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US20150168412 Methods And Marker Combinations For Screening For Predisposition To Lung Cancer  
The present invention relates to rapid, sensitive methods for determining whether a subject has or is at risk of developing lung cancer based on certain combinations of biomarkers, or biomarkers...
US20150087532 AFFINITY REAGENTS FOR PROTEIN PURIFICATION  
Disclosed herein are methods and compositions for purifying proteins from crude solutions.
US20150167085 Methods and Systems for Analysis of Organ Transplantation  
Disclosed herein are methods of detecting, predicting or monitoring a status or outcome of a transplant in a transplant recipient.
US20150247196 IN VITRO GENETIC DIAGNOSTIC OF INHERITED NEUROMUSCULAR DISORDERS  
The present invention provides a method for determining all the molecular causes of Inherited Neuromuscular Disorders comprising determining a number of copy number variation(s), and/or...
US20130288909 miRNA DETECTION OF PANCREATIC CANCER  
Methods for the diagnosis and/or monitoring of pancreatic cancer by detection of micro-RNAs (miRNA) are provided. In certain embodiments, detection of miR-21, miR-210, miR-155, and/or miR-196a in...
US20150259732 NUCLEIC ACID ANALYSIS KIT AND NUCLEIC ACID ANALYSIS METHOD  
A number of samples provided for analysis are identified correctly by making use of smaller kinds of nucleic acids. Provided is a nucleic acid analysis kit having a plurality of supports that...
US20120329660 METHODS AND COMPOSITIONS FOR SORTING AND/OR DETERMINING ORGANISMS  
This invention is directed to methods and compositions for sorting and/or determining microscopic organisms or cells. The methods and compositions are directed to the use of molecular probes to...
US20120122703 DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE  
The invention relates to novel variants that associate with Alzheimer's disease AD and their use in kits as a means for diagnosing AD; and also their use in nucleic acid molecules or cells/cell...
US20140274747 SUPER RESOLUTION IMAGING  
A detection apparatus that includes (a) an array of responsive pads on a substrate surface; (b) an array of pixels, wherein each pixel in the array has a detection zone on the surface that...
US20140274746 SUPER RESOLUTION IMAGING  
A detection apparatus that includes (a) an array of responsive pads on a substrate surface; (b) an array of pixels, wherein each pixel in the array has a detection zone on the surface that...
US20150099645 MEANS AND METHODS FOR DIAGNOSTICS AND THERAPEUTICS OF DISEASES  
The present invention discloses a method of detecting T-cell proliferation in a subject comprising the steps of (a) obtaining a sample from said subject; and (b) profiling at least one parameter...
US20150159196 COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING  
Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant...
US20110319274 Identification of Compounds Modifying a Cellular Response  
The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of...
US20150067923 Transgenic Plants And A Transient Transformation System For Genome-Wide Transcription Factor Target Discovery  
Plant genes regulated by transcription factors that control the gene network response to an environmental perturbation or signal are described. This class of genes responds to the perturbation of...
US20150038345 Random Array DNA Analysis by Hybridization  
The invention relates to methods and devices for analyzing single molecules, i.e., nucleic acids. Such single molecules may be derived from natural samples, such as cells, tissues, soil, air and...
US20150119350 DNA METHYLATION ANALYSIS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF ADRENAL NEOPLASMS  
Disclosed herein are methods for detecting, diagnosing and/or prognosing a malignant adrenocortical tumor. Also disclosed are methods of treating a malignant adrenocortical tumor, such as ACC. In...
US20150240301 METHODS AND COMPOSITIONS RELATING TO NEXT GENERATION SEQUENCING FOR GENETIC TESTING IN ALK RELATED CANCERS  
Disclosed are methods, assays, and compositions for detecting the presence of a kinase inhibitor resistance. The disclosed method and primer panels work with any method for detecting nucleic acid...
US20120258869 Method for Sequencing a Polynucelotide Template  
Improved compositions, methods, apparatus, and kits for high-throughput nucleic acid amplification, detection and sequencing are disclosed. A nucleic acid cluster having an identifiable center is...
US20120015824 Method For Diagnosing Allergic Reactions  
The invention provides a method for multiple cytokine detection from single cells for the purpose of generating immunological profiles of diseases.
US20110245086 SHORT CYCLE METHODS FOR SEQUENCING POLYNUCLEOTIDES  
The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion.
US20150141269 HYBRIDIZATION-BASED REPLICATION OF NUCLEIC ACID MOLECULES  
The present invention provides methods for replication of nucleic acid molecules distributed on a surface or within a layer by transferring them to a target surface covered with oligonucleotides,...
US20150260681 DIP-STICK WESTERN BLOT  
Methods, kits, and systems are provided for separating, immobilizing, and/or detecting analytes of one or more samples using dipsticks. A ‘dipstick’ is an object that can be embedded and...
US20150225787 METHODS FOR SEQUENCING POLYNUCLEOTIDES  
Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first...
US20120258868 Capturing sequences adjacent to type IIs restriction sites for genomic library mapping  
The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result...
US20120108443 Dual polarity analysis of nucleic acids  
This invention provides methods for characterizing the amounts of nucleic acids, including plus/minus determinations, the use of different constructs, the use of a library and a reference library....
US20110172106 Detection of Interactions Between Lipid Complexes and Lipid Binding Agents  
The invention relates to materials and methods for detecting interactions between lipid complexes and lipid binding agents. More specifically, the invention provides materials and methods for...
US20150148239 SPATIAL MOLECULAR BARCODING OF IN SITU NUCLEIC ACIDS  
This disclosure provides, among other things, a method for analyzing a planar cellular sample. In some embodiments, the method comprises: (a) indirectly or directly attaching nucleic acid tags to...
