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US20120128651 ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) BIOMARKERS  
The present invention concerns the use of biomarkers for acute lymphoblastic leukemia (ALL) to prognose or evaluate a patient with ALL who is Ph+. Methods and compositions are provided that concern...
US20120277999 METHODS, KITS AND ARRAYS FOR SCREENING FOR, PREDICTING AND IDENTIFYING DONORS FOR HEMATOPOIETIC CELL TRANSPLANTATION, AND PREDICTING RISK OF HEMATOPOIETIC CELL TRANSPLANT (HCT) TO INDUCE GRAFT VS. HOST DISEASE (GVHD)  
The invention relates to predicting or determining risk of a hematopoietic cell transplant (HCT) from a donor to induce Graft vs. Host Disease (GVHD) in a HCT recipient; to classifying HCT from a...
US20120172247 Method for measuring glycoprotein, method for examining liver disease, reagent for quantitative determination of glycoprotein, and glycan-marker glycoprotein as an index for clinical conditions of liver disease  
An object of the present invention is to provide a method for measuring a glycan-marker glycoprotein, by which liver disease can be detected with higher accuracy than is possible with conventional...
US20140018258 METHODS FOR GENETIC ANALYSIS  
Methods of treating an individual exhibiting a medical condition are disclosed. The methods involve determining a score of an individual based on the individual's genotypic information, comparing...
US20130296178 METHODS FOR GENETIC ANALYSIS  
Methods of treating an individual exhibiting a medical condition are disclosed. The methods involve determining a score of an individual based on the individual's genotypic information, comparing...
US20110250179 METHODS FOR TREATMENT AND DIAGNOSIS OF CANCER  
The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoK╬▓) activity as well as to methods for the design of ...
US20130090329 Methods and Compositions for the Treatment of Psychotic Disorders Through the Identification of the Olanzapine Poor Response Predictor Genetic Signature  
Methods and compositions relate to genetic markers of psychotic disorders, e.g., schizophrenia (SZ), are provided. For example, in certain aspects methods for determinations of a OPRP genetic...
US20110008914 Biomarkers for the Diagnosis and Treatment of Pancreatic Cancer  
Compositions and methods which indicate an increased risk for pancreatic carcinoma are disclosed.
US20130157895 TISSUE STAINING METHOD, TISSUE EVALUATION METHOD AND BIOSUBSTANCE DETECTION METHOD  
A tissue staining method which comprises: staining a tissue with a staining reagent wherein a biosubstance recognition site is bonded to particles carrying multiple fluorescent substances...
US20120269802 Treatment And Prognosis With Thalidomide In Multiple Myeloma Based on Karyotyping And Gene Expression Profiling  
The present invention provides a method treating a myeloma patient by administering one or more of thalidomide, a Total Therapy 2 regimen, an interleukin-6 signaling suppressor, an interleukin-6R...
US20140206563 BIOMARKERS FOR PSORIASIS  
A group of polypeptides that are modulated in a psoriatic sample as compared to a normal sample is provided. These polypeptides can be used as biomarkers for diagnosis and monitoring treatment of...
US20130303389 METHOD OF CLASSIFYING GENE EXPRESSION STRENGTH IN LUNG CANCER TISSUES  
The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the...
US20110059016 OPTICAL ASSAY SYSTEM WITH A MULTI-PROBE IMAGING ARRAY  
The subject matter described herein relates to an optical assay system having a multi-probe imaging array that orients a plurality of probes with respect to one another and to a sample. According...
US20130217600 METHODS OF DETERMINING EFFICACY OF TREATMENTS OF DISEASES OF THE BOWEL  
Novel methods of determining efficacy of a treatment of inflammatory diseases of the bowel in mammals are provided. The methods are of use in screening and determining the efficacy of treatments of...
US20110152117 METHODS OF DETERMINING EFFICACY OF TREATMENTS OF DISEASES OF THE BOWEL  
Novel methods of determining efficacy of a treatment of inflammatory diseases of the bowel in mammals are provided. The methods are of use in screening and determining the efficacy of treatments of...
