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US20130079234 |
GENE EXPRESSION PROFILING OF PRIMARY BREAST CARCINOMAS USING ARRAYS OF CANDIDATE GENES
A method for predicting the sensitivity of tumor cells to an anthracycline-based chemotherapy includes determining the differential expression level of a MYBL2 gene in tumors cells. A...
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US20130040853 |
Context Specific Genetic Screen Platform to Aid in Gene Discovery and Target Validation
The present invention relates to a context-specific forward genetic screen designed to systematically assign relative weight of biological evidence to a library of high-probability driver genetic...
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US20120108791 |
Rotamer Libraries and Methods of Use Thereof
Rotamer libraries and methods of use thereof are provided.
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US20120255044 |
URATE TRANSPORTER, AS WELL AS METHOD AND KIT FOR EVALUATING URATE TRANSPORT-RELATED DISEASE FACTOR AND INFLAMMATION-RELATED DISEASE FACTOR, AND TEST SAMPLE AND DRUG
A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and...
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US20120322680 |
USE OF MIRNAS AS BIOMARKERS IN GLIOMA DIAGNOSIS
The present application relates to the use of miRNAs as biomarkers in glioma diagnosis. It also relates to the use of miRNAs as biomarkers in glioblastoma and oligodendroglioma diagnosis.
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US20120245041 |
BASE-BY-BASE MUTATION SCREENING
Aspects of the present invention are drawn to screening assays for isolating polynucleotides having a sequence variation or mutation. Embodiments of the screening assays include generating a...
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US20120227120 |
HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
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US20110277046 |
HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
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US20110212119 |
METHODS FOR MAKING HIV VACCINES AND RELATED COMPOSITIONS
Provided herein are methods and kits for making a targeted therapeutic for prevent and treating HIV infection. In one of these methods, the method includes preparing a library of soluble peptides,...
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US20120277112 |
PREDICTING RESPONSE TO ANTI-CANCER THERAPY VIA ARRAY COMPARATIVE GENOMIC HYBRIDIZATION
Array comparative genomic hybridization classifiers, arrays comprising the classifiers, and related methods of using the same for predicting the therapeutic efficacy of anti-cancer therapy by...
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US20130023488 |
METHODS AND COMPOUNDS FOR REDUCING INTRACELLULAR LIPID STORAGE
Compounds and compositions for reducing intracellular lipid accumulation in a cell are described herein. These compounds are useful for the treatment and prevention of lipid/glycogen disorders, as...
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US20110003708 |
BIOMARKERS FOR THE PREDICTION OF RENAL INJURY
The present invention relates to means and methods for predicting the onset of renal injury based on measuring the expression of polynucleotides and proteins, particularly on measuring the...
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US20110082072 |
Methods of Inhibiting Cell Death or Inflammation in a Mammal
In one aspect the present invention provides methods for inhibiting cell death or inflammation in a mammal, wherein the methods each include the step of administering to a mammal a Bcl protein in...
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US20130123133 |
SCREENING METHODS
The present invention provides materials and methods relating to screening for compounds useful in the treatment of Alzheimer's disease and related conditions. In particular, screening methods...
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US20110015081 |
Genetic Variants on chr 5p12 and 10q26 as Markers for Use in Breast Cancer Risk Assessment, Diagnosis, Prognosis and Treatment
The invention pertains to certain genetic variants on Chr5p12 and Chr10q26 as susceptibility variants of breast cancer. Methods of disease management, including diagnosing increased and/or...
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US20120070450 |
LEUKEMIA STEM CELL MARKERS
The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (AML) comprising (1) measuring the expression level of human leukemic stem cell (LSC)...
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US20110136685 |
METHOD FOR DETERMINING A PREDISPOSITION TO BASAL CELL CARCINOMA AND FOR SCREENING TREATMENTS THEREOF
The present invention relates to methods for detecting a predisposition to a basal cell carcinoma and methods for screening a treatment of a basal cell carcinoma.