US20090118129 VIRTUAL READS FOR READLENGTH ENHANCEMENT  
Methods arrays and systems that facilitate contig assembly during nucleic acid sequencing are provided. Geographical locations of analyte molecules on an array are correlated with subsequence...
US20080132417 Molecular Basis For The Identification Of Chemotherapy Resistance In Human Tumors And The Treatment Thereof  
Provided are compositions and methods for determining whether a tumor in a subject is sensitive or resistant to a chemotherapeutic agent. Further provided are methods and compositions for...
US20080214403 Parallel Methods For Insertional Mutagenesis  
The present invention provides parallel methods for identifying the locations of insertion elements that are distributed at different sites in the genome among a collection of cells.
US20110251074 METHOD FOR IDENTIFYING HLA COMPLEXES ASSOCIATED WITH ADVERSE DRUG REACTIONS  
A method for identifying from an HLA library an HLA complex that specifically binds to a compound. This method can be relied on to assess whether a compound is likely to induce an adverse drug...
US20050118617 Methods employing combinatorial artificial receptors  
The present invention relates to methods employing artificial receptors, such as combinatorial artificial receptor arrays. The present receptors include heterogeneous and immobilized combinations...
US20050069901 Method for detecting microbial antibiotic resistance  
The present invention provides methods for detecting a micro-organism in a biological sample and simultaneously determining its resistance to antibiotics. The methods utilize micro-arrays to...
US20090156412 SURFACE-CAPTURE OF TARGET NUCLEIC ACIDS  
The disclosure provides methods of capturing target nucleic acids (e.g., gene or gene fragments) onto a solid support for further analysis. The disclosed methods utilize a capture probe that...
US20140100123 MICROVESSELS, MICROPARTICLES, AND METHODS OF MANUFACTURING AND USING THE SAME  
A plurality of isolated microvessels including a plurality of encoded microvessels each having a microbody and a reservoir core. The microbody is configured to separate a biological or chemical...
US20070281863 Dual polarity analysis of nucleic acids  
This invention provides methods for characterizing the amounts of nucleic acids, including plus/minus determinations, the use of different constructs, the use of a library and a reference library....
US20150217257 Flow Cell Array and Uses Thereof  
Apparatus and methods for using a flow cell array are provided herein. An apparatus includes an array comprising one or more pixels, wherein each of the one or more pixels comprises multiple...
US20080269063 METHOD AND SYSTEM FOR PREPARING A MICROARRAY FOR A DISEASE ASSOCIATION GENE TRANSCRIPT TEST  
System and method for preparing a microarray for a disease association gene transcript test. Disease considerations for this unique test include a custom set of genetic sequences associated in...
US20150260616 Devices for Automated Sample Collection, Quantificatoin, and Detection for Insect Borne Bio-Agent Surveillance  
Devices and methods for insect surveillance are disclosed. In particular, the invention relates to devices for collecting samples of salivary fluid from insects and multiplexed high-throughput...
US20080312090 Combinatorial Processing Including Stirring  
Combinatorial processing including stirring is described, including defining multiple regions of a substrate, processing the multiple regions of the substrate in a combinatorial manner,...
US20140066318 METHOD AND PRODUCT FOR LOCALIZED OR SPATIAL DETECTION OF NUCLEIC ACID IN A TISSUE SAMPLE  
The present invention relates to methods and products for the localized or spatial detection of nucleic acid in a tissue sample and in particular to a method for localized detection of nucleic...
US20150005178 INTEGRATED COMPOUND DISCOVERY SYSTEMS AND METHODS  
Methods, systems, devices and apparatus for use in screening and/or selecting a library of nucleic acid molecules and/or nucleic acid tagged or encoded molecules for binding to or interaction with...
US20130345072 METHOD OF DESIGNING ADDRESSABLE ARRAY SUITABLE FOR DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING LIGASE DETECTION REACTION  
The present invention is directed to a method of designing a plurality of capture oligonucleotide probes for use on a support to which complementary oligonucleotide probes will hybridize with...
US20100204050 TARGET PREPARATION FOR PARALLEL SEQUENCING OF COMPLEX GENOMES  
The present invention provides a method for the isolation and analysis of a target nucleic acid, the target nucleic acid being present in a sample of genomic DNA, comprising the steps of a)...
US20150080231 METHOD AND SYSTEM FOR ACCURATE ALIGNMENT AND REGISTRATION OF ARRAY FOR DNA SEQUENCING  
In a genome sequencing system and methodology, a protocol is provided to achieve precise alignment and accurate registration of an image of a planar array of nanoballs subject to optical analysis....
US20090299130 METHODS AND COMPOSITIONS FOR IMPROVED FERTILIZATION AND EMBRYONIC SURVIAL  
Single nucleotide polymorphic site at position 11646 of the bovine FGF2 gene is associated with improved fertilization rate and/or improved embryo survival rate, as well as improved milk...
US20080139395 Microarray and Spotting Apparatus  
A microarray disc characterized in that a substrate is provided with a pregroove and a thin film with an excellent adherence to a probe DNA or protein is disposed at least on the pregroove, and...
US20080207460 Determination of methylation of nucleic acid sequences  
The invention relates to a method of detecting the precise locations of methyl-cytosines in a given nucleic acid sequence. In particular, the invention features a method which includes sequencing...
US20050042623 Systems for capture and analysis of biological particles and methods using the systems  
Cell based methods designed to assess intracellular and extracellular activities and interactions and to identify compounds and conditions that modulate such activities and interactions are...
US20100099574 METHODS OF IDENTIFYING AN ANALYTE AND NUCLEIC ACID ANALYSIS  
A method of identifying an analyte. The method includes providing a plurality of microparticles. The microparticles have optically detectable codes extending along bodies of the corresponding...

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