US20140141998 NEOPLASIA SCREENING COMPOSITIONS AND METHODS OF USE  
As described in more detail below, the present invention generally features compositions and non-invasive methods useful for the screening, identification, monitoring, or diagnosis of subjects...
US20120046181 Biomarkers for the Diagnosis of Renal Allograft and Kidney Status  
The present invention relates to the identification and use of protein biomarkers with clinical relevance to kidney status and chronic renal injury or disorder. In particular, the invention...
US20110212860 Modulation of Bacterial Quorum Sensing With Synthetic Ligands  
The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for...
US20120142545 SOLID PHASE AND CATALYZED ENABLED AUTOMATED ISOTOPE DILUTION AND SPECIATED ISOTOPE DILUTION MASS SPECTROMETRY  
A method for the equilibration of enriched isotope species and natural isotope species prior to mass spectrometric analysis using solid phase and/or microwave isotope ratio equilibration and...
US20140242092 VHZ FOR DIAGNOSIS AND TREATMENT OF CANCER  
We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer, such as breast cancer, in an individual. We provide an anti-VHZ agent for the treatment, prophylaxis or...
US20120142558 DIAGNOSTIC LUNG CANCER PANEL AND METHODS FOR ITS USE  
Disclosed herein are novel diagnostic lung cancer panels and the use of these panels to diagnose, predict, and characterize lung cancer and to monitor or predict treatment efficacy.
US20120135879 Method and Composition for Cancer Diagnosis and Treatment  
Methods and compositions for inhibiting the onset of cancer, and cancer diagnosis and treatment are provided. The treatment method comprises inhibiting the level or function of transcriptional...
US20130039908 PROGNOSTIC MARKERS AND METHODS FOR PROSTATE CANCER  
The present invention relates to methods and compositions for the diagnosis, prognosis and treatment of neoplastic disorders. Some embodiments include methods, compositions, and kits for the...
US20110189173 PHOSPHORYLATED C-ErbB2 AS A SUPERIOR PREDICTIVE THERANOSTIC MARKER FOR THE DIAGNOSIS AND TREATMENT OF CANCER  
The present invention provides reliable methods to identify subsets of subjects with a cancer of epithelial origin characterized by a high level of phosphorylated c-erbB2 which does not correlate...
US20110039714 Probes, Systems, and Methods for Drug Discovery  
Aspects of the present invention include probes, methods, systems that have stand alone utility and may comprise features of a drug discovery system or method. The present invention also includes...
US20110287961 EXPRESSION ANALYSIS OF CORONARY ARTERY ATHEROSCLEROSIS  
This invention relates, e.g., to a method for screening a subject for the presence of coronary atherosclerosis, said method comprising measuring the expression level of at least 5 of the genes of...
US20130347136 Compositions and Methods for Characterizing and Treating Muscular Dystrophy  
Compositions and methods for identifying new treatments for Facioscapulohumeral muscular dystrophy (FSHD), and uses thereof.
US20140057802 METHOD AND KIT FOR DETERMINING IN VITRO THE PROBABILITY FOR AN INDIVIDUAL TO SUFFER FROM COLORECTAL CANCER  
The present invention provides a method for determining in vitro, in a peripheral blood sample, the probability for an individual to suffer from a colorectal cancer, using the comparison of the...
US20120028836 USE OF PROTEIN SATB2 AS A MARKER FOR COLORECTAL CANCER  
The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for...
US20120208706 OPTIMIZATION OF MULTIGENE ANALYSIS OF TUMOR SAMPLES  
A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample;(b) contacting the library with a bait set to provide selected...
US20130196866 EXPRESSION OF ETS RELATED GENE (ERG) AND PHOSPHATASE AND TENSIN HOMOLOG (PTEN) CORRELATES WITH PROSTATE CANCER CAPSULAR PENETRATION  
The disclosure provides methods for characterizing a prostate cancer sample by detecting expression of ERG, PTEN or both, changes in which relative to a normal control are shown herein to be...
US20140206575 Collection and Methods For Its Use  
The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties...
US20120129717 Collection and Methods For Its Use  
The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties...
US20110136680 TUMOR GRADING AND CANCER PROGNOSIS  
The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to cancer. In particular, the disclosure includes the identities of genes that...
US20130137601 LAMINAR LIBRARY SCREEN  
Described is a method of screening libraries of variant proteins produced in plant leaves using a plant viral vector to identify a gene of interest comprising, inoculating leaves with a library of...
US20130137600 LAMINAR LIBRARY SCREEN  
Described is a method of screening libraries of variant proteins produced in plant leaves using a plant viral vector to identify a gene of interest comprising, inoculating leaves with a library of...
US20110318344 Tumor Treatment  
The patent discloses the use of Hepatocellular Carcinoma Related Protein 1 (HCRP1) as a marker for the efficiency of an anti-EGFR antibody treatment of a tumour patient. If a tumour biopsy sample...
US20120302450 Bacterial Metastructure and Methods of Use  
The present invention provides a method of determining bacterial metastructure by integrating multiple genome-scale information yielded by high-throughput technologies. The metastructure constructs...
US20120004134 Diagnostic Assay For Source of Inflammation  
A method of diagnosing the source of local, acute inflammation has been developed based on the discovery that white cells have different patterns of gene expression, and therefore protein markers,...
US20120004121 Diagnostic Assay For Source of Inflammation  
A method of diagnosing the source of local, acute inflammation has been developed based on the discovery that white cells have different patterns of gene expression, and therefore protein markers,...
US20110201513 PROTEIN SPLICE VARIANT / ISOFORM DISCRIMINATION AND QUANTITATIVE MEASUREMENTS THEREOF  
The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a...
US20120129880 METHOD FOR DETERMINING SENSITIVITY TO IRINOTECAN AND USE THEREOF  
To provide a method for determining the sensitivity of a patient to irinotecan, SN-38, and/or a salt thereof, which method can determine the therapeutic response of the patient and to provide a...
US20110294681 METHODS FOR BREAST CANCER RISK ASSESSMENT  
The present invention relates to methods and systems for assessing the overall risk of a human female subject for developing a breast cancer phenotype. In particular, the present invention relates...
US20100331193 Methods for generating polynucleotides having desired characteristics by iterative selection and recombination  
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are...
US20120094854 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PSYCHOTIC DISORDERS THROUGH THE IDENTIFICATION OF THE OLANZAPINE POOR RESPONSE PREDICTOR GENE SIGNATURE  
Methods and compositions relate to genetic markers of psychotic disorders, e.g., schizophrenia (SZ), are provided. For example, in certain aspects methods for determinations of a OPRP genetic...
US20100298164 STRUCTURE-BASED APPROACH TO DESIGN OF INHIBITORS OF PROTEIN-PROCESSIVITY FACTOR INTERACTIONS  
A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor...
US20130137753 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF BREAST CANCER  
Embodiments of the present disclosure relate to methods and compositions for the diagnosis and treatment of breast cancer. In some embodiments, the present disclosure relates to the use of Merlin,...
US20120302447 MOCK COMMUNITY FOR MEASURING PYROSEQUENCING ACCURACY AND METHOD OF MEASURING PYROSEQUENCING ACCURACY USING THE SAME  
The present invention describes a method of measurement of pyrosequencing accuracy by directly calculating sequence errors from FLX Titanium pyrosequencing using mock community, according to the...
US20130203814 Association of Rare Recurrent Genetic Variations to Attention-Deficit, Hyperactivity Disorder (ADHD) and Methods of Use Thereof for the Diagnosis and Treatment of the Same  
Compositions and methods for the detection and treatment of ADHD are provided.
US20140051585 METHODS AND COMPOSITIONS FOR REDUCING GENETIC LIBRARY CONTAMINATION  
Embodiments include methods, compositions, and kits for creating genetic libraries useful for massively parallel genetic sequencing. Some embodiments are directed to methods of preventing the...