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US20110160067 |
High throughput system for isolation, growth, and detection of lipid inclusions in bacteria
A method of high throughput growth and quantitative analysis of microorganisms is provided that includes providing a microtiter plate growth and gas delivery system having well plates disposed for...
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US20130023421 |
PROTEIN DISPLAY
The present invention relates to methods for screening a polypeptide for desired activity against a target molecule In particular, the present invention relates to methods for screening a...
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US20120052071 |
TUMOR MARKERS AND METHODS OF USE THEREOF
The invention provides newly identified proteins as markers for the detection of tumors, or as targets for their treatment, particularly of tumors affecting lung, colon, breast, ovary; affinity...
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US20120045439 |
TUMOR MARKERS AND METHODS OF USE THEREOF
The invention provides newly identified proteins as markers for the detection of tumors, or as targets for their treatment, particularly of tumors affecting lung, colon, breast, ovary; affinity...
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US20130005592 |
METHODS AND COMPOSITIONS FOR PREDICTING CANCER THERAPY RESPONSE
The invention generally relates to molecular diagnostics, and particularly to molecular markers for cancer therapy response and methods of use thereof.
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US20130059903 |
Compositions and Methods for Characterizing Breast Cancer
The invention provides compositions and methods for characterizing breast cancer stem In particular, the invention provides for the identification of cells expressing Twist and CD44 that express...
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US20120165209 |
METHODS AND COMPOSITIONS FOR DIRECTED MICROWAVE CHEMISTRY
The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special cartridges using microwave energy. The chips contain materials that...
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US20130052160 |
COMPOUNDS AND USES THEREOF TO INDUCE AN IMMUNOGENIC CANCER CELL DEATH IN A SUBJECT
The present invention relates to the fields of genetics, immunology and medicine. The present invention more specifically relates to in vitro or ex vivo methods for determining the susceptibility...
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US20110111443 |
APPARATUS FOR AUTO-PRETREATING SUGAR CHAIN
To provide an autoanalyzer for analyzing a sugar chain contained in a biological sample, in particular, serum. Namely, it is intended to provide a method of analyzing a sugar chain in a sample,...
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US20110212847 |
COMPOSITIONS AND METHODS RELATING TO MONITORING ALCOHOL CONSUMPTION AND ALCOHOL ABUSE
Methods and compositions according to embodiments of the present invention are provided that specifically and sensitively detect alcohol consumption and whether alcohol consumption is moderate or...
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US20120088689 |
METHOD OF DIAGNOSING RENAL DISORDERS
The invention refers to an in vitro method of determining the risk of renal disorders, in a patient, by measuring a VCAN parameter, characterized in that at least one of the isoforms V0 and V1 are...
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US20130012602 |
METHODS OF USING ZNF365 GENETIC VARIANTS TO DIAGNOSE CROHN'S DISEASE
The present invention relates to prognosing, diagnosing and treating of Crohn's disease. The invention also provides prognosis, diagnosis, and treatment that are based upon the presence of one or...
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US20120020953 |
DIAGNOSIS AND TREATMENT OF CANCER
Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an...
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US20110177503 |
CARDIAC RISK STRATIFICATION BY NOS1AP GENOTYPING
A risk-conferring genetic modifier is found in a large LQTS cohort. A NOS1AP tag SNP genotype provides an additional clinical assessment, which helps assess risk and choice of therapeutic...
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US20120322682 |
BRAIN INJURY BIOMARKER PANEL
A panel of biomarkers for diagnosis, monitoring of progression and prognosis of various brain injuries and PTSD.
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US20120328567 |
BIOMARKERS PREDICTIVE OF THERAPEUTIC RESPONSIVENESS TO IFNB AND USES THEREOF
Methods, assays and kits for the identification, assessment and/or treatment of a subject having multiple sclerosis (MS) (e.g., a patient with relapsing-remitting multiple sclerosis (RRMS)) are...
