver disease  
An object of the present invention is to provide a method for measuring a glycan-marker glycoprotein, by which liver disease can be detected with higher accuracy than is possible with conventional...
US20140018258 METHODS FOR GENETIC ANALYSIS  
Methods of treating an individual exhibiting a medical condition are disclosed. The methods involve determining a score of an individual based on the individual's genotypic information, comparing...
US20130296178 METHODS FOR GENETIC ANALYSIS  
Methods of treating an individual exhibiting a medical condition are disclosed. The methods involve determining a score of an individual based on the individual's genotypic information, comparing...
US20110250179 METHODS FOR TREATMENT AND DIAGNOSIS OF CANCER  
The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoKβ) activity as well as to methods for the design of ...
US20130090329 Methods and Compositions for the Treatment of Psychotic Disorders Through the Identification of the Olanzapine Poor Response Predictor Genetic Signature  
Methods and compositions relate to genetic markers of psychotic disorders, e.g., schizophrenia (SZ), are provided. For example, in certain aspects methods for determinations of a OPRP genetic...
US20110008914 Biomarkers for the Diagnosis and Treatment of Pancreatic Cancer  
Compositions and methods which indicate an increased risk for pancreatic carcinoma are disclosed.
US20130157895 TISSUE STAINING METHOD, TISSUE EVALUATION METHOD AND BIOSUBSTANCE DETECTION METHOD  
A tissue staining method which comprises: staining a tissue with a staining reagent wherein a biosubstance recognition site is bonded to particles carrying multiple fluorescent substances...
US20120269802 Treatment And Prognosis With Thalidomide In Multiple Myeloma Based on Karyotyping And Gene Expression Profiling  
The present invention provides a method treating a myeloma patient by administering one or more of thalidomide, a Total Therapy 2 regimen, an interleukin-6 signaling suppressor, an interleukin-6R...
US20140274923 MIRNAS AS A PROGNOSTIC BIOMARKER IN PEDIATRIC HEART FAILURE  
The present invention provides for methods of predicting progression of pediatric heart failure using miRNA biomarkers, as well as subsequent treatment of patients based on their classification.
US20140206563 BIOMARKERS FOR PSORIASIS  
A group of polypeptides that are modulated in a psoriatic sample as compared to a normal sample is provided. These polypeptides can be used as biomarkers for diagnosis and monitoring treatment of...
US20130303389 METHOD OF CLASSIFYING GENE EXPRESSION STRENGTH IN LUNG CANCER TISSUES  
The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the...
US20110059016 OPTICAL ASSAY SYSTEM WITH A MULTI-PROBE IMAGING ARRAY  
The subject matter described herein relates to an optical assay system having a multi-probe imaging array that orients a plurality of probes with respect to one another and to a sample. According...
US20130217600 METHODS OF DETERMINING EFFICACY OF TREATMENTS OF DISEASES OF THE BOWEL  
Novel methods of determining efficacy of a treatment of inflammatory diseases of the bowel in mammals are provided. The methods are of use in screening and determining the efficacy of treatments of...
US20110152117 METHODS OF DETERMINING EFFICACY OF TREATMENTS OF DISEASES OF THE BOWEL  
Novel methods of determining efficacy of a treatment of inflammatory diseases of the bowel in mammals are provided. The methods are of use in screening and determining the efficacy of treatments of...
US20140141998 NEOPLASIA SCREENING COMPOSITIONS AND METHODS OF USE  
As described in more detail below, the present invention generally features compositions and non-invasive methods useful for the screening, identification, monitoring, or diagnosis of subjects...
US20120046181 Biomarkers for the Diagnosis of Renal Allograft and Kidney Status  
The present invention relates to the identification and use of protein biomarkers with clinical relevance to kidney status and chronic renal injury or disorder. In particular, the invention...
US20110212860 Modulation of Bacterial Quorum Sensing With Synthetic Ligands  
The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for...
US20120142545 SOLID PHASE AND CATALYZED ENABLED AUTOMATED ISOTOPE DILUTION AND SPECIATED ISOTOPE DILUTION MASS SPECTROMETRY  
A method for the equilibration of enriched isotope species and natural isotope species prior to mass spectrometric analysis using solid phase and/or microwave isotope ratio equilibration and...
US20140242092 VHZ FOR DIAGNOSIS AND TREATMENT OF CANCER  
We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer, such as breast cancer, in an individual. We provide an anti-VHZ agent for the treatment, prophylaxis or...
US20120142558 DIAGNOSTIC LUNG CANCER PANEL AND METHODS FOR ITS USE  
Disclosed herein are novel diagnostic lung cancer panels and the use of these panels to diagnose, predict, and characterize lung cancer and to monitor or predict treatment efficacy.
US20120135879 Method and Composition for Cancer Diagnosis and Treatment  
Methods and compositions for inhibiting the onset of cancer, and cancer diagnosis and treatment are provided. The treatment method comprises inhibiting the level or function of transcriptional...
US20130039908 PROGNOSTIC MARKERS AND METHODS FOR PROSTATE CANCER  
The present invention relates to methods and compositions for the diagnosis, prognosis and treatment of neoplastic disorders. Some embodiments include methods, compositions, and kits for the...
US20110189173 PHOSPHORYLATED C-ErbB2 AS A SUPERIOR PREDICTIVE THERANOSTIC MARKER FOR THE DIAGNOSIS AND TREATMENT OF CANCER  
The present invention provides reliable methods to identify subsets of subjects with a cancer of epithelial origin characterized by a high level of phosphorylated c-erbB2 which does not correlate...
US20110039714 Probes, Systems, and Methods for Drug Discovery  
Aspects of the present invention include probes, methods, systems that have stand alone utility and may comprise features of a drug discovery system or method. The present invention also includes...
US20110287961 EXPRESSION ANALYSIS OF CORONARY ARTERY ATHEROSCLEROSIS  
This invention relates, e.g., to a method for screening a subject for the presence of coronary atherosclerosis, said method comprising measuring the expression level of at least 5 of the genes of...
US20130347136 Compositions and Methods for Characterizing and Treating Muscular Dystrophy  
Compositions and methods for identifying new treatments for Facioscapulohumeral muscular dystrophy (FSHD), and uses thereof.