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US20120322675 |
GENOME-SCALE ANALYSIS OF REPLICATION TIMING
Methods for identifying and/or distinguishing a homogeneous population of cells based on their replication domain timing profile using high resolution genomic arrays or sequencing procedures are...
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US20120094857 |
Methods of Subclassification of Ductal Carcinoma of the Breast
Provided herein are methods of determining the aggressiveness or indolence of a ductal carcinoma in situ lesion. Also provided are methods of developing treatment plans for subjects with a ductal...
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US20110092385 |
COMPOSITIONS AND METHODS TO DETECT INFLUENZA VARIANTS
Methods and kits used in the detection of variants of the Influenza virus are disclosed, including variants that are resistant to treatment with antiviral compositions.
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US20120095074 |
Genetic Alterations on Chromosome 12 and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes
Compositions and methods for the detection and treatment of T1D are provided.
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US20110286997 |
Genetic Alterations on Chromosome 16 and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes
Compositions and methods for the detection and treatment of T1D are provided.
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US20110236370 |
Genetic Alterations on Chromosomes 21q, 6q and 15q and Methods of Use Thereof for the Diagnosis and Treatment of Type I Diabetes
Compositions and methods for the detection and treatment of T1D are provided.
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US20120100144 |
Biomarker and Treatment for Cancer
A correlation between expression of JMJD6 polypeptide and breast cancer metastasis exists accordingly the present invention relates a diagnostic, prognostic and therapeutic biomarker to distinguish...
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US20110269633 |
INFLAMMATORY BIOMARKERS FOR MONITORING DEPRESSIVE DISORDERS
Materials and Methods related to developing a unipolar depression (MDD) disease score in a subject using a multi-parameter system to measure a plurality of parameters, and an algorithm to calculate...
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US20130116132 |
ALZHEIMER'S PROBE KIT
Oligonucleotide probes for use in assessing gene transcript levels in a sample, which may be used in analytical techniques, particularly diagnostic techniques, are disclosed. Conveniently the...
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US20110212850 |
USING PHYLOGENETIC PROBES FOR QUANTIFICATION OF STABLE ISOTOPE LABELING AND MICROBIAL COMMUNITY ANALYSIS
Herein is described methods for a high-sensitivity means to measure the incorporation of stable isotope labeled substrates into RNA following stable isotope probing experiments (SIP). RNA is...
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US20110046005 |
METHOD AND NUCLEIC ACIDS FOR THE ANALYSIS OF COLON CELL PROLIFERATIVE DISORDERS
Provided are methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders by analysis of one or more of the genes Versican, TPEF,...
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US20110275544 |
MICROFLUIDIC INTEGRATION WITH NANOSENSOR PLATFORM
The present invention describes microfluidics being employed to achieve multiplex surface functionalization of nanosensor chips by selectively delivering probe molecules to individual nanosensors...
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US20120122701 |
Methods for Non-Invasive Prenatal Paternity Testing
Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the...
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US20120004115 |
SYSTEM AND METHOD FOR PURIFICATION AND USE OF INORGANIC PYROPHOSPHATASE FROM AQUIFEX AEOLICUS
The present invention provides a nucleic acid that comprises a nucleic acid of SEQ ID NO: 1 or 3 encoding an Aae pyrophosphatase protein, an enzyme protein of SEQ ID NO: 2 or 4, and methods of...
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US20120220474 |
METHODS AND COMPOSITIONS FOR DIAGNOSIS OF THYROID CONDITIONS
The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to genomic DNA markers associated with cancer. In...
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US20120270743 |
Genetic Signatures and Gene Chips Associated With Administration of Electrically Conducted Radio Frequency Current to Skin and Methods and Treatments Relating Thereto
A gene panel comprising genes regulated in mammalian skin in response to generation of a radio frequency current in a tissue volume of the mammalian skin sufficient to heat the tissue volume to a...
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US20110294693 |
Compositions and Methods for Identifying Autism Spectrum Disorders
The compositions and methods described are directed to gene chips having a plurality of different oligonucleotides with specificity for genes associated with autism spectrum disorders. The